The immunoglobulin superfamily--domains for cell surface recognition.

When Ig chains were first sequenced, segments within the constant regions of H and L chains showed sequence similarities, and this led to the idea that the Ig chains had all evolved from a primordial gene coding for about 100 amino acids (1). The domains within the Ig chains all contained a characteristic intrachain disulfide bond, and the idea of the domain as an independent structural unit was proposed (2). The domain hypothesis was firmly established when the structures of V and C domains were determined to reveal a common fold forming a sandwich of two p-sheets that was stabilized by the conserved disulfide bond (3, 4). Beta-2 microglobulin (P2-m), identified in the urine of patients with kidney disease, was the first nonimmunoglobulin structure found to share sequence similarities with Ig-domains. The pz-m sequence looked like an Ig C-domain (5, 6). P2-m was subsequently discovered to be part of the major histocompatibility complex (MH C) class I structure, and sequencing of the class I heavy chain showed that a segment of sequence adjacent to the transmembrane region was also similar to Ig C-domains (7, 7a). MHC antigens were known to play some role in the specificity of T lymphocyte

[1]  R. Hill,et al.  THE EVOLUTIONARY ORIGINS OF THE IMMUNOGLOBULINS* , 1966, Proceedings of the National Academy of Sciences of the United States of America.

[2]  The covalent structure of a human gamma G-immunoglobulin. XI. Functional implications. , 1970, Biochemistry.

[3]  A. Bourgois.  Evidence for an ancestral immunoglobulin gene coding for half a domain. , 1975, Immunochemistry.

[4]  D C Richardson,et al.  Similarity of three-dimensional structure between the immunoglobulin domain and the copper, zinc superoxide dismutase subunit. , 1976, Journal of molecular biology.

[5]  D. Lancet,et al.  The heavy chain of human histocompatibility antigen HLA-B7 contains an immunoglobulin-like region , 1979, Nature.

[6]  P. Bayley,et al.  Structural similarities between Thy-1 antigen from rat brain and immunoglobulin , 1979, Nature.

[7]  A M Lesk,et al.  Evolution of proteins formed by beta-sheets. II. The core of the immunoglobulin domains. , 1982, Journal of molecular biology.

[8]  A. Williams,et al.  Surface molecules and cell interactions. , 1982, Journal of theoretical biology.

[9]  J. Sulston,et al.  Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans. , 1983, Science.

[10]  M. O. Dayhoff,et al.  Establishing homologies in protein sequences. , 1983, Methods in enzymology.

[11]  Charles Auffray,et al.  The class II molecules of the human and murine major histocompatibility complex , 1984, Cell.

[12]  G. Blobel,et al.  The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains , 1984, Nature.

[13]  J. Maizel,et al.  Homology of adenoviral E3 glycoprotein with HLA-DR heavy chain. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[14]  A. Barclay,et al.  A glycophospholipid tail at the carboxyl terminus of the Thy-1 glycoprotein of neurons and thymocytes. , 1985, Science.

[15]  F. Grosveld,et al.  Structure of the murine Thy‐1 gene. , 1985, The EMBO journal.

[16]  L. Hood,et al.  Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse , 1985, The Journal of experimental medicine.

[17]  J. Silver,et al.  A hydrophobic transmembrane segment at the carboxyl terminus of thy-1. , 1985, Science.

[18]  T. Matsunaga.  Evolution of the immunoglobulin superfamily by duplication of complementarity. , 1985, Immunology today.

[19]  R. Axel,et al.  Isolation and sequence of a cDNA encoding the major structural protein of peripheral myelin , 1985, Cell.

[20]  R. Spielman,et al.  Structure, Sequence and Polymorphism in the HLA‐D Region , 1985, Immunological reviews.

[21]  Charles J. Sherr,et al.  The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1 , 1985, Cell.

[22]  R. Flavell,et al.  Duplicated gene pairs and alleles of class I genes in the Qa2 region of the murine major histocompatibility complex: a comparison. , 1985, The EMBO journal.

[23]  V A McKusick,et al.  The human gene map. , 1986, Cold Spring Harbor symposia on quantitative biology.

[24]  Robin A. Weiss,et al.  The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain , 1986, Cell.

[25]  S. Frutiger,et al.  The amino-terminal domain of rabbit secretory component is responsible for noncovalent binding to immunoglobulin A dimers. , 1986, The Journal of biological chemistry.

[26]  C. Milstein,et al.  Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[27]  D. Portnoy,et al.  Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors. , 1986, Science.

[28]  C. Sherr,et al.  The c-fms Proto-Oncogene and the CSF-1 Receptor , 1986 .

[29]  P. Neame,et al.  The primary structure of link protein from rat chondrosarcoma proteoglycan aggregate. , 1986, The Journal of biological chemistry.

[30]  K. Mostov,et al.  Deletion of the cytoplasmic domain of the polymeric immunoglobulin receptor prevents basolateral localization and endocytosis , 1986, Cell.

[31]  R. Poljak,et al.  Three-dimensional structure of an antigen-antibody complex at 2.8 A resolution , 1986, Science.

[32]  L. Hood,et al.  The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition. , 1986, Annual review of immunology.

[33]  Alan F. Williams,et al.  Striking similarities between antigen receptor J pieces and sequence in the second chain of the murine CD8 antigen , 1986, Nature.

[34]  J. Coligan,et al.  Class I genes and molecules: an update. , 1986, Immunology.

[35]  I. Mellman,et al.  A complementary DNA clone for a macrophage-lymphocyte Fc receptor , 1986, Nature.

[36]  A. Ullrich,et al.  Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors , 1986, Nature.

[37]  S. Rudikoff,et al.  Functional antibody lacking a variable-region disulfide bridge. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[38]  N. Ishioka,et al.  Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[39]  L. Hood,et al.  A single gene encodes soluble and membrane-bound forms of the major histocompatibility Qa-2 antigen: Anchoring of the product by a phospholipid tail , 1987, Cell.

[40]  H. Clevers,et al.  Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[41]  A cDNA presumptively coding for the alpha subunit of the receptor with high affinity for immunoglobulin E. , 1987 .

[42]  A. Ullrich,et al.  Human proto‐oncogene c‐kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. , 1987, The EMBO journal.

[43]  Michael Loran Dustin,et al.  Anchoring mechanisms for LFA-3 cell adhesion glycoprotein at membrane surface , 1987, Nature.

[44]  A. F. Williams,et al.  A year in the life of the immunoglobulin superfamily. , 1987, Immunology today.

[45]  J. Salzer,et al.  The amino acid sequences of the myelin-associated glycoproteins: homology to the immunoglobulin gene superfamily , 1987, The Journal of cell biology.

[46]  G. Edelman,et al.  Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing. , 1987, Science.

[47]  D. Staunton,et al.  Molecular cloning of the lymphocyte activation marker Blast‐1. , 1987, The EMBO journal.

[48]  Mark M. Davis,et al.  A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation , 1987, Nature.

[49]  P. Kincade,et al.  Removal of lymphocyte surface molecules with phosphatidylinositol-specific phospholipase C: effects on mitogen responses and evidence that ThB and certain Qa antigens are membrane-anchored via phosphatidylinositol. , 1987, Journal of immunology.

[50]  M. Sternberg,et al.  Prediction of protein secondary structure and active sites using the alignment of homologous sequences. , 1987, Journal of molecular biology.

[51]  Michael Loran Dustin,et al.  The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3 , 1987, Nature.

[52]  Isolation and nucleotide sequence of mouse NCAM cDNA that codes for a M(r) 79 000 polypeptide without a membrane-spanning region. , 1987, The EMBO journal.

[53]  R. Dwek,et al.  Tissue‐specific N‐glycosylation, site‐specific oligosaccharide patterns and lentil lectin recognition of rat Thy‐1. , 1987, The EMBO journal.

[54]  B. Seed.  An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2 , 1987, Nature.

[55]  B. Seed,et al.  Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[56]  S. N. Gettner,et al.  Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene , 1987, Nature.

[57]  D. Paterson,et al.  Similarities in sequences and cellular expression between rat CD2 and CD4 antigens , 1987, The Journal of experimental medicine.

[58]  L. Buluwela,et al.  Physical linkage of three CD3 genes on human chromosome 11. , 1987, The EMBO journal.

[59]  B. Seed,et al.  Molecular cloning of two CD7 (T‐cell leukemia antigen) cDNAs by a COS cell expression system. , 1987, The EMBO journal.

[60]  S. Oikawa,et al.  The carcinoembryonic antigen (CEA) contains multiple immunoglobulin-like domains. , 1987, Biochemical and biophysical research communications.

[61]  M. Ferguson,et al.  Cell-surface anchoring of proteins via glycosyl-phosphatidylinositol structures. , 1988, Annual review of biochemistry.

[62]  G. Lemke,et al.  Isolation and analysis of the gene encoding peripheral myelin protein zero , 1988, Neuron.

[63]  M. Hibbs,et al.  The structure of the murine Fc receptor for IgG. Assignment of intrachain disulfide bonds, identification of N-linked glycosylation sites, and evidence for a fourth form of Fc receptor. , 1988, Journal of immunology.

[64]  A. Barclay,et al.  Immunoglobulin-Related Structures Associated with Vertebrate Cell Surfaces , 1988 .

[65]  R. Campbell,et al.  Structure, organization, and regulation of the complement genes. , 1988, Annual review of immunology.

[66]  Two forms of lB 236 / myelin '-associated glycoprotein , a cell adhesion molecule for postnatal neural development , are produced by alternative splicing ( immunoglobulin super family / myelinogenesis / platelet-derived growth factor / PO protein ) , .