Thalamic Lesions and Aphasia or Neglect

Purpose of ReviewWhen the thalamus is damaged, not only are there neurological symptoms such as sensory impairment, hemianopia, or motor control disorders, but there are also various neuropsychological symptoms. We discuss the basic anatomy and function of the thalamus followed by a discussion of thalamic aphasia and hemineglect.Recent FindingsSubcortical lesions in patients with hemineglect involved the anatomical network directly linked to the superior temporal gyrus. Furthermore, the pulvinar, part of the thalamus, may be associated with hemineglect. General linguistic tasks activated the thalami, depending on the difficulty, as well as the frontal and temporal lobes. The thalamus may play a role in language and be involved in the activation of cortical language areas, and in the linguistic integration function via verbal memory and semantic mechanisms.SummaryThalamic lesions are associated with aphasia and hemineglect. It is possible the mechanisms and such neuropsychological may be different depending on the size and site of the thalamic lesion.

[1]  A. Morel THE THALAMUS AND BEHAVIOR: EFFECTS OF ANATOMICALLY DISTINCT STROKES , 2007, Neurology.

[2]  H. Karnath,et al.  The subcortical anatomy of human spatial neglect: putamen, caudate nucleus and pulvinar. , 2002, Brain : a journal of neurology.

[3]  S. Cobb Speech and Brain-Mechanisms. , 1960 .

[4]  M. Pessin,et al.  Thalamic haemorrhage. , 1996, Brain : a journal of neurology.

[5]  A. Hillis,et al.  Aphasia or Neglect after Thalamic Stroke: The Various Ways They may be Related to Cortical Hypoperfusion , 2014, Front. Neurol..

[6]  H. Jasper,et al.  A stereotaxic atlas of the diencephalon of the cat , 1960 .

[7]  A. Damasio,et al.  Nonhaemorrhagic thalamic infarction. Clinical, neuropsychological and electrophysiological findings in four anatomical groups defined by computerized tomography. , 1985, Brain : a journal of neurology.

[8]  D. Benson,et al.  Subcortical Dementia: Review of an Emerging Concept , 1984 .

[9]  R. Bruyn,et al.  Thalamic aphasia , 2004, Journal of Neurology.

[10]  D. Llano Functional imaging of the thalamus in language , 2013, Brain and Language.

[11]  K. Uemura,et al.  CT classification of small thalamic hemorrhages and their clinical implications , 1986, Neurology.

[12]  Steven L. Small,et al.  Subcortical aphasia. Commentaries. Reply , 1997 .

[13]  D. Perani,et al.  The anatomy of unilateral neglect after right-hemisphere stroke lesions. A clinical/CT-scan correlation study in man , 1986, Neuropsychologia.

[14]  K. Heilman,et al.  Thalamic neglect , 1979, Neurology.

[15]  J. Schmahmann Vascular syndromes of the thalamus. , 2003, Stroke.

[16]  S. Ibayashi,et al.  Impact of thalamic hematoma on six-month mortality and motor and cognitive functional outcome. , 1995, Stroke.

[17]  G. Assal,et al.  Thalamic hematomas: neuropsychological aspects. Report of 11 cases and review of literature. , 1984, Schweizer Archiv fur Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie.

[18]  D. Karussis,et al.  Cognitive dysfunction following thalamic stroke: a study of 16 cases and review of the literature , 2000, Journal of the Neurological Sciences.

[19]  Giuseppe Vallar,et al.  The Anatomy of Spatial Neglect in Humans , 1987 .

[20]  B. Crosson Subcortical functions in language: A working model , 1985, Brain and Language.

[21]  J. Bogousslavsky,et al.  Thalamic infarcts , 1988, Neurology.

[22]  D. Benson,et al.  Speech and Language Alterations in Dementia Syndromes , 1989 .

[23]  E. Kumral,et al.  Thalamic hemorrhage. A prospective study of 100 patients. , 1995, Stroke.

[24]  L. Caplan,et al.  Vertebrobasilar Occlusive Disease: Review of Selected Aspects , 1992 .

[25]  B. Crosson Role of the dominant thalamus in language: a review. , 1984, Psychological bulletin.

[26]  N. Motomura,et al.  Unilateral spatial neglect due to hemorrhage in the thalamic region , 1986, Acta neurologica Scandinavica.

[27]  K M Heilman,et al.  Mechanisms underlying the unilateral neglect syndrome. , 1977, Advances in neurology.

[28]  J. Bogousslavsky,et al.  Thalamic aphasia , 1988, Neurology.

[29]  A. Luria,et al.  On quasi-aphasic speech disturbances in lesions of the deep structures of the brain , 1977, Brain and Language.

[30]  M. Mesulam A cortical network for directed attention and unilateral neglect , 1981, Annals of neurology.

[31]  J. Bogousslavsky,et al.  The syndrome of unilateral tuberothalamic artery territory infarction. , 1986, Stroke.

[32]  D. S. Bell Speech functions of the thalamus inferred from the effects of thalamotomy. , 1968, Brain : a journal of neurology.

[33]  M. Herrero,et al.  Functional anatomy of thalamus and basal ganglia , 2002, Child’s Nervous System.

[34]  R. Morison,et al.  A STUDY OF THALAMO-CORTICAL RELATIONS , 1941 .

[35]  P. Deyn,et al.  Cognitive, affective and behavioural disturbances following vascular thalamic lesions: A review , 2011, Cortex.

[36]  M. Tuszynski,et al.  Ischemic thalamic aphasia with pathologic confirmation , 1988, Neurology.

[37]  G. Ojemann,et al.  Effect of stimulation of the human thalamus and parietal and temporal white matter on short-term memory. , 1968, Journal of neurosurgery.

[38]  S. Maeshima,et al.  Aphasia and unilateral spatial neglect due to acute thalamic hemorrhage: clinical correlations and outcomes , 2016, Neurological Sciences.

[39]  J. Mohr,et al.  Thalamic hemorrhage and aphasia , 1975, Brain and Language.

[40]  K. Heilman,et al.  Neglect and Related Disorders , 1984, Seminars in neurology.