Silibinin inhibits in vitro ketosis by regulating HMGCS2 and NF-kB: elucidation of signaling molecule relationship under ketotic conditions

[1]  H. Lee,et al.  Methylsulfonylmethane Inhibits RANKL-Induced Osteoclastogenesis in BMMs by Suppressing NF-κB and STAT3 Activities , 2016, PloS one.

[2]  J. Ash,et al.  The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair. , 2016, Advances in experimental medicine and biology.

[3]  S. Y. Kim,et al.  Induction of in vitro ketosis condition and suppression using methylsulfonylmethane by altering ANGPTL3 expression through STAT5b signaling mechanism , 2015 .

[4]  R. Agarwal,et al.  Silibinin strongly inhibits the growth kinetics of colon cancer stem cell-enriched spheroids by modulating interleukin 4/6-mediated survival signals , 2014, Oncotarget.

[5]  D. D'avignon,et al.  Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia. , 2014, The Journal of clinical investigation.

[6]  H. Ding,et al.  ß-Hydroxybutyrate Activates the NF-κB Signaling Pathway to Promote the Expression of Pro-Inflammatory Factors in Calf Hepatocytes , 2014, Cellular Physiology and Biochemistry.

[7]  Anil Kumar,et al.  HIV-1 Tat-Mediated Induction of CCL5 in Astrocytes Involves NF-κB, AP-1, C/EBPα and C/EBPγ Transcription Factors and JAK, PI3K/Akt and p38 MAPK Signaling Pathways , 2013, PloS one.

[8]  Hong-Bo Xiao,et al.  1,3,5,8-tetrahydroxyxanthone regulates ANGPTL3-LPL pathway to lessen the ketosis in mice. , 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[9]  D. Haro,et al.  Human HMGCS2 Regulates Mitochondrial Fatty Acid Oxidation and FGF21 Expression in HepG2 Cell Line* , 2011, The Journal of Biological Chemistry.

[10]  Xin-yang Wang,et al.  Chemopreventive and Chemotherapeutic Effects of Intravesical Silibinin against Bladder Cancer by Acting on Mitochondria , 2011, Molecular Cancer Therapeutics.

[11]  E. Ferrannini,et al.  CXCL9 and CXCL11 chemokines modulation by peroxisome proliferator-activated receptor-alpha agonists secretion in Graves' and normal thyrocytes. , 2010, The Journal of clinical endocrinology and metabolism.

[12]  L. Berthiaume,et al.  Palmitoylation of ketogenic enzyme HMGCS2 enhances its interaction with PPARα and transcription at the Hmgcs2 PPRE , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[13]  R. Agarwal,et al.  Silibinin inhibits human nonsmall cell lung cancer cell growth through cell‐cycle arrest by modulating expression and function of key cell‐cycle regulators , 2010, Molecular carcinogenesis.

[14]  David W. Johnson,et al.  Silibinin--a promising new treatment for cancer. , 2010, Anti-cancer agents in medicinal chemistry.

[15]  T. Ikejima,et al.  Silibinin induces protective superoxide generation in human breast cancer MCF-7 cells , 2009, Free radical research.

[16]  T. Lawrence The nuclear factor NF-kappaB pathway in inflammation. , 2009, Cold Spring Harbor perspectives in biology.

[17]  R. Saller,et al.  An Updated Systematic Review with Meta-Analysis for the Clinical Evidence of Silymarin , 2008, Complementary Medicine Research.

[18]  M. Kahlenberg,et al.  Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer. , 2007, The Journal of surgical research.

[19]  R. Agarwal,et al.  Mechanisms and preclinical efficacy of silibinin in preventing skin cancer. , 2005, European journal of cancer.

[20]  R. Agarwal,et al.  Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells. , 2005, Cancer research.

[21]  J. Flier,et al.  Genomic organization, sequence and transcriptional regulation of the human CXCL 11(1) gene. , 1999, Biochimica et biophysica acta.

[22]  F. Hegardt Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis. , 1999, The Biochemical journal.

[23]  S. Ohno,et al.  NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene. , 1994, Journal of immunology.

[24]  G. Rosen,et al.  Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1). , 1992, The Journal of biological chemistry.

[25]  G. Sonenshein,et al.  Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[26]  A. Garber,et al.  Hepatic ketogenesis and gluconeogenesis in humans. , 1974, The Journal of clinical investigation.