A double fluorescent nanoprobe based on phosphorus/nitrogen co-doped carbon dots for detecting dichromate ions and dopamine

An “on–off–on” fluorescent phosphorus/nitrogen co-doped carbon dot (PNCD) probe was explored for the determination of Cr(VI) and dopamine resulting from the inner filter effect (IFE). The blue-emitting carbon dots with high quantum yields of 25.47% as well as a narrow size distribution were synthesized by a rapid, convenient route using H3PO4 and ethylenediamine as the precursors without any surface passivation. A wide linear region in the range of 7–70 μM with a detection limit of 0.71 μM was achieved for Cr(VI). Moreover, the proper reductants can weaken the inner filter effect to recover the PNCD fluorescence by converting Cr(VI) into Cr(III). Therefore, the PNCDs/Cr(VI) hybrid could also be used as an “off–on” fluorescent probe for detecting dopamine (DA) with a detection limit of 0.49 μM. Consequently, the PNCDs could serve as a powerful fluorescent bi-sensor for detection of both Cr(VI) and DA in practical applications.

[1]  Jianding Qiu,et al.  One-step, stabilizer-free and green synthesis of Cu nanoclusters as fluorescent probes for sensitive and selective detection of nitrite ions , 2016 .

[2]  Kang Meng,et al.  Graphene oxide based photoinduced charge transfer label-free near-infrared fluorescent biosensor for dopamine. , 2011, Analytical chemistry.

[3]  R. Šlamberová,et al.  Monitoring of dopamine and its metabolites in brain microdialysates: method combining freeze-drying with liquid chromatography-tandem mass spectrometry. , 2011, Journal of chromatography. A.

[4]  Weiqian Kong,et al.  Non-metal single/dual doped carbon quantum dots: a general flame synthetic method and electro-catalytic properties. , 2015, Nanoscale.

[5]  A. Zhitkovich.  Chromium in Drinking Water: Sources, Metabolism, and Cancer Risks , 2011, Chemical research in toxicology.

[6]  Yi Lin,et al.  Reduced graphene oxide-carbon dots composite as an enhanced material for electrochemical determination of dopamine , 2014 .

[7]  H. Karimi-Maleh,et al.  Nanomolar and selective determination of epinephrine in the presence of norepinephrine using carbon paste electrode modified with carbon nanotubes and novel 2-(4-oxo-3-phenyl-3,4-dihydro-quinazolinyl)-N'-phenyl-hydrazinecarbothioamide. , 2008, Analytical chemistry.

[8]  Guonan Chen,et al.  Extraction of Electrochemiluminescent Oxidized Carbon Quantum Dots from Activated Carbon , 2010 .

[9]  Xiaogang Qu,et al.  Carbon dots prepared by hydrothermal treatment of dopamine as an effective fluorescent sensing platform for the label-free detection of iron(III) ions and dopamine. , 2013, Chemistry.

[10]  Xiaoling Yang,et al.  Graphene quantum dots: emergent nanolights for bioimaging, sensors, catalysis and photovoltaic devices. , 2012, Chemical communications.

[11]  Huzhi Zheng,et al.  Enhancing the luminescence of carbon dots with a reduction pathway. , 2011, Chemical communications.

[12]  Q. Huo,et al.  Commercially activated carbon as the source for producing multicolor photoluminescent carbon dots by chemical oxidation. , 2010, Chemical communications.

[13]  Chunxi Zhao,et al.  Green synthesis of carbon dots from pork and application as nanosensors for uric acid detection. , 2018, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[14]  Jinping Wang,et al.  pH-sensitive carbon dots for the visualization of regulation of intracellular pH inside living pathogenic fungal cells , 2015 .

[15]  Chenjie Xu,et al.  Ultrasensitive Profiling of Metabolites Using Tyramine-Functionalized Graphene Quantum Dots. , 2016, ACS nano.

[16]  S. H. Hasan,et al.  Bright-blue-emission nitrogen and phosphorus-doped carbon quantum dots as a promising nanoprobe for detection of Cr(VI) and ascorbic acid in pure aqueous solution and in living cells , 2018 .

[17]  F. Jiang,et al.  Low temperature synthesis of highly stable phosphate functionalized two color carbon nanodots and their application in cell imaging , 2014 .

[18]  J. Weng,et al.  A facile approach for the synthesis of highly luminescent carbon dots using vitamin-based small organic molecules with benzene ring structure as precursors , 2015 .

[19]  C. Huang,et al.  An inner filter effect based sensor of tetracycline hydrochloride as developed by loading photoluminescent carbon nanodots in the electrospun nanofibers. , 2016, Nanoscale.

[20]  M. Ganjali,et al.  A novel dichromate-sensitive fluorescent nano-chemosensor using new functionalized SBA-15. , 2012, Analytica chimica acta.

[21]  Amit Kumar,et al.  One-pot synthesis of carbon dot-entrenched chitosan-modified magnetic nanoparticles for fluorescence-based Cu2+ ion sensing and cell imaging , 2016 .

[22]  Sheila N. Baker,et al.  Luminescent carbon nanodots: emergent nanolights. , 2010, Angewandte Chemie.

[23]  Sandeep Kumar Jha,et al.  Dopamine biosensor based on surface functionalized nanostructured nickel oxide platform. , 2016, Biosensors & bioelectronics.

[24]  Xiaoyun Qin,et al.  Hydrothermal Treatment of Grass: A Low‐Cost, Green Route to Nitrogen‐Doped, Carbon‐Rich, Photoluminescent Polymer Nanodots as an Effective Fluorescent Sensing Platform for Label‐Free Detection of Cu(II) Ions , 2012, Advanced materials.

[25]  G. De,et al.  Magic sized ZnS quantum dots as a highly sensitive and selective fluorescence sensor probe for Ag+ ions. , 2012, The Analyst.

[26]  Martin M. F. Choi,et al.  Red-green-blue fluorescent hollow carbon nanoparticles isolated from chromatographic fractions for cellular imaging. , 2014, Nanoscale.

[27]  Ju-Xiang Qin,et al.  Bright carbon dots via inner filter effect for the sensitive determination of the purine metabolic disorder in human fluids. , 2018, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[28]  Yaqi Cai,et al.  One-step fabrication of high quantum yield sulfur- and nitrogen-doped carbon dots for sensitive and selective detection of Cr(VI) , 2016 .

[29]  Xiangcheng Sun,et al.  One-pot and ultrafast synthesis of nitrogen and phosphorus co-doped carbon dots possessing bright dual wavelength fluorescence emission. , 2015, Nanoscale.

[30]  H. Mizuseki,et al.  Designing nanogadgetry for nanoelectronic devices with nitrogen-doped capped carbon nanotubes. , 2009, Small.

[31]  Louzhen Fan,et al.  Sulfur-doped graphene quantum dots as a novel fluorescent probe for highly selective and sensitive detection of Fe(3+). , 2014, Analytical chemistry.

[32]  Xiwen He,et al.  Nitrogen-doped carbon dots: a facile and general preparation method, photoluminescence investigation, and imaging applications. , 2013, Chemistry.

[33]  Gui Yu,et al.  Synthesis of N-doped graphene by chemical vapor deposition and its electrical properties. , 2009, Nano letters.

[34]  Zhiqiang Gao,et al.  Carbon quantum dots and their applications. , 2015, Chemical Society reviews.

[35]  Jishan Li,et al.  Target-Activated Modulation of Dual-Color and Two-Photon Fluorescence of Graphene Quantum Dots for in Vivo Imaging of Hydrogen Peroxide. , 2016, Analytical chemistry.

[36]  Patrik Brundin,et al.  Pathogenesis of parkinson's disease: dopamine, vesicles and α-synuclein , 2002, Nature Reviews Neuroscience.

[37]  Xiao-yan Li,et al.  Kinetics of the reduction of chromium(VI) by vitamin C , 2005, Environmental toxicology and chemistry.

[38]  Jie Shen,et al.  Highly fluorescent N, S-co-doped carbon dots and their potential applications as antioxidants and sensitive probes for Cr (VI) detection , 2017 .

[39]  C. Dong,et al.  An "on-off-on" fluorescent nanoprobe for recognition of chromium(VI) and ascorbic acid based on phosphorus/nitrogen dual-doped carbon quantum dot. , 2017, Analytica chimica acta.

[40]  X. Jing,et al.  On-off-on fluorescent carbon dot nanosensor for recognition of chromium(VI) and ascorbic acid based on the inner filter effect. , 2013, ACS applied materials & interfaces.

[41]  Shuai Chen,et al.  In situ growth of silver nanoparticles on graphene quantum dots for ultrasensitive colorimetric detection of H₂O₂ and glucose. , 2014, Analytical chemistry.

[42]  Hongjie Song,et al.  Luminescent ZnO quantum dots for sensitive and selective detection of dopamine. , 2013, Talanta.

[43]  Jianrong Chen,et al.  Facile synthesis of P-doped carbon quantum dots with highly efficient photoluminescence , 2014 .

[44]  Feng Lu,et al.  An upconversion fluorescent resonant energy transfer biosensor for hepatitis B virus (HBV) DNA hybridization detection. , 2015, The Analyst.

[45]  Xingguo Chen,et al.  Solid-phase synthesis of highly fluorescent nitrogen-doped carbon dots for sensitive and selective probing ferric ions in living cells. , 2014, Analytical chemistry.

[46]  B. D. Pandey,et al.  Chemical and microbial remediation of hexavalent chromium from contaminated soil and mining/metallurgical solid waste: a review. , 2013, Journal of hazardous materials.

[47]  Xi Chen,et al.  Intrinsic peroxidase-like catalytic activity of nitrogen-doped graphene quantum dots and their application in the colorimetric detection of H2O2 and glucose. , 2015, Analytica chimica acta.

[48]  Zhenhui Kang,et al.  Carbon nanodots: synthesis, properties and applications , 2012 .

[49]  Hong-yu Zhang,et al.  Rapid detection of Cr(VI) ions based on cobalt(II)-doped carbon dots. , 2017, Biosensors & bioelectronics.

[50]  Guolin Zhang,et al.  Fluorescent nanothermometers based on mixed shell carbon nanodots , 2015 .

[51]  Erqun Song,et al.  Dual-Recognition Förster Resonance Energy Transfer Based Platform for One-Step Sensitive Detection of Pathogenic Bacteria Using Fluorescent Vancomycin-Gold Nanoclusters and Aptamer-Gold Nanoparticles. , 2017, Analytical chemistry.