On the toxic effects of tetraethyl lead and its derivatives on the chrysophyte Poterioochromonas malhamensis. III. Chemical analyses

The photolytic decomposition of tetraethyl lead (TEL) into the derivatives triethyl lead (TriEL), diethyl lead (DiEL), and into inorganic lead in an aqueous environment was examined by using a single-step dithizone extraction method. The results of the experiments conclusively indicated that TriEL is the toxic derivative of TEL which is created upon illumination and causes severe inhibitory effects in cultures of Poterioochromonas malhamensis poisoned by TEL. The significance of these findings for polluted natural environments and for the metabolic pathway of organolead in intoxicated mammalia is discussed briefly, and a diagrammatical model is presented describing the presumed fate of TEL and its derivatives under experimental conditions. (JMT)

[1]  W. Bolanowska,et al.  Triethyllead in the biological material in cases of acute tetraethyllead poisoning , 1967, Archiv für Toxikologie.

[2]  G. Röderer.  On the toxic effects of tetraethyl lead and its derivatives on the chrysophyte Poterioochromonas malhamensis. II. Triethyl lead, diethyl lead, and inorganic lead. , 1981, Environmental research.

[3]  J. Ingle,et al.  Microprocessor-based data acquisition system for chemiluminescence measurements , 1981 .

[4]  G. Röderer.  On the toxic effects of tetraethyl lead and its derivatives on the chrysophyte Poterioochromonas malhamensis. I. Tetraethyl lead. , 1980, Environmental research.

[5]  G. Tiravanti,et al.  Potential pollution of a marine environment by lead alkyls: the Cavtat incident , 1979 .

[6]  U. Schmidt,et al.  Aqueous Chemistry of Organolead and Organothallium Compounds in the Presence of Microorganisms , 1979 .

[7]  J. W. Robinson,et al.  Studies of interactions between tetraethyl lead and sea water using GC‐AA , 1979 .

[8]  Roy M. Harrison,et al.  Sink processes for tetraalkyllead compounds in the atmosphere , 1978 .

[9]  R M Harrison,et al.  The analysis of tetra-alkyl lead compounds and their significance as urban air pollutants. , 1978, Atmospheric environment.

[10]  K. Hayakawa.  Microdetermination and dynamic aspects of in vivo alkyl lead compounds. II. Studies on the dynamic aspects of alkyl lead compounds in vivo. , 1972, Nihon eiseigaku zasshi. Japanese journal of hygiene.

[11]  J. Casida,et al.  Oxidative Dealkylation of Tetra-, Tri-, and Dialkyltins and Tetra- and Trialkylleads by Liver Microsomes. , 1971 .

[12]  F. Frey,et al.  Commercial organolead compounds , 1971 .

[13]  W. Bolanowska.  Distribution and Excretion of Triethyllead in Rats , 1968, British journal of industrial medicine.

[14]  F. Frey,et al.  The organic compounds of lead , 1968 .

[15]  L. J. Snyder,et al.  A New Field Method for the Determination of Organolead Compounds in Air , 1961 .

[16]  L. J. Snyder,et al.  Rapid Spectrophotometric Determination of Triethyllead, Diethyllead, and Inorganic Lead Ions and Application to the Determination of Tetraorganolead Compounds , 1961 .

[17]  R. Kehoe,et al.  Isolation of triethyllead ion from liver after inhalation of tetraethyllead. , 1960, The Journal of pharmacology and experimental therapeutics.

[18]  J. E. Cremer.  Biochemical Studies on the Toxicity of Tetraethyl Lead and Other Organo-Lead Compounds , 1959, British journal of industrial medicine.

[19]  H. Beatty,et al.  Chemical Reactions of Tetraethyllead , 1959 .

[20]  G. Calingaert,et al.  The decomposition of alkyllead compounds. , 1948, Journal of the American Chemical Society.