Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types

[1]  M. Serrano,et al.  Hallmarks of aging: An expanding universe , 2022, Cell.

[2]  I. Weissman,et al.  Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain , 2022, Nature Aging.

[3]  X. Zhuang,et al.  Molecular and spatial signatures of mouse brain aging at single-cell resolution , 2022, Cell.

[4]  J. Qu,et al.  Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues. , 2022, Cell stem cell.

[5]  I. Weissman,et al.  Cell type-specific aging clocks to quantify aging and rejuvenation in regenerative regions of the brain , 2022, bioRxiv.

[6]  S. Horvath,et al.  Multi-omic rejuvenation and lifespan extension upon exposure to youthful circulation , 2021, bioRxiv.

[7]  C. Adams,et al.  Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells , 2021, Cell metabolism.

[8]  J. Włodarczyk,et al.  Cellular Senescence in Brain Aging , 2021, Frontiers in Aging Neuroscience.

[9]  T. Järvinen,et al.  Pathological Angiogenesis Requires Syndecan-4 for Efficient VEGFA-Induced VE-Cadherin Internalization , 2021, Arteriosclerosis, thrombosis, and vascular biology.

[10]  H. Augustin,et al.  Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor–endothelial cell crosstalk , 2021, Nature Neuroscience.

[11]  L. Rubin,et al.  GDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis , 2021, Molecular brain.

[12]  A. Molina,et al.  Heterochronic Parabiosis: Old Blood Induces Changes in Mitochondrial Structure and Function of Young Mice. , 2020, The journals of gerontology. Series A, Biological sciences and medical sciences.

[13]  Y. Zuo,et al.  Plasma dilution improves cognition and attenuates neuroinflammation in old mice , 2020, GeroScience.

[14]  James T. Webber,et al.  Molecular hallmarks of heterochronic parabiosis at single cell resolution , 2020, bioRxiv.

[15]  H. Cao,et al.  Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease , 2020, Proceedings of the National Academy of Sciences.

[16]  Leo Y. C. Yan,et al.  Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain , 2020, Nature Communications.

[17]  Lihua Zhang,et al.  Inference and analysis of cell-cell communication using CellChat , 2020, Nature Communications.

[18]  M. Lampugnani,et al.  JAM-A Acts via C/EBP-α to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function , 2020, Circulation research.

[19]  I. Conboy,et al.  Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin , 2020, Aging.

[20]  J. Huard,et al.  Heterogenetic parabiosis between healthy and dystrophic mice improve the histopathology in muscular dystrophy , 2020, Scientific Reports.

[21]  P. Robbins,et al.  Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues , 2020, GeroScience.

[22]  T. Wyss-Coray,et al.  Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1 , 2020, Nature Metabolism.

[23]  T. Kiss,et al.  Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain , 2020, GeroScience.

[24]  T. Kiss,et al.  Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood , 2020, GeroScience.

[25]  Guoji Guo,et al.  Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging , 2020, Cell.

[26]  J. Qu,et al.  The ageing epigenome and its rejuvenation , 2020, Nature Reviews Molecular Cell Biology.

[27]  L. Bolund,et al.  Single-Cell Transcriptome Atlas of Murine Endothelial Cells , 2020, Cell.

[28]  P. Galie,et al.  CD44 regulates blood-brain barrier integrity in response to fluid shear stress , 2020, bioRxiv.

[29]  K. Hirata,et al.  Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype , 2020, Nature Communications.

[30]  T. Lassmann,et al.  Systematic assessment of tissue dissociation and storage biases in single-cell and single-nucleus RNA-seq workflows , 2019, Genome Biology.

[31]  Andreas Keller,et al.  Undulating changes in human plasma proteome profiles across the lifespan , 2019, Nature Medicine.

[32]  Gennady Korotkevich,et al.  Fast gene set enrichment analysis , 2019, bioRxiv.

[33]  Katsuhiko Suzuki,et al.  Muscle-derived SDF-1α/CXCL12 modulates endothelial cell proliferation but not exercise training-induced angiogenesis. , 2019, American journal of physiology. Regulatory, integrative and comparative physiology.

[34]  A. Chambers,et al.  Isoform-specific promotion of breast cancer tumorigenicity by TBX3 involves induction of angiogenesis , 2019, Laboratory Investigation.

[35]  Gary D. Bader,et al.  Single-cell transcriptomic profiling of the aging mouse brain , 2019, Nature Neuroscience.

[36]  Kieran R. Campbell,et al.  Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling , 2019, Nature Methods.

[37]  G. Bu,et al.  Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies , 2019, Nature Reviews Neurology.

[38]  P. Kapahi,et al.  From discoveries in ageing research to therapeutics for healthy ageing , 2019, Nature.

[39]  Mark M. Davis,et al.  Single cell analysis reveals T cell infiltration in old neurogenic niches , 2019, Nature.

[40]  G. Hong,et al.  Gas6 Attenuates Sepsis-Induced Tight Junction Injury and Vascular Endothelial Hyperpermeability via the Axl/NF-κB Signaling Pathway , 2019, Front. Pharmacol..

[41]  T. Südhof,et al.  Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment , 2019, Proceedings of the National Academy of Sciences.

[42]  L. Santambrogio,et al.  Parabiosis Incompletely Reverses Aging-Induced Metabolic Changes and Oxidant Stress in Mouse Red Blood Cells , 2019, Nutrients.

[43]  Paul J. Hoffman,et al.  Comprehensive Integration of Single-Cell Data , 2018, Cell.

[44]  S. Quake,et al.  Brain endothelial cells are exquisite sensors of age-related circulatory cues , 2019, bioRxiv.

[45]  S. Quake,et al.  Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1 , 2019, Nature Medicine.

[46]  D. Merlo,et al.  Inhibiting Bone Morphogenetic Protein 4 Type I Receptor Signaling Promotes Remyelination by Potentiating Oligodendrocyte Differentiation , 2019, eNeuro.

[47]  S. Lovestone,et al.  Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies , 2019, Front. Neurosci..

[48]  C. Svendsen,et al.  Young bone marrow transplantation preserves learning and memory in old mice , 2019, Communications Biology.

[49]  M. Hipp,et al.  The proteostasis network and its decline in ageing , 2019, Nature Reviews Molecular Cell Biology.

[50]  Gary D Bader,et al.  Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap , 2019, Nature Protocols.

[51]  Nathan R. Qi,et al.  Adipose tissue senescence and inflammation in aging is reversed by the young milieu. , 2018, The journals of gerontology. Series A, Biological sciences and medical sciences.

[52]  Chen-Yu Liao,et al.  MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage , 2018, Nature Metabolism.

[53]  L. Rubin,et al.  Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice , 2018, Scientific Reports.

[54]  F. Tovar-Moll,et al.  Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models , 2018, Nature Medicine.

[55]  E. Kandel,et al.  RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss , 2018, Cell reports.

[56]  M. Mattson,et al.  Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States. , 2018, Cell metabolism.

[57]  Lars E. Borm,et al.  Molecular Architecture of the Mouse Nervous System , 2018, Cell.

[58]  Gregor Bieri,et al.  Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain , 2018, Cell reports.

[59]  Koji Ando,et al.  A molecular atlas of cell types and zonation in the brain vasculature , 2018, Nature.

[60]  R. Nusslock,et al.  Exercise-Mediated Neurogenesis in the Hippocampus via BDNF , 2018, Front. Neurosci..

[61]  Berislav V. Zlokovic,et al.  Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders , 2018, Nature Reviews Neurology.

[62]  O. Dirsch,et al.  Young plasma reverses age‐dependent alterations in hepatic function through the restoration of autophagy , 2017, Aging cell.

[63]  Allon M. Klein,et al.  Single-Cell Analysis of Experience-Dependent Transcriptomic States in Mouse Visual Cortex , 2017, Nature Neuroscience.

[64]  E. Kandel,et al.  Gpr158 mediates osteocalcin’s regulation of cognition , 2017, The Journal of experimental medicine.

[65]  Aviv Regev,et al.  Massively-parallel single nucleus RNA-seq with DroNc-seq , 2017, Nature Methods.

[66]  J. Aerts,et al.  SCENIC: Single-cell regulatory network inference and clustering , 2017, Nature Methods.

[67]  Izumi V. Hinkson,et al.  Human umbilical cord plasma proteins revitalize hippocampal function in aged mice , 2017, Nature.

[68]  L. McCullough,et al.  Abstract WP122: Heterochronic Parabiosis Reverses the Epigenetic Imbalance of the Aged Central Nervous System , 2017 .

[69]  S. Herculano‐Houzel,et al.  The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting , 2016, The Journal of comparative neurology.

[70]  C. R. Esteban,et al.  In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming , 2016, Cell.

[71]  I. Conboy,et al.  A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood , 2016, Nature Communications.

[72]  Tony Wyss-Coray,et al.  Ageing, neurodegeneration and brain rejuvenation , 2016, Nature.

[73]  E. Masliah,et al.  Preclinical Assessment of Young Blood Plasma for Alzheimer Disease. , 2016, JAMA neurology.

[74]  Patrik L. Ståhl,et al.  Visualization and analysis of gene expression in tissue sections by spatial transcriptomics , 2016, Science.

[75]  L. Lecea,et al.  In vivo assessment of behavioral recovery and circulatory exchange in the peritoneal parabiosis model , 2016, Scientific Reports.

[76]  S. A. Arriola Apelo,et al.  Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice. , 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

[77]  Pallav Sengupta,et al.  Men and mice: Relating their ages. , 2016, Life sciences.

[78]  T. Brott,et al.  Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown , 2016, Stroke.

[79]  K. Aoki,et al.  Delivery of RANKL-Binding Peptide OP3-4 Promotes BMP-2–Induced Maxillary Bone Regeneration , 2016, Journal of dental research.

[80]  M. Jensen,et al.  Targeting senescent cells enhances adipogenesis and metabolic function in old age , 2015, eLife.

[81]  N. Sharpless,et al.  Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice , 2015, Nature Medicine.

[82]  P. Linsley,et al.  MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data , 2015, Genome Biology.

[83]  M. Diamond,et al.  The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity , 2015, Nature Medicine.

[84]  E. D. Kirby,et al.  Blood-Borne Revitalization of the Aged Brain. , 2015, JAMA neurology.

[85]  L. Probert TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects , 2015, Neuroscience.

[86]  S. Groshen,et al.  A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. , 2015, Cell metabolism.

[87]  Gregor Bieri,et al.  β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis , 2015, Nature Medicine.

[88]  B. Alman,et al.  Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin , 2015, Nature Communications.

[89]  M. Hughes,et al.  A circadian gene expression atlas in mammals: Implications for biology and medicine , 2014, Proceedings of the National Academy of Sciences.

[90]  Roland Eils,et al.  circlize implements and enhances circular visualization in R , 2014, Bioinform..

[91]  C. Oliveira,et al.  Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells. , 2014, Biochimica et biophysica acta.

[92]  P. Kharchenko,et al.  Bayesian approach to single-cell differential expression analysis , 2014, Nature Methods.

[93]  Richard T. Lee,et al.  Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle , 2014, Science.

[94]  Richard T. Lee,et al.  Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors , 2014, Science.

[95]  Danielle A. Simmons,et al.  Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice , 2014, Nature Medicine.

[96]  J. Madri,et al.  CD44 Regulation of Endothelial Cell Proliferation and Apoptosis via Modulation of CD31 and VE-cadherin Expression* , 2014, The Journal of Biological Chemistry.

[97]  D. Beezhold,et al.  Expression of non-structural-1A binding protein in lung epithelial cells is modulated by miRNA-548an on exposure to influenza A virus. , 2013, Virology.

[98]  I. Weissman,et al.  Parabiosis in mice: a detailed protocol. , 2013, Journal of visualized experiments : JoVE.

[99]  J. Greenwood,et al.  LRG1 promotes angiogenesis by modulating endothelial TGF-beta signalling (vol 499, pg 306, 2013) , 2013 .

[100]  E. Mercken,et al.  Metformin improves healthspan and lifespan in mice , 2013, Nature Communications.

[101]  Y. Dor,et al.  Systemic Regulation of the Age-Related Decline of Pancreatic β-Cell Replication , 2013, Diabetes.

[102]  John Greenwood,et al.  LRG1 promotes angiogenesis by modulating endothelial TGFß signalling , 2013, Nature.

[103]  Manuel Serrano,et al.  The Hallmarks of Aging , 2013, Cell.

[104]  T. Rando,et al.  Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity , 2013, Aging cell.

[105]  E. Giraudo,et al.  The role of semaphorins and their receptors in vascular development and cancer. , 2013, Experimental cell research.

[106]  Richard T. Lee,et al.  Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy , 2013, Cell.

[107]  D. Cai,et al.  Hypothalamic Programming of Systemic Aging Involving IKKβ/NF-κB and GnRH , 2013, Nature.

[108]  T. Rando,et al.  Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches , 2012, Cell cycle.

[109]  I. Pishel',et al.  Accelerated aging versus rejuvenation of the immune system in heterochronic parabiosis. , 2012, Rejuvenation research.

[110]  Davis J. McCarthy,et al.  Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation , 2012, Nucleic acids research.

[111]  R. Franklin,et al.  Rejuvenation of regeneration in the aging central nervous system. , 2012, Cell stem cell.

[112]  B. Zlokovic Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders , 2011, Nature Reviews Neuroscience.

[113]  M. Kim,et al.  POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) inhibits endothelial cell senescence through a p53 dependent pathway , 2011, Cell Death and Differentiation.

[114]  J. Kaye,et al.  The aging systemic milieu negatively regulates neurogenesis and cognitive function , 2011, Nature.

[115]  Chenghua Gu,et al.  Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism. , 2011, Genes & development.

[116]  Axel R Pries,et al.  Expression of ADAMTS1 in endothelial cells is induced by shear stress and suppressed in sprouting capillaries , 2011, Journal of cellular physiology.

[117]  R. Klein,et al.  CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination , 2010, Proceedings of the National Academy of Sciences.

[118]  G. Molema,et al.  FOXO3 Modulates Endothelial Gene Expression and Function by Classical and Alternative Mechanisms* , 2010, The Journal of Biological Chemistry.

[119]  J. Campisi,et al.  The senescence-associated secretory phenotype: the dark side of tumor suppression. , 2010, Annual review of pathology.

[120]  P. Bastiaens,et al.  VEGF autoregulates its proliferative and migratory ERK1/2 and p38 cascades by enhancing the expression of DUSP1 and DUSP5 phosphatases in endothelial cells. , 2009, American journal of physiology. Cell physiology.

[121]  Davis J. McCarthy,et al.  edgeR: a Bioconductor package for differential expression analysis of digital gene expression data , 2009, Bioinform..

[122]  M. Chopp,et al.  Angiopoietin 2 Mediates the Differentiation and Migration of Neural Progenitor Cells in the Subventricular Zone after Stroke* , 2009, The Journal of Biological Chemistry.

[123]  J. Malva,et al.  Tumor Necrosis Factor‐α Modulates Survival, Proliferation, and Neuronal Differentiation in Neonatal Subventricular Zone Cell Cultures , 2008, Stem cells.

[124]  R. Ransohoff,et al.  Multiple roles of chemokine CXCL12 in the central nervous system: A migration from immunology to neurobiology , 2008, Progress in Neurobiology.

[125]  C. Keller,et al.  Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis , 2007, Science.

[126]  J. Kuiper,et al.  KLF2 Suppresses TGF-&bgr; Signaling in Endothelium Through Induction of Smad7 and Inhibition of AP-1 , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[127]  Allan R. Jones,et al.  Genome-wide atlas of gene expression in the adult mouse brain , 2007, Nature.

[128]  O. Gavrilova,et al.  Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice , 2006, Hepatology.

[129]  A. Woods,et al.  Syndecan-2 Is Expressed in the Microvasculature of Gliomas and Regulates Angiogenic Processes in Microvascular Endothelial Cells* , 2006, Journal of Biological Chemistry.

[130]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[131]  R. DePinho,et al.  Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. , 2005, The Journal of clinical investigation.

[132]  I. Weissman,et al.  Rejuvenation of aged progenitor cells by exposure to a young systemic environment , 2005, Nature.

[133]  M. Höltje,et al.  Effects of brain‐derived neurotrophic factor (BDNF) on glial cells and serotonergic neurones during development , 2005, Journal of neurochemistry.

[134]  Sally Temple,et al.  Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells , 2004, Science.

[135]  C. Barnes,et al.  Verge: A Novel Vascular Early Response Gene , 2004, The Journal of Neuroscience.

[136]  A. Navarro,et al.  Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer. , 2004, American journal of physiology. Regulatory, integrative and comparative physiology.

[137]  Bruce J Aronow,et al.  ApoE and Clusterin Cooperatively Suppress Aβ Levels and Deposition Evidence that ApoE Regulates Extracellular Aβ Metabolism In Vivo , 2004, Neuron.

[138]  S. Friedman,et al.  Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury. , 2002, Blood.

[139]  Irving L. Weissman,et al.  Physiological Migration of Hematopoietic Stem and Progenitor Cells , 2001, Science.

[140]  W. Kamphorst,et al.  Decreased Vasopressin Gene Expression in the Biological Clock of Alzheimer Disease Patients With and Without Depression , 2000, Journal of neuropathology and experimental neurology.

[141]  T. V. Kolesnikova,et al.  CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[142]  G. Piras,et al.  A role for TGF-beta in oligodendrocyte differentiation , 1993, The Journal of cell biology.

[143]  E. C. Lustgraaf,et al.  Genetic factors in parabiosis. , 1959, Journal of the National Cancer Institute.

[144]  B. Vanyushin,et al.  The Effects of Parabiosis on Aging and Age-Related Diseases. , 2020, Advances in experimental medicine and biology.

[145]  C. Barnes,et al.  Neural plasticity in the ageing brain , 2006, Nature Reviews Neuroscience.

[146]  R. Busse,et al.  Endothelial aging. , 2005, Cardiovascular research.

[147]  S. Friedman,et al.  1 in vascular endothelial cells β Zf 9 / COPEB activates latent TGF-Transcriptional activation of urokinase by the Krüppel-like factor , 2000 .

[148]  N. K. Bell Health care's moral quandary. , 1986, Journal of the South Carolina Medical Association.