Optimization with Experimental Design of Nonionic, Anionic, and Amphoteric Surfactants in a Mixed System

AbstractIn a mixture experiment the response depends only on the relative proportions of material present in the mixture. In this study, we consider shampoo formulations with three different classes of surface-active agents: amphoteric, nonionic, and anionic mild sufactants. A major purpose of this study is to help the formulator with a strategy using a three-component simplex-centroid design. This methodology offers the maximum return in terms of information about the interplay of multiple factors while requiring the minimum investment.