Syntheses of oxanosine and carbocyclic oxanosine derivatives as anti-HIV agents.

(carbocyclic 2',3 '-didehydro-2',3 '-dideoxyguanosine) are undergoing clinical or preclinical development.^ However, it is still necessary to search for newanti-HIV agents that are more potent and less toxic. Moreover, drug-resistant HIVs continue to emerge rapidly. Oxanosine 1, a novel guanosine analog antibiotic isolated from the culture broth of Streptomyces capreolus MG265CF3 has been reported to show antibacterial activity and to inhibit growth of HeLa cells in culture.3) Furthermore, 1 has been proved to alter tumor cell morphology into normal morphology in temperature-sensitive K-ras transformed rat kidney (K-rasts-NRK) cells by inhibiting inosine

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