Acoustically Induced Microenvironments: Building blocks for organ models in-vitro

The goals of this graduation project are to introduce and prove the concept of an Acoustically Induced Microenvironment (AIM), and feature the application of Capacitive Micro machined Ultrasonic Transducers (CMUTs) in microfluidics. AIMs are conceived as a series of building blocks for more complex systems where the driving technology is reconfigurable without major hardware changes and easily embedded with current CMOS and Microfluidic technologies. In the biological context, the development of organ models such as a Liver on a Chip for Drug Screening is a leading example. A proof of principle is delivered for AIMs that perform operations of mixing, stirring, sorting, gradient tuning, that can be implemented for microfluidic operations.

[1]  Cheng-Hsien Liu,et al.  A microfluidic device mimicking acinar concentration gradients across the liver acinus , 2013, Biomedical microdevices.

[2]  H. Saunders,et al.  Acoustics: An Introduction to Its Physical Principles and Applications , 1984 .

[3]  Martin Wiklund,et al.  Acoustofluidics 14: Applications of acoustic streaming in microfluidic devices. , 2012, Lab on a chip.

[4]  Nerys E. Thomas,et al.  Sub-micron particle manipulation in an ultrasonic standing wave: Applications in detection of clinically important biomolecules , 2000, Bioseparation.

[5]  T. Velten,et al.  Polymer-based acoustic streaming for improving mixing and reaction times in microfluidic applications , 2014 .

[6]  H Tom Soh,et al.  Integrated acoustic and magnetic separation in microfluidic channels. , 2009, Applied physics letters.

[7]  J. Hossack,et al.  Intravascular ultrasound catheter to enhance microbubble-based drug delivery via acoustic radiation force , 2012, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[8]  O T von Ramm.  2-D arrays. , 2000, Ultrasound in medicine & biology.

[9]  Byungkyu Kim,et al.  Separation of malignant human breast cancer epithelial cells from healthy epithelial cells using an advanced dielectrophoresis-activated cell sorter (DACS) , 2009, Analytical and bioanalytical chemistry.

[10]  K. Kirk Shung,et al.  Passive materials for high-frequency ultrasound transducers , 1999, Medical Imaging.

[11]  G. Yaralioglu,et al.  Ultrasonic heating and temperature measurement in microfluidic channels , 2011 .

[12]  Unyoung Kim,et al.  Multitarget magnetic activated cell sorter , 2008, Proceedings of the National Academy of Sciences.

[13]  S. Yedgar,et al.  Role of red blood cell flow behavior in hemodynamics and hemostasis , 2007, Expert review of cardiovascular therapy.

[14]  F. Foster,et al.  Fabrication and characterization of transducer elements in two-dimensional arrays for medical ultrasound imaging , 1992, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[15]  Yonggang Zhu,et al.  Cavitation microstreaming and material transport around microbubbles , 2010 .

[16]  Thomas Laurell,et al.  Acoustofluidics 8: applications of acoustophoresis in continuous flow microsystems. , 2012, Lab on a chip.

[17]  N. Mabbott,et al.  Progress in Molecular Biology and Translational Science , 2017 .

[18]  B. Auld.  Acoustic fields and waves in solids. Vol. 1 , 1990 .

[19]  D. Beebe,et al.  Physics and applications of microfluidics in biology. , 2002, Annual review of biomedical engineering.