Carcinoma of adrenal cortex with adrenogenital syndrome in children; complete review of the literature and report of a case with recovery in a child 8 months of age.

NEOPLASM of the adrenal cortex is a fascinating pathologic condition in which little girls become little boys and little boys little men. These little men pass through the "seven ages" of Shakespeare in as many years. The clinical syndrome produced by active carcinomas of the adrenal cortex has been variously classified by many authors, these classifications depending mainly on the age of the patient affected. The syndrome manifests itself by sexual precocity, with adult size genitalia in boys and early appearance of pubic hair with hypertrophy of the clitoris in girls, each manifestation with its corresponding secondary sexual characteristics. In this paper we are concerned only with the adrenogenital syndrome as it involves the boy and the girl before the menarche. This paper is further limited to the consideration only of malignant cortical neoplasms which produce the aforementioned syndrome. The reason for reporting this case is its extreme rarity and

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