Circulating microRNAs as candidate markers to distinguish heart failure in breathless patients

Since their identification in the circulation, microRNAs have received considerable interest as putative biomarkers of cardiovascular disease. We have investigated the diagnostic utility of microRNAs in differentiating between patients with heart failure (HF) and non‐HF‐related breathlessness, and between HF with reduced (HF‐REF) and preserved (HF‐PEF) EF.

[1]  S. Manzano-Fernández,et al.  Highly sensitive troponin T for risk stratification of acutely destabilized heart failure. , 2012, American heart journal.

[2]  A. Tijsen,et al.  Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease? , 2012, Circulation research.

[3]  Offer Amir,et al.  Serum levels of microRNAs in patients with heart failure , 2012, European journal of heart failure.

[4]  J. Bauersachs,et al.  Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome. , 2011, Journal of molecular and cellular cardiology.

[5]  Min Liu,et al.  MicroRNA‐142‐3p, a new regulator of RAC1, suppresses the migration and invasion of hepatocellular carcinoma cells , 2011, FEBS letters.

[6]  Y. Liu,et al.  MicroRNA expression signature in atrial fibrillation with mitral stenosis. , 2011, Physiological genomics.

[7]  H. Nonogi,et al.  Assessment of plasma miRNAs in congestive heart failure. , 2011, Circulation journal : official journal of the Japanese Circulation Society.

[8]  Jan A Staessen,et al.  Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease , 2010, Circulation. Cardiovascular genetics.

[9]  Christopher M O'Connor,et al.  Troponin elevation in heart failure prevalence, mechanisms, and clinical implications. , 2010, Journal of the American College of Cardiology.

[10]  F. Crea,et al.  MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients. , 2010, Physiological genomics.

[11]  Kunihiro Nishimura,et al.  Plasma microRNA 499 as a biomarker of acute myocardial infarction. , 2010, Clinical chemistry.

[12]  Federica Limana,et al.  Circulating microRNAs are new and sensitive biomarkers of myocardial infarction , 2010, European heart journal.

[13]  Perry D Moerland,et al.  MiR423-5p As a Circulating Biomarker for Heart Failure , 2010, Circulation research.

[14]  N. Sawada,et al.  Novel aspects of the roles of Rac1 GTPase in the cardiovascular system. , 2010, Current opinion in pharmacology.

[15]  R. Jaenisch,et al.  Loss of Cardiac microRNA-Mediated Regulation Leads to Dilated Cardiomyopathy and Heart Failure , 2009, Circulation research.

[16]  Jianqin Jiao,et al.  miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy , 2009, Proceedings of the National Academy of Sciences.

[17]  Frank Speleman,et al.  A novel and universal method for microRNA RT-qPCR data normalization , 2009, Genome Biology.

[18]  S. Vatner,et al.  Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes , 2009, Circulation research.

[19]  Derek J Van Booven,et al.  Reciprocal Regulation of Myocardial microRNAs and Messenger RNA in Human Cardiomyopathy and Reversal of the microRNA Signature by Biomechanical Support , 2009, Circulation.

[20]  Susan Anderson,et al.  Irbesartan in patients with heart failure and preserved ejection fraction. , 2008, The New England journal of medicine.

[21]  I. Bozzoni,et al.  Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells , 2008, The EMBO journal.

[22]  M. Washington,et al.  Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer , 2008, Oncogene.

[23]  Sek Won Kong,et al.  Altered microRNA expression in human heart disease. , 2007, Physiological genomics.

[24]  Peter T Nelson,et al.  Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways. , 2007, Molecular genetics and metabolism.

[25]  Thomas Thum,et al.  MicroRNAs in the Human Heart: A Clue to Fetal Gene Reprogramming in Heart Failure , 2007, Circulation.

[26]  George A. Calin,et al.  A MicroRNA Signature of Hypoxia , 2006, Molecular and Cellular Biology.

[27]  M. Peppelenbosch,et al.  Hedgehog morphogen in cardiovascular disease. , 2006, Circulation.

[28]  V. Roger,et al.  Trends in prevalence and outcome of heart failure with preserved ejection fraction. , 2006, The New England journal of medicine.

[29]  D. Bartel.  MicroRNAs Genomics, Biogenesis, Mechanism, and Function , 2004, Cell.

[30]  Karl Swedberg,et al.  Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial , 2003, The Lancet.

[31]  Daniel Levy,et al.  Long-term trends in the incidence of and survival with heart failure. , 2002, The New England journal of medicine.

[32]  F. Speleman,et al.  Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes , 2002, Genome Biology.

[33]  Y. Yazaki,et al.  The role of the natriuretic peptides in the cardiovascular system. , 2001, Cardiovascular research.

[34]  C. Frampton,et al.  Plasma N-terminal pro-brain natriuretic peptide and adrenomedullin: new neurohormonal predictors of left ventricular function and prognosis after myocardial infarction. , 1998, Circulation.

[35]  R. Doughty,et al.  Immunoreactive amino‐terminal pro‐brain natriuretic peptide (NT‐PROBNP): a new marker of cardiac impairment , 1997, Clinical endocrinology.

[36]  A. Richards,et al.  Plasma brain natriuretic peptide in assessment of acute dyspnoea , 1994, The Lancet.

[37]  N. Reichek,et al.  Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. , 1989, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.