[18F]AV‐1451 clustering of entorhinal and cortical uptake in Alzheimer's disease

To use a cluster analysis of [18F]AV‐1451 tau‐PET data to determine how subjects with Alzheimer's disease (AD) vary in the relative involvement of the entorhinal cortex and neocortex, and determine whether relative involvement of these two regions can help explain variability in age and clinical phenotype in AD.

[1]  Hanna Cho,et al.  Off-Target 18F-AV-1451 Binding in the Basal Ganglia Correlates with Age-Related Iron Accumulation , 2018, The Journal of Nuclear Medicine.

[2]  Christopher G Schwarz,et al.  Widespread brain tau and its association with ageing, Braak stage and Alzheimer's dementia. , 2018, Brain : a journal of neurology.

[3]  M. Mintun,et al.  Kinetic Modeling of the Tau PET Tracer 18F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects , 2017, The Journal of Nuclear Medicine.

[4]  A. Dale,et al.  Entorhinal Cortex: Antemortem Cortical Thickness and Postmortem Neurofibrillary Tangles and Amyloid Pathology , 2017, American Journal of Neuroradiology.

[5]  Camille Roth,et al.  Natural Scales in Geographical Patterns , 2017, Scientific Reports.

[6]  Keith A. Johnson,et al.  Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease , 2017, JAMA neurology.

[7]  J. Graff‐Radford,et al.  18F-FDG PET in Posterior Cortical Atrophy and Dementia with Lewy Bodies , 2017, The Journal of Nuclear Medicine.

[8]  Nick C. Fox,et al.  Consensus classification of posterior cortical atrophy , 2017, Alzheimer's & Dementia.

[9]  David T. Jones,et al.  Defining imaging biomarker cut points for brain aging and Alzheimer's disease , 2017, Alzheimer's & Dementia.

[10]  Anthony J. Spychalla,et al.  [18F]AV‐1451 tau positron emission tomography in progressive supranuclear palsy , 2017, Movement disorders : official journal of the Movement Disorder Society.

[11]  B. Dickerson,et al.  PART II. State of the Field: Advances in Neuroimaging from the 2016 Alzheimer’s Imaging Consortium Alzheimer’s disease: The influence of age on clinical heterogeneity through the human brain connectome , 2017 .

[12]  Nick C Fox,et al.  Characterization of tau positron emission tomography tracer [18F]AV-1451 binding to postmortem tissue in Alzheimer's disease, primary tauopathies, and other dementias , 2016, Alzheimer's & Dementia.

[13]  W. Klunk,et al.  [F‐18]AV‐1451 positron emission tomography retention in choroid plexus: More than “off‐target” binding , 2016, Annals of neurology.

[14]  Nick C. Fox,et al.  Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease , 2016, Alzheimer's & Dementia.

[15]  Clifford R. Jack,et al.  An autoradiographic evaluation of AV-1451 Tau PET in dementia , 2016, Acta Neuropathologica Communications.

[16]  C. Jack,et al.  A large-scale comparison of cortical thickness and volume methods for measuring Alzheimer's disease severity , 2016, NeuroImage: Clinical.

[17]  Jorge Sepulcre,et al.  Tau positron emission tomographic imaging in aging and early Alzheimer disease , 2016, Annals of neurology.

[18]  Keith A. Johnson,et al.  Validating novel tau positron emission tomography tracer [F‐18]‐AV‐1451 (T807) on postmortem brain tissue , 2015, Annals of neurology.

[19]  Frederik Barkhof,et al.  The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features. , 2015, Brain : a journal of neurology.

[20]  M. Cugmas,et al.  On comparing partitions , 2015 .

[21]  Daniel R. Schonhaut,et al.  Tau, amyloid, and hypometabolism in a patient with posterior cortical atrophy , 2015, Annals of neurology.

[22]  C. Jack,et al.  APOE ε4 influences β-amyloid deposition in primary progressive aphasia and speech apraxia , 2014, Alzheimer's & Dementia.

[23]  Nick C Fox,et al.  Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria , 2014, The Lancet Neurology.

[24]  Nilüfer Ertekin-Taner,et al.  Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD , 2014, Neurology.

[25]  C. Jack,et al.  Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer’s disease presenting as logopenic progressive aphasia , 2013, Brain and Language.

[26]  H. Kolb,et al.  [18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease , 2013, Alzheimer's & Dementia.

[27]  Frederik Barkhof,et al.  Different patterns of gray matter atrophy in early- and late-onset Alzheimer’s disease , 2013, Neurobiology of Aging.

[28]  Clifford R. Jack,et al.  FDG PET and MRI in Logopenic Primary Progressive Aphasia versus Dementia of the Alzheimer’s Type , 2013, PloS one.

[29]  Min-Ying Su,et al.  Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807. , 2013, Journal of Alzheimer's disease : JAD.

[30]  Matthew L Senjem,et al.  Indicators of amyloid burden in a population-based study of cognitively normal elderly , 2012, Neurology.

[31]  C. Jack,et al.  Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study , 2012, The Lancet Neurology.

[32]  J. Schneider,et al.  National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease , 2012, Alzheimer's & Dementia.

[33]  R. Petersen,et al.  Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study , 2011, The Lancet Neurology.

[34]  J. Molinuevo,et al.  Clinical features and APOE genotype of pathologically proven early-onset Alzheimer disease , 2011, Neurology.

[35]  J. Morris,et al.  The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011, Alzheimer's & Dementia.

[36]  Nick C Fox,et al.  Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE ɛ4 allele , 2011, The Lancet Neurology.

[37]  B. Miller,et al.  Classification of primary progressive aphasia and its variants , 2011, Neurology.

[38]  Charles Duyckaerts,et al.  National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach , 2011, Acta Neuropathologica.

[39]  Friedrich Leisch,et al.  Evaluation of structure and reproducibility of cluster solutions using the bootstrap , 2010 .

[40]  C. Jack,et al.  MRI correlates of neurofibrillary tangle pathology at autopsy , 2008, Neurology.

[41]  C. Jack,et al.  11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. , 2008, Brain : a journal of neurology.

[42]  V. Pankratz,et al.  The Mayo Clinic Study of Aging: Design and Sampling, Participation, Baseline Measures and Sample Characteristics , 2008, Neuroepidemiology.

[43]  Brian B. Avants,et al.  Symmetric diffeomorphic image registration with cross-correlation: Evaluating automated labeling of elderly and neurodegenerative brain , 2008, Medical Image Anal..

[44]  C. Jack,et al.  Imaging correlates of posterior cortical atrophy , 2007, Neurobiology of Aging.

[45]  Karl J. Friston,et al.  Unified segmentation , 2005, NeuroImage.

[46]  K. Ishii,et al.  Voxel-based morphometric comparison between early- and late-onset mild Alzheimer's disease and assessment of diagnostic performance of z score images. , 2005, AJNR. American journal of neuroradiology.

[47]  G. Frisoni,et al.  Structural correlates of early and late onset Alzheimer’s disease: voxel based morphometric study , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[48]  R. Petersen.  Mild cognitive impairment as a diagnostic entity , 2004, Journal of internal medicine.

[49]  M. Greicius,et al.  Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI , 2004, Proc. Natl. Acad. Sci. USA.

[50]  H. Braak,et al.  Neuropathological stageing of Alzheimer-related changes , 2004, Acta Neuropathologica.

[51]  William M. Rand,et al.  Objective Criteria for the Evaluation of Clustering Methods , 1971 .