Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine

The intestinal microbiota is involved in the pathogenesis of arthritis. Altered microbiota composition has been demonstrated in patients with rheumatoid arthritis (RA). However, it remains unclear how dysbiosis contributes to the development of arthritis. The aim of this study was to investigate whether altered composition of human intestinal microbiota in RA patients contributes to the development of arthritis.

[1]  S. Hazen,et al.  Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis , 2015, Cell.

[2]  F. Bäckhed,et al.  Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella. , 2015, Cell metabolism.

[3]  K. Honda,et al.  Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site. , 2015, Immunity.

[4]  Qiang Feng,et al.  The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment , 2015, Nature Medicine.

[5]  Kousuke Tashiro,et al.  Diversity in gut bacterial community of school-age children in Asia , 2015, Scientific Reports.

[6]  T. Nomura,et al.  Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease , 2014, Science.

[7]  Toshio Tanaka,et al.  IL-6 in inflammation, immunity, and disease. , 2014, Cold Spring Harbor perspectives in biology.

[8]  D. Aguirre de Cárcer,et al.  ZAP‐70 Genotype Disrupts the Relationship Between Microbiota and Host, Leading to Spondyloarthritis and Ileitis in SKG Mice , 2014, Arthritis & rheumatology.

[9]  Krzysztof Lis,et al.  TNF inhibitors — Mechanisms of action, approved and off-label indications , 2014, Pharmacological reports : PR.

[10]  M. Brown,et al.  Interleukin‐23 Mediates the Intestinal Response to Microbial β‐1,3‐Glucan and the Development of Spondyloarthritis Pathology in SKG Mice , 2014, Arthritis & rheumatology.

[11]  Y. Belkaid,et al.  Role of the Microbiota in Immunity and Inflammation , 2014, Cell.

[12]  Jun S. Liu,et al.  Genetics of rheumatoid arthritis contributes to biology and drug discovery , 2013 .

[13]  C. Huttenhower,et al.  Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis , 2013, eLife.

[14]  A. Zarzuelo,et al.  Minocycline: far beyond an antibiotic , 2013, British journal of pharmacology.

[15]  E. Zoetendal,et al.  Duodenal infusion of donor feces for recurrent Clostridium difficile. , 2013, The New England journal of medicine.

[16]  Pelin Yilmaz,et al.  The SILVA ribosomal RNA gene database project: improved data processing and web-based tools , 2012, Nucleic Acids Res..

[17]  M. Brown,et al.  β-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice. , 2012, Arthritis and rheumatism.

[18]  David A. Relman,et al.  Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota , 2012, Cell.

[19]  A. Macpherson,et al.  Interactions Between the Microbiota and the Immune System , 2012, Science.

[20]  E. Pamer,et al.  Role of the commensal microbiota in normal and pathogenic host immune responses. , 2011, Cell host & microbe.

[21]  F. Bushman,et al.  Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes , 2011, Science.

[22]  Vineet K. Sharma,et al.  Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of th17 cell differentiation. , 2011, Cell host & microbe.

[23]  P. Bork,et al.  Enterotypes of the human gut microbiome , 2011, Nature.

[24]  Robert C. Edgar,et al.  Search and clustering orders of magnitude faster than BLAST , 2010, Bioinform..

[25]  A. Silman,et al.  UvA-DARE (Digital Academic Repository) 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative Aletaha, , 2010 .

[26]  S. Massart,et al.  Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa , 2010, Proceedings of the National Academy of Sciences.

[27]  Christophe Benoist,et al.  Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. , 2010, Immunity.

[28]  Jing Cui,et al.  Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci , 2010, Nature Genetics.

[29]  Kazumasa Matsumoto,et al.  Establishment of an Analytical System for the Human Fecal Microbiota, Based on Reverse Transcription-Quantitative PCR Targeting of Multicopy rRNA Molecules , 2009, Applied and Environmental Microbiology.

[30]  Masahiro Yamamoto,et al.  ATP drives lamina propria TH17 cell differentiation , 2008, Nature.

[31]  P. Toivanen,et al.  Fecal microbiota in early rheumatoid arthritis. , 2008, The Journal of rheumatology.

[32]  Anders F. Andersson,et al.  Comparative Analysis of Human Gut Microbiota by Barcoded Pyrosequencing , 2008, PloS one.

[33]  L. Joosten,et al.  Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. , 2008, The Journal of clinical investigation.

[34]  B. Pulendran,et al.  Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses , 2007, Nature Immunology.

[35]  A. Koch.  The pathogenesis of rheumatoid arthritis. , 2007, American journal of orthopedics.

[36]  Satoshi Tanaka,et al.  T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis , 2007, The Journal of experimental medicine.

[37]  T. Kato,et al.  The effects of tetracycline, minocycline, doxycycline and ofloxacin on Prevotella intermedia biofilm. , 2006, Oral microbiology and immunology.

[38]  James R. Cole,et al.  The ribosomal database project (RDP-II): introducing myRDP space and quality controlled public data , 2006, Nucleic Acids Res..

[39]  J. Fujimoto,et al.  Quantitative PCR with 16S rRNA-Gene-Targeted Species-Specific Primers for Analysis of Human Intestinal Bifidobacteria , 2004, Applied and Environmental Microbiology.

[40]  T. Nomura,et al.  Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice , 2003, Nature.

[41]  J. Fujimoto,et al.  Development of 16S rRNA-Gene-Targeted Group-Specific Primers for the Detection and Identification of Predominant Bacteria in Human Feces , 2002, Applied and Environmental Microbiology.

[42]  J. O'dell,et al.  Treatment of early seropositive rheumatoid arthritis: a two-year, double-blind comparison of minocycline and hydroxychloroquine. , 2001, Arthritis and rheumatism.

[43]  S. Pillemer,et al.  Minocycline in Rheumatoid Arthritis: A 48-Week, Double-Blind, Placebo-Controlled Trial , 1995, Annals of Internal Medicine.

[44]  R. Hammer,et al.  The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats , 1994, The Journal of experimental medicine.

[45]  K. Kornman,et al.  Clinical and microbiological effects of controlled-release locally delivered minocycline in periodontitis. , 1994, Journal of periodontology.

[46]  D. van Steenberghe,et al.  Subgingival minocycline hydrochloride ointment in moderate to severe chronic adult periodontitis: a randomized, double-blind, vehicle-controlled, multicenter study. , 1993, Journal of periodontology.

[47]  F. Epstein,et al.  Rheumatoid arthritis. Pathophysiology and implications for therapy. , 1990, The New England journal of medicine.

[48]  吉富 啓之.  A role for fungal β-glucans and their receptor dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice , 2005 .