Topical treatment with paromomycin for cutaneous leishmaniasis

Cutaneous leishmaniasis, especially on the face, continues to present a complex therapeutic problem because of the potential formation of ugly scars. We present a 6-year-old girl who recently immigrated to Israel from Ethiopia with extensive facial lesions of cutaneous leishmaniasis. Treatment with ketoconazole caused liver damage. Local application of an ointment containing paromomycin sulfate and methylbenzethonium chloride for 3 weeks resulted in complete recovery with minimal scarring.

[1]  P. Craig,et al.  Topical treatment of New World cutaneous leishmaniasis in Belize: a clinical study. , 1993, Journal of the American Academy of Dermatology.

[2]  S. Halevy,et al.  Topical treatment of Old World cutaneous leishmaniasis caused by Leishmania major: a double-blind control study. , 1992, Journal of the American Academy of Dermatology.

[3]  J. Marr,et al.  Allopurinol in the treatment of American cutaneous leishmaniasis. , 1992, The New England journal of medicine.

[4]  Rj Lowe,et al.  Third annual report , 1992 .

[5]  K. B. Babajev,et al.  Treatment of cutaneous leishmaniasis using a carbon dioxide laser. , 1991, Bulletin of the World Health Organization.

[6]  R. K. Joshi,et al.  Dermal Leishmaniasis and Rifampicin , 1989, International journal of dermatology.

[7]  L. Santagostino,et al.  Cutaneous Leishmaniasis: Treatment With Itraconazole , 1989 .

[8]  P. Rácz,et al.  EFFECTS OF INTRADERMAL GAMMA-INTERFERON IN CUTANEOUS LEISHMANIASIS , 1989, The Lancet.

[9]  A. Chu,et al.  Intralesional therapy of cutaneous leishmaniasis with sodium stibogluconate antimony , 1988, The British journal of dermatology.

[10]  J. Berman.  Chemotherapy for leishmaniasis: biochemical mechanisms, clinical efficacy, and future strategies. , 1988, Reviews of infectious diseases.

[11]  H. Aram,et al.  Ultrasound-induced hyperthermia in the treatment of cutaneous leishmaniasis. , 1987, Cutis.

[12]  H. Aram,et al.  Cryotherapy in Acute Cutaneous Leishmaniasis , 1986, International journal of dermatology.

[13]  J. Dogra,et al.  Dapsone in the Treatment of Cutaneous Leishmaniasis , 1986, International journal of dermatology.

[14]  S. Brenner.  Topical treatment with imidazole for cutaneous leishmaniasis. , 1985, Israel journal of medical sciences.

[15]  G. P. Jacobs,et al.  Development of topical treatment for cutaneous leishmaniasis caused by Leishmania major in experimental animals , 1984, Antimicrobial Agents and Chemotherapy.

[16]  E. Petersen,et al.  Observations on local heat treatment for cutaneous leishmaniasis. , 1984, The American journal of tropical medicine and hygiene.

[17]  J. El-on,et al.  Cutaneous leishmaniasis: treatment with ketoconazole. , 1983, Cutis.

[18]  T. Henriksen,et al.  TREATMENT OF DIFFUSE CUTANEOUS LEISHMANIASIS WITH CHLORPROMAZINE OINTMENT , 1983, The Lancet.

[19]  A. Zuckerman,et al.  Current status of the immunology of blood and tissue Protozoa. I. Leishmania. , 1975, Experimental parasitology.

[20]  E. Gerdts.  Letter: Cervical cancer and gonorrhoea. , 1974, Lancet.

[21]  P. Long.  Cutaneous leishmaniasis treated with metronidazole. , 1973, JAMA.

[22]  E. Kandil.  Treatment of cutaneous leishmaniasis with trimethoprim-sulfamethoxazole combination. , 1973, Dermatologica.

[23]  S. Shibolet,et al.  Ecology and attempted control of cutaneous leishmaniasis around Jericho, in the Jordan Valley. , 1970, The Journal of infectious diseases.