A case of nonoliguric renal failure after general anesthesia with sevoflurane and desflurane.

B iodegradation of sevoflurane to fluoride ion has raised concerns regarding the nephrotoxicity of sevoflurane in humans (1,2). In addition, soda lime and Baralyme @ degrade sevoflurane to a nephrotoxin (pentafluoroisopropenyl fluoromethyl ether) known as Compound A (3-7). Although sevofluranerelated nephrotoxicity has been demonstrated in volunteers (8), nephrotoxicity severe enough to require therapeutic action has not been reported. We report acute nonoliguric renal failure occurring in a 25-yearold man with previously normal renal function after anesthesia with sevoflurane and desflurane.

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