Diabetic vascular diseases: molecular mechanisms and therapeutic strategies

[1]  Shining Wang,et al.  The Role of Aldose Reductase in Beta-Amyloid-Induced Microglia Activation , 2022, International journal of molecular sciences.

[2]  Bindesh Shrestha,et al.  Redox phospholipidomics analysis reveals specific oxidized phospholipids and regions in the diabetic mouse kidney , 2022, Redox biology.

[3]  E. Feldman,et al.  Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments , 2022, The Lancet Neurology.

[4]  Sachin Aryal,et al.  Faecalibacterium prausnitzii Attenuates CKD via Butyrate-Renal GPR43 Axis , 2022, Circulation research.

[5]  P. Carmeliet,et al.  Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast , 2022, Nature Communications.

[6]  Ling-Bo Qian,et al.  Profile of crosstalk between glucose and lipid metabolic disturbance and diabetic cardiomyopathy: Inflammation and oxidative stress , 2022, Frontiers in Endocrinology.

[7]  F. Skjøth,et al.  Retinal artery occlusion as an early indicator of macrovascular complications in diabetes. , 2022, The American journal of medicine.

[8]  M. Khandelwal,et al.  AdipoRon induces AMPK activation and ameliorates Alzheimer's like pathologies and associated cognitive impairment in APP/PS1 mice , 2022, Neurobiology of Disease.

[9]  R. Simó,et al.  Diabetic retinopathy as a predictor of cardiovascular morbidity and mortality in subjects with type 2 diabetes , 2022, Frontiers in Medicine.

[10]  S. Govoni,et al.  Effect of troxerutin in counteracting hyperglycemia-induced VEGF upregulation in endothelial cells: a new option to target early stages of diabetic retinopathy? , 2022, Frontiers in Pharmacology.

[11]  Q. Han,et al.  A systematic review and Meta-analysis of urinary extracellular vesicles proteome in diabetic nephropathy , 2022, Frontiers in Endocrinology.

[12]  P. Patwari,et al.  Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart , 2022, Circulation research.

[13]  Tingwen Shen,et al.  Cerebral small vessel disease combined with cerebral collaterals to predict the prognosis of patients with acute large artery atherosclerotic stroke , 2022, Frontiers in Neurology.

[14]  Yiheng Zhao,et al.  Panvascular medicine: an emerging discipline focusing on atherosclerotic diseases. , 2022, European heart journal.

[15]  J. Eikelboom,et al.  Impact of Insulin Receptor Substrate‐1 rs956115 and CYP2C19 rs4244285 Genotypes on Clinical Outcome of Patients Undergoing Percutaneous Coronary Intervention , 2022, Journal of the American Heart Association.

[16]  Zheng-Rong Lu,et al.  Disruption of retinal inflammation and the development of diabetic retinopathy in mice by a CD40-derived peptide or mutation of CD40 in Müller cells , 2022, Diabetologia.

[17]  B. Feng,et al.  Association between Circulating Oxidized OxLDL/LDL-C Ratio and the Severity of Coronary Atherosclerosis, Along With Other Emerging Biomarkers of Cardiovascular Disease in Patients With Type 2 Diabetes. , 2022, Diabetes research and clinical practice.

[18]  J. Penn,et al.  Effect of cytokine-induced alterations in extracellular matrix composition on diabetic retinopathy-relevant endothelial cell behaviors , 2022, Scientific Reports.

[19]  Wen Zhang,et al.  Plasma fingerprint of free fatty acids and their correlations with the traditional cardiac biomarkers in patients with type 2 diabetes complicated by coronary heart disease , 2022, Frontiers in Cardiovascular Medicine.

[20]  Jennifer K. Sun,et al.  Elevated Retinol Binding Protein 3 Concentrations Are Associated With Decreased Vitreous Inflammatory Cytokines, VEGF, and Progression of Diabetic Retinopathy. , 2022, Diabetes care.

[21]  T. Kern,et al.  ICAM-1 on the luminal surface of endothelial cells is induced to a greater extent in mouse retina than in other tissues in diabetes , 2022, Diabetologia.

[22]  Yuan-yuan Mi,et al.  IL-6 gene rs1800795 polymorphism and diabetes mellitus: a comprehensive analysis involving 42,150 participants from a meta-analysis , 2022, Diabetology & Metabolic Syndrome.

[23]  M. L. de Ceballos,et al.  Insulin regulates neurovascular coupling through astrocytes , 2022, Proceedings of the National Academy of Sciences of the United States of America.

[24]  E. Chew,et al.  Evidence for Step Therapy in Diabetic Macular Edema. , 2022, The New England journal of medicine.

[25]  Jennifer K. Sun,et al.  Aflibercept Monotherapy or Bevacizumab First for Diabetic Macular Edema. , 2022, The New England journal of medicine.

[26]  D. Do,et al.  Efficacy and safety of intravitreal anti-VEGF therapy in diabetic retinopathy: what we have learned and what should we learn further? , 2022, Expert opinion on biological therapy.

[27]  C. Sims-Robinson,et al.  Hyperinsulinemia alters insulin receptor presentation and internalization in brain microvascular endothelial cells , 2022, Diabetes & vascular disease research.

[28]  Tasmia Ahmed,et al.  EPDR1 is a noncanonical effector of insulin-mediated angiogenesis regulated by an endothelial-specific TGF-β receptor complex , 2022, The Journal of biological chemistry.

[29]  T. Pieber,et al.  Differential In Vitro Effects of SGLT2 Inhibitors on Mitochondrial Oxidative Phosphorylation, Glucose Uptake and Cell Metabolism , 2022, International journal of molecular sciences.

[30]  H. C. Beck,et al.  Endothelial Cell Insulin Signaling Regulates CXCR4 (C-X-C Motif Chemokine Receptor 4) and Limits Leukocyte Adhesion to Endothelium , 2022, Arteriosclerosis, thrombosis, and vascular biology.

[31]  L. Gambotti,et al.  Efficacy of Combined Abelmoschus manihot and Irbesartan for Reduction of Albuminuria in Patients With Type 2 Diabetes and Diabetic Kidney Disease: A Multicenter Randomized Double-Blind Parallel Controlled Clinical Trial , 2022, Diabetes care.

[32]  H. Aisa,et al.  Shabyar Ameliorates High Glucose Induced Retinal Pigment Epithelium Injury Through Suppressing Aldose Reductase and AMPK/mTOR/ULK1 Autophagy Pathway , 2022, Frontiers in Pharmacology.

[33]  P. Li,et al.  Dorzagliatin in drug-naïve patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial , 2022, Nature Medicine.

[34]  P. Li,et al.  Dorzagliatin add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial , 2022, Nature Medicine.

[35]  M. Bhojaraja,et al.  Microparticles in Diabetic Kidney Disease. , 2022, Clinica chimica acta; international journal of clinical chemistry.

[36]  E. Han,et al.  Glycolaldehyde, an Advanced Glycation End Products Precursor, Induces Apoptosis via ROS-Mediated Mitochondrial Dysfunction in Renal Mesangial Cells , 2022, Antioxidants.

[37]  C. Wykoff,et al.  MERLIN: Phase 3a, Multicenter, Randomized, Double-Masked Trial of Brolucizumab in Participants With nAMD and Persistent Retinal Fluid. , 2022, Ophthalmology.

[38]  Shangcong Han,et al.  A Ternary Synergistic eNOS Gene Delivery System Based on Calcium Ion and L-Arginine for Accelerating Angiogenesis by Maximizing NO Production , 2022, International journal of nanomedicine.

[39]  Yue Liu,et al.  Monosodium Glutamate-Induced Mouse Model With Unique Diabetic Retinal Neuropathy Features and Artificial Intelligence Techniques for Quantitative Evaluation , 2022, Frontiers in Immunology.

[40]  R. V. Dúran,et al.  Glutamine, MTOR and autophagy: a multiconnection relationship , 2022, Autophagy.

[41]  Chun-Qiang Lu,et al.  Beyond collaterals: brain frailty additionally improves prediction of clinical outcome in acute ischemic stroke , 2022, European Radiology.

[42]  Moshi Song,et al.  Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy , 2022, Nature Communications.

[43]  T. Yoo,et al.  Pathophysiologic Mechanisms and Potential Biomarkers in Diabetic Kidney Disease , 2022, Diabetes & metabolism journal.

[44]  Sanjiv J. Shah,et al.  Baseline Characteristics of Patients With HF With Mildly Reduced and Preserved Ejection Fraction: DELIVER Trial. , 2022, JACC. Heart failure.

[45]  Zibin Gao,et al.  Treatment of Cerebral Ischemia Through NMDA Receptors: Metabotropic Signaling and Future Directions , 2022, Frontiers in Pharmacology.

[46]  F. Perez-Vizcaino,et al.  Supplementation with a Cocoa–Carob Blend, Alone or in Combination with Metformin, Attenuates Diabetic Cardiomyopathy, Cardiac Oxidative Stress and Inflammation in Zucker Diabetic Rats , 2022, Antioxidants.

[47]  Xinyuan Gao,et al.  Exosomal ncRNAs: Novel Therapeutic Target and Biomarker for Diabetic Complications. , 2022, Pharmacological research.

[48]  E. Trucco,et al.  Prediction of Major Adverse Cardiovascular Events From Retinal, Clinical, and Genomic Data in Individuals With Type 2 Diabetes: A Population Cohort Study , 2022 .

[49]  J. Zierath,et al.  Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes , 2022, Diabetes.

[50]  G. Paolisso,et al.  Cognitive impairment and Type 2 Diabetes Mellitus: Focus of SGLT2 Inhibitors Treatment. , 2022, Pharmacological research.

[51]  Hyo-Jong Lee,et al.  miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1 , 2022, Cell death and differentiation.

[52]  Arthur D. Fu,et al.  Efficacy, durability, and safety of intravitreal faricimab with extended dosing up to every 16 weeks in patients with diabetic macular oedema (YOSEMITE and RHINE): two randomised, double-masked, phase 3 trials. , 2022, Lancet.

[53]  Jin Yao,et al.  METTL3-mediated N6-methyladenosine modification governs pericyte dysfunction during diabetes-induced retinal vascular complication , 2022, Theranostics.

[54]  Alan W. Stitt,et al.  Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline , 2021, Trends in Endocrinology & Metabolism.

[55]  R. Chen,et al.  PARP1 Is Upregulated by Hyperglycemia Via N6-methyladenosine Modification and Promotes Diabetic Retinopathy. , 2022, Discovery medicine.

[56]  W. Kuo,et al.  Carboxyl terminus of HSP70‐interacting protein attenuates advanced glycation end products‐induced cardiac injuries by promoting NFκB proteasomal degradation , 2021, Journal of cellular physiology.

[57]  Daowen Wang,et al.  Hyperglycemic memory in diabetic cardiomyopathy , 2021, Frontiers of Medicine.

[58]  Xianliang Gu,et al.  Glucocorticoids Promote Extracellular Matrix Component Remodeling by Activating YAP in Human Retinal Capillary Endothelial Cells , 2021, Frontiers in Cell and Developmental Biology.

[59]  J. Sadoshima,et al.  Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance , 2021, Science advances.

[60]  G. Paolisso,et al.  Sodium/glucose cotransporter 2 (SGLT2) inhibitors improve cardiac function by reducing JunD expression in human diabetic hearts. , 2021, Metabolism: clinical and experimental.

[61]  Sanjiv J. Shah,et al.  The SGLT2 inhibitor dapagliflozin in heart failure with preserved ejection fraction: a multicenter randomized trial , 2021, Nature Medicine.

[62]  Jiawen Cui,et al.  Cyanidin-3-o-glucoside (C3G) inhibits vascular leakage regulated by microglial activation in early diabetic retinopathy and neovascularization in advanced diabetic retinopathy , 2021, Bioengineered.

[63]  Yanjie Lu,et al.  LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathy , 2021, Science China Life Sciences.

[64]  Zhu-qiu Jin MicroRNA targets and biomarker validation for diabetes-associated cardiac fibrosis. , 2021, Pharmacological research.

[65]  R. Kowluru,et al.  Epigenetic modifications in diabetes. , 2021, Metabolism: clinical and experimental.

[66]  Dinender K Singla,et al.  BMP-7 Attenuates Inflammation-Induced Pyroptosis and Improves Cardiac Repair in Diabetic Cardiomyopathy , 2021, Cells.

[67]  Bin-Nan Wu,et al.  Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats , 2021, Cells.

[68]  K. Toyka,et al.  Inflammatory Mechanisms in the Pathophysiology of Diabetic Peripheral Neuropathy (DN)—New Aspects , 2021, International journal of molecular sciences.

[69]  S. Goswami,et al.  Management of inflammation in cardiovascular diseases. , 2021, Pharmacological research.

[70]  A. Sposito,et al.  Dapagliflozin increases retinal thickness in type 2 diabetic patients as compared with glibenclamide: a randomized controlled trial. , 2021, Diabetes & metabolism.

[71]  Bin He,et al.  Platelet biomarkers identifying mild cognitive impairment in type 2 diabetes patients , 2021, Aging cell.

[72]  Deepak L. Bhatt,et al.  Obesity and effects of dapagliflozin on cardiovascular and renal outcomes in patients with type 2 diabetes mellitus in the DECLARE-TIMI 58 trial. , 2021, European heart journal.

[73]  L. Lv,et al.  Urinary small extracellular vesicles derived CCL21 mRNA as biomarker linked with pathogenesis for diabetic nephropathy , 2021, Journal of translational medicine.

[74]  A. Avogaro,et al.  Fenofibrate increases circulating haematopoietic stem cells in people with diabetic retinopathy: a randomised, placebo-controlled trial , 2021, Diabetologia.

[75]  B. Ludvik,et al.  Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial , 2021, The Lancet.

[76]  J. Penn,et al.  Nuclear factor of activated T-cells (NFAT) regulation of IL-1β-induced retinal vascular inflammation. , 2021, Biochimica et biophysica acta. Molecular basis of disease.

[77]  S. Herzig,et al.  Emerging Targets in Type 2 Diabetes and Diabetic Complications , 2021, Advanced science.

[78]  S. M. Mohammadi,et al.  WT1 and ACE mRNAs of blood extracellular vesicle as biomarkers of diabetic nephropathy , 2021, Journal of translational medicine.

[79]  M. Grandoch,et al.  Red Blood Cell and Endothelial eNOS Independently Regulate Circulating Nitric Oxide Metabolites and Blood Pressure , 2021, Circulation.

[80]  R. El Bekay,et al.  miR-21 mimic blocks obesity in mice: A novel therapeutic option , 2021, Molecular therapy. Nucleic acids.

[81]  Z. Dai,et al.  Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019 , 2021, Frontiers in Endocrinology.

[82]  T. MacGillivray,et al.  Retinal arteriolar tortuosity and fractal dimension are associated with long-term cardiovascular outcomes in people with type 2 diabetes , 2021, Diabetologia.

[83]  K. Matsushita,et al.  Epidemiology of Peripheral Artery Disease and Polyvascular Disease , 2021, Circulation research.

[84]  E. Galić,et al.  The Mystery of Diabetic Cardiomyopathy: From Early Concepts and Underlying Mechanisms to Novel Therapeutic Possibilities , 2021, International journal of molecular sciences.

[85]  Xinling Liang,et al.  Receptor Activator of NF-κB Mediates Podocyte Injury in Diabetic Nephropathy. , 2021, Kidney international.

[86]  A. Ceriello,et al.  Diabetes and kidney disease: emphasis on treatment with SGLT-2 inhibitors and GLP-1 receptor agonists. , 2021, Metabolism: clinical and experimental.

[87]  P. Kaiser,et al.  Intravitreal conbercept for diabetic macular oedema: 2-year results from a randomised controlled trial and open-label extension study , 2021, British Journal of Ophthalmology.

[88]  S. Sivaprasad,et al.  Recently updated global diabetic retinopathy screening guidelines: commonalities, differences, and future possibilities , 2021, Eye.

[89]  H. Maegawa,et al.  Cardio- and reno-protective effects of dipeptidyl peptidase III in diabetic mice , 2021, The Journal of biological chemistry.

[90]  Yingying Jiang,et al.  Berberine Slows the Progression of Prediabetes to Diabetes in Zucker Diabetic Fatty Rats by Enhancing Intestinal Secretion of Glucagon-Like Peptide-2 and Improving the Gut Microbiota , 2021, Frontiers in Endocrinology.

[91]  Bo Deng,et al.  Knockout RAGE alleviates cardiac fibrosis through repressing endothelial-to-mesenchymal transition (EndMT) mediated by autophagy , 2021, Cell Death & Disease.

[92]  S. Menini,et al.  Diabetic Complications and Oxidative Stress: A 20-Year Voyage Back in Time and Back to the Future , 2021, Antioxidants.

[93]  R. Roylance,et al.  Prevalence of peripheral neuropathy in pre-diabetes: a systematic review , 2021, BMJ Open Diabetes Research & Care.

[94]  C. Cannon,et al.  Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease , 2021, Stroke.

[95]  Tao Yan,et al.  MD2 blockade prevents modified LDL-induced retinal injury in diabetes by suppressing NADPH oxidase-4 interaction with Toll-like receptor-4 , 2021, Experimental & Molecular Medicine.

[96]  Qin He,et al.  Melatonin prevents diabetes‐associated cognitive dysfunction from microglia‐mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway , 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[97]  S. Rhee,et al.  Dietary glutamic acid and aspartic acid as biomarkers for predicting diabetic retinopathy , 2021, Scientific Reports.

[98]  C. Cannon,et al.  Effects of ertugliflozin on kidney composite outcomes, renal function and albuminuria in patients with type 2 diabetes mellitus: an analysis from the randomised VERTIS CV trial , 2021, Diabetologia.

[99]  A. Justin,et al.  Glitazones, PPAR-γ and Neuroprotection. , 2021, Mini reviews in medicinal chemistry.

[100]  T. Wong,et al.  Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations , 2021, Scientific Reports.

[101]  George Liu,et al.  Apolipoprotein C3 aggravates diabetic nephropathy in type 1 diabetes by activating the renal TLR2/NF-κB pathway. , 2021, Metabolism: clinical and experimental.

[102]  M. S. Kirkman,et al.  The SimpliciT1 Study: A Randomized, Double-Blind, Placebo-Controlled Phase 1b/2 Adaptive Study of TTP399, a Hepatoselective Glucokinase Activator, for Adjunctive Treatment of Type 1 Diabetes , 2021, Diabetes Care.

[103]  J. Uribarri,et al.  Design and Feasibility of a Randomized Controlled Pilot Trial to Reduce Exposure and Cognitive Risk Associated With Advanced Glycation End Products in Older Adults With Type 2 Diabetes , 2021, Frontiers in Nutrition.

[104]  B. Hendry,et al.  Evaluation of Urinary Biomarkers of Proximal Tubular Injury, Inflammation, and Fibrosis in Patients With Albuminuric and Nonalbuminuric Diabetic Kidney Disease , 2021, Kidney international reports.

[105]  S. Catrina,et al.  Hypoxia and hypoxia-inducible factors in diabetes and its complications , 2021, Diabetologia.

[106]  C. Sang,et al.  Gene therapy for diabetic peripheral neuropathy: A randomized, placebo‐controlled phase III study of VM202, a plasmid DNA encoding human hepatocyte growth factor , 2021, Clinical and translational science.

[107]  R. Natarajan Epigenetic Mechanisms in Diabetic Vascular Complications and Metabolic Memory: The 2020 Edwin Bierman Award Lecture , 2021, Diabetes.

[108]  David W. Johnson,et al.  Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials , 2021, BMJ.

[109]  J. Danesh,et al.  A cross-platform approach identifies genetic regulators of human metabolism and health , 2021, Nature Genetics.

[110]  K. Jellinger Pathomechanisms of Vascular Depression in Older Adults , 2020, International journal of molecular sciences.

[111]  James C. Young,et al.  Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy , 2020, Proceedings of the National Academy of Sciences.

[112]  G. Opdenakker,et al.  Evaluation of Proteoforms of the Transmembrane Chemokines CXCL16 and CX3CL1, Their Receptors, and Their Processing Metalloproteinases ADAM10 and ADAM17 in Proliferative Diabetic Retinopathy , 2021, Frontiers in Immunology.

[113]  J. Gagné,et al.  CARM1 regulates replication fork speed and stress response by stimulating PARP1. , 2020, Molecular cell.

[114]  Shengzhou or sheng-zhou wu,et al.  Overexpression of d-amino acid oxidase prevents retinal neurovascular pathologies in diabetic rats , 2020, Diabetologia.

[115]  V. Mohan,et al.  Impact of age at type 2 diabetes mellitus diagnosis on mortality and vascular complications: systematic review and meta-analyses , 2020, Diabetologia.

[116]  E. Schiffrin,et al.  Assessment and pathophysiology of microvascular disease: recent progress and clinical implications , 2020, European heart journal.

[117]  Deepak L. Bhatt,et al.  The association of amputations and peripheral artery disease in patients with type 2 diabetes mellitus receiving sodium-glucose cotransporter type-2 inhibitors: real-world study. , 2020, European heart journal.

[118]  Deepak L. Bhatt,et al.  Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease. , 2020, The New England journal of medicine.

[119]  G. Dagenais,et al.  Similar cardiovascular outcomes in patients with diabetes and established or high risk for coronary vascular disease treated with dulaglutide with and without baseline metformin. , 2020, European heart journal.

[120]  J. McMurray,et al.  Effect of Empagliflozin on Left Ventricular Volumes in Patients With Type 2 Diabetes, or Prediabetes, and Heart Failure With Reduced Ejection Fraction (SUGAR-DM-HF) , 2020, Circulation.

[121]  S. Solomon,et al.  Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study , 2020, European heart journal.

[122]  H. Tanila,et al.  Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques , 2020, Molecular neurodegeneration.

[123]  Yi Fu,et al.  Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism. , 2020, Cell metabolism.

[124]  Mohammed H Rashed,et al.  MicroRNAs (−146a, −21 and −34a) are diagnostic and prognostic biomarkers for diabetic retinopathy , 2020, Biomedical journal.

[125]  Samantha J. Ma,et al.  Brain arteriolosclerosis , 2020, Acta Neuropathologica.

[126]  G. Filippatos,et al.  Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes. , 2020, The New England journal of medicine.

[127]  Guibo Sun,et al.  Corrigendum: Ginsenoside Re Attenuates High Glucose-Induced RF/6A Injury via Regulating PI3K/AKT Inhibited HIF-1a/VEGF Signaling Pathway , 2020, Frontiers in Pharmacology.

[128]  Shuangmei Liu,et al.  Glucokinase in stellate ganglia cooperates with P2X3 receptor to develop cardiac sympathetic neuropathy in type 2 diabetes rats , 2020, Brain Research Bulletin.

[129]  Chunxue Yang,et al.  Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications , 2020, Redox biology.

[130]  S. Yusuf,et al.  Rivaroxaban and Aspirin in Patients With Symptomatic Lower Extremity Peripheral Artery Disease: A Subanalysis of the COMPASS Randomized Clinical Trial. , 2020, JAMA cardiology.

[131]  J. McMurray,et al.  Dapagliflozin in Patients with Chronic Kidney Disease. , 2020, The New England journal of medicine.

[132]  P. Sachdev,et al.  Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study , 2020, Diabetes Care.

[133]  Jianhua Zhang,et al.  Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications. , 2020, Current opinion in pharmacology.

[134]  G. Filippatos,et al.  SGLT2 inhibitors in patients with heart failure with reduced ejection fraction: a meta-analysis of the EMPEROR-Reduced and DAPA-HF trials , 2020, The Lancet.

[135]  Frédérick A. Mallette,et al.  Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy , 2020, Science.

[136]  Abdul Waheed Khan,et al.  Hyperglycemia Induces Myocardial Dysfunction via Epigenetic Regulation of JunD , 2020, Circulation research.

[137]  Yue Zhang,et al.  Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation , 2020, Acta Pharmacologica Sinica.

[138]  Lei Yang,et al.  Syringaresinol Protects against Type 1 Diabetic Cardiomyopathy by Alleviating Inflammation Responses, Cardiac Fibrosis and Oxidative Stress. , 2020, Molecular nutrition & food research.

[139]  A. Zampetaki,et al.  Targeting QKI-7 in vivo restores endothelial cell function in diabetes , 2020, Nature Communications.

[140]  H. Noels,et al.  Lipoproteins and lipids in cardiovascular disease: from mechanistic insights to therapeutic targeting. , 2020, Advanced drug delivery reviews.

[141]  J. Wautier,et al.  Cellular and Molecular Aspects of Blood Cell–Endothelium Interactions in Vascular Disorders , 2020, International journal of molecular sciences.

[142]  D. Vigetti,et al.  Cell Energy Metabolism and Hyaluronan Synthesis , 2020, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[143]  A. Nicolucci,et al.  Legacy effect of intensive glucose control on major adverse cardiovascular outcome: systematic review and meta-analyses of trials according to different scenarios. , 2020, Metabolism: clinical and experimental.

[144]  Ahmad M. N. Alhendi,et al.  Thermostable small-molecule inhibitor of angiogenesis and vascular permeability that suppresses a pERK-FosB/ΔFosB–VCAM-1 axis , 2020, Science Advances.

[145]  D. Ajayi,et al.  Diabetic neuropathy is associated with increased pain perception, low serum beta-endorphin and increase insulin resistance among Nigerian cohorts in Ekiti State , 2020, Heliyon.

[146]  A. Ballabio,et al.  A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome , 2020, Nature.

[147]  C. Hsieh,et al.  Effect of Acupuncture on the p38 Signaling Pathway in Several Nervous System Diseases: A Systematic Review , 2020, International journal of molecular sciences.

[148]  David W. Johnson,et al.  Effects of Allopurinol on the Progression of Chronic Kidney Disease. , 2020, The New England journal of medicine.

[149]  J. McGill,et al.  Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes. , 2020, The New England journal of medicine.

[150]  R. Hui,et al.  Diabetes mellitus exacerbates post‐myocardial infarction heart failure by reducing sarcolipin promoter methylation , 2020, ESC heart failure.

[151]  R. Rehman,et al.  Relation of Copeptin with Diabetic and Renal Function Markers Among Patients with Diabetes Mellitus Progressing Towards Diabetic Nephropathy. , 2020, Archives of medical research.

[152]  Dong-wei Liu,et al.  Diabetic Nephropathy: Perspective on Extracellular Vesicles , 2020, Frontiers in Immunology.

[153]  Yue Liu,et al.  An Innovative Method for Screening and Evaluating the Degree of Diabetic Retinopathy and Drug Treatment Based on Artificial Intelligence Algorithms. , 2020, Pharmacological research.

[154]  H. Mak,et al.  Impaired cerebral blood flow in type 2 diabetes mellitus – A comparative study with subjective cognitive decline, vascular dementia and Alzheimer’s disease subjects , 2020, NeuroImage: Clinical.

[155]  B. Zinman,et al.  Effects of Linagliptin on Cardiovascular and Kidney Outcomes in People With Normal and Reduced Kidney Function: Secondary Analysis of the CARMELINA Randomized Trial , 2020, Diabetes Care.

[156]  J. Florez,et al.  Genetics of diabetes mellitus and diabetes complications , 2020, Nature Reviews Nephrology.

[157]  H. Lum,et al.  MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy , 2020, Nature Communications.

[158]  Ralf J. M. Weber,et al.  Multi-Omics Analysis of Diabetic Heart Disease in the db/db Model Reveals Potential Targets for Treatment by a Longevity-Associated Gene , 2020, Cells.

[159]  J. Mielgo-Ayuso,et al.  Effects of Arginine Supplementation on Athletic Performance Based on Energy Metabolism: A Systematic Review and Meta-Analysis , 2020, Nutrients.

[160]  Dana M. Bis-Brewer,et al.  Biallelic mutations in SORD cause a common and potentially treatable hereditary neuropathy with implications for diabetes , 2020, Nature Genetics.

[161]  Y. Persidsky,et al.  Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles , 2020, Scientific Reports.

[162]  Ling Wei,et al.  Adipocyte fatty acid-binding protein exacerbates cerebral ischaemia injury by disrupting the blood–brain barrier , 2020, European heart journal.

[163]  G. Laverman,et al.  The role of renal hypoxia in the pathogenesis of diabetic kidney disease: a promising target for newer renoprotective agents including SGLT2 inhibitors? , 2020, Kidney international.

[164]  E. Souied,et al.  Efficacy and Safety of Abicipar in Neovascular Age-Related Macular Degeneration: 52-Week Results of Phase 3 Randomized Controlled Study. , 2020, Ophthalmology.

[165]  T. Brott,et al.  Collateral Recruitment Is Impaired by Cerebral Small Vessel Disease , 2020, Stroke.

[166]  G. Vistoli,et al.  Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs , 2020, Molecules.

[167]  Nicholas S. McCarty,et al.  Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling. , 2020, JCI insight.

[168]  Yingying Gao,et al.  The effect of total lignans from Fructus Arctii on Streptozotocin-induced diabetic retinopathy in Wistar rats. , 2020, Journal of ethnopharmacology.

[169]  G. Nijpels,et al.  Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective observational study and embedded randomised placebo-controlled trial. , 2020, The lancet. Diabetes & endocrinology.

[170]  M. Carnethon,et al.  Cerebral microvascular complications of type 2 diabetes: stroke, cognitive dysfunction, and depression. , 2020, The lancet. Diabetes & endocrinology.

[171]  I. Sharma,et al.  Homocysteine Induces Inflammation in Retina and Brain , 2020, Biomolecules.

[172]  P. Rorsman,et al.  Incretin hormones, insulin, glucagon and advanced glycation end products in relation to cognitive function in older people with and without diabetes, a population‐based study , 2020, Diabetic medicine : a journal of the British Diabetic Association.

[173]  C. Lang,et al.  Letter by Mordi et al Regarding Article, "Metformin Use and Clinical Outcomes Among Patients With Diabetes Mellitus With or Without Heart Failure or Kidney Dysfunction: Observations From the SAVOR-TIMI 53 Trial". , 2020, Circulation.

[174]  R. Abdel-Rahman,et al.  Metformin and trimetazidine ameliorate diabetes-induced cognitive impediment in status epileptic rats , 2020, Epilepsy & Behavior.

[175]  M. Chopp,et al.  Exosomes Derived From Schwann Cells Ameliorate Peripheral Neuropathy in Type 2 Diabetic Mice , 2020, Diabetes.

[176]  Jianliang Fu,et al.  TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus , 2020, Journal of Neuroinflammation.

[177]  Q. Ren,et al.  Positive and negative regulatory effects of transcription factor activator protein 1 (AP1) on the expression of antimicrobial peptides in Macrobrachium nipponense. , 2020, Fish & shellfish immunology.

[178]  Mona Sharifi Sarabi,et al.  Automated Deformation-Based Analysis of 3D Optical Coherence Tomography in Diabetic Retinopathy , 2020, IEEE Transactions on Medical Imaging.

[179]  T. Mochizuki,et al.  Roles of Insulin Receptor Substrates (IRS) in renal function and renal hemodynamics , 2009, PloS one.

[180]  N. Prabhakar,et al.  Hypoxia-inducible factors and obstructive sleep apnea , 2020 .

[181]  F. Crea,et al.  Endothelial dysfunction and cardiovascular outcome in asymptomatic patients with type 2 diabetes: A pilot study , 2019, Diabetes/metabolism research and reviews.

[182]  Yue Liu,et al.  New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach , 2019, Oxidative medicine and cellular longevity.

[183]  L. Lund,et al.  Type 2 diabetes increases the long‐term risk of heart failure and mortality in patients with atrial fibrillation , 2019, European journal of heart failure.

[184]  G. Opdenakker,et al.  The Proinflammatory and Proangiogenic Macrophage Migration Inhibitory Factor Is a Potential Regulator in Proliferative Diabetic Retinopathy , 2019, Front. Immunol..

[185]  M. Ihara,et al.  Animal Models of Chronic Cerebral Hypoperfusion: From Mouse to Primate , 2019, International journal of molecular sciences.

[186]  Mingjun Shi,et al.  BMP-7 inhibits renal fibrosis in diabetic nephropathy via miR-21 downregulation. , 2019, Life sciences.

[187]  Yuge Wang,et al.  The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke , 2019, Journal of Neuroinflammation.

[188]  X. Qin,et al.  Repression of microRNA-21 inhibits retinal vascular endothelial cell growth and angiogenesis via PTEN dependent-PI3K/Akt/VEGF signaling pathway in diabetic retinopathy. , 2019, Experimental eye research.

[189]  M. Chopp,et al.  Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes , 2019, Diabetologia.

[190]  Lu Lu,et al.  Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK/NF-κB/NLRP3 signaling pathway in AGEs-induced HUVECs. , 2019, European journal of pharmacology.

[191]  Yue Liu,et al.  Interplay between Exosomes and Autophagy in Cardiovascular Diseases: Novel Promising Target for Diagnostic and Therapeutic Application , 2019, Aging and disease.

[192]  T. Hansen,et al.  Diabetes as a cardiovascular risk factor: An overview of global trends of macro and micro vascular complications , 2019, European journal of preventive cardiology.

[193]  Chunguo Wang,et al.  Research progress on Traditional Chinese Medicine syndromes of diabetes mellitus. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[194]  K. Ohashi,et al.  Retinopathy progression and the risk of end-stage kidney disease: results from a longitudinal Japanese cohort of 232 patients with type 2 diabetes and biopsy-proven diabetic kidney disease , 2019, BMJ Open Diabetes Research & Care.

[195]  A. Levin,et al.  SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis. , 2019, The lancet. Diabetes & endocrinology.

[196]  L. Tan,et al.  Diabetes mellitus and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 144 prospective studies , 2019, Ageing Research Reviews.

[197]  Y. Liu,et al.  Traditional Chinese medicine foot bath combined with acupoint massage for the treatment of diabetic peripheral neuropathy: A systematic review and meta‐analysis of 31 RCTs , 2019, Diabetes/metabolism research and reviews.

[198]  E. Rhee,et al.  Proteomics and Metabolomics in Kidney Disease, including Insights into Etiology, Treatment, and Prevention. , 2019, Clinical journal of the American Society of Nephrology : CJASN.

[199]  F. Geurts,et al.  The renal hemodynamic effects of the SGLT2 inhibitor dapagliflozin are caused by post-glomerular vasodilatation rather than pre-glomerular vasoconstriction in metformin-treated patients with type 2 diabetes in the randomized, double-blind RED trial. , 2019, Kidney international.

[200]  B. Molyneaux,et al.  Intravenous Glibenclamide Reduces Lesional Water Uptake in Large Hemispheric Infarction. , 2019, Stroke.

[201]  Yingliang Wu,et al.  One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages. , 2019, Molecular cell.

[202]  A. Avogaro,et al.  Microvascular complications in diabetes: A growing concern for cardiologists. , 2019, International journal of cardiology.

[203]  Y. Hung,et al.  Cilostazol inhibits hyperglucose-induced vascular smooth muscle cell dysfunction by modulating the RAGE/ERK/NF-κB signaling pathways , 2019, Journal of Biomedical Science.

[204]  Qifu Li,et al.  Standards of medical care for type 2 diabetes in China 2019 , 2019, Diabetes/metabolism research and reviews.

[205]  T. Vilsbøll,et al.  Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. , 2019, The New England journal of medicine.

[206]  E. Selvin,et al.  Epidemiology of Peripheral Neuropathy and Lower Extremity Disease in Diabetes , 2019, Current Diabetes Reports.

[207]  B. Viollet,et al.  Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus , 2019, Nature Reviews Endocrinology.

[208]  Chao-shu Tang,et al.  Calcium Dobesilate Restores Autophagy by Inhibiting the VEGF/PI3K/AKT/mTOR Signaling Pathway , 2019, Front. Pharmacol..

[209]  H. Park,et al.  Diabetic retinopathy is a prognostic factor for progression of chronic kidney disease in the patients with type 2 diabetes mellitus , 2019, PloS one.

[210]  Michael T. McManus,et al.  BCAA catabolism in brown fat controls energy homeostasis through SLC25A44 , 2019, Nature.

[211]  G. Michailidis,et al.  Impaired Amino Acid and TCA Metabolism and Cardiovascular Autonomic Neuropathy Progression in Type 1 Diabetes , 2019, Diabetes.

[212]  H. Nagasu,et al.  Evaluation of Glomerular Hemodynamic Function by Empagliflozin in Diabetic Mice using In Vivo Imaging. , 2019, Circulation.

[213]  W. E. Sanabria,et al.  Dulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial. , 2019, Lancet.

[214]  Jennifer K. Sun,et al.  Retinol binding protein 3 is increased in the retina of patients with diabetes resistant to diabetic retinopathy , 2019, Science Translational Medicine.

[215]  E. Braunwald Diabetes, heart failure, and renal dysfunction: The vicious circles. , 2019, Progress in cardiovascular diseases.

[216]  S. Heller,et al.  Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial. , 2019, The lancet. Diabetes & endocrinology.

[217]  F. Drago,et al.  Retinal and circulating miRNA expression patterns in diabetic retinopathy: An in silico and in vivo approach , 2019, British journal of pharmacology.

[218]  R. Inagi,et al.  SMPDL3b modulates insulin receptor signaling in diabetic kidney disease , 2019, Nature Communications.

[219]  D. Reda,et al.  Intensive Glucose Control in Patients with Type 2 Diabetes - 15-Year Follow-up. , 2019, The New England journal of medicine.

[220]  O. Pedersen,et al.  Beneficial impact of intensified multifactorial intervention on risk of stroke: outcome of 21 years of follow-up in the randomised Steno-2 Study , 2019, Diabetologia.

[221]  Mitsuo Kato,et al.  Epigenetics and epigenomics in diabetic kidney disease and metabolic memory , 2019, Nature Reviews Nephrology.

[222]  Debra F. Weinstein,et al.  Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial. , 2019, Lancet.

[223]  Shuai Jiang,et al.  Mitochondrial electron transport chain, ROS generation and uncoupling (Review) , 2019, International journal of molecular medicine.

[224]  E. Feldman,et al.  The Divergent Roles of Dietary Saturated and Monounsaturated Fatty Acids on Nerve Function in Murine Models of Obesity , 2019, The Journal of Neuroscience.

[225]  T. Abe,et al.  Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease , 2019, Nature Communications.

[226]  Radhika S. Khetani,et al.  Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression , 2019, Cell.

[227]  B. Zinman,et al.  Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy. , 2019, The New England journal of medicine.

[228]  M. Rogero,et al.  Glutamine as an Anti-Fatigue Amino Acid in Sports Nutrition , 2019, Nutrients.

[229]  Yue Liu,et al.  Ginkgo Biloba Leaf Extract Attenuates Atherosclerosis in Streptozotocin-Induced Diabetic ApoE-/- Mice by Inhibiting Endoplasmic Reticulum Stress via Restoration of Autophagy through the mTOR Signaling Pathway , 2019, Oxidative medicine and cellular longevity.

[230]  Young Seol Kim,et al.  Presence of Carotid Plaque Is Associated with Rapid Renal Function Decline in Patients with Type 2 Diabetes Mellitus and Normal Renal Function , 2019, Diabetes & metabolism journal.

[231]  C. Zheng,et al.  Diabetic Retinopathy as a Risk Factor for Chronic Kidney Disease Progression: A Multicenter Case–Control Study in Taiwan , 2019, Nutrients.

[232]  P. Carmeliet,et al.  Metabolic Pathways Fueling the Endothelial Cell Drive. , 2019, Annual review of physiology.

[233]  G. Fadini,et al.  Modulation of Obesity and Insulin Resistance by the Redox Enzyme and Adaptor Protein p66Shc , 2019, International journal of molecular sciences.

[234]  L. Moons,et al.  Longitudinal In Vivo Characterization of the Streptozotocin-Induced Diabetic Mouse Model: Focus on Early Inner Retinal Responses. , 2019, Investigative ophthalmology & visual science.

[235]  G. Nadkarni,et al.  Plasma endostatin predicts kidney outcomes in patients with type 2 diabetes. , 2019, Kidney international.

[236]  H. Hong,et al.  ERα and/or ERβ activation ameliorates cognitive impairment, neurogenesis and apoptosis in type 2 diabetes mellitus mice , 2019, Experimental Neurology.

[237]  Deepak L. Bhatt,et al.  Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes , 2019, The New England journal of medicine.

[238]  J. Buse,et al.  Targeting hepatic glucokinase to treat diabetes with TTP399, a hepatoselective glucokinase activator , 2019, Science Translational Medicine.

[239]  E. Abel,et al.  Heart Failure in Type 2 Diabetes Mellitus. , 2019, Circulation research.

[240]  Fengtang Yang,et al.  Human blood vessel organoids as a model of diabetic vasculopathy , 2019, Nature.

[241]  M. Pencina,et al.  Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk: The CARMELINA Randomized Clinical Trial , 2019, JAMA.

[242]  V. Aeri,et al.  Development and characterization of late‐stage diabetes mellitus and ‐associated vascular complications , 2019, Life sciences.

[243]  A. Sahebkar,et al.  Insulin resistance: Review of the underlying molecular mechanisms , 2018, Journal of cellular physiology.

[244]  M. Roden,et al.  Emerging Biomarkers, Tools, and Treatments for Diabetic Polyneuropathy. , 2018, Endocrine reviews.

[245]  D. Liao,et al.  Nicotinate‐curcumin ameliorates cognitive impairment in diabetic rats by rescuing autophagic flux in CA1 hippocampus , 2018, CNS neuroscience & therapeutics.

[246]  A. Sabri,et al.  Hyperglycemia-Driven Neuroinflammation Compromises BBB Leading to Memory Loss in Both Diabetes Mellitus (DM) Type 1 and Type 2 Mouse Models , 2018, Molecular Neurobiology.

[247]  Marc P. Bonaca,et al.  Prevalence and Outcomes of Polyvascular (Coronary, Peripheral, or Cerebrovascular) Disease in Patients With Diabetes Mellitus (From the SAVOR-TIMI 53 Trial). , 2019, The American journal of cardiology.

[248]  L. Tao,et al.  AKF-PD alleviates diabetic nephropathy via blocking the RAGE/AGEs/NOX and PKC/NOX Pathways , 2019, Scientific Reports.

[249]  M. White,et al.  Hyperglycemia induces vascular smooth muscle cell dedifferentiation by suppressing insulin receptor substrate-1–mediated p53/KLF4 complex stabilization , 2018, The Journal of Biological Chemistry.

[250]  C. Held,et al.  Stroke Outcomes With Vorapaxar Versus Placebo in Patients With Acute Coronary Syndromes: Insights From the TRACER Trial , 2018, Journal of the American Heart Association.

[251]  G. Bakris,et al.  Efficacy of a novel inhibitor of vascular adhesion protein-1 in reducing albuminuria in patients with diabetic kidney disease (ALBUM): a randomised, placebo-controlled, phase 2 trial. , 2018, The lancet. Diabetes & endocrinology.

[252]  Hao Wu,et al.  Ectopic lipid accumulation: potential role in tubular injury and inflammation in diabetic kidney disease. , 2018, Clinical science.

[253]  J. Bauersachs,et al.  Of mice and men: models and mechanisms of diabetic cardiomyopathy , 2018, Basic Research in Cardiology.

[254]  T. Craven,et al.  Long-Term Effects of Intensive Glycemic and Blood Pressure Control and Fenofibrate Use on Kidney Outcomes. , 2018, Clinical journal of the American Society of Nephrology : CJASN.

[255]  Min Chen,et al.  Associations of urinary epidermal growth factor and monocyte chemotactic protein-1 with kidney involvement in patients with diabetic kidney disease. , 2018, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[256]  Q. Cui,et al.  Commutative regulation between endothelial NO synthase and insulin receptor substrate 2 by microRNAs. , 2018, Journal of molecular cell biology.

[257]  A. Ortiz,et al.  Inflammation in Diabetic Kidney Disease , 2018, Nephron.

[258]  R. Curi,et al.  Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation , 2018, Nutrients.

[259]  J. Sidney,et al.  Regulatory CD4+ T Cells Recognize Major Histocompatibility Complex Class II Molecule– Restricted Peptide Epitopes of Apolipoprotein B , 2018 .

[260]  G. Bochi,et al.  Urinary kidney injury molecule-1 in renal disease. , 2018, Clinica chimica acta; international journal of clinical chemistry.

[261]  Akiyoshi Uemura,et al.  A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor-dependent pathway after renal injury in mice. , 2018, Kidney international.

[262]  Eugene Y. Kim,et al.  Syndecans in chronic inflammatory and autoimmune diseases: Pathological insights and therapeutic opportunities , 2018, Journal of cellular physiology.

[263]  J. Shaw,et al.  Global trends in diabetes complications: a review of current evidence , 2018, Diabetologia.

[264]  B. Carstensen,et al.  Development of Microvascular Complications and Effect of Concurrent Risk Factors in Type 1 Diabetes: A Multistate Model From an Observational Clinical Cohort Study , 2018, Diabetes Care.

[265]  W. Kuo,et al.  Pkcδ Activation is Involved in ROS-Mediated Mitochondrial Dysfunction and Apoptosis in Cardiomyocytes Exposed to Advanced Glycation End Products (Ages) , 2018, Aging and disease.

[266]  Young‐Hee Kang,et al.  Chrysin Ameliorates Malfunction of Retinoid Visual Cycle through Blocking Activation of AGE-RAGE-ER Stress in Glucose-Stimulated Retinal Pigment Epithelial Cells and Diabetic Eyes , 2018, Nutrients.

[267]  Y. Bao,et al.  Dorzagliatin monotherapy in Chinese patients with type 2 diabetes: a dose-ranging, randomised, double-blind, placebo-controlled, phase 2 study. , 2018, The lancet. Diabetes & endocrinology.

[268]  Yusuke Suzuki,et al.  Clinical predictive biomarkers for normoalbuminuric diabetic kidney disease. , 2018, Diabetes research and clinical practice.

[269]  Riccardo Bellazzi,et al.  Risk factors for the development of micro-vascular complications of type 2 diabetes in a single-centre cohort of patients , 2018, Diabetes & vascular disease research.

[270]  Sang Ho Lee,et al.  Chloroquine and amodiaquine enhance AMPK phosphorylation and improve mitochondrial fragmentation in diabetic tubulopathy , 2018, Scientific Reports.

[271]  D. Chuang,et al.  The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase. , 2018, Cell metabolism.

[272]  Wei Wang,et al.  Diabetic Retinopathy: Pathophysiology and Treatments , 2018, International journal of molecular sciences.

[273]  O. Pedersen,et al.  Reduced risk of heart failure with intensified multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: 21 years of follow-up in the randomised Steno-2 study , 2018, Diabetologia.

[274]  Xiao-ying Li,et al.  Dorzagliatin (HMS5552), a novel dual‐acting glucokinase activator, improves glycaemic control and pancreatic β‐cell function in patients with type 2 diabetes: A 28‐day treatment study using biomarker‐guided patient selection , 2018, Diabetes, obesity & metabolism.

[275]  Parvesh Singh,et al.  Current anti-diabetic agents and their molecular targets: A review. , 2018, European journal of medicinal chemistry.

[276]  Deepak L. Bhatt,et al.  Effect of Liraglutide on Cardiovascular Events in Patients With Type 2 Diabetes Mellitus and Polyvascular Disease: Results of the LEADER Trial. , 2018, Circulation.

[277]  T. Wilt,et al.  Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians , 2018, Annals of Internal Medicine.

[278]  S. C. Chan,et al.  Mapping the contribution and strategic distribution patterns of neuroimaging features of small vessel disease in poststroke cognitive impairment , 2018, Journal of Neurology, Neurosurgery, and Psychiatry.

[279]  Yu Geng,et al.  Levels of Inflammatory Cytokines IL-1β, IL-6, IL-8, IL-17A, and TNF-α in Aqueous Humour of Patients with Diabetic Retinopathy , 2018, Journal of diabetes research.

[280]  Deepak L. Bhatt,et al.  Major Adverse Limb Events and Mortality in Patients With Peripheral Artery Disease: The COMPASS Trial. , 2018, Journal of the American College of Cardiology.

[281]  S. Solomon,et al.  Canagliflozin and Heart Failure in Type 2 Diabetes Mellitus , 2018, Circulation.

[282]  M. Marcovecchio,et al.  Biomarkers of diabetic kidney disease , 2018, Diabetologia.

[283]  M. Kretzler,et al.  OP-NDTJ180031 1942..2019 , 2018 .

[284]  Lin Sun,et al.  Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis , 2018, Redox biology.

[285]  S. Das,et al.  Specific PKC βII inhibitor: one stone two birds in the treatment of diabetic foot ulcers , 2018, Bioscience reports.

[286]  R. Roman,et al.  Genetic Susceptibility to Hypertension-Induced Renal Injury. , 2018, Hypertension.

[287]  Yali Ye,et al.  Clinical Significance of Hemostatic Parameters in the Prediction for Type 2 Diabetes Mellitus and Diabetic Nephropathy , 2018, Disease markers.

[288]  S. Qu,et al.  Endoplasmic reticulum stress/autophagy pathway is involved in diabetes-induced neuronal apoptosis and cognitive decline in mice. , 2018, Clinical science.

[289]  R. Guthrie Canagliflozin and cardiovascular and renal events in type 2 diabetes , 2018, Postgraduate medicine.

[290]  B. Zinman,et al.  Cardiovascular Outcomes and Safety of Empagliflozin in Patients With Type 2 Diabetes Mellitus and Peripheral Artery Disease: A Subanalysis of EMPA-REG OUTCOME. , 2017, Circulation.

[291]  P. Carmeliet,et al.  Endothelial Cell Metabolism in Health and Disease. , 2017, Trends in cell biology.

[292]  D. Accili,et al.  Biochemical and cellular properties of insulin receptor signalling , 2017, Nature Reviews Molecular Cell Biology.

[293]  H. Anders,et al.  CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease , 2018, Nature Reviews Nephrology.

[294]  Shuiqing Hu,et al.  Gambogic acid ameliorates diabetes‐induced proliferative retinopathy through inhibition of the HIF‐1&agr;/VEGF expression via targeting PI3K/AKT pathway , 2018, Life sciences.

[295]  T. Coffman,et al.  Modelling diabetic nephropathy in mice , 2018, Nature Reviews Nephrology.

[296]  Guilherme C. Salles,et al.  Aortic stiffness and ambulatory blood pressure as predictors of diabetic kidney disease: a competing risks analysis from the Rio de Janeiro Type 2 Diabetes Cohort Study , 2018, Diabetologia.

[297]  D. Gutsaeva,et al.  Protective effects of agonists of growth hormone-releasing hormone (GHRH) in early experimental diabetic retinopathy , 2017, Proceedings of the National Academy of Sciences.

[298]  Yu-sheng Wang,et al.  Advanced glycation end products promote VEGF expression and thus choroidal neovascularization via Cyr61-PI3K/AKT signaling pathway , 2017, Scientific Reports.

[299]  M. Rewers,et al.  Predictors of early renal function decline in adults with Type 1 diabetes: the Coronary Artery Calcification in Type 1 Diabetes and the Pittsburgh Epidemiology of Diabetes Complications studies , 2017, Diabetic medicine : a journal of the British Diabetic Association.

[300]  M. Edmonds,et al.  Prediabetes: moving away from a glucocentric definition. , 2017, The lancet. Diabetes & endocrinology.

[301]  M. Boemi,et al.  Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial. , 2017, The lancet. Diabetes & endocrinology.

[302]  Jean B. Cormack,et al.  Metformin vs sulfonylurea use and risk of dementia in US veterans aged ≥65 years with diabetes , 2017, Neurology.

[303]  L. Joosten,et al.  Monocyte and macrophage immunometabolism in atherosclerosis , 2017, Seminars in Immunopathology.

[304]  Jakub Toczek,et al.  Characterization of Macrophage Polarization States Using Combined Measurement of 2-Deoxyglucose and Glutamine Accumulation: Implications for Imaging of Atherosclerosis , 2017, Arteriosclerosis, thrombosis, and vascular biology.

[305]  C. Held,et al.  Inflammatory Biomarkers Interleukin‐6 and C‐Reactive Protein and Outcomes in Stable Coronary Heart Disease: Experiences From the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) Trial , 2017, Journal of the American Heart Association.

[306]  C. Iadecola The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease , 2017, Neuron.

[307]  Neha J. Pagidipati,et al.  Effects of Once‐Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes , 2017, The New England journal of medicine.

[308]  S. Engel,et al.  A randomized, placebo-controlled study of the cardiovascular safety of the once-weekly DPP-4 inhibitor omarigliptin in patients with type 2 diabetes mellitus , 2017, Cardiovascular Diabetology.

[309]  M. Gurol Atrial fibrillation and FLAIR/T2 white matter hyperintensities on MRI , 2017, Journal of Neurology, Neurosurgery, and Psychiatry.

[310]  N. Yuldasheva,et al.  Role of glutamine and interlinked asparagine metabolism in vessel formation , 2017, The EMBO journal.

[311]  T. Chenevert,et al.  Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. , 2017, Cell metabolism.

[312]  I. Papassotiriou,et al.  Biomarkers of diabetic nephropathy: A 2017 update , 2017, Critical reviews in clinical laboratory sciences.

[313]  C. Morizzo,et al.  Impact of glycemic control on aortic stiffness, left ventricular mass and diastolic longitudinal function in type 2 diabetes mellitus , 2017, Cardiovascular Diabetology.

[314]  R. Vernooij,et al.  Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia. , 2017, The Cochrane database of systematic reviews.

[315]  B. Zinman,et al.  Efficacy and Safety of Degludec versus Glargine in Type 2 Diabetes , 2017, The New England journal of medicine.

[316]  W. Min,et al.  The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk , 2017, Antioxidants.

[317]  M. Ushio-Fukai,et al.  ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria in VEGF signaling and angiogenesis. , 2017, American journal of physiology. Cell physiology.

[318]  Y. Persidsky,et al.  Blood Brain Barrier Injury in Diabetes: Unrecognized Effects on Brain and Cognition , 2017, Journal of Neuroimmune Pharmacology.

[319]  L. Fried,et al.  Plasma Biomarkers and Kidney Function Decline in Early and Established Diabetic Kidney Disease. , 2017, Journal of the American Society of Nephrology : JASN.

[320]  Alan W. Stitt,et al.  The pathology associated with diabetic retinopathy , 2017, Vision Research.

[321]  B. Zinman,et al.  Association of Glycemic Variability in Type 1 Diabetes With Progression of Microvascular Outcomes in the Diabetes Control and Complications Trial , 2017, Diabetes Care.

[322]  M. Afkarian,et al.  Immunity and inflammation in diabetic kidney disease: translating mechanisms to biomarkers and treatment targets. , 2017, American journal of physiology. Renal physiology.

[323]  Dania O. Govea-Alonso,et al.  Progress and future opportunities in the development of vaccines against atherosclerosis , 2017, Expert review of vaccines.

[324]  Xinghui Sun,et al.  Emerging Roles for MicroRNAs in Diabetic Microvascular Disease: Novel Targets for Therapy , 2017, Endocrine reviews.

[325]  K. Nave,et al.  New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain , 2017, Neuron.

[326]  D. Platt,et al.  Type II diabetes mellitus and hyperhomocysteinemia: a complex interaction , 2017, Diabetology & Metabolic Syndrome.

[327]  V. Parra,et al.  Calcium Transport and Signaling in Mitochondria. , 2017, Comprehensive Physiology.

[328]  R. Kramann,et al.  Gli1+ Pericyte Loss Induces Capillary Rarefaction and Proximal Tubular Injury. , 2017, Journal of the American Society of Nephrology : JASN.

[329]  T. Wong,et al.  Imaging retina to study dementia and stroke , 2017, Progress in Retinal and Eye Research.

[330]  R. Hamman,et al.  Association of Type 1 Diabetes vs Type 2 Diabetes Diagnosed During Childhood and Adolescence With Complications During Teenage Years and Young Adulthood , 2017, JAMA.

[331]  Sherif Hamed Brain injury with diabetes mellitus: evidence, mechanisms and treatment implications , 2017, Expert review of clinical pharmacology.

[332]  Ahmad Esmaillzadeh,et al.  Probiotic supplementation in diabetic hemodialysis patients has beneficial metabolic effects. , 2017, Kidney international.

[333]  Gabor Mark Somfai,et al.  Retinal microvascular network alterations: potential biomarkers of cerebrovascular and neural diseases. , 2017, American journal of physiology. Heart and circulatory physiology.

[334]  Cecil Thomas,et al.  Prevention and treatment of diabetic foot ulcers , 2017, Journal of the Royal Society of Medicine.

[335]  L. Tarnow,et al.  Effect of liraglutide, a glucagon‐like peptide‐1 analogue, on left ventricular function in stable chronic heart failure patients with and without diabetes (LIVE)—a multicentre, double‐blind, randomised, placebo‐controlled trial , 2017, European journal of heart failure.

[336]  Chang-Qing Zhang,et al.  Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model , 2017, Theranostics.

[337]  Heung-Kook Choi,et al.  Stroke outcomes are worse with larger leukoaraiosis volumes , 2017, Brain : a journal of neurology.

[338]  H. Hammes Diabetic retinopathy: hyperglycaemia, oxidative stress and beyond , 2017, Diabetologia.

[339]  J. Sowers,et al.  Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease , 2017, Diabetologia.

[340]  A. Mahmoud,et al.  Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism , 2017, European Journal of Nutrition.

[341]  Stephen J. Aldington,et al.  Association of Retinopathy and Retinal Microvascular Abnormalities With Stroke and Cerebrovascular Disease , 2016, Stroke.

[342]  Daniel Chappell,et al.  Regulation of blood flow and volume exchange across the microcirculation , 2016, Critical Care.

[343]  Lawrence A Leiter,et al.  Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. , 2016, The New England journal of medicine.

[344]  P. Wiedemann,et al.  Osmotic expression of aldose reductase in retinal pigment epithelial cells: involvement of NFAT5 , 2016, Graefe's Archive for Clinical and Experimental Ophthalmology.

[345]  D. Fitchett,et al.  Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications. , 2016, Circulation.

[346]  M. Woodward,et al.  Presentations of major peripheral arterial disease and risk of major outcomes in patients with type 2 diabetes: results from the ADVANCE-ON study , 2016, Cardiovascular Diabetology.

[347]  Z. Attieh,et al.  Experimental Diabetes Mellitus in Different Animal Models , 2016, Journal of diabetes research.

[348]  S. Ito,et al.  Coagulation Factor Xa and Protease-Activated Receptor 2 as Novel Therapeutic Targets for Diabetic Nephropathy , 2016, Arteriosclerosis, thrombosis, and vascular biology.

[349]  C. Östenson,et al.  Arginase Inhibition Improves Microvascular Endothelial Function in Patients With Type 2 Diabetes Mellitus. , 2016, The Journal of clinical endocrinology and metabolism.

[350]  A. Veves,et al.  Endothelial Dysfunction as a Link Between Cardiovascular Risk Factors and Peripheral Neuropathy in Diabetes. , 2016, The Journal of clinical endocrinology and metabolism.

[351]  Guojun Jiang,et al.  Metformin improves the angiogenic functions of endothelial progenitor cells via activating AMPK/eNOS pathway in diabetic mice , 2016, Cardiovascular Diabetology.

[352]  E. Mannucci,et al.  Perspectives in GLP-1 Research: New Targets, New Receptors , 2016, Trends in Endocrinology & Metabolism.

[353]  P. Pais,et al.  Lipoprotein‐Associated Phospholipase A2 Activity Is a Marker of Risk But Not a Useful Target for Treatment in Patients With Stable Coronary Heart Disease , 2016, Journal of the American Heart Association.

[354]  M. Eriksson,et al.  Arginase inhibition improves endothelial function in patients with familial hypercholesterolaemia irrespective of their cholesterol levels , 2016, Journal of internal medicine.

[355]  D. Green,et al.  Arterial structure and function in vascular ageing: are you as old as your arteries? , 2016, The Journal of physiology.

[356]  M. Roden,et al.  Adiponectin, markers of subclinical inflammation and nerve conduction in individuals with recently diagnosed type 1 and type 2 diabetes. , 2016, European journal of endocrinology.

[357]  C. Furberg,et al.  Lipoprotein-Associated Phospholipase A2 and Incident Peripheral Arterial Disease in Older Adults: The Cardiovascular Health Study , 2016, Arteriosclerosis, thrombosis, and vascular biology.

[358]  A. Koster,et al.  Atrasentan Reduces Albuminuria by Restoring the Glomerular Endothelial Glycocalyx Barrier in Diabetic Nephropathy , 2016, Diabetes.

[359]  M. Fischereder,et al.  Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. , 2016, The New England journal of medicine.

[360]  T. Assimes,et al.  The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease , 2016, The Journal of experimental medicine.

[361]  E. Lammert,et al.  Exciting Times for Pancreatic Islets: Glutamate Signaling in Endocrine Cells , 2016, Trends in Endocrinology & Metabolism.

[362]  E Erdmann,et al.  Ten‐year observational follow‐up of PROactive: a randomized cardiovascular outcomes trial evaluating pioglitazone in type 2 diabetes , 2016, Diabetes, obesity & metabolism.

[363]  J. Sowers,et al.  Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy , 2016, Nature Reviews Endocrinology.

[364]  Hyung-Ryong Kim,et al.  Endoplasmic Reticulum Stress and Associated ROS , 2016, International journal of molecular sciences.

[365]  Frédéric Larrieu-Lahargue,et al.  Impaired Hedgehog signalling-induced endothelial dysfunction is sufficient to induce neuropathy: implication in diabetes. , 2016, Cardiovascular research.

[366]  W. Cushman,et al.  Nine-Year Effects of 3.7 Years of Intensive Glycemic Control on Cardiovascular Outcomes , 2016, Diabetes Care.

[367]  B. Zinman,et al.  Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial , 2016, European heart journal.

[368]  P. Grieco,et al.  Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy , 2016, Mediators of inflammation.

[369]  Seung-Hyun Jung,et al.  High glucose‐induced changes in hyaloid‐retinal vessels during early ocular development of zebrafish: a short‐term animal model of diabetic retinopathy , 2016, British journal of pharmacology.

[370]  B. S. Sekhon,et al.  Updates on Aldose Reductase Inhibitors for Management of Diabetic Complications and Non-diabetic Diseases. , 2015, Mini reviews in medicinal chemistry.

[371]  N. Shu,et al.  Disrupted White Matter Network and Cognitive Decline in Type 2 Diabetes Patients. , 2016, Journal of Alzheimer's disease : JAD.

[372]  D. Devanand,et al.  Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial. , 2016, Journal of Alzheimer's disease : JAD.

[373]  F. Porzsolt,et al.  Using machine learning to predict laboratory test results , 2016, Annals of clinical biochemistry.

[374]  S. Solomon,et al.  Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome. , 2015, The New England journal of medicine.

[375]  C. Ince,et al.  Microcirculation in Acute and Chronic Kidney Diseases. , 2015, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[376]  Guixia Wang,et al.  Metabolomic biomarkers in diabetic kidney diseases--A systematic review. , 2015, Journal of diabetes and its complications.

[377]  Shuainan Liu,et al.  Antidiabetic potential of a novel dual-target activator of glucokinase and peroxisome proliferator activated receptor-γ. , 2015, Metabolism: clinical and experimental.

[378]  Se-Yun Kim,et al.  Targeting T helper 17 by mycophenolate mofetil attenuates diabetic nephropathy progression. , 2015, Translational research : the journal of laboratory and clinical medicine.

[379]  R. Gadsby,et al.  Current prevalence of Type 1 and Type 2 diabetes in adults and children in the UK , 2015, Diabetic medicine : a journal of the British Diabetic Association.

[380]  Merlin C. Thomas,et al.  Diabetic kidney disease , 2015, Nature Reviews Disease Primers.

[381]  P. Austin,et al.  Risk of Dementia in Seniors With Newly Diagnosed Diabetes: A Population-Based Study , 2015, Diabetes Care.

[382]  N. Newman,et al.  Ocular fundus photography of patients with focal neurologic deficits in an emergency department , 2015, Neurology.

[383]  M. Pencina,et al.  Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes. , 2015, The New England journal of medicine.

[384]  A. Krolewski,et al.  Cardiac autonomic neuropathy and early progressive renal decline in patients with nonmacroalbuminuric type 1 diabetes. , 2015, Clinical journal of the American Society of Nephrology : CJASN.

[385]  Jian-jun Liu,et al.  Vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1, is associated with diabetic kidney disease in Asians with type 2 diabetes. , 2015, Journal of diabetes and its complications.

[386]  J. M. Petrash,et al.  Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells. , 2015, Chemico-biological interactions.

[387]  T. Coffman,et al.  Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney. , 2015, Journal of the American Society of Nephrology : JASN.

[388]  W. Arendshorst,et al.  Renal autoregulation in health and disease. , 2015, Physiological Reviews.

[389]  G. Lip,et al.  The impact of associated diabetic retinopathy on stroke and severe bleeding risk in diabetic patients with atrial fibrillation: the loire valley atrial fibrillation project. , 2015, Chest.

[390]  Michael Simons,et al.  Endothelial cell metabolism in normal and diseased vasculature. , 2015, Circulation research.

[391]  J. Holst,et al.  l-Glutamine and Whole Protein Restore First-Phase Insulin Response and Increase Glucagon-Like Peptide-1 in Type 2 Diabetes Patients , 2015, Nutrients.

[392]  Abhishek K. Jha,et al.  Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. , 2015, Immunity.

[393]  P. Carmeliet,et al.  Fatty acid carbon is essential for dNTP synthesis in endothelial cells , 2015, Nature.

[394]  J. Wardlaw,et al.  Pharmacological treatment and prevention of cerebral small vessel disease: a review of potential interventions , 2015, International journal of stroke : official journal of the International Stroke Society.

[395]  Spiros Denaxas,et al.  Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1·9 million people , 2015, The Lancet.

[396]  G. A. Limb,et al.  IL-1β induces IL-6 production in retinal Müller cells predominantly through the activation of p38 MAPK/NF-κB signaling pathway. , 2015, Experimental cell research.

[397]  G. Biessels,et al.  Glucose regulation, cognition, and brain MRI in type 2 diabetes: a systematic review. , 2015, The lancet. Diabetes & endocrinology.

[398]  Yongyan Wang,et al.  White Matter Integrity Disruptions Associated With Cognitive Impairments in Type 2 Diabetic Patients , 2014, Diabetes.

[399]  T. Wong,et al.  Retinal Vessel Calibers Predict Long-term Microvascular Complications in Type 1 Diabetes: The Danish Cohort of Pediatric Diabetes 1987 (DCPD1987) , 2014, Diabetes.

[400]  Anthony Dohan,et al.  Diabetic Microangiopathy: Impact of Impaired Cerebral Vasoreactivity and Delayed Angiogenesis After Permanent Middle Cerebral Artery Occlusion on Stroke Damage and Cerebral Repair in Mice , 2014, Diabetes.

[401]  Tetsuhiro Tanaka,et al.  The potential for renoprotection with incretin-based drugs. , 2014, Kidney international.

[402]  J. Górriz,et al.  Diabetic kidney disease: from physiology to therapeutics , 2014, The Journal of physiology.

[403]  J. Becker,et al.  eEOC-mediated modulation of endothelial autophagy, senescence, and EnMT in murine diabetic nephropathy. , 2014, American journal of physiology. Renal physiology.

[404]  L. Sobrin,et al.  The relationship between diabetic retinopathy and diabetic nephropathy in a population-based study in Korea (KNHANES V-2, 3). , 2014, Investigative ophthalmology & visual science.

[405]  R. Kardon,et al.  Effect of glycemic control on corneal nerves and peripheral neuropathy in streptozotocin‐induced diabetic C57Bl/6J mice , 2014, Journal of the peripheral nervous system : JPNS.

[406]  J. W. Miller,et al.  Ischemic diabetic retinopathy as a possible prognostic factor for chronic kidney disease progression , 2014, Eye.

[407]  D. Gordin,et al.  Different Risk Factor Profiles for Ischemic and Hemorrhagic Stroke in Type 1 Diabetes Mellitus , 2014, Stroke.

[408]  A. Ortiz,et al.  Inflammation in Diabetic Kidney Disease , 2018, Nephron.

[409]  Merlin C. Thomas,et al.  Osteopontin Is a Strong Predictor of Incipient Diabetic Nephropathy, Cardiovascular Disease, and All-Cause Mortality in Patients With Type 1 Diabetes , 2014, Diabetes Care.

[410]  S. Yusuf,et al.  Effects of basal insulin glargine and omega-3 fatty acid on cognitive decline and probable cognitive impairment in people with dysglycaemia: a substudy of the ORIGIN trial. , 2014, The lancet. Diabetes & endocrinology.

[411]  M. Matsuhisa,et al.  Effects of pioglitazone on macrovascular events in patients with type 2 diabetes mellitus at high risk of stroke: the PROFIT-J study. , 2014, Journal of atherosclerosis and thrombosis.

[412]  A. Soloviev,et al.  Protein kinase C in enhanced vascular tone in diabetes mellitus. , 2014, International journal of cardiology.

[413]  W. Ahmad Effect of Aleglitazar on Cardiovascular Outcomes After Acute Coronary Syndrome in Patients With Type 2 Diabetes Mellitus The AleCardio Randomized Clinical Trial , 2014 .

[414]  Andrea Glasauer,et al.  Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis , 2014, eLife.

[415]  De-Pei Liu,et al.  Mitochondria, endothelial cell function, and vascular diseases , 2014, Front. Physiol..

[416]  R. Hoffmann,et al.  The Receptor for Advanced Glycation End Products (RAGE) Specifically Recognizes Methylglyoxal-Derived AGEs , 2014, Biochemistry.

[417]  N. Ferrara,et al.  Platelet-derived growth factor C promotes revascularization in ischemic limbs of diabetic mice. , 2014, Journal of vascular surgery.

[418]  D. Grobbee,et al.  Effect of aleglitazar on cardiovascular outcomes after acute coronary syndrome in patients with type 2 diabetes mellitus: the AleCardio randomized clinical trial. , 2014, JAMA.

[419]  I. Amelio,et al.  Serine and glycine metabolism in cancer☆ , 2014, Trends in biochemical sciences.

[420]  T. Hornemann,et al.  Deoxysphingolipids, Novel Biomarkers for Type 2 Diabetes, Are Cytotoxic for Insulin-Producing Cells , 2014, Diabetes.

[421]  S. Reddy,et al.  Reactive oxygen species in inflammation and tissue injury. , 2014, Antioxidants & redox signaling.

[422]  D. Lindholm,et al.  Diabetes drugs and neurological disorders: new views and therapeutic possibilities. , 2014, The lancet. Diabetes & endocrinology.

[423]  H. Ichijo,et al.  Apoptosis Signal–Regulating Kinase 1 Is a Novel Target Molecule for Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[424]  Jennette P. Moreno,et al.  Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes , 2014, Current Atherosclerosis Reports.

[425]  Navpreet Kaur,et al.  Diabetic peripheral neuropathy: current perspective and future directions. , 2014, Pharmacological research.

[426]  J. Helenius,et al.  Extensive Leukoaraiosis Is Associated With High Early Risk of Recurrence After Ischemic Stroke , 2014, Stroke.

[427]  Nirmal Singh,et al.  Advanced Glycation End Products and Diabetic Complications , 2014, The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.

[428]  Ming Liu,et al.  Expression and cell distribution of receptor for advanced glycation end-products in the rat cortex following experimental subarachnoid hemorrhage , 2014, Brain Research.

[429]  M. Rubart,et al.  In situ three-dimensional reconstruction of mouse heart sympathetic innervation by two-photon excitation fluorescence imaging , 2014, Journal of Neuroscience Methods.

[430]  A. Simm,et al.  Role of advanced glycation end products in cellular signaling , 2014, Redox biology.

[431]  T. Ma,et al.  Aggravated cognitive and brain functional impairment in mild cognitive impairment patients with type 2 diabetes: a resting-state functional MRI study. , 2014, Journal of Alzheimer's disease : JAD.

[432]  J. Simard,et al.  Effect of glibenclamide on the prevention of secondary brain injury following ischemic stroke in humans. , 2014, Neurosurgical Focus.

[433]  R. Retnakaran,et al.  Concordance of retinopathy and nephropathy over time in Type 1 diabetes: an analysis of data from the Diabetes Control and Complications Trial , 2013, Diabetic medicine : a journal of the British Diabetic Association.

[434]  W. Katon,et al.  Risk score for prediction of 10 year dementia risk in individuals with type 2 diabetes: a cohort study. , 2013, The lancet. Diabetes & endocrinology.

[435]  D. Gordin,et al.  Incidence of Stroke According to Presence of Diabetic Nephropathy and Severe Diabetic Retinopathy in Patients With Type 1 Diabetes , 2013, Diabetes Care.

[436]  Deepak L. Bhatt,et al.  Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. , 2013, The New England journal of medicine.

[437]  E. Rimm,et al.  Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes. , 2013, JAMA.

[438]  H. Yamashita,et al.  Diabetic Retinopathy and Microalbuminuria Can Predict Macroalbuminuria and Renal Function Decline in Japanese Type 2 Diabetic Patients , 2013, Diabetes Care.

[439]  S. Haneuse,et al.  Glucose levels and risk of dementia. , 2013, The New England journal of medicine.

[440]  T. Wong,et al.  Microvascular Structure and Network in the Retina of Patients With Ischemic Stroke , 2013, Stroke.

[441]  P. Carmeliet,et al.  Role of PFKFB3-Driven Glycolysis in Vessel Sprouting , 2013, Cell.

[442]  U. Förstermann,et al.  Oxidative stress in vascular disease and its pharmacological prevention. , 2013, Trends in pharmacological sciences.

[443]  Alexander Leemans,et al.  Disruption of the Cerebral White Matter Network Is Related to Slowing of Information Processing Speed in Patients With Type 2 Diabetes , 2013, Diabetes.

[444]  H. Mischak,et al.  CKD273, a New Proteomics Classifier Assessing CKD and Its Prognosis , 2013, PloS one.

[445]  T. Sasaoka,et al.  Cilostazol ameliorates systemic insulin resistance in diabetic db/db mice by suppressing chronic inflammation in adipose tissue via modulation of both adipocyte and macrophage functions. , 2013, European journal of pharmacology.

[446]  J. Beckman,et al.  Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I , 2013, European heart journal.

[447]  K. Siamopoulos,et al.  Optimal Medical Management in Patients with Renovascular Hypertension , 2013, American Journal of Cardiovascular Drugs.

[448]  E. Michelakis,et al.  Mitochondria in vascular health and disease. , 2013, Annual review of physiology.

[449]  R. Loutzenhiser,et al.  Renal microvascular dysfunction, hypertension and CKD progression , 2013, Current opinion in nephrology and hypertension.

[450]  Dhiren P. Shah,et al.  ON OXIDATIVE STRESS AND DIABETIC COMPLICATIONS , 2013 .

[451]  H. Yamashita,et al.  Diabetic Retinopathy and Microalbuminuria Can Predict Macroalbuminuria and Renal Function Decline in Japanese Type 2 Diabetic Patients Japan Diabetes Complications Study , 2013 .

[452]  W. Banks,et al.  Insulin in the brain: there and back again. , 2012, Pharmacology & therapeutics.

[453]  W. Rathmann,et al.  Postchallenge Hyperglycemia Is Positively Associated With Diabetic Polyneuropathy , 2012, Diabetes Care.

[454]  Salim Yusuf,et al.  Basal insulin and cardiovascular and other outcomes in dysglycemia. , 2012, The New England journal of medicine.

[455]  J. Schneider,et al.  Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. , 2012, The Journal of clinical investigation.

[456]  W. Graier,et al.  Endothelial mitochondria—less respiration, more integration , 2012, Pflügers Archiv - European Journal of Physiology.

[457]  Hong He,et al.  ERK and Akt signaling pathways are involved in advanced glycation end product-induced autophagy in rat vascular smooth muscle cells , 2012, International journal of molecular medicine.

[458]  A. Boulton,et al.  Prevalence and Characteristics of Painful Diabetic Neuropathy in a Large Community-Based Diabetic Population in the U.K. , 2011, Diabetes Care.

[459]  F. Tinahones,et al.  Modulation of human monocyte CD36 by type 2 diabetes mellitus and other atherosclerotic risk factors , 2011, European journal of clinical investigation.

[460]  Mark Henkelman,et al.  Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. , 2011, The Journal of clinical investigation.

[461]  A. Ergul Endothelin-1 and diabetic complications: focus on the vasculature. , 2011, Pharmacological research.

[462]  C. Kahn,et al.  Insulin signaling to the glomerular podocyte is critical for normal kidney function. , 2010, Cell metabolism.

[463]  Katrin J. Svensson,et al.  Ornithine decarboxylase and extracellular polyamines regulate microvascular sprouting and actin cytoskeleton dynamics in endothelial cells. , 2010, Experimental cell research.

[464]  R. Dobrowsky,et al.  Diminished Superoxide Generation Is Associated With Respiratory Chain Dysfunction and Changes in the Mitochondrial Proteome of Sensory Neurons From Diabetic Rats , 2010, Diabetes.

[465]  R. Bautista,et al.  Effect of phlorizin on SGLT2 expression in the kidney of diabetic rats. , 2010, Journal of nephrology.

[466]  D. Appling,et al.  Compartmentalization of Mammalian folate-mediated one-carbon metabolism. , 2010, Annual review of nutrition.

[467]  M. Girolami,et al.  Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease* , 2010, Molecular & Cellular Proteomics.

[468]  L. Holzman,et al.  Podocyte-specific overexpression of GLUT1 surprisingly reduces mesangial matrix expansion in diabetic nephropathy in mice. , 2010, American journal of physiology. Renal physiology.

[469]  The Emerging Risk Factors Collaboration Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies , 2010, The Lancet.

[470]  L. Rui,et al.  SH2B regulation of growth, metabolism, and longevity in both insects and mammals. , 2010, Cell metabolism.

[471]  J. Kopp,et al.  Bioenergetic characterization of mouse podocytes. , 2010, American journal of physiology. Cell physiology.

[472]  B. Janssen,et al.  Impaired cardiac functional reserve in type 2 diabetic db/db mice is associated with metabolic, but not structural, remodelling , 2010, Acta physiologica.

[473]  A. Zholos,et al.  Rho kinase and protein kinase C involvement in vascular smooth muscle myofilament calcium sensitization in arteries from diabetic rats , 2010, British journal of pharmacology.

[474]  Jeroen J. Bax,et al.  Long-term prognosis of patients with peripheral arterial disease with or without polyvascular atherosclerotic disease. , 2010, European heart journal.

[475]  J. Salomon,et al.  Event Rates, Hospital Utilization, and Costs Associated with Major Complications of Diabetes: A Multicountry Comparative Analysis , 2010, PLoS medicine.

[476]  T. Hornemann,et al.  Hereditary Sensory Neuropathy Type 1 Is Caused by the Accumulation of Two Neurotoxic Sphingolipids*♦ , 2010, The Journal of Biological Chemistry.

[477]  J. Shaw,et al.  Global estimates of the prevalence of diabetes for 2010 and 2030. , 2010, Diabetes research and clinical practice.

[478]  H. Gröne,et al.  Effects of increased renal tubular vascular endothelial growth factor (VEGF) on fibrosis, cyst formation, and glomerular disease. , 2009, The American journal of pathology.

[479]  L. Aiello,et al.  Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy , 2009, Nature Medicine.

[480]  M. Woodward,et al.  Cognitive function and risks of cardiovascular disease and hypoglycaemia in patients with type 2 diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial , 2009, Diabetologia.

[481]  Jin-Tung Liang,et al.  Prevention of arterial stiffening by pyridoxamine in diabetes is associated with inhibition of the pathogenic glycation on aortic collagen , 2009, British journal of pharmacology.

[482]  B. Ganesan,et al.  Tissue-Specific Remodeling of the Mitochondrial Proteome in Type 1 Diabetic Akita Mice , 2009, Diabetes.

[483]  R. Liao,et al.  Increased Glucose Uptake and Oxidation in Mouse Hearts Prevent High Fatty Acid Oxidation but Cause Cardiac Dysfunction in Diet-Induced Obesity , 2009, Circulation.

[484]  M. Cooper,et al.  RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes. , 2009, Journal of the American Society of Nephrology : JASN.

[485]  B. Winblad,et al.  Uncontrolled diabetes increases the risk of Alzheimer’s disease: a population-based cohort study , 2009, Diabetologia.

[486]  E. Abel,et al.  Contribution of Impaired Myocardial Insulin Signaling to Mitochondrial Dysfunction and Oxidative Stress in the Heart , 2009, Circulation.

[487]  R. Ramasamy,et al.  The receptor for advanced glycation endproducts (RAGE) and cardiovascular disease , 2009, Expert Reviews in Molecular Medicine.

[488]  Grant D. Huang,et al.  Glucose control and vascular complications in veterans with type 2 diabetes. , 2009, The New England journal of medicine.

[489]  R. Holman,et al.  10-year follow-up of intensive glucose control in type 2 diabetes. , 2008, The New England journal of medicine.

[490]  C. Schalkwijk,et al.  Advanced Glycation End Products Accumulate in Vascular Smooth Muscle and Modify Vascular but Not Ventricular Properties in Elderly Hypertensive Canines , 2008, Circulation.

[491]  C. Ahn,et al.  The activation of NF-kappaB and AP-1 in peripheral blood mononuclear cells isolated from patients with diabetic nephropathy. , 2008, Diabetes research and clinical practice.

[492]  V. Monnier,et al.  RAGE and Modulation of Ischemic Injury in the Diabetic Myocardium , 2008, Diabetes.

[493]  Geert Jan Biessels,et al.  Diabetes and other vascular risk factors for dementia: which factor matters most? A systematic review. , 2008, European journal of pharmacology.

[494]  J. Navarro-González,et al.  The role of inflammatory cytokines in diabetic nephropathy. , 2008, Journal of the American Society of Nephrology : JASN.

[495]  Jian-Mei Li,et al.  Diabetes-Associated Cognitive Impairment Is Improved by a Calcium Channel Blocker, Nifedipine , 2008, Hypertension.

[496]  M. Cerinic,et al.  Early Atherosclerosis and Autoantibodies to Heat‐Shock Proteins and Oxidized LDL in Systemic Sclerosis , 2007, Annals of the New York Academy of Sciences.

[497]  E. Grzęda,et al.  Effect of an NMDA receptor agonist on T-maze and passive avoidance test in 12-week streptozotocin-induced diabetic rats. , 2007, Pharmacological reports : PR.

[498]  Ronald Klein,et al.  Is Diabetic Retinopathy an Independent Risk Factor For Ischemic Stroke? , 2007, Stroke.

[499]  Brian Rodrigues,et al.  Role of changes in cardiac metabolism in development of diabetic cardiomyopathy. , 2006, American journal of physiology. Heart and circulatory physiology.

[500]  Ann Marie Schmidt,et al.  Advanced glycation end products: sparking the development of diabetic vascular injury. , 2006, Circulation.

[501]  M. Szklo,et al.  Diabetic cardiomyopathy and subclinical cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis (MESA). , 2006, Diabetes care.

[502]  P. Scheltens,et al.  Risk of dementia in diabetes mellitus: a systematic review , 2006, The Lancet Neurology.

[503]  F. Cerutti,et al.  Incidence of type 1 and type 2 diabetes in adults aged 30-49 years: the population-based registry in the province of Turin, Italy. , 2005, Diabetes care.

[504]  A. Tall,et al.  Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice. , 2005, The Journal of clinical investigation.

[505]  K. Eriksson,et al.  Inflammatory markers and IL-6 polymorphism in peripheral arterial disease with and without diabetes mellitus , 2005, Vascular medicine.

[506]  E. Inscho,et al.  TGF-β impairs renal autoregulation via generation of ROS , 2005 .

[507]  L. Raij The pathophysiologic basis for blocking the renin-angiotensin system in hypertensive patients with renal disease. , 2005, American journal of hypertension.

[508]  E. Inscho,et al.  TGF-beta impairs renal autoregulation via generation of ROS. , 2005, American journal of physiology. Renal physiology.

[509]  Y. Sekino,et al.  Osmotic Diuretics Induce Adenosine A1 Receptor Expression and Protect Renal Proximal Tubular Epithelial Cells against Cisplatin-mediated Apoptosis* , 2004, Journal of Biological Chemistry.

[510]  Ann Marie Schmidt,et al.  Protein Glycation: A Firm Link to Endothelial Cell Dysfunction , 2004, Circulation research.

[511]  S. Homma,et al.  Central role for aldose reductase pathway in myocardial ischemic injury , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[512]  M. Stumpf,et al.  Interleukin-6 Induces Oxidative Stress and Endothelial Dysfunction by Overexpression of the Angiotensin II Type 1 Receptor , 2004, Circulation research.

[513]  L. Rossetti,et al.  Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. , 2003, The Journal of clinical investigation.

[514]  J. Beckman,et al.  Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I , 2013, European heart journal.

[515]  Kumar Sharma,et al.  Diabetic kidney disease in the db/db mouse. , 2003, American journal of physiology. Renal physiology.

[516]  D. Kass,et al.  Improved Arterial Compliance by a Novel Advanced Glycation End-Product Crosslink Breaker , 2001, Circulation.

[517]  P. Bennett,et al.  Vascular disease prevalence in diabetic patients in China: standardised comparison with the 14 centres in the WHO multinational study of vascular disease in diabetes , 2001, Diabetologia.

[518]  G Premalatha,et al.  Coronary Artery Disease Prevalence of Coronary Artery Disease and Its Relationship to Lipids in a Selected Population in South India The Chennai Urban Population Study (CUPS No. 5) , 2001 .

[519]  T. Sano,et al.  [Diabetic retinopathy]. , 2001, Nihon rinsho. Japanese journal of clinical medicine.

[520]  W. Pan,et al.  Interactions of IGF-1 with the Blood-Brain Barrier in vivo and in situ , 2000, Neuroendocrinology.

[521]  M. Sans,et al.  VCAM-1 and ICAM-1 mediate leukocyte-endothelial cell adhesion in rat experimental colitis. , 1999, Gastroenterology.

[522]  J. Lagendijk,et al.  Modelling the thermal impact of a discrete vessel tree. , 1999, Physics in medicine and biology.

[523]  D. Petitti,et al.  Retinopathy as a risk factor for nonembolic stroke in diabetic subjects. , 1995, Stroke.

[524]  S. Genuth,et al.  The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. , 1993, The New England journal of medicine.

[525]  M. Steffes,et al.  Effects of Sorbinil on Glomerular Structure and Function in Long-Term–Diabetic Rats , 1989, Diabetes.

[526]  S. Moncada,et al.  Vascular endothelial cells synthesize nitric oxide from L-arginine , 1988, Nature.