Generating large field of view en-face projection images from intra-acquisition motion compensated volumetric optical coherence tomography data

A technique to generate large field of view projection maps of arbitrary optical coherence tomography (OCT) data is described. The technique is divided into two stages - an image acquisition stage that features a simple to use fast and robust retinal tracker to get motion free retinal OCT volume scans - and a stitching stage where OCT data from different retinal locations is first registered against a reference image using a custom pyramid-based approach and finally stitched together into one seamless large field of view (FOV) image. The method is applied to data recorded with a polarization sensitive OCT instrument in healthy subjects and glaucoma patients. The tracking and stitching accuracies are quantified, and finally, large FOV images of retinal nerve fiber layer retardation that contain the arcuate nerve fiber bundles from the optic nerve head to the raphe are demonstrated.

[1]  Andre J. Witkin,et al.  Swept Source Optical Coherence Tomography: a Review , 2018, Current Ophthalmology Reports.

[2]  Robert J Zawadzki,et al.  Review of adaptive optics OCT (AO-OCT): principles and applications for retinal imaging [Invited]. , 2017, Biomedical optics express.

[3]  Y. Hwang,et al.  Retinal Nerve Fiber Layer Thickness Measurement Repeatability for Cirrus HD-OCT Retinal Tracking System During Eye Movement , 2016, Journal of glaucoma.

[4]  Marcus Kernt,et al.  Nonmydriatic screening for diabetic retinopathy by ultra-widefield scanning laser ophthalmoscopy (Optomap) , 2006, Graefe's Archive for Clinical and Experimental Ophthalmology.

[5]  Geoff Rose,et al.  High-speed camera characterization of voluntary eye blinking kinematics , 2013, Journal of The Royal Society Interface.

[6]  Michael Pircher,et al.  Drusen volume development over time and its relevance to the course of age-related macular degeneration , 2016, British Journal of Ophthalmology.

[7]  Gadi Wollstein,et al.  OCT for glaucoma diagnosis, screening and detection of glaucoma progression , 2013, British Journal of Ophthalmology.

[8]  Donald G. Bailey,et al.  A Real-time FPGA Implementation of a Barrel Distortion Correction Algorithm with Bilinear Interpolation , 2003 .

[9]  Prajoy Podder,et al.  Comparative Performance Analysis of Hamming, Hanning and Blackman Window , 2014 .

[10]  Michael Pircher,et al.  Retinal nerve fiber bundle tracing and analysis in human eye by polarization sensitive OCT. , 2015, Biomedical optics express.

[11]  Michael Pircher,et al.  Corneal birefringence compensation for polarization sensitive optical coherence tomography of the human retina. , 2007, Journal of biomedical optics.

[12]  Austin Roorda,et al.  Real-time eye motion compensation for OCT imaging with tracking SLO , 2012, Biomedical optics express.

[13]  Kenichi Saito,et al.  Analysis of optimum conditions of depolarization imaging by polarization-sensitive optical coherence tomography in the human retina , 2015, Journal of biomedical optics.

[14]  Ying Li,et al.  Automatic montage of SD-OCT data sets , 2011, Optics express.

[15]  Guillermo Sapiro,et al.  Segmentation guided registration of wide field-of-view retinal optical coherence tomography volumes. , 2016, Biomedical optics express.

[16]  Michael Pircher,et al.  Analysis of longitudinal sections of retinal vessels using Doppler OCT , 2020, Biomedical optics express.

[17]  R. Leitgeb,et al.  Speckle noise reduction in high speed polarization sensitive spectral domain optical coherence tomography. , 2011, Optics express.

[18]  J. Duker,et al.  Optical coherence tomography – current and future applications , 2013, Current Opinion in Ophthalmology.

[19]  Hassan Foroosh,et al.  Extension of phase correlation to subpixel registration , 2002, IEEE Trans. Image Process..

[20]  SriniVas R Sadda,et al.  ULTRA-WIDEFIELD FUNDUS IMAGING: A Review of Clinical Applications and Future Trends , 2016, Retina.

[21]  Wolfgang Wieser,et al.  Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle. , 2015, Biomedical optics express.

[22]  Christoph K. Hitzenberger,et al.  Progression of Retinal Pigment Epithelial Atrophy in Antiangiogenic Therapy of Neovascular Age-Related Macular Degeneration , 2015, American journal of ophthalmology.

[23]  U. Schmidt-Erfurth,et al.  Polarization sensitive optical coherence tomography in the human eye , 2011, Progress in Retinal and Eye Research.

[24]  Shuichi Makita,et al.  Three-dimensional eye motion correction by Lissajous scan optical coherence tomography. , 2017, Biomedical optics express.

[25]  A. Fercher,et al.  Measurement and imaging of birefringence and optic axis orientation by phase resolved polarization sensitive optical coherence tomography. , 2001, Optics express.

[26]  Matthias Bolz,et al.  Lesion size detection in geographic atrophy by polarization-sensitive optical coherence tomography and correlation to conventional imaging techniques. , 2013, Investigative ophthalmology & visual science.

[27]  D. Hubel,et al.  The role of fixational eye movements in visual perception , 2004, Nature Reviews Neuroscience.

[28]  U. Schmidt-Erfurth,et al.  Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography. , 2008, Optics express.

[29]  F. Harris.  On the use of windows for harmonic analysis with the discrete Fourier transform , 1978, Proceedings of the IEEE.

[30]  Michael Pircher,et al.  Review on Retrospective Procedures to Correct Retinal Motion Artefacts in OCT Imaging , 2019, Applied Sciences.

[31]  Mei Chen,et al.  Correcting Motion Artifacts in Retinal Spectral Domain Optical Coherence Tomography via Image Registration , 2009, MICCAI.

[32]  Alireza Dehghani,et al.  Registration of fluorescein angiography and optical coherence tomography images of curved retina via scanning laser ophthalmoscopy photographs. , 2020, Biomedical optics express.

[33]  Jay S Duker,et al.  A review of optical coherence tomography angiography (OCTA) , 2015, International Journal of Retina and Vitreous.

[34]  Ji Yi,et al.  Measuring oxygen saturation in retinal and choroidal circulations in rats using visible light optical coherence tomography angiography. , 2015, Biomedical optics express.

[35]  James G. Fujimoto,et al.  Quantitative 3D-OCT motion correction with tilt and illumination correction, robust similarity measure and regularization , 2014, Biomedical optics express.

[36]  Shaharyar Ahmed Khan Tareen,et al.  A comparative analysis of SIFT, SURF, KAZE, AKAZE, ORB, and BRISK , 2018, 2018 International Conference on Computing, Mathematics and Engineering Technologies (iCoMET).

[37]  Alexander Wong,et al.  Intra-retinal layer segmentation in optical coherence tomography images. , 2009, Optics express.

[38]  Gary R. Bradski,et al.  ORB: An efficient alternative to SIFT or SURF , 2011, 2011 International Conference on Computer Vision.

[39]  A. Ardeshir Goshtasby,et al.  Piecewise linear mapping functions for image registration , 1986, Pattern Recognit..

[40]  A. Ardeshir Goshtasby,et al.  Image registration by local approximation methods , 1988, Image Vis. Comput..

[41]  Randy H. Kardon,et al.  Role of the Macular Optical Coherence Tomography Scan in Neuro-Ophthalmology , 2011, Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society.

[42]  Yali Jia,et al.  High-resolution wide-field OCT angiography with a self-navigation method to correct microsaccades and blinks. , 2020, Biomedical optics express.

[43]  George Wolberg,et al.  Robust image registration using log-polar transform , 2000, Proceedings 2000 International Conference on Image Processing (Cat. No.00CH37101).

[44]  C. Hitzenberger,et al.  Polarization maintaining fiber based ultra-high resolution spectral domain polarization sensitive optical coherence tomography. , 2009, Optics express.

[45]  Sharath Pankanti,et al.  Adaptive as-natural-as-possible image stitching , 2015, 2015 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[46]  Gangjun Liu,et al.  Optical Coherence Tomography Angiography , 2016, Investigative ophthalmology & visual science.

[47]  James G. Fujimoto,et al.  Optical coherence tomography angiography , 2017, Progress in Retinal and Eye Research.

[48]  Gangjun Liu,et al.  Handheld Optical Coherence Tomography Angiography and Ultra–Wide-Field Optical Coherence Tomography in Retinopathy of Prematurity , 2017, JAMA ophthalmology.

[49]  R. Huber,et al.  Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser. , 2011, Optics express.

[50]  Kenichi Saito,et al.  Motion artifact and speckle noise reduction in polarization sensitive optical coherence tomography by retinal tracking. , 2013, Biomedical optics express.