HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
暂无分享,去创建一个
Hynek Pikhart | Bengt Sennblad | Tom R. Gaunt | Jackie A Cooper | Fotios Drenos | Meena Kumari | Rebecca Hardy | Debbie A Lawlor | Nicholas J Timpson | Yoav Ben-Shlomo | Frank Dudbridge | Michael Tsai | Claudia Giambartolomei | Jennifer G. Robinson | Michael V Holmes | Tom R Gaunt | Pamela J Schreiner | Yiran Guo | Luigi Tavazzi | Ioanna Tzoulaki | Mary Cushman | Martin Bobak | Gianni Tognoni | Bruce M Psaty | Philippa J Talmud | Roberto Marchioli | Susan Redline | Abdonas Tamosiunas | Sekar Kathiresan | Claudia Langenberg | Elena Tremoli | Diana Kuh | Mika Kivimäki | John C Whittaker | Peter H Whincup | Hakon Hakonarson | Richard W Morris | Fabrizio Veglia | J Wouter Jukema | Myriam Fornage | Andrzej Pajak | Tina Shah | Ruzena Kubinova | JoAnn E Manson | Pim A de Jong | Terje R Pedersen | Paul C D Johnson | Ale Algra | Anne Peasey | Alex P Reiner | Jutta Palmen | Reecha Sofat | Daniel I Chasman | Paul M Ridker | Anders Hamsten | Josef Coresh | Pim van der Harst | John Gallacher | Nita G Forouhi | Paul C. D. Johnson | Damiano Baldassarre | Pierre Amarenco | Charles B Eaton | Sanjay R Patel | Folkert W Asselbergs | Sanjay R. Patel | Robert A Scott | James D Lewsey | Ulf de Faire | Anthonius de Boer | Naveed Sattar | George Davey Smith | Pieter A Doevendans | J. Gallacher | M. Fornage | J. Manson | A. Reiner | D. Lawlor | S. Redline | H. Hakonarson | D. van der A | P. Ridker | D. Chasman | R. Krauss | N. Timpson | R. Schnabel | Yiran Guo | A. Gotto | J. McMurray | J. Lewsey | A. Keech | S. Humphries | D. Duggan | A. Hingorani | A. Algra | J. Coresh | B. Psaty | D. Siscovick | P. Talmud | P. Whincup | N. Sattar | L. Tavazzi | M. Marmot | S. Kathiresan | J. Whittaker | M. Kivimäki | R. Topor-Madry | S. Sharp | N. Wareham | A. Hamsten | U. de Faire | J. A. Delaney | D. Waters | J. Jukema | J. Robinson | W. Spiering | R. Westendorp | F. Dudbridge | G. Lowe | James G. Wilson | Philip N. Howard | G. Smith | R. Scott | C. Eaton | N. Forouhi | C. Langenberg | N. Poulter | P. Schreiner | P. Sever | P. van der Harst | Y. Ben-Shlomo | B. Sennblad | F. Veglia | J. Price | D. Baldassarre | E. Tremoli | A. Wong | M. Kumari | D. Kuh | I. Tzoulaki | E. Brunner | A. Amuzu | M. Bobák | R. Hardy | R. Kubínová | S. Malyutina | A. Pająk | H. Pikhart | A. Tamosiunas | W. Verschuren | P. Amarenco | M. Cushman | P. D. de Jong | N. Verweij | I. Ford | F. Asselbergs | G. D. de Borst | F. Drenos | L. Lange | A. Tybjaerg-hansen | M. Holmes | R. Morris | Y. T. van der Schouw | N. Onland-Moret | A. Maggioni | G. Tognoni | A. de Boer | Y. Li | Haruo M D Nakamura | J. Cooper | B. Keating | O. Klungel | J. Kjekshus | K. Kuchenbaecker | M. Voevoda | R. Sofat | C. Giambartolomei | Paul C D Johnson | M. Leusink | Marlene C. W. Stewart | J. Palmen | J. Hubacek | S. Buxbaum | J. Downs | T. Pedersen | P. Doevendans | S. Stender | A. Peasey | C. Dale | T. Shah | K. Ray | D. Preiss | Kawah Li | J. Engmann | D. Swerdlow | R. Hoogeveen | C. Chung | M. Baceviciene | B. A. Castillo | M. Tsai | R. Marchioli | S. Seshasai | David S Siscovick | Niek Verweij | Kausik K Ray | Sreenivasa Rao Kondapally Seshasai | Ian Ford | Michael G Marmot | Yun R Li | Anthony C Keech | Peter S Sever | Yvonne T van der Schouw | Renate B Schnabel | Nick J Wareham | Aroon D Hingorani | Rudi G J Westendorp | David Duggan | Aldo P Maggioni | James G Wilson | Steve E Humphries | Neil R Poulter | Ronald M Krauss | Andrew Wong | Olaf H Klungel | John J V McMurray | Sarah G Buxbaum | Stefan Stender | Jennifer G Robinson | Jaroslav A Hubacek | Antoinette Amuzu | Haruo Nakamura | Migle Baceviciene | Brendan J Keating | Leslie A Lange | David Preiss | Jackie F Price | U. Stepaniak | Eric J Brunner | Karoline B Kuchenbaecker | N Charlotte Onland-Moret | Daniel I Swerdlow | Wilko Spiering | Philip Howard | Stephen J Sharp | Daphne L van der A | John Kjekshus | Anne Tybjaerg-Hansen | Antonio M Gotto | W M Monique Verschuren | Anke H Maitland-van der Zee | David D Waters | John R Downs | Sofia Malyutina | Gert Jan de Borst | Mikhail Voevoda | Caroline Dale | Berta A Castillo | Maarten Leusink | Gordon Lowe | Jorgen E L Engmann | Christina Chung | KaWah Li | Marlene C W Stewart | Romanvan Topor-Madry | Urszula Stepaniak | Joseph A Delaney | Ronald C Hoogeveen | H. Nakamura | S. Patel | Caroline Dale | P. van der harst | A. Tamošiūnas | J. Coresh | R. Scott | B. Psaty | R. Scott | R. Scott | J. Cooper | J. Price | Karoline B. Kuchenbaecker
[1] D. Kim,et al. 1242: THE GOOD, THE BAD, AND, THE UNKNOWN , 2014 .
[2] Tom S. Price,et al. Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis. , 2014, American journal of human genetics.
[3] Michael J Pencina,et al. Application of new cholesterol guidelines to a population-based sample. , 2014, The New England journal of medicine.
[4] Andrew Steptoe,et al. COHORT PROFILE Cohort Profile : The English Longitudinal Study of Ageing , 2014 .
[5] Tanya M. Teslovich,et al. Common variants associated with plasma triglycerides and risk for coronary artery disease , 2013, Nature Genetics.
[6] Tanya M. Teslovich,et al. Discovery and refinement of loci associated with lipid levels , 2013, Nature Genetics.
[7] Tara Gomes,et al. Risk of incident diabetes among patients treated with statins: population based study , 2013, BMJ.
[8] S. de Servi,et al. Meta-analysis of impact of different types and doses of statins on new-onset diabetes mellitus. , 2013, The American journal of cardiology.
[9] M. Hernán,et al. Statins and Risk of Diabetes , 2013, Diabetes Care.
[10] J. Berger,et al. Statins and Diabetes: The Good, the Bad, and the Unknown , 2013, Current Atherosclerosis Reports.
[11] P. Libby,et al. Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trial , 2012, The Lancet.
[12] R. Collins,et al. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. , 2012, Lancet.
[13] R. Collins,et al. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials , 2012, The Lancet.
[14] John Spertus,et al. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study , 2012, The Lancet.
[15] Tanya M. Teslovich,et al. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways , 2012, Nature Genetics.
[16] N. Sattar,et al. Statins are diabetogenic--myth or reality? , 2012, Atherosclerosis. Supplements.
[17] Tanya M. Teslovich,et al. The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits , 2012, PLoS genetics.
[18] Tanya M. Teslovich,et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes , 2012, Nature Genetics.
[19] Jennifer G. Robinson,et al. The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis , 2012, The Lancet.
[20] P. Toth. Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy: A Meta-analysis , 2012 .
[21] R. Collins,et al. Prevention of Coronary and Stroke Events with Atorvastatin in Hypertensive Patients who have Average or Lower-than-Average Cholesterol Concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial— Lipid Lowering Arm (ASCOT-LLA): A Multicentre Randomised Controlled Trial , 2012, Drugs.
[22] S. McGuire. Shields M., Carroll M.D., Ogden C.L. adult obesity prevalence in Canada and the United States. NCHS data brief no. 56, Hyattsville, MD: National Center for Health Statistics, 2011. , 2011, Advances in nutrition.
[23] Paul Welsh,et al. Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis. , 2011, JAMA.
[24] P. Barter,et al. Predictors of new-onset diabetes in patients treated with atorvastatin: results from 3 large randomized clinical trials. , 2011, Journal of the American College of Cardiology.
[25] J. Danesh,et al. Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data , 2011, BMJ : British Medical Journal.
[26] D. Makuc,et al. Health, United States, 2010; with special feature on death and dying , 2011 .
[27] M. Gnant,et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials , 2010 .
[28] R. Collins,et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials , 2010, The Lancet.
[29] Tanya M. Teslovich,et al. Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids , 2010, Nature.
[30] M. Quon,et al. Atorvastatin causes insulin resistance and increases ambient glycemia in hypercholesterolemic patients. , 2010, Journal of the American College of Cardiology.
[31] Yasuo Ohashi,et al. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials , 2010, The Lancet.
[32] C. White,et al. Differing effect of statins on insulin sensitivity in non-diabetics: a systematic review and meta-analysis. , 2010, Diabetes research and clinical practice.
[33] Tanya M. Teslovich,et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index , 2010 .
[34] Thomas Meitinger,et al. Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations , 2009, PLoS genetics.
[35] Paul M. Ridker,et al. Statin Therapy and Risk of Developing Type 2 Diabetes: A Meta-Analysis , 2009, Diabetes Care.
[36] G. Moneta,et al. Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein , 2009 .
[37] Rebecca M Reynolds,et al. The Edinburgh Type 2 Diabetes Study: study protocol , 2008, BMC endocrine disorders.
[38] M. Daly,et al. Common SNPs in HMGCR in Micronesians and Whites Associated With LDL-Cholesterol Levels Affect Alternative Splicing of Exon13 , 2008, Arteriosclerosis, thrombosis, and vascular biology.
[39] Mark I. McCarthy,et al. Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies , 2008, PloS one.
[40] M. Tobin,et al. Mendelian Randomisation and Causal Inference in Observational Epidemiology , 2008, PLoS medicine.
[41] W. Feeman. Statins and diabetes , 2008, The Lancet.
[42] C. Meisinger,et al. RANTES/CCL5 gene polymorphisms, serum concentrations, and incident type 2 diabetes: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. , 2008, European journal of endocrinology.
[43] George Davey Smith,et al. Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology , 2008, Statistics in medicine.
[44] Cholesterol Treatment Trialists' Collaborators. Efficacy of cholesterol-lowering therapy in 18 686 people with diabetes in 14 randomised trials of statins: a meta-analysis , 2008, The Lancet.
[45] Dolores Corella,et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans , 2008, Nature Genetics.
[46] R Peto,et al. Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis. , 2008, Lancet.
[47] P. Arora,et al. Statin therapy in stroke prevention: a meta-analysis involving 121,000 patients. , 2008, The American journal of medicine.
[48] L. Tavazzi,et al. Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. , 2008, Lancet.
[49] R. Holman,et al. Atorvastatin in Factorial with Omega-3 EE90 Risk Reduction in Diabetes (AFORRD): a randomised controlled trial , 2008, Diabetologia.
[50] D. Lawlor,et al. Clustered Environments and Randomized Genes: A Fundamental Distinction between Conventional and Genetic Epidemiology , 2007, PLoS medicine.
[51] A. Jánosi,et al. Rosuvastatin in older patients with systolic heart failure. , 2007, The New England journal of medicine.
[52] A. Hofman,et al. The Rotterdam Study: objectives and design update , 2007, European Journal of Epidemiology.
[53] Simon C. Potter,et al. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls , 2007, Nature.
[54] J. Farmer. High-dose atorvastatin after stroke or transient ischemic attack. , 2007, Current atherosclerosis reports.
[55] Thomas Meitinger,et al. The genetic study of three population microisolates in South Tyrol (MICROS): study design and epidemiological perspectives , 2007, BMC Medical Genetics.
[56] Yasuo Ohashi,et al. Primary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study): a prospective randomised controlled trial , 2006, The Lancet.
[57] D. Kuh,et al. Cohort Profile: The 1946 National Birth Cohort (MRC National Survey of Health and Development). , 2006, International journal of epidemiology.
[58] A. Hingorani,et al. Nature's randomised trials , 2005, The Lancet.
[59] O. Faergeman,et al. High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial. , 2005, JAMA.
[60] C. Gieger,et al. KORA-gen - Resource for Population Genetics, Controls and a Broad Spectrum of Disease Phenotypes , 2005 .
[61] Philip J. Barter,et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. , 2005, The New England journal of medicine.
[62] Michael Marmot,et al. Cohort Profile: the Whitehall II study. , 2005, International journal of epidemiology.
[63] U. Laufs,et al. Pleiotropic effects of statins. - Basic research and clinical perspectives -. , 2010, Circulation journal : official journal of the Japanese Circulation Society.
[64] D. Betteridge,et al. Statins and Diabetes , 2004, Seminars in vascular medicine.
[65] M. Pfeffer,et al. Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z trial. , 2004, JAMA.
[66] J. Davignon. Beneficial Cardiovascular Pleiotropic Effects of Statins , 2004, Circulation.
[67] Thomas Weber,et al. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. , 2004, The New England journal of medicine.
[68] D. Altman,et al. Measuring inconsistency in meta-analyses , 2003, BMJ : British Medical Journal.
[69] S. Ebrahim,et al. 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? , 2003, International journal of epidemiology.
[70] D. Lawlor,et al. Geographical variation in cardiovascular disease, risk factors, and their control in older women: British Women's Heart and Health Study , 2003, Journal of epidemiology and community health.
[71] Barry R. Davis,et al. Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT). , 2002, JAMA.
[72] P. Macfarlane,et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial , 2002, The Lancet.
[73] P. Serruys,et al. Fluvastatin for prevention of cardiac events following successful first percutaneous coronary intervention: a randomized controlled trial. , 2002, JAMA.
[74] S. Redline,et al. Genetics of the apnea hypopnea index in Caucasians and African Americans: I. Segregation analysis , 2002, Genetic epidemiology.
[75] Results of the low-dose (20 mg) pravastatin GISSI Prevenzione trial in 4271 patients with recent myocardial infarction: do stopped trials contribute to overall knowledge? GISSI Prevenzione Investigators (Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico). , 2000, Italian heart journal : official journal of the Italian Federation of Cardiology.
[76] R. Collins,et al. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. , 1998, The New England journal of medicine.
[77] A. Gotto,et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. , 1998, JAMA.
[78] B. Davis,et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. , 1996, The New England journal of medicine.
[79] P. Macfarlane,et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. , 1995, The New England journal of medicine.
[80] S. Redline,et al. The familial aggregation of obstructive sleep apnea. , 1995, American journal of respiratory and critical care medicine.
[81] J. Cooper,et al. The Effects of Quality and Timing of Venepuncture on Markers of Blood Coagulation in Healthy Middle-aged Men , 1995, Thrombosis and Haemostasis.
[82] Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S) , 1994, The Lancet.
[83] Gower Street,et al. Health inequalities among British civil servants: the Whitehall II study , 1991, The Lancet.
[84] R. Prescott,et al. Edinburgh Artery Study: prevalence of asymptomatic and symptomatic peripheral arterial disease in the general population. , 1991, International journal of epidemiology.
[85] R. Kronmal,et al. The Cardiovascular Health Study: design and rationale. , 1991, Annals of epidemiology.
[86] A. Folsom,et al. The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators. , 1989, American journal of epidemiology.
[87] S B Hulley,et al. CARDIA: study design, recruitment, and some characteristics of the examined subjects. , 1988, Journal of clinical epidemiology.
[88] A. Fehily,et al. Caerphilly and Speedwell collaborative heart disease studies. The Caerphilly and Speedwell Collaborative Group. , 1984, Journal of epidemiology and community health.
[89] M Walker,et al. British regional heart study. , 1984, Nursing mirror.
[90] R. Levy,et al. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. , 1972, Clinical chemistry.