A study on the microheterogeneity of alpha‐fetoproteins produced by yolk sac and germ cell tumors

Background.  It is generally believed that the lower the grade of differentiation of glycoprotein‐producing cells, the more often modification by bisecting N‐acetylglucosamine (GlcNAc) or fucose (Fuc) at the sugar chain of the glycoprotein or increase in branching of side chains occurs. We examined the characteristics of the alpha‐fetoprotein (AFP) sugar chain stored in amniotic and exocoelomic fluid during 5–9 weeks of gestation and analyzed serum‐derived AFP of patients with germ cell tumors.

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