Influence investigation of a void region on modeling light propagation in a heterogeneous medium.

A void region exists in some biological tissues, and previous studies have shown that inaccurate images would be obtained if it were not processed. A hybrid radiosity-diffusion method (HRDM) that couples the radiosity theory and the diffusion equation has been proposed to deal with the void problem and has been well demonstrated in two-dimensional and three-dimensional (3D) simple models. However, the extent of the impact of the void region on the accuracy of modeling light propagation has not been investigated. In this paper, we first implemented and verified the HRDM in 3D models, including both the regular geometries and a digital mouse model, and then investigated the influences of the void region on modeling light propagation in a heterogeneous medium. Our investigation results show that the influence of the region can be neglected when the size of the void is less than a certain range, and other cases must be taken into account.

[1]  D T Delpy,et al.  Linear single-step image reconstruction in the presence of nonscattering regions. , 2002, Journal of the Optical Society of America. A, Optics, image science, and vision.

[2]  S Arridge,et al.  3D optical tomography in the presence of void regions. , 2000, Optics express.

[3]  S. Arridge,et al.  Photon migration in non-scattering tissue and the effects on image reconstruction. , 1999, Physics in medicine and biology.

[4]  S R Arridge,et al.  An investigation of light transport through scattering bodies with non-scattering regions. , 1996, Physics in medicine and biology.

[5]  Ge Wang,et al.  A mouse optical simulation environment (MOSE) to investigate bioluminescent phenomena in the living mouse with the Monte Carlo method. , 2004, Academic radiology.

[6]  Jie Tian,et al.  Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models. , 2010, Optics express.

[7]  Jie Tian,et al.  Spectrally resolved bioluminescence tomography with the third-order simplified spherical harmonics approximation. , 2009, Physics in medicine and biology.

[8]  Jari P. Kaipio,et al.  Finite element model for the coupled radiative transfer equation and diffusion approximation , 2006 .

[9]  Eiji Okada,et al.  Analysis of Light Propagation in a Realistic Head Model by a Hybrid Method for Optical Brain Function Measurement , 2005 .

[10]  Alexander D Klose,et al.  The forward and inverse problem in tissue optics based on the radiative transfer equation: a brief review. , 2010, Journal of quantitative spectroscopy & radiative transfer.

[11]  S. Arridge,et al.  Optical imaging in medicine: II. Modelling and reconstruction , 1997, Physics in medicine and biology.

[12]  Stephen J. Wright,et al.  Reconstruction in optical tomography using the PN approximations , 2006 .

[13]  D. Delpy,et al.  Optical Imaging in Medicine , 1998, CLEO/Europe Conference on Lasers and Electro-Optics.

[14]  S. Arridge,et al.  Coupled radiative transfer equation and diffusion approximation model for photon migration in turbid medium with low-scattering and non-scattering regions , 2005, Physics in medicine and biology.

[15]  Huabei Jiang,et al.  A higher order diffusion model for three-dimensional photon migration and image reconstruction in optical tomography , 2009, Physics in medicine and biology.

[16]  Arridge,et al.  Boundary conditions for light propagation in diffusive media with nonscattering regions , 2000, Journal of the Optical Society of America. A, Optics, image science, and vision.

[17]  S R Arridge,et al.  Recent advances in diffuse optical imaging , 2005, Physics in medicine and biology.

[18]  Jie Tian,et al.  Multimodality Molecular Imaging , 2008, IEEE Engineering in Medicine and Biology Magazine.

[19]  Y Liu,et al.  Flux vector formulation for photon propagation in the biological tissue. , 2007, Optics letters.

[20]  Vasilis Ntziachristos,et al.  Looking and listening to light: the evolution of whole-body photonic imaging , 2005, Nature Biotechnology.

[21]  Jie Tian,et al.  Generalized free-space diffuse photon transport model based on the influence analysis of a camera lens diaphragm. , 2010, Applied optics.

[22]  Geoffrey McLennan,et al.  Practical reconstruction method for bioluminescence tomography. , 2005, Optics express.

[23]  Hao Hu,et al.  Multi-modality molecular imaging for gastric cancer research , 2011, 2011 Asia Communications and Photonics Conference and Exhibition (ACP).

[24]  Dimitris Gorpas,et al.  A three-dimensional finite elements approach for the coupled radiative transfer equation and diffusion approximation modeling in fluorescence imaging , 2010 .

[25]  Jae Hoon Lee,et al.  Modeling of diffuse-diffuse photon coupling via a nonscattering region: a comparative study. , 2004, Applied optics.

[26]  M. Schweiger,et al.  The finite element method for the propagation of light in scattering media: boundary and source conditions. , 1995, Medical physics.

[27]  Jie Tian,et al.  Graphics processing unit parallel accelerated solution of the discrete ordinates for photon transport in biological tissues. , 2011, Applied optics.

[28]  R. Leahy,et al.  Digimouse: a 3D whole body mouse atlas from CT and cryosection data , 2007, Physics in medicine and biology.

[29]  J. Vesecky,et al.  Wave propagation and scattering. , 1989 .

[30]  Jie Tian,et al.  GPU-based Monte Carlo simulation for light propagation in complex heterogeneous tissues. , 2010, Optics express.

[31]  Vasilis Ntziachristos,et al.  The inverse source problem based on the radiative transfer equation in optical molecular imaging , 2005 .

[32]  Edward W. Larsen,et al.  Light transport in biological tissue based on the simplified spherical harmonics equations , 2006, J. Comput. Phys..

[33]  A. Chatziioannou,et al.  Tomographic bioluminescence imaging by use of a combined optical-PET (OPET) system: a computer simulation feasibility study , 2005, Physics in medicine and biology.

[34]  Vasilis Ntziachristos,et al.  Shedding light onto live molecular targets , 2003, Nature Medicine.

[35]  E. Okada,et al.  Hybrid Monte Carlo-diffusion method for light propagation in tissue with a low-scattering region. , 2003, Applied optics.

[36]  Arridge,et al.  Optical tomography in the presence of void regions , 2000, Journal of the Optical Society of America. A, Optics, image science, and vision.

[37]  M. Schweiger,et al.  The finite element model for the propagation of light in scattering media: a direct method for domains with nonscattering regions. , 2000, Medical physics.

[38]  Jie Tian,et al.  Comparisons of hybrid radiosity-diffusion model and diffusion equation for bioluminescence tomography in cavity cancer detection. , 2012, Journal of biomedical optics.

[39]  Akira Ishimaru,et al.  Wave propagation and scattering in random media , 1997 .