Pre-clinical effects of metformin and aspirin on the cell lines of different breast cancer subtypes

[1]  A. Sultan,et al.  Targeting AMPK, mTOR and β-Catenin by Combined Metformin and Aspirin Therapy in HCC: An Appraisal in Egyptian HCC Patients , 2018, Molecular Diagnosis & Therapy.

[2]  Jinyong Peng,et al.  Dioscin induces prostate cancer cell apoptosis through activation of estrogen receptor-β , 2017, Cell Death & Disease.

[3]  Jing Xu,et al.  Metformin inhibits castration-induced EMT in prostate cancer by repressing COX2/PGE2/STAT3 axis. , 2017, Cancer letters.

[4]  A. Bera,et al.  Aspirin induces cell death by directly modulating mitochondrial voltage-dependent anion channel (VDAC) , 2017, Scientific Reports.

[5]  Xiaoling Liu,et al.  Aspirin regulation of c-myc and cyclinD1 proteins to overcome tamoxifen resistance in estrogen receptor-positive breast cancer cells , 2017, Oncotarget.

[6]  S. J. Shbailat,et al.  Combination of metformin and curcumin targets breast cancer in mice by angiogenesis inhibition, immune system modulation and induction of p53 independent apoptosis , 2017, Therapeutic advances in medical oncology.

[7]  Prabhjot S. Mundi,et al.  Proteomic modulation in breast tumors after metformin exposure: results from a “window of opportunity” trial , 2017, Clinical and Translational Oncology.

[8]  A. Gamian,et al.  Protective effects of levamisole, acetylsalicylic acid, and α-tocopherol against dioxin toxicity measured as the expression of AhR and COX-2 in a chicken embryo model , 2016, Histochemistry and Cell Biology.

[9]  J. Kanwar,et al.  Redox Control of Antioxidant and Antihepatotoxic Activities of Cassia surattensis Seed Extract against Paracetamol Intoxication in Mice: In Vitro and In Vivo Studies of Herbal Green Antioxidant , 2016, Oxidative medicine and cellular longevity.

[10]  Val Oliveira Pintro,et al.  SAnDReS a Computational Tool for Statistical Analysis of Docking Results and Development of Scoring Functions. , 2016, Combinatorial chemistry & high throughput screening.

[11]  S. Vacher,et al.  Combination of COX-2 expression and PIK3CA mutation as prognostic and predictive markers for celecoxib treatment in breast cancer , 2016, Oncotarget.

[12]  Lisa E. Vaughan,et al.  Aspirin use and the incidence of breast, colon, ovarian, and pancreatic cancers in elderly women in the Iowa Women’s Health Study , 2016, Cancer Causes & Control.

[13]  Hsueh-Wei Chang,et al.  RelA-Mediated BECN1 Expression Is Required for Reactive Oxygen Species-Induced Autophagy in Oral Cancer Cells Exposed to Low-Power Laser Irradiation , 2016, PloS one.

[14]  W. Rathmann,et al.  Impact of metformin on metastases in patients with breast cancer and type 2 diabetes. , 2016, Journal of diabetes and its complications.

[15]  C. Tseng,et al.  Metformin reduces gastric cancer risk in patients with type 2 diabetes mellitus , 2016, Aging.

[16]  Dongyu Zhang,et al.  Is aspirin use associated with a decreased risk of ovarian cancer? A systematic review and meta-analysis of observational studies with dose-response analysis. , 2016, Gynecologic oncology.

[17]  P. Elwood,et al.  Aspirin in the Treatment of Cancer: Reductions in Metastatic Spread and in Mortality: A Systematic Review and Meta-Analyses of Published Studies , 2016, PloS one.

[18]  Jun Jiang,et al.  Metformin represses bladder cancer progression by inhibiting stem cell repopulation via COX2/PGE2/STAT3 axis , 2016, Oncotarget.

[19]  L. Berstein,et al.  The phenomenon of acquired resistance to metformin in breast cancer cells: The interaction of growth pathways and estrogen receptor signaling , 2016, IUBMB life.

[20]  Yong Sup Lee,et al.  Identification of novel estrogen receptor (ER) agonists that have additional and complementary anti-cancer activities via ER-independent mechanism. , 2016, Bioorganic & medicinal chemistry letters.

[21]  C. V. D. van de Velde,et al.  The effect of aspirin and nonsteroidal anti-inflammatory drug use after diagnosis on survival of oesophageal cancer patients , 2016, British Journal of Cancer.

[22]  Xiao Han,et al.  Metformin induces apoptosis via a mitochondria-mediated pathway in human breast cancer cells in vitro , 2016, Experimental and therapeutic medicine.

[23]  M. Malkowski,et al.  Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry. , 2016, Biochemistry.

[24]  C. Hsieh,et al.  Aspirin Breaks the Crosstalk between 3T3-L1 Adipocytes and 4T1 Breast Cancer Cells by Regulating Cytokine Production , 2016, PloS one.

[25]  D. Noonan,et al.  Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells , 2016, Scientific Reports.

[26]  Jack A. Taylor,et al.  Lifetime use of nonsteroidal anti-inflammatory drugs and breast cancer risk: results from a prospective study of women with a sister with breast cancer , 2015, BMC Cancer.

[27]  Q. Ma,et al.  Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer , 2015, Oxidative medicine and cellular longevity.

[28]  Peijun Liu,et al.  Suppression of tumor angiogenesis by metformin treatment via a mechanism linked to targeting of HER2/HIF-1α/VEGF secretion axis , 2015, Oncotarget.

[29]  M. Johnson,et al.  Circulating microRNAs in Sera Correlate with Soluble Biomarkers of Immune Activation but Do Not Predict Mortality in ART Treated Individuals with HIV-1 Infection: A Case Control Study , 2015, PloS one.

[30]  Minyoung Lee,et al.  Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells , 2015, Molecular Pharmacology.

[31]  Fang Hu,et al.  Metformin affects the features of a human hepatocellular cell line (HepG2) by regulating macrophage polarization in a co‐culture microenviroment , 2015, Diabetes/metabolism research and reviews.

[32]  Lei Wang,et al.  Metformin attenuated the inflammation after renal ischemia/reperfusion and suppressed apoptosis of renal tubular epithelial cell in rats. , 2015, Acta cirurgica brasileira.

[33]  Z. Wang,et al.  Lipid mediator lipoxin A4 inhibits tumor growth by targeting IL-10-producing regulatory B (Breg) cells. , 2015, Cancer letters.

[34]  N. Sharma-Walia,et al.  Lipoxins exert antiangiogenic and anti-inflammatory effects on Kaposi's sarcoma cells. , 2015, Translational research : the journal of laboratory and clinical medicine.

[35]  I. Haviv,et al.  Increased COX-2 expression in epithelial and stromal cells of high mammographic density tissues and in a xenograft model of mammographic density , 2015, Breast Cancer Research and Treatment.

[36]  Xi Hu,et al.  Metformin Induced AMPK Activation, G0/G1 Phase Cell Cycle Arrest and the Inhibition of Growth of Esophageal Squamous Cell Carcinomas In Vitro and In Vivo , 2015, PloS one.

[37]  Jun Wang,et al.  Metformin inhibits the proliferation, metastasis, and cancer stem-like sphere formation in osteosarcoma MG63 cells in vitro , 2015, Tumor Biology.

[38]  G. Maity,et al.  Aspirin blocks growth of breast tumor cells and tumor-initiating cells and induces reprogramming factors of mesenchymal to epithelial transition , 2015, Laboratory Investigation.

[39]  Yunshan Wang,et al.  Metformin exerts anticancer effects through the inhibition of the Sonic hedgehog signaling pathway in breast cancer , 2015, International journal of molecular medicine.

[40]  N. Inagaki,et al.  DEPTOR-related mTOR suppression is involved in metformin's anti-cancer action in human liver cancer cells. , 2015, Biochemical and biophysical research communications.

[41]  R. DiPaola,et al.  Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2 , 2015, Oncotarget.

[42]  S. Ahn,et al.  Metformin increases survival in hormone receptor-positive, HER2-positive breast cancer patients with diabetes , 2015, Breast Cancer Research.

[43]  D. Noonan,et al.  The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells , 2015, International journal of cancer.

[44]  X. Zou,et al.  Metformin inhibits gastric cancer via the inhibition of HIF1α/PKM2 signaling. , 2015, American journal of cancer research.

[45]  P. Goodwin,et al.  Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: a prospective window of opportunity neoadjuvant study , 2015, Breast Cancer Research.

[46]  H. Guillou,et al.  Protective effects of n‐6 fatty acids‐enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor , 2015, British journal of pharmacology.

[47]  T. Halazonetis,et al.  DNA replication stress as an Achilles' heel of cancer , 2014, Oncotarget.

[48]  De-guang Sun,et al.  Metformin reverses multidrug resistance in human hepatocellular carcinoma Bel-7402/5-fluorouracil cells , 2014, Molecular medicine reports.

[49]  Jianguo Sun,et al.  Aspirin inhibits lipopolysaccharide-induced COX-2 expression and PGE2 production in porcine alveolar macrophages by modulating protein kinase C and protein tyrosine phosphatase activity , 2014, BMB reports.

[50]  P. Goodwin,et al.  Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study , 2012, Breast Cancer Research and Treatment.

[51]  M. Romano.  Lipoxin and Aspirin-Triggered Lipoxins , 2010, TheScientificWorldJournal.

[52]  F. Pamplona,et al.  Aspirin-triggered lipoxin induces CB1-dependent catalepsy in mice , 2010, Neuroscience Letters.

[53]  David S. Goodsell,et al.  AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility , 2009, J. Comput. Chem..

[54]  A. Olson,et al.  AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading , 2009, J. Comput. Chem..

[55]  A. Thor,et al.  Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro , 2009, Cell cycle.

[56]  C. Liang,et al.  In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro , 2007, Nature Protocols.

[57]  S. Bustin,et al.  Cyclo-oxygenase-2 (COX-2) mRNA expression and hormone receptor status in breast cancer. , 2006, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[58]  René Thomsen,et al.  MolDock: a new technique for high-accuracy molecular docking. , 2006, Journal of medicinal chemistry.

[59]  H. Juneja,et al.  Aspirin and salicylate inhibit colon cancer medium‐ and VEGF‐induced endothelial tube formation: correlation with suppression of cyclooxygenase‐2 expression , 2003, Journal of thrombosis and haemostasis : JTH.

[60]  X. Chen,et al.  Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[61]  N. Davies,et al.  Aspirin causes rapid up‐regulation of cyclo‐oxygenase‐2 expression in the stomach of rats , 1997, Alimentary pharmacology & therapeutics.

[62]  C. Serhan,et al.  Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[63]  C. Ji,et al.  Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin. , 1994, The Journal of biological chemistry.

[64]  T. Mosmann.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.

[65]  V. Padmanaban,et al.  Anticancer effect of acid ceramidase inhibitor ceranib-2 in human breast cancer cell lines MCF-7, MDA MB-231 by the activation of SAPK/JNK, p38 MAPK apoptotic pathways, inhibition of the Akt pathway, downregulation of ER&agr; , 2018, Anti-cancer drugs.

[66]  U. Das.  Radiation resistance, invasiveness and metastasis are inflammatory events that could be suppressed by lipoxin A4. , 2012, Prostaglandins, leukotrienes, and essential fatty acids.

[67]  T. N. Bhat,et al.  The Protein Data Bank , 2000, Nucleic Acids Res..