Allopregnanolone: Regenerative therapeutic to restore neurological health

[1]  L. Bettio,et al.  P.104 Beyond the hippocampus and the SVZ: adult neurogenesis throughout the brain , 2022, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[2]  L. Schneider,et al.  Exploratory imaging outcomes of a phase 1b/2a clinical trial of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: Structural effects and functional connectivity outcomes , 2022, Alzheimer's & dementia.

[3]  H. Gunduz-Bruce,et al.  Effect of Zuranolone vs Placebo in Postpartum Depression , 2021, JAMA psychiatry.

[4]  C. Belzung,et al.  Adult hippocampal neurogenesis shapes adaptation and improves stress response: a mechanistic and integrative perspective , 2021, Molecular Psychiatry.

[5]  E. Bellei,et al.  Serum levels of allopregnanolone, progesterone and testosterone in menstrually-related and postmenopausal migraine: A cross-sectional study , 2020, Cephalalgia : an international journal of headache.

[6]  O. Butovsky,et al.  Microglia, Lifestyle Stress, and Neurodegeneration. , 2020, Immunity.

[7]  L. Schneider,et al.  Safety, tolerability, and pharmacokinetics of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: A single and multiple ascending dose phase 1b/2a clinical trial , 2020, Alzheimer's & dementia.

[8]  L. Schneider,et al.  Retrospective analysis of phytoSERM for management of menopause-associated vasomotor symptoms and cognitive decline: a pilot study on pharmacogenomic effects of mitochondrial haplogroup and APOE genotype on therapeutic efficacy. , 2019, Menopause.

[9]  L. Schneider,et al.  Safety and feasibility of estrogen receptor-β targeted phytoSERM formulation for menopausal symptoms: phase 1b/2a randomized clinical trial. , 2019, Menopause.

[10]  G. Yenokyan,et al.  The Role of Allopregnanolone in Pregnancy in Predicting Postpartum Anxiety Symptoms , 2019, Front. Psychol..

[11]  N. Kalin,et al.  The mediating role of hippocampal networks on stress regulation in amnestic mild cognitive impairment , 2019, Neurobiology of Stress.

[12]  R. Brinton,et al.  Inflammation: Bridging Age, Menopause and APOEε4 Genotype to Alzheimer’s Disease , 2018, Front. Aging Neurosci..

[13]  Oscar Marín,et al.  Development and Functional Diversification of Cortical Interneurons , 2018, Neuron.

[14]  D. Rubinow,et al.  Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials , 2018, The Lancet.

[15]  R. Hen,et al.  Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus , 2018, Nature.

[16]  M. Boldrini,et al.  Human Hippocampal Neurogenesis Persists throughout Aging. , 2018, Cell stem cell.

[17]  N. Justice The relationship between stress and Alzheimer's disease , 2018, Neurobiology of Stress.

[18]  L. Schneider,et al.  Pharmacokinetics and safety profile of single-dose administration of an estrogen receptor &bgr;-selective phytoestrogenic (phytoSERM) formulation in perimenopausal and postmenopausal women , 2017, Menopause.

[19]  R. Hen,et al.  Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood , 2017, Nature Reviews Neuroscience.

[20]  Suzanna Becker,et al.  Neurogenesis and pattern separation: time for a divorce. , 2017, Wiley interdisciplinary reviews. Cognitive science.

[21]  J. Quinn,et al.  Does Psychological Stress Affect the Progression of Parkinson’s Disease (N5.002) , 2017, Neurology.

[22]  Bruce S McEwen,et al.  In pursuit of resilience: stress, epigenetics, and brain plasticity , 2016, Annals of the New York Academy of Sciences.

[23]  R. Morey,et al.  Neurosteroids and Traumatic Brain Injury: Translating Biomarkers to Therapeutics; Overview and Pilot Investigations in Iraq and Afghanistan Era Veterans , 2016 .

[24]  A. Rodrigues,et al.  Chronic Stress and Glucocorticoids: From Neuronal Plasticity to Neurodegeneration , 2016, Neural plasticity.

[25]  Carla Nasca,et al.  Mechanisms of stress in the brain , 2015, Nature Neuroscience.

[26]  Albert García-Quintanilla,et al.  Relevance of chronic stress and the two faces of microglia in Parkinson’s disease , 2015, Front. Cell. Neurosci..

[27]  T. Rowe The Stress of Pregnancy. , 2015, Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC.

[28]  O. Garaschuk,et al.  Neuroinflammation in Alzheimer's disease , 2015, The Lancet Neurology.

[29]  A. Guidotti,et al.  5α-reductase type I expression is downregulated in the prefrontal cortex/Brodmann’s area 9 (BA9) of depressed patients , 2014, Psychopharmacology.

[30]  R. Irwin,et al.  Allopregnanolone as regenerative therapeutic for Alzheimer's disease: Translational development and clinical promise , 2014, Progress in Neurobiology.

[31]  A. Jaggi,et al.  Multifunctional aspects of allopregnanolone in stress and related disorders , 2014, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[32]  Martial Mermillod,et al.  The stability-plasticity dilemma: investigating the continuum from catastrophic forgetting to age-limited learning effects , 2013, Front. Psychol..

[33]  I. Savic,et al.  Increased neurosteroid sensitivity – An explanation to symptoms associated with chronic work related stress in women? , 2013, Psychoneuroendocrinology.

[34]  Hagen B. Huttner,et al.  Dynamics of Hippocampal Neurogenesis in Adult Humans , 2013, Cell.

[35]  S. Shaffer,et al.  GABAergic neuroactive steroids and resting-state functional connectivity in postpartum depression: a preliminary study. , 2013, Journal of psychiatric research.

[36]  R. Brinton Neurosteroids as regenerative agents in the brain: therapeutic implications , 2013, Nature Reviews Endocrinology.

[37]  C. Holmes Review: Systemic inflammation and Alzheimer's disease , 2013, Neuropathology and applied neurobiology.

[38]  S. Paul,et al.  Neurosteroids, stress and depression: Potential therapeutic opportunities , 2013, Neuroscience & Biobehavioral Reviews.

[39]  Richard F. Thompson,et al.  Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice , 2012, Neurobiology of Aging.

[40]  C. Stark,et al.  Pattern separation in the hippocampus , 2011, Trends in Neurosciences.

[41]  L. Ossewaarde,et al.  Paradoxical effects of GABA-A modulators may explain sex steroid induced negative mood symptoms in some persons , 2011, Neuroscience.

[42]  R. Irwin,et al.  Allopregnanolone Promotes Regeneration and Reduces β-Amyloid Burden in a Preclinical Model of Alzheimer's Disease , 2011, PloS one.

[43]  Jason S. Snyder,et al.  Adult hippocampal neurogenesis buffers stress responses and depressive behavior , 2011, Nature.

[44]  B. McEwen,et al.  Stress- and allostasis-induced brain plasticity. , 2011, Annual review of medicine.

[45]  Kee Hyung Park Relationship Between Serum Uric Acid and Cerebral Ischemia in Patients With Cognitive Impairment. , 2010, Alzheimer's & Dementia.

[46]  Richard F. Thompson,et al.  Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease , 2010, Proceedings of the National Academy of Sciences.

[47]  Gerd Kempermann,et al.  Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years , 2010, PloS one.

[48]  L. Saksida,et al.  A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation , 2009, Science.

[49]  C. Spong,et al.  The 2008 National Institute of Child Health and Human Development workshop report on electronic fetal monitoring: update on definitions, interpretation, and research guidelines. , 2008, Obstetrics and gynecology.

[50]  H. Cameron,et al.  New Interneurons in the Adult Neocortex: Small, Sparse, but Significant? , 2008, Biological Psychiatry.

[51]  G. Biggio,et al.  Changes in neuroactive steroid content during social isolation stress modulate GABAA receptor plasticity and function , 2008, Brain Research Reviews.

[52]  B. McEwen Physiology and neurobiology of stress and adaptation: central role of the brain. , 2007, Physiological reviews.

[53]  D. Walker,et al.  Stress in Pregnancy Activates Neurosteroid Production in the Fetal Brain , 2007, Neuroendocrinology.

[54]  E. Dong,et al.  GABAA receptor neurotransmission dysfunction in a mouse model of social isolation-induced stress: Possible insights into a non-serotonergic mechanism of action of SSRIs in mood and anxiety disorders , 2007 .

[55]  B. McEwen,et al.  Protective and damaging effects of stress mediators: central role of the brain , 2006, Dialogues in clinical neuroscience.

[56]  A. Guidotti,et al.  Decreased Cerebrospinal Fluid Allopregnanolone Levels in Women with Posttraumatic Stress Disorder , 2006, Biological Psychiatry.

[57]  A. Guidotti,et al.  Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake , 2006, Psychopharmacology.

[58]  R. Brinton,et al.  The Neurosteroid Allopregnanolone Promotes Proliferation of Rodent and Human Neural Progenitor Cells and Regulates Cell-Cycle Gene and Protein Expression , 2005, The Journal of Neuroscience.

[59]  D. Swaab,et al.  The stress system in the human brain in depression and neurodegeneration , 2005, Ageing Research Reviews.

[60]  M. Schumacher,et al.  3α,5α‐tetrahydroprogesterone (allopregnanolone) and γ‐aminobutyric acid: Autocrine/paracrine interactions in the control of neonatal PSA‐NCAM+ progenitor proliferation , 2004 .

[61]  K. Miczek,et al.  Neurosteroids, GABAA receptors, and escalated aggressive behavior , 2003, Hormones and Behavior.

[62]  K. Light,et al.  Allopregnanolone levels and reactivity to mental stress in premenstrual dysphoric disorder , 2001, Biological Psychiatry.

[63]  F. Petraglia,et al.  Serum allopregnanolone levels in pregnant women: changes during pregnancy, at delivery, and in hypertensive patients. , 2000, The Journal of clinical endocrinology and metabolism.

[64]  R. McKay,et al.  Restoring production of hippocampal neurons in old age , 1999, Nature Neuroscience.

[65]  F. Gage,et al.  Neurogenesis in the adult human hippocampus , 1998, Nature Medicine.

[66]  R. Conley,et al.  Effects of antidepressant treatment on neuroactive steroids in major depression. , 1998, The American journal of psychiatry.

[67]  F. Petraglia,et al.  Circulating levels of allopregnanolone in humans: gender, age, and endocrine influences. , 1998, The Journal of clinical endocrinology and metabolism.

[68]  A. Guidotti,et al.  Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[69]  M. Casey,et al.  5α-dihydroprogesterone formation in human placenta from 5α-pregnan- 3β α -ol-20-ones and 5-pregnan-3β-yl-20-one sulfate , 1997, The Journal of Steroid Biochemistry and Molecular Biology.

[70]  G. Biggio,et al.  The effects of inhibitors of GABAergic transmission and stress on brain and plasma allopregnanolone concentrations , 1997, British journal of pharmacology.

[71]  M. Joëls,et al.  Glucocorticoid Feedback Resistance , 1997, Trends in Endocrinology & Metabolism.

[72]  F. Holsboer,et al.  Antidepressants and hypothalamic-pituitary-adrenocortical regulation. , 1996, Endocrine reviews.

[73]  T. Palmer,et al.  Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[74]  G. Biggio,et al.  Time-dependent changes in rat brain neuroactive steroid concentrations and GABAA receptor function after acute stress. , 1996, Neuroendocrinology.

[75]  F. Petraglia,et al.  Evidence for a role of neurosteroids in modulation of diurnal changes and acute stress-induced corticosterone secretion in rats. , 1995, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.

[76]  F. Holsboer,et al.  The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus , 1994, Neuroscience.

[77]  R. Brinton The neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one induces cytoarchitectural regression in cultured fetal hippocampal neurons , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[78]  P. H. Moore,et al.  Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[79]  E. Baulieu,et al.  Neurosteroids: A new brain function? , 1990, The Journal of Steroid Biochemistry and Molecular Biology.

[80]  M. Bolger,et al.  Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one , 1989 .

[81]  D. Koshland Frontiers in neuroscience. , 1988, Science.

[82]  B. McEwen,et al.  Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action. , 1988, The Journal of pharmacology and experimental therapeutics.

[83]  A. L. Taylor,et al.  Corticotropin-releasing hormone. , 1988, The New England journal of medicine.

[84]  E. Baulieu,et al.  Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[85]  S. Paul,et al.  Sleep induction by an adrenal steroid in the rat , 1987, Psychopharmacology.

[86]  B. McEwen,et al.  GABA-dependent modulation of the Cl- ionophore by steroids in rat brain. , 1987, European journal of pharmacology.

[87]  S. Paul,et al.  Anxiolytic activity of an endogenous adrenal steroid , 1986, Brain Research.

[88]  E. Baulieu,et al.  Pregnenolone and its sulfate ester in the rat brain , 1983, Brain Research.

[89]  E. Hon,et al.  Fetal Hemodynamic Response to Umbilical Cord Compression , 1963, Obstetrics and gynecology.

[90]  K. Barlow Traumatic brain injury. , 2013, Handbook of clinical neurology.

[91]  K. Gee Steroid modulation of the GABA/benzodiazepine receptor-linked chloride lonophore , 2008, Molecular Neurobiology.

[92]  M. Ballabio,et al.  Neuroactive steroids , 2007, Journal of Molecular Neuroscience.

[93]  K. Grant,et al.  Neurosteroids and behavior. , 2001, International review of neurobiology.

[94]  M. Schumacher,et al.  Neurosteroids: beginning of the story. , 2001, International review of neurobiology.

[95]  M. Casey,et al.  5-Alpha-dihydroprogesterone formation in human placenta from 5alpha-pregnan-3beta/alpha-ol-20-ones and 5-pregnan-3beta-yl-20-one sulfate. , 1997, The Journal of steroid biochemistry and molecular biology.

[96]  E. Baulieu STEROID HORMONES IN THE BRAIN: SEVERAL MECHANISMS? , 1981 .

[97]  Peter J Gianaros,et al.  Annals of the New York Academy of Sciences Central Role of the Brain in Stress and Adaptation: Links to Socioeconomic Status, Health, and Disease , 2022 .