TGF-beta and fibrosis in different organs - molecular pathway imprints.

[1]  R. Kizek,et al.  Matrix metalloproteinases. , 2010, Current medicinal chemistry.

[2]  L. Cosmi,et al.  TGF‐β indirectly favors the development of human Th17 cells by inhibiting Th1 cells , 2009, European journal of immunology.

[3]  Yunliang Chen,et al.  Requirement of transforming growth factor beta-activated kinase 1 for transforming growth factor beta-induced alpha-smooth muscle actin expression and extracellular matrix contraction in fibroblasts. , 2009, Arthritis and rheumatism.

[4]  B. Hinz,et al.  Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship. , 2008, European journal of cell biology.

[5]  R. Flavell,et al.  TGF-β: A Master of All T Cell Trades , 2008, Cell.

[6]  Lars Rogge,et al.  Faculty Opinions recommendation of IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. , 2008 .

[7]  E. Buchdunger,et al.  Imatinib mesylate attenuates fibrosis in coxsackievirus b3-induced chronic myocarditis. , 2008, Cardiovascular research.

[8]  E. Barillot,et al.  A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses , 2008, Nature Immunology.

[9]  Gerard C Blobe,et al.  Role of transforming growth factor-beta superfamily signaling pathways in human disease. , 2008, Biochimica et biophysica acta.

[10]  You-yi Zhang,et al.  UNDERSTANDING THE ROLE OF TRANSFORMING GROWTH FACTOR‐β SIGNALLING IN THE HEART: OVERVIEW OF STUDIES USING GENETIC MOUSE MODELS , 2008, Clinical and experimental pharmacology & physiology.

[11]  Vijay G Divakaran,et al.  Transforming growth factor-beta receptor antagonism attenuates myocardial fibrosis in mice with cardiac-restricted overexpression of tumor necrosis factor. , 2008, Basic research in cardiology.

[12]  H. You,et al.  The type III TGF-beta receptor signals through both Smad3 and the p38 MAP kinase pathways to contribute to inhibition of cell proliferation. , 2007, Carcinogenesis.

[13]  J. Pichler,et al.  Inhibition of TGF-β2 with AP 12009 in Recurrent Malignant Gliomas: From Preclinical to Phase I/II Studies , 2007 .

[14]  G. Parmigiani,et al.  Genome‐wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: Insights into distinctive pathogenesis , 2007, Inflammatory bowel diseases.

[15]  T. Wilhelm,et al.  Constitutive upregulation of the transforming growth factor-β pathway in rheumatoid arthritis synovial fibroblasts , 2007, Arthritis research & therapy.

[16]  Yunliang Chen,et al.  FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype. , 2007, Molecular biology of the cell.

[17]  Juswinder Singh,et al.  A Novel Small-Molecule Inhibitor of Transforming Growth Factor β Type I Receptor Kinase (SM16) Inhibits Murine Mesothelioma Tumor Growth In vivo and Prevents Tumor Recurrence after Surgical Resection , 2007 .

[18]  Stefano Piccolo,et al.  Integration of TGF-ß and Ras/MAPK Signaling Through p53 Phosphorylation , 2007, Science.

[19]  R. Katoh,et al.  TGF-beta type I receptor kinase inhibitor down-regulates rheumatoid synoviocytes and prevents the arthritis induced by type II collagen antibody. , 2006, International immunology.

[20]  Stefano Piccolo,et al.  Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation. , 2007, Science.

[21]  John Powell,et al.  Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. , 2007, Arthritis and rheumatism.

[22]  Vijay G Divakaran,et al.  Transforming growth factor-β receptor antagonism attenuates myocardial fibrosis in mice with cardiac-restricted overexpression of tumor necrosis factor , 2007, Basic Research in Cardiology.

[23]  R. Hernández-Pando,et al.  Soluble betaglycan reduces renal damage progression in db/db mice. , 2007, American journal of physiology. Renal physiology.

[24]  Juswinder Singh,et al.  A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection. , 2007, Cancer research.

[25]  N. Senzer,et al.  Phase II study of belagenpumatucel-L, a transforming growth factor beta-2 antisense gene-modified allogeneic tumor cell vaccine in non-small-cell lung cancer. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[26]  F. M. Thomas,et al.  Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis. , 2006, The Journal of clinical investigation.

[27]  F. Powrie,et al.  Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation , 2006, Immunological reviews.

[28]  J. Cañete,et al.  Synovial vascular patterns and angiogenic factors expression in synovial tissue and serum of patients with rheumatoid arthritis. , 2006, Rheumatology.

[29]  H. Weiner,et al.  Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells , 2006, Nature.

[30]  D. Goumenos,et al.  Accurate Measurement and Clinical Significance of Urinary Transforming Growth Factor-Beta1 , 2006, American Journal of Nephrology.

[31]  B. Maisch,et al.  Myokardfibrose: ein kardiopathophysiologischer Januskopf , 2006, Herz Kardiovaskuläre Erkrankungen.

[32]  L. Mishra,et al.  Transforming growth factor-beta and wound healing. , 2006, Perspectives in vascular surgery and endovascular therapy.

[33]  R. J. Hocking,et al.  TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. , 2006, Immunity.

[34]  J. Reichen,et al.  Oral imatinib treatment reduces early fibrogenesis but does not prevent progression in the long term. , 2006, Journal of hepatology.

[35]  F. Rödel,et al.  Plasminogen activator inhibitor-I-related regulation of procollagen I (α1 and α2) by antitransforming growth factor-β1 treatment during radiation-impaired wound healing , 2006 .

[36]  B. Maisch,et al.  [Myocardial fibrosis: a cardiopathophysiologic Janus head]. , 2006, Herz.

[37]  R. D. Hatton,et al.  Transforming growth factor-beta induces development of the T(H)17 lineage. , 2006, Nature.

[38]  F. Rödel,et al.  Plasminogen activator inhibitor-I-related regulation of procollagen I (alpha1 and alpha2) by antitransforming growth factor-beta1 treatment during radiation-impaired wound healing. , 2006, International journal of radiation oncology, biology, physics.

[39]  J. Doré,et al.  Transforming Growth Factor-B Activation of Phosphatidylinositol 3-Kinase Is Independent of Smad 2 and Smad 3 and Regulates Fibroblast Responses via p 21-Activated Kinase-2 , 2005 .

[40]  K. Pietras,et al.  Platelet-Derived Growth Factor D Induces Cardiac Fibrosis and Proliferation of Vascular Smooth Muscle Cells in Heart-Specific Transgenic Mice , 2005, Circulation research.

[41]  B. Weston,et al.  Glomerular expression of thrombospondin-1, transforming growth factor beta and connective tissue growth factor at different stages of diabetic nephropathy and their interdependent roles in mesangial response to diabetic stimuli , 2005, Diabetologia.

[42]  G. Federici,et al.  Post-transcriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease. , 2005, Gastroenterology.

[43]  W. Ju,et al.  TGF-beta concentration specifies differential signaling profiles of growth arrest/differentiation and apoptosis in podocytes. , 2005, Journal of the American Society of Nephrology : JASN.

[44]  B. Maisch,et al.  Inflammatory Dilated Cardiomyopathy (DCMI) , 2005, Herz Kardiovaskuläre Erkrankungen.

[45]  M. Entman,et al.  Critical Role of Endogenous Thrombospondin-1 in Preventing Expansion of Healing Myocardial Infarcts , 2005, Circulation.

[46]  S. Sone,et al.  Imatinib as a novel antifibrotic agent in bleomycin-induced pulmonary fibrosis in mice. , 2005, American journal of respiratory and critical care medicine.

[47]  G. Wolf,et al.  From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy. , 2005, Diabetes.

[48]  H. Kosmehl,et al.  Elevated expression of PDGF-C in coxsackievirus B3-induced chronic myocarditis. , 2005, European heart journal.

[49]  S. Wahl,et al.  Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases , 2005, Arthritis research & therapy.

[50]  E. Leof,et al.  The FASEB Journal • Research Communication Imatinib mesylate blocks a non-Smad TGF- � pathway and reduces renal fibrogenesis in vivo , 2022 .

[51]  A. Nakao,et al.  Activation of the Smad Pathway in Glomeruli from a Spontaneously Diabetic Rat Model, OLETF Rats , 2004, Nephron Experimental Nephrology.

[52]  P. Doevendans,et al.  Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction , 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

[53]  C. Daniels,et al.  Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis. , 2004, The Journal of clinical investigation.

[54]  A. Shaw,et al.  A Novel Role for the Adaptor Molecule CD2-associated Protein in Transforming Growth Factor-β-induced Apoptosis* , 2004, Journal of Biological Chemistry.

[55]  K. Wary,et al.  Transforming growth factor β regulates cell–cell adhesion through extracellular matrix remodeling and activation of focal adhesion kinase in human colon carcinoma Moser cells , 2004, Oncogene.

[56]  N. Pallua,et al.  Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinases, Aminoterminal Propeptide of Procollagen Type III, and Hyaluronan in Sera and Tissue of Patients with Capsular Contracture after Augmentation with Trilucent Breast Implants , 2004, Plastic and reconstructive surgery.

[57]  Andrew Leask,et al.  TGF‐β signaling and the fibrotic response , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[58]  A. Woods,et al.  Syndecan-2 Regulates Transforming Growth Factor-β Signaling* , 2004, Journal of Biological Chemistry.

[59]  K. Luo,et al.  Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis , 2004, Nature Cell Biology.

[60]  L. Spagnoli,et al.  Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection. , 2004, Gastroenterology.

[61]  H. Rodemann,et al.  Smad-3 and Smad-7 expression following anti-transforming growth factor beta 1 (TGFbeta1)-treatment in irradiated rat tissue. , 2004, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[62]  K. Flanders,et al.  Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury. , 2004, The American journal of pathology.

[63]  J. Kriegsmann,et al.  Susceptibility to collagen-induced arthritis is modulated by TGFβ responsiveness of T cells , 2004, Arthritis research & therapy.

[64]  Jm Lee,et al.  TGF-ß1 polymorphism determines the progression of joint damage in rheumatoid arthritis , 2004 .

[65]  M. Satoh,et al.  Expression of cytokine genes and presence of enteroviral genomic RNA in endomyocardial biopsy tissues of myocarditis and dilated cardiomyopathy , 1996, Virchows Archiv.

[66]  A. Woods,et al.  Syndecan-2 regulates transforming growth factor-beta signaling. , 2004, The Journal of biological chemistry.

[67]  D. Chopin,et al.  Epithelial Cell Plasticity in Development and Tumor Progression , 2004, Cancer and Metastasis Reviews.

[68]  J. Massagué Integration of Smad and MAPK pathways: a link and a linker revisited. , 2003, Genes & development.

[69]  R. Kalluri,et al.  Epithelial-mesenchymal transition and its implications for fibrosis. , 2003, The Journal of clinical investigation.

[70]  A. Roberts,et al.  Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. , 2003, The Journal of clinical investigation.

[71]  T. Sjöblom,et al.  Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy. , 2003, The American journal of pathology.

[72]  P. Khaw,et al.  Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery. , 2003, Investigative ophthalmology & visual science.

[73]  F. Rödel,et al.  Transforming growth factor‐β receptor‐II up‐regulation during wound healing in previously irradiated graft beds in vivo , 2003, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[74]  J. Massagué,et al.  Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus , 2003, Cell.

[75]  F. Rödel,et al.  In Vivo TGF-β3 Expression during Wound Healing in Irradiated Tissue , 2003, Strahlentherapie und Onkologie.

[76]  Gábor Sirokmány,et al.  Central role for Rho in TGF-β1-induced α-smooth muscle actin expression during epithelial-mesenchymal transition , 2003 .

[77]  R. Day,et al.  Myofibroblast Differentiation by Transforming Growth Factor-β1 Is Dependent on Cell Adhesion and Integrin Signaling via Focal Adhesion Kinase* , 2003, The Journal of Biological Chemistry.

[78]  E. Lechman,et al.  Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees , 2003, Arthritis research & therapy.

[79]  A. Bruu,et al.  Enteroviruses: Polioviruses, Coxsackieviruses, Echoviruses and Newer Enteroviruses , 2003 .

[80]  Justin P. Annes,et al.  Making sense of latent TGFβ activation , 2003, Journal of Cell Science.

[81]  Gábor Sirokmány,et al.  Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition. , 2003, American journal of physiology. Renal physiology.

[82]  J. Massagué,et al.  Mechanisms of TGF-beta signaling from cell membrane to the nucleus. , 2003, Cell.

[83]  F. Rödel,et al.  In Vivo TGF-beta 3 expression during wound healing in irradiated tissue. An experimental study. , 2003, Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al].

[84]  D. Rifkin,et al.  Making sense of latent TGFbeta activation. , 2003, Journal of cell science.

[85]  R. Derynck,et al.  Smad-dependent and Smad-independent pathways in TGF-beta family signalling. , 2003, Nature.

[86]  G. Remuzzi,et al.  Transforming Growth Factor- (cid:1) 1 Is Up-Regulated by Podocytes in Response to Excess Intraglomerular Passage of Proteins A Central Pathway in Progressive Glomerulosclerosis , 2022 .

[87]  E. Bottinger,et al.  Inhibitory Smads and TGF-β Signaling in Glomerular Cells , 2002 .

[88]  S. Hong,et al.  Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-beta-induced fibronectin in mesangial cells. , 2002, Biochemical and biophysical research communications.

[89]  G. Berx,et al.  Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells , 2002, Oncogene.

[90]  H. Kosmehl,et al.  Fibronectin Splice Variants – Prognostic Markers for the Stage of Renal Interstitial Fibrosis in the Rat , 2002, Nephron.

[91]  S. Rosenkranz,et al.  Alterations of β-adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-β1 , 2002 .

[92]  C. Arteaga,et al.  Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases , 2002 .

[93]  Richard A. Flavell,et al.  Mechanism of Transforming Growth Factor β–induced Inhibition of T Helper Type 1 Differentiation , 2002, The Journal of experimental medicine.

[94]  Matthias Boehm,et al.  Myocardial fibrosis in transforming growth factor‐β1 (TGF‐β1) transgenic mice is associated with inhibition of interstitial collagenase , 2002 .

[95]  D. Sheppard,et al.  The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1 , 2002, The Journal of cell biology.

[96]  J. Sohn,et al.  Increased expression of pro‐inflammatory cytokines and metalloproteinase‐1 by TGF‐β1 in synovial fibroblasts from rheumatoid arthritis and normal individuals , 2002, Clinical and experimental immunology.

[97]  C. Heldin,et al.  New members of the platelet-derived growth factor family of mitogens. , 2002, Archives of biochemistry and biophysics.

[98]  R. Maki,et al.  References Subscriptions Permissions Email Alerts Expression and Regulation of Aggrecanase in Arthritis: The Role of TGF- β , 2013 .

[99]  F. Neukam,et al.  Transforming growth factor ß1 and ß2 (TGFβ2 / TGFβ2) profile changes in previously irradiated free flap beds , 2002 .

[100]  F. Neukam,et al.  Vascularization in the transition area between free grafted soft tissues and pre‐irradiated graft bed tissues following preoperative radiotherapy in the head and neck region , 2002, Head & neck.

[101]  R. Flavell,et al.  Mechanism of Transforming Growth Factor (cid:2) –induced Inhibition of T Helper Type 1 Differentiation , 2002 .

[102]  A. Shaw,et al.  Inhibitory smads and tgf-Beta signaling in glomerular cells. , 2002, Journal of the American Society of Nephrology : JASN.

[103]  P. Tighe,et al.  Differential expression of TGF-beta isoforms by normal and inflammatory bowel disease intestinal myofibroblasts. , 2002, American journal of physiology. Cell physiology.

[104]  S. Rosenkranz,et al.  Alterations of beta-adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-beta(1). , 2002, American journal of physiology. Heart and circulatory physiology.

[105]  S. Rosenkranz,et al.  Myocardial fibrosis in transforming growth factor-beta(1) (TGF-beta(1)) transgenic mice is associated with inhibition of interstitial collagenase. , 2002, European journal of clinical investigation.

[106]  F. Neukam,et al.  Transforming growth factor beta1 and beta2 (TGFbeta2 / TGFbeta2) profile changes in previously irradiated free flap beds. , 2002, Head & neck.

[107]  R. Maki,et al.  Expression and regulation of aggrecanase in arthritis: the role of TGF-beta. , 2002, Journal of immunology.

[108]  C. Arteaga,et al.  Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. , 2002, The Journal of clinical investigation.

[109]  M. Korc,et al.  Soluble type II transforming growth factor-beta receptor attenuates expression of metastasis-associated genes and suppresses pancreatic cancer cell metastasis. , 2002, Molecular cancer therapeutics.

[110]  F. Ohsuzu,et al.  Myocardial hypertrophy in transgenic mice overexpressing human interleukin 1alpha. , 2001, Journal of cardiac failure.

[111]  D. Gemsa,et al.  Persistent expression of cytokines in the chronic stage of CVB3-induced myocarditis in NMRI mice. , 2001, Journal of molecular and cellular cardiology.

[112]  T. Macdonald,et al.  Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease. , 2001, The Journal of clinical investigation.

[113]  C. Fiocchi,et al.  TGF-beta/Smad signaling defects in inflammatory bowel disease: mechanisms and possible novel therapies for chronic inflammation. , 2001, The Journal of clinical investigation.

[114]  S. Markowitz,et al.  Loss of transforming growth factor β signalling in the intestine contributes to tissue injury in inflammatory bowel disease , 2001, Gut.

[115]  H. Sheng,et al.  Transforming Growth Factor-β1 Promotes Invasiveness after Cellular Transformation with Activated Ras in Intestinal Epithelial Cells , 2001 .

[116]  L. Andréoletti,et al.  Detection of enteroviruses ribonucleic acid sequences in endomyocardial tissue from adult patients with chronic dilated cardiomyopathy by a rapid RT‐PCR and hybridization assay , 2001, Journal of medical virology.

[117]  A. M. Arias Epithelial Mesenchymal Interactions in Cancer and Development , 2001, Cell.

[118]  T. Seufferlein,et al.  Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation. , 2001, Cancer research.

[119]  M. Isono,et al.  Increased Glomerular and Tubular Expression of Transforming Growth Factor-β1, Its Type II Receptor, and Activation of the Smad Signaling Pathway in the db/db Mouse , 2001 .

[120]  Serhiy Souchelnytskyi,et al.  Regulation of Smad signaling by protein kinase C , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[121]  K. Klingel,et al.  Cardioselective Infection With Coxsackievirus B3 Requires Intact Type I Interferon Signaling: Implications for Mortality and Early Viral Replication , 2001, Circulation.

[122]  I. Lawrance,et al.  Inflammation Location, But Not Type, Determines the Increase in TGF-&bgr;1 and IGF-1 Expression and Collagen Deposition in IBD Intestine , 2001, Inflammatory bowel diseases.

[123]  J. Massagué,et al.  Smad Transcriptional Corepressors in TGFβ Family Signaling , 2001 .

[124]  J. Massagué,et al.  Smad transcriptional corepressors in TGF beta family signaling. , 2001, Current topics in microbiology and immunology.

[125]  H. Moses,et al.  Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. , 2001, Molecular biology of the cell.

[126]  A. Schulze,et al.  Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. , 2000, Genes & development.

[127]  J. Pucilowska,et al.  Fibrogenesis. IV. Fibrosis and inflammatory bowel disease: cellular mediators and animal models. , 2000, American journal of physiology. Gastrointestinal and liver physiology.

[128]  D. Gemsa,et al.  Cytokine profiles in heart, spleen, and thymus during the acute stage of experimental coxsackievirus B3‐induced chronic myocarditis , 2000, Journal of medical virology.

[129]  K. Sharma,et al.  Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[130]  J. Malm,et al.  Increased presence of eosinophilic granulocytes expressing transforming growth factor-beta1 in collagenous colitis , 2000 .

[131]  H. Lodish,et al.  Role of transforming growth factor beta in human disease. , 2000, The New England journal of medicine.

[132]  M. Isono,et al.  Stimulation of TGF-beta type II receptor by high glucose in mouse mesangial cells and in diabetic kidney. , 2000, American journal of physiology. Renal physiology.

[133]  M. Martin,et al.  TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target? , 2000, International journal of radiation oncology, biology, physics.

[134]  J. Murphy-Ullrich,et al.  Activation of latent TGF-β by thrombospondin-1: mechanisms and physiology , 2000 .

[135]  D. C. Han,et al.  Therapy with antisense TGF-beta1 oligodeoxynucleotides reduces kidney weight and matrix mRNAs in diabetic mice. , 2000, American journal of physiology. Renal physiology.

[136]  I. Stamenkovic,et al.  Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. , 2000, Genes & development.

[137]  P. Howe,et al.  Analysis of TGFβ-Mediated Synthesis of Extracellular Matrix Components , 2000 .

[138]  J. Massagué How cells read TGF-beta signals. , 2000, Nature reviews. Molecular cell biology.

[139]  J. Murphy-Ullrich,et al.  Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology. , 2000, Cytokine & growth factor reviews.

[140]  P. Howe,et al.  Analysis of TGF-beta-mediated synthesis of extracellular matrix components. , 2000, Methods in molecular biology.

[141]  E. Lewis,et al.  Captopril-induced reduction of serum levels of transforming growth factor-beta1 correlates with long-term renoprotection in insulin-dependent diabetic patients. , 1999, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[142]  A. Kazlauskas,et al.  c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. , 1999, Genes & development.

[143]  S. Klahr Mechanisms of progression of chronic renal damage. , 1999, Journal of nephrology.

[144]  S. Kumar,et al.  TGF‐β1 levels in pre‐treatment plasma identify breast cancer patients at risk of developing post‐radiotherapy fibrosis , 1999, International journal of cancer.

[145]  C. McCulloch,et al.  The compliance of collagen gels regulates transforming growth factor-β induction of α-smooth muscle actin in fibroblasts , 1999 .

[146]  I. Dixon,et al.  Elevation of expression of Smads 2, 3, and 4, decorin and TGF-beta in the chronic phase of myocardial infarct scar healing. , 1999, Journal of molecular and cellular cardiology.

[147]  A. Roberts,et al.  Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF‐β , 1999, The EMBO journal.

[148]  N. Kaminski,et al.  The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. , 1999, Cell.

[149]  D. Podolsky,et al.  Growth factors in inflammatory bowel disease. , 1999, Inflammatory bowel diseases.

[150]  H. V. van Houwelingen,et al.  Serum transforming growth factor-beta1 levels in bone marrow transplant recipients correlate with blood cell counts and chronic graft-versus-host disease. , 1999, Transplantation.

[151]  H. Friess,et al.  Transforming Growth Factor-βs and Their Signaling Receptors Are Coexpressed in Crohn's Disease , 1999 .

[152]  C. McCulloch,et al.  The compliance of collagen gels regulates transforming growth factor-beta induction of alpha-smooth muscle actin in fibroblasts. , 1999, The American journal of pathology.

[153]  H. Beug,et al.  TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis , 1998, Current Biology.

[154]  W. Strober,et al.  Oxazolone Colitis: A Murine Model of  T Helper Cell Type 2 Colitis Treatable with Antibodies to Interleukin 4 , 1998, The Journal of experimental medicine.

[155]  M. Hauer-Jensen,et al.  Cellular sources of transforming growth factor-beta isoforms in early and chronic radiation enteropathy. , 1998, The American journal of pathology.

[156]  A. Balmain,et al.  Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[157]  R. Peshock,et al.  Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha. , 1998, Circulation.

[158]  G. Jerums,et al.  Expression of transforming growth factor-beta1 and type IV collagen in the renal tubulointerstitium in experimental diabetes: effects of ACE inhibition. , 1998, Diabetes.

[159]  C. Heldin,et al.  Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling , 1997, Nature.

[160]  P. Hogg,et al.  Significant correlation between thrombospondin 1 and serine proteinase expression in rheumatoid synovium. , 1997, Arthritis and rheumatism.

[161]  J. Wrana,et al.  The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling , 1997, Cell.

[162]  A. Demetris,et al.  Cardiac-specific overexpression of tumor necrosis factor-alpha causes lethal myocarditis in transgenic mice. , 1997, Journal of cardiac failure.

[163]  Y. Chernajovsky,et al.  Pathogenic lymphoid cells engineered to express TGF β1 ameliorate disease in a collagen-induced arthritis model , 1997, Gene Therapy.

[164]  K. Sharma,et al.  Increased Renal Production of Transforming Growth Factor-β1 in Patients with Type II Diabetes , 1997, Diabetes.

[165]  M. Tibbs,et al.  Wound healing following radiation therapy: a review. , 1997, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[166]  L. Klareskog,et al.  Dynamic expression of transforming growth factor‐betas (TGF‐β) and their type I and type II receptors in the synovial tissue of arthritic rats , 1997, Clinical and experimental immunology.

[167]  D Falb,et al.  The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. , 1997, Cell.

[168]  A. Matsumori,et al.  Persistent expression of cytokine in the chronic stage of viral myocarditis in mice. , 1996, Circulation.

[169]  M. Neurath,et al.  Local administration of antisense phosphorothiate olignucleotides to the p65 subunit of NF–κB abrogates established experimental colitis in mice , 1996, Nature Medicine.

[170]  R. Coffman,et al.  A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells , 1996, The Journal of experimental medicine.

[171]  Jia Guo,et al.  Neutralization of TGF-β by Anti-TGF-β Antibody Attenuates Kidney Hypertrophy and the Enhanced Extracellular Matrix Gene Expression in STZ-Induced Diabetic Mice , 1996, Diabetes.

[172]  D. Podolsky,et al.  Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease. , 1996, Gastroenterology.

[173]  S. Kusachi,et al.  Tenascin expression in endomyocardial biopsy specimens in patients with dilated cardiomyopathy: distribution along margin of fibrotic lesions. , 1996, Heart.

[174]  C. Nast,et al.  Expression of transforming growth factor-β isoforms in human glomerular diseases , 1996 .

[175]  G. Wolf,et al.  Transforming growth factor beta mediates the angiotensin-II-induced stimulation of collagen type IV synthesis in cultured murine proximal tubular cells. , 1996, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[176]  C. Nast,et al.  Expression of transforming growth factor-beta isoforms in human glomerular diseases. , 1996, Kidney international.

[177]  J. Coggle,et al.  Long-term expression of transforming growth factor TGF beta 1 in mouse skin after localized beta-irradiation. , 1996, International journal of radiation biology.

[178]  L. Bonewald,et al.  Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein , 1995, The Journal of cell biology.

[179]  J. Coggle,et al.  Expression of transforming growth factor-beta 1 in mouse skin during the acute phase of radiation damage. , 1995, International journal of radiation biology.

[180]  G. Haines,et al.  Increased synovial expression of transforming growth factor (TGF)-beta receptor endoglin and TGF-beta 1 in rheumatoid arthritis: possible interactions in the pathogenesis of the disease. , 1995, Clinical immunology and immunopathology.

[181]  K. Sharma,et al.  Renal hypertrophy is associated with upregulation of TGF-beta 1 gene expression in diabetic BB rat and NOD mouse. , 1994, The American journal of physiology.

[182]  W. Border,et al.  Transforming Growth Factor β in Tissue Fibrosis , 1994 .

[183]  K. Miyazono,et al.  Enhanced expression of transforming growth factor-beta s and transforming growth factor-beta type II receptor in the synovial tissues of patients with rheumatoid arthritis. , 1994, Laboratory investigation; a journal of technical methods and pathology.

[184]  K. Sharma,et al.  Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta. , 1994, The Journal of clinical investigation.

[185]  J. Uitto,et al.  Effect of therapeutic radiation on wound healing. , 1994, Clinics in dermatology.

[186]  W. Border,et al.  Transforming growth factor beta in tissue fibrosis. , 1994, The New England journal of medicine.

[187]  G. Wolf,et al.  Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta. , 1993, The Journal of clinical investigation.

[188]  M. Martin,et al.  Temporal modulation of TGF-beta 1 and beta-actin gene expression in pig skin and muscular fibrosis after ionizing radiation. , 1993, Radiation research.

[189]  E Ruoslahti,et al.  Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[190]  K. Yoshioka,et al.  Transforming growth factor-beta protein and mRNA in glomeruli in normal and diseased human kidneys. , 1993, Laboratory investigation; a journal of technical methods and pathology.

[191]  M. Sporn,et al.  Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[192]  S. Wahl,et al.  Reversal of acute and chronic synovial inflammation by anti- transforming growth factor beta , 1993, The Journal of experimental medicine.

[193]  K. Miyazono,et al.  Involvement of transforming growth factor-beta in the formation of fibrotic lesions in carcinoid heart disease. , 1993, The American journal of pathology.

[194]  D. Weiner,et al.  Regulation of synovial cell growth. Coexpression of transforming growth factor beta and basic fibroblast growth factor by cultured synovial cells. , 1992, Arthritis and rheumatism.

[195]  K. Sharma,et al.  High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β , 1992 .

[196]  H. Stein,et al.  Cellular localization of procollagen gene transcripts in inflammatory bowel diseases. , 1992, Gastroenterology.

[197]  D. Schuppan,et al.  Increased collagen type III synthesis by fibroblasts isolated from strictures of patients with Crohn's disease. , 1992, Gastroenterology.

[198]  K. Sharma,et al.  High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-beta. , 1992, Kidney international.

[199]  A. Herskowitz,et al.  Coxsackievirus myocarditis. , 1992, Advances in internal medicine.

[200]  M. Feldmann,et al.  Transforming growth factor‐β1 in rheumatoid synovial membrane and cartilage pannus junction , 1991, Clinical and experimental immunology.

[201]  A. Eisen,et al.  Integrin α2β1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells , 1991, Cell.

[202]  J. Hamilton,et al.  Transforming growth factor beta stimulates urokinase-type plasminogen activator and DNA synthesis, but not prostaglandin E2 production, in human synovial fibroblasts. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[203]  S. Wahl,et al.  Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animals. , 1991, The Journal of clinical investigation.

[204]  A. Eisen,et al.  Integrin alpha 2 beta 1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells. , 1991, Cell.

[205]  M. Feldmann,et al.  Detection of transforming growth factor‐beta in rheumatoid arthritis synovial tissue: lack of effect on spontaneous cytokine production in joint cell cultures , 1990, Clinical and experimental immunology.

[206]  S. Wahl,et al.  Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor beta , 1990, The Journal of experimental medicine.

[207]  D. Rifkin,et al.  Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture , 1989, The Journal of cell biology.

[208]  T. Pincus,et al.  Active and latent forms of transforming growth factor beta activity in synovial effusions , 1989, The Journal of experimental medicine.

[209]  H. Moses,et al.  Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium , 1988, The Journal of cell biology.

[210]  J. Harington Fibrogenesis , 1974, Environmental health perspectives.

[211]  R. Fleischmajer Epithelial-mesenchymal interactions. , 1967, Science.

[212]  Sheldon Jm,et al.  Advances in internal medicine. , 1956, Journal - Michigan State Medical Society.