Innervation of the Tumor Microenvironment-Letter.
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The intriguing article by Allen and colleagues recently published in Cancer Research ([1][1]) further elucidates how the catecholamine norepinephrine is produced in the tumor microenvironment and leads to cancer progression and metastasis ([2][2]). The authors demonstrated, in mice, that
[1] Stephen T. C. Wong,et al. Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction. , 2018, Cancer research.
[2] B. Bryan,et al. Beta-adrenergic receptors are expressed across diverse cancers , 2017, Oncoscience.
[3] K. McVary,et al. Autonomic nerve development contributes to prostate cancer progression. , 2013, Asian journal of andrology.