Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-beta kinase antagonist, in mice.
暂无分享,去创建一个
Iñaki F Trocóniz | Sophie Glatt | J. Yingling | I. Trocóniz | D. D. de Alwis | C. Pitou | Lorea Bueno | Dinesh P de Alwis | Celine Pitou | Jonathan Yingling | Michael Lahn | M. Lahn | Lorea Bueno | S. Glatt
[1] Evelyn D. Lobo,et al. Pharmacodynamic modeling of chemotherapeutic effects: Application of a transit compartment model to characterize methotrexate effects in vitro , 2008, AAPS PharmSci.
[2] S. A. Watkins,et al. Kinetic characterization of novel pyrazole TGF-beta receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition. , 2005, Biochemistry.
[3] Carlos L Arteaga,et al. Dual role of transforming growth factor beta in mammary tumorigenesis and metastatic progression. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.
[4] Varun Garg,et al. Comparison of four basic models of indirect pharmacodynamic responses , 1993, Journal of Pharmacokinetics and Biopharmaceutics.
[5] Lewis B. Sheiner,et al. Pharmacostatistical modeling for observational data , 1991, Journal of Pharmacokinetics and Biopharmaceutics.
[6] Jonathan M. Yingling,et al. Development of TGF-β signalling inhibitors for cancer therapy , 2004, Nature Reviews Drug Discovery.
[7] M. Weller,et al. SD-208, a Novel Transforming Growth Factor β Receptor I Kinase Inhibitor, Inhibits Growth and Invasiveness and Enhances Immunogenicity of Murine and Human Glioma Cells In vitro and In vivo , 2004, Cancer Research.
[8] R. Campbell,et al. Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain. , 2004, Bioorganic & medicinal chemistry letters.
[9] R. Campbell,et al. Novel and potent transforming growth factor beta type I receptor kinase domain inhibitor: 7-amino 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinolines. , 2004, Bioorganic & medicinal chemistry letters.
[10] P. Dijke,et al. New insights into TGF-β–Smad signalling , 2004 .
[11] Paolo Magni,et al. Predictive Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Kinetics in Xenograft Models after Administration of Anticancer Agents , 2004, Cancer Research.
[12] Jin Y. Jin,et al. Modeling of Corticosteroid Pharmacogenomics in Rat Liver Using Gene Microarrays , 2003, Journal of Pharmacology and Experimental Therapeutics.
[13] M. Vieth,et al. Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain. , 2003, Journal of medicinal chemistry.
[14] T. Kubota,et al. Significance of transforming growth factor β1 as a new tumor marker for colorectal cancer , 2002, International journal of cancer.
[15] A. Roberts,et al. Suppressor and oncogenic roles of transforming growth factor-beta and its signaling pathways in tumorigenesis. , 2001, Advances in cancer research.
[16] M. Karlsson,et al. Semiphysiological model for the time course of leukocytes after varying schedules of 5-fluorouracil in rats. , 2000, The Journal of pharmacology and experimental therapeutics.
[17] R. Calvo,et al. Altered plasma and brain disposition and pharmacodynamics of methadone in abstinent rats. , 1999, The Journal of pharmacology and experimental therapeutics.
[18] J. Kleeff,et al. Transfection of the type I TGF‐β receptor restores TGF‐β responsiveness in pancreatic cancer , 1998 .
[19] W J Jusko,et al. Transit compartments versus gamma distribution function to model signal transduction processes in pharmacodynamics. , 1998, Journal of pharmaceutical sciences.
[20] J. Massagué. TGF-beta signal transduction. , 1998, Annual review of biochemistry.
[21] J. O’Donoghue,et al. The response of tumours with Gompertzian growth characteristics to fractionated radiotherapy. , 1997, International journal of radiation biology.
[22] Xiao-Fan Wang,et al. Signaling by the transforming growth factor-β receptor , 1995 .
[23] W J Jusko,et al. Physiologic indirect response models characterize diverse types of pharmacodynamic effects , 1994, Clinical pharmacology and therapeutics.
[24] L. Sheiner,et al. An introduction to mixed effect modeling: Concepts, definitions, and justification , 1991 .
[25] L. Norton. A Gompertzian model of human breast cancer growth. , 1988, Cancer research.
[26] L. Norton,et al. Predicting the course of Gompertzian growth , 1976, Nature.