The mitochondrial carrier pathway transports non-canonical substrates with an odd number of transmembrane segments

[1]  N. Pfanner,et al.  Versatility of Preprotein Transfer from the Cytosol to Mitochondria. , 2019, Trends in cell biology.

[2]  A. Caumont-Sarcos,et al.  Mitochondrial presequence import: Multiple regulatory knobs fine-tune mitochondrial biogenesis and homeostasis. , 2019, Biochimica et biophysica acta. Molecular cell research.

[3]  J. Martinou,et al.  The yeast mitochondrial pyruvate carrier is a hetero‐dimer in its functional state , 2019, The EMBO journal.

[4]  J. Herrmann,et al.  Transport of Proteins into Mitochondria , 2019, The Protein Journal.

[5]  N. Pfanner,et al.  Dual Role of Mitochondrial Porin in Metabolite Transport across the Outer Membrane and Protein Transfer to the Inner Membrane. , 2019, Molecular cell.

[6]  Antoniya A. Aleksandrova,et al.  The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier , 2019, Cell.

[7]  K. Lindorff-Larsen,et al.  Structural Basis of Membrane Protein Chaperoning through the Mitochondrial Intermembrane Space , 2018, Cell.

[8]  T. Mühlhaus,et al.  Tom70 enhances mitochondrial preprotein import efficiency by binding to internal targeting sequences , 2018, The Journal of cell biology.

[9]  Steffen Rupp,et al.  The E. coli S30 lysate proteome: A prototype for cell-free protein production. , 2018, New biotechnology.

[10]  N. Pfanner,et al.  Mitochondrial Machineries for Protein Import and Assembly. , 2017, Annual review of biochemistry.

[11]  M. Monné,et al.  Discoveries, metabolic roles and diseases of mitochondrial carriers: A review. , 2016, Biochimica et biophysica acta.

[12]  E. Taylor,et al.  Mitochondrial pyruvate carrier function and cancer metabolism. , 2016, Current opinion in genetics & development.

[13]  W. Frommer,et al.  Structure and function of SemiSWEET and SWEET sugar transporters. , 2015, Trends in biochemical sciences.

[14]  W. Kühlbrandt,et al.  Central role of Mic10 in the mitochondrial contact site and cristae organizing system. , 2015, Cell metabolism.

[15]  J. Martinou,et al.  Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes , 2015, The EMBO journal.

[16]  Benoît Vanderperre,et al.  Mitochondrial pyruvate import and its effects on homeostasis. , 2015, Current opinion in cell biology.

[17]  W. Neupert A perspective on transport of proteins into mitochondria: a myriad of open questions. , 2015, Journal of molecular biology.

[18]  D. Mokranjac,et al.  Cooperation of TOM and TIM23 complexes during translocation of proteins into mitochondria. , 2015, Journal of molecular biology.

[19]  N. Pfanner,et al.  Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane. , 2014, Molecular cell.

[20]  Jianxin Xie,et al.  A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth. , 2014, Molecular cell.

[21]  Lily S. Cheung,et al.  Structures of bacterial homologues of SWEET transporters in two distinct conformations , 2014, Nature.

[22]  M. Proft,et al.  Differential Regulation of Mitochondrial Pyruvate Carrier Genes Modulates Respiratory Capacity and Stress Tolerance in Yeast , 2013, PloS one.

[23]  Edmund R. S. Kunji,et al.  Lipid, Detergent, and Coomassie Blue G-250 Affect the Migration of Small Membrane Proteins in Blue Native Gels , 2013, The Journal of Biological Chemistry.

[24]  Jan Dudek,et al.  The Channel-Forming Sym1 Protein Is Transported by the TIM23 Complex in a Presequence-Independent Manner , 2012, Molecular and Cellular Biology.

[25]  J. Veuthey,et al.  Identification and Functional Expression of the Mitochondrial Pyruvate Carrier , 2012, Science.

[26]  Claire Redin,et al.  A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans , 2012, Science.

[27]  T. Lithgow,et al.  The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins , 2011, The Journal of cell biology.

[28]  K. Dimmer,et al.  Multispan mitochondrial outer membrane protein Ugo1 follows a unique Mim1-dependent import pathway , 2011, The Journal of cell biology.

[29]  B. Schönfisch,et al.  Regulation of Mitochondrial Protein Import by Cytosolic Kinases , 2011, Cell.

[30]  D. Kohda,et al.  Dual role of the receptor Tom20 in specificity and efficiency of protein import into mitochondria , 2010, Proceedings of the National Academy of Sciences.

[31]  N. Pfanner,et al.  Cooperation of Stop-Transfer and Conservative Sorting Mechanisms in Mitochondrial Protein Transport , 2010, Current Biology.

[32]  N. Pfanner,et al.  Distinct Forms of Mitochondrial TOM-TIM Supercomplexes Define Signal-Dependent States of Preprotein Sorting , 2009, Molecular and Cellular Biology.

[33]  N. Pfanner,et al.  Global Analysis of the Mitochondrial N-Proteome Identifies a Processing Peptidase Critical for Protein Stability , 2009, Cell.

[34]  K. Fukui,et al.  Roles of Tom70 in Import of Presequence-containing Mitochondrial Proteins* , 2009, The Journal of Biological Chemistry.

[35]  J. McCaffery,et al.  Mitochondrial outer and inner membrane fusion requires a modified carrier protein , 2009, The Journal of cell biology.

[36]  T. Endo,et al.  Tim23–Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import , 2009, The Journal of cell biology.

[37]  N. Pfanner,et al.  Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase , 2008, EMBO reports.

[38]  N. Pfanner,et al.  The Assembly Pathway of the Mitochondrial Carrier Translocase Involves Four Preprotein Translocases , 2008, Molecular and Cellular Biology.

[39]  R. Jensen,et al.  Tom20 and Tom22 Share the Common Signal Recognition Pathway in Mitochondrial Protein Import* , 2008, Journal of Biological Chemistry.

[40]  D. Kohda,et al.  Tom20 recognizes mitochondrial presequences through dynamic equilibrium among multiple bound states , 2007, The EMBO journal.

[41]  Emily M. Coonrod,et al.  Ugo1p Is a Multipass Transmembrane Protein with a Single Carrier Domain Required for Mitochondrial Fusion , 2007, Traffic.

[42]  J. Gulbis,et al.  Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller. , 2006, Molecular cell.

[43]  Albert Sickmann,et al.  Mitochondrial Presequence Translocase: Switching between TOM Tethering and Motor Recruitment Involves Tim21 and Tim17 , 2005, Cell.

[44]  T. Endo,et al.  The Phosphate Carrier Has an Ability to be Sorted to either the TIM22 Pathway or the TIM23 Pathway for Its Import into Yeast Mitochondria* , 2005, Journal of Biological Chemistry.

[45]  P. Rehling,et al.  The Carboxyl-terminal Third of the Dicarboxylate Carrier Is Crucial for Productive Association with the Inner Membrane Twin-pore Translocase* , 2005, Journal of Biological Chemistry.

[46]  N. Pfanner,et al.  Biogenesis of the Protein Import Channel Tom40 of the Mitochondrial Outer Membrane , 2004, Journal of Biological Chemistry.

[47]  Eva Pebay-Peyroula,et al.  Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside , 2003, Nature.

[48]  Albert Sickmann,et al.  Protein Insertion into the Mitochondrial Inner Membrane by a Twin-Pore Translocase , 2003, Science.

[49]  C. Koehler,et al.  The role of the Tim8p–Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins , 2002, The Journal of cell biology.

[50]  N. Pfanner,et al.  The three modules of ADP/ATP carrier cooperate in receptor recruitment and translocation into mitochondria , 2001, The EMBO journal.

[51]  W. Neupert,et al.  Biogenesis of Porin of the Outer Mitochondrial Membrane Involves an Import Pathway via Receptors and the General Import Pore of the Tom Complex , 2001, The Journal of cell biology.

[52]  W. Neupert,et al.  Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22·54 complex , 1999, The EMBO journal.

[53]  J. Schneider-Mergener,et al.  Distribution of Binding Sequences for the Mitochondrial Import Receptors Tom20, Tom22, and Tom70 in a Presequence-carrying Preprotein and a Non-cleavable Preprotein* , 1999, The Journal of Biological Chemistry.

[54]  S. Merchant,et al.  Tim9p, an essential partner subunit of Tim10p for the import of mitochondrial carrier proteins , 1998, The EMBO journal.

[55]  R. Jensen,et al.  Tim23p contains separate and distinct signals for targeting to mitochondria and insertion into the inner membrane. , 1998, Molecular biology of the cell.

[56]  M. Bauer,et al.  Biogenesis of Tim23 and Tim17, integral components of the TIM machinery for matrix‐targeted preproteins , 1998, The EMBO journal.

[57]  W. Neupert,et al.  Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5 , 1998, Nature.

[58]  C. Koehler,et al.  Import of mitochondrial carriers mediated by essential proteins of the intermembrane space. , 1998, Science.

[59]  K. Dietmeier,et al.  Differential Recognition of Preproteins by the Purified Cytosolic Domains of the Mitochondrial Import Receptors Tom20, Tom22, and Tom70* , 1997, The Journal of Biological Chemistry.

[60]  K. Dietmeier,et al.  Identification of a third yeast mitochondrial Tom protein with tetratrico peptide repeats , 1996, FEBS letters.

[61]  N. Pfanner,et al.  Deletion of the receptor MOM19 strongly impairs import of cleavable preproteins into Saccharomyces cerevisiae mitochondria. , 1994, The Journal of biological chemistry.

[62]  N. Pfanner,et al.  Role of an energized inner membrane in mitochondrial protein import. Delta psi drives the movement of presequences. , 1991, The Journal of biological chemistry.

[63]  R. Sikorski,et al.  A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. , 1989, Genetics.

[64]  N. Pfanner,et al.  Import of proteins into mitochondria. , 1988, Methods in cell biology.

[65]  V. Dötsch,et al.  Membrane protein expression in cell-free systems. , 2010, Methods in molecular biology.

[66]  H. Schägger,et al.  Blue native PAGE , 2006, Nature Protocols.

[67]  N. Pfanner,et al.  Isolation of yeast mitochondria. , 2006, Methods in molecular biology.

[68]  T. Junne,et al.  A cryptic matrix targeting signal of the yeast ADP/ATP carrier normally inserted by the TIM22 complex is recognized by the TIM23 machinery. , 2005, The Biochemical journal.