Ventilation: Total, Alveolar, and Dead Space

The sections in this article are: 1 Alveolar Ventilation and Alveolar Gas Composition 1.1 Alveolar and Dead-Space Ventilation 1.2 Alveolar Gas Equation and Alveolar Gas Composition 1.3 Assessment of Alveolar Gas Composition 2 Dead Space 2.1 General Considerations: Gas Mixing in Airways 2.2 Measurement of Dead Space 2.3 Factors Affecting Dead Space

[1]  C. Bohr Ueber die Lungenathmung1 , 1891 .

[2]  A. Krogh On the Mechanism of the Gas‐Exchange in the Lungs1 , 1910 .

[3]  J S Haldane,et al.  The capacity of the air passages under varying physiological conditions , 1912, The Journal of physiology.

[4]  A. Krogh,et al.  The volume of the dead space in breathing and the mixing of gases in the lungs of man , 1917, The Journal of physiology.

[5]  A. E. Clark-Kennedy,et al.  On the fluctuation in the composition of the alveolar air during the respiratory cycle in muscular exercise , 1928, The Journal of physiology.

[6]  A. Cournand,et al.  STUDIES ON INTRAPULMONARY MIXTURE OF GASES. V. FORMS OF INADEQUATE VENTILATION IN NORMAL AND EMPHYSEMATOUS LUNGS, ANALYZED BY MEANS OF BREATHING PURE OXYGEN. , 1944, The Journal of clinical investigation.

[7]  J. L. Lilienthal,et al.  On the determination of the physiologically effective pressures of oxygen and carbon dioxide in alveolar air. , 1946, The American journal of physiology.

[8]  H RAHN,et al.  A theoretical study of the composition of the alveolar air at altitude. , 1946, The American journal of physiology.

[9]  W. S. Fowler Lung function studies; the respiratory dead space. , 1948, The American journal of physiology.

[10]  H. Rahn A concept of mean alveolar air and the ventilation-blood flow relationships during pulmonary gas exchange. , 1949, The American journal of physiology.

[11]  W. S. Fowler Lung function studies. V. Respiratory dead space in old age and in pulmonary emphysema. , 1950, The Journal of clinical investigation.

[12]  Studies of lung volume and intrapulmonary mixing. Nitrogen clearance curves: apparent respiratory dead space and its significance. , 1950, Journal of applied physiology.

[13]  A. Dubois Alveolar CO2 and O2 during breath holding, expiration, and inspiration. , 1952, Journal of applied physiology.

[14]  J. Pappenheimer,et al.  New experimental methods for determination of effective alveolar gas composition and respiratory dead space, in the anesthetized dog and in man. , 1952, Journal of applied physiology.

[15]  W. S. Fowler,et al.  Lung function studies. VIII. Analysis of alveolar ventilation by pulmonary N2 clearance curves. , 1952, The Journal of clinical investigation.

[16]  G. Taylor Dispersion of soluble matter in solvent flowing slowly through a tube , 1953, Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences.

[17]  J. H. Comroe,et al.  Alveolar ventilation at very low tidal volumes. , 1954, Journal of applied physiology.

[18]  D V BATES,et al.  The respiratory dead space measured by single breath analysis of oxygen, carbon dioxide, nitrogen or helium. , 1954, The Journal of clinical investigation.

[19]  Geoffrey Ingram Taylor,et al.  The dispersion of matter in turbulent flow through a pipe , 1954, Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences.

[20]  A. Roos,et al.  Distribution of inspired air in the lungs. , 1955, Journal of applied physiology.

[21]  R. B. Cherry,et al.  Studies of respiratory physiology in the newborn infant. I. Observations on normal premature and full-term infants. , 1955, The Journal of clinical investigation.

[22]  E. Radford,et al.  Ventilation standards for use in artificial respiration. , 1955, Journal of applied physiology.

[23]  J. Pappenheimer,et al.  Components of the respiratory dead space and their variation with pressure breathing and with bronchoactive drugs. , 1955, Journal of applied physiology.

[24]  A. C. Young Dead space at rest and during exercise. , 1955, Journal of applied physiology.

[25]  E. Asmussen,et al.  Physiological dead space and alveolar gas pressures at rest and during muscular exercise. , 1956, Acta physiologica Scandinavica.

[26]  S. Tenney,et al.  Dead Space Ventilation in Old Age , 1956 .

[27]  J. Severinghaus,et al.  Alveolar Dead Space as an Index of Distribution of Blood Flow in Pulmonary Capillaries , 1957 .

[28]  B. B. Ross Influence of bronchial tree structure on ventilation in the dog's lung as inferred from measurements of a plastic cast. , 1957, Journal of applied physiology.

[29]  R. H. Shepard,et al.  Factors affecting the pulmonary dead space as determined by single breath analysis. , 1957, Journal of applied physiology.

[30]  Respiratory dead space measurements in a model lung and healthy human subjects according to the single breath method , 1959 .

[31]  J. Nunn,et al.  Anatomical subdivisions of the volume of respiratory dead space and effect of position of the jaw. , 1959, Journal of applied physiology.

[32]  The Respiratory Dead Space of the Giraffe , 1960, Nature.

[33]  B. B. Ross,et al.  Dead-space ventilation as a determinant in the ventilation-perfusion concept. , 1960, Journal of applied physiology.

[34]  M. Mcilroy,et al.  Effects of chest compression on reflex ventilatory drive and pulmonary function , 1962 .

[35]  J. Severinghaus,et al.  Postural variations in dead space and CO2 gradients breathing air and O2. , 1962, Journal of applied physiology.

[36]  H BJURSTEDT,et al.  Effects of posture on alveolar-arterial CO2 and O2 differences and on alveolar dead space in man. , 1962, Acta physiologica Scandinavica.

[37]  M C Hart,et al.  Relation between anatomic respiratory dead space and body size and lung volume , 1963, Journal of applied physiology.

[38]  R. J. Mills,et al.  FACTORS INFLUENCING THE CONCENTRATION OF EXPIRED NITROGEN AFTER A BREATH OF OXYGEN. , 1965, Journal of applied physiology.

[39]  C. Lenfant Arterial-alveolar difference in PCO2 during air and oxygen breathing. , 1966, Journal of applied physiology.

[40]  D. Muir Distribution of aerosol particles in exhaled air. , 1967, Journal of applied physiology.

[41]  R H Ingram,et al.  Effect of expiratory flow rate on the nitrogen concentration vs. volume relationship. , 1967, Journal of applied physiology.

[42]  S. Tenney,et al.  Comparative quantitative morphology of the mammalian lung: trachea. , 1967, Respiration physiology.

[43]  Change in PaCO2 with mechanical dead space during artificial ventilation. , 1968 .

[44]  J. Mead,et al.  Relative hysteresis of the dead space and lung in vivo. , 1968, Journal of applied physiology.

[45]  Edward D. Crandall,et al.  An analysis of external respiration in man , 1968 .

[46]  K. Horsfield,et al.  Morphology of the bronchial tree in man. , 1968, Journal of applied physiology.

[47]  G Cumming,et al.  Functional consequences of airway morphology. , 1968, Journal of applied physiology.

[48]  Gaseous diffusion between airways and alveoli in the human lung. , 1969, Journal of applied physiology.

[49]  Inhaled argon boluses in man. , 1969, Journal of applied physiology.

[50]  L. Farhi,et al.  Alveolar to mixed venous PCO2 difference under conditions of no gas exchange. , 1969, Respiration physiology.

[51]  Nye Re,et al.  Influence of the cyclical pattern of ventilatory flow on pulmonary gas exchange. , 1970 .

[52]  J. Glazier,et al.  Effects of changes in respiratory pattern on physiological dead space. , 1971, Journal of applied physiology.

[53]  G. Cumming,et al.  A model of time-varying gas exchange in the human lung during a respiratory cycle at rest. , 1971, Scandinavian journal of respiratory diseases. Supplementum.

[54]  J. Piiper,et al.  Gas-blood CO 2 equilibration in dog lungs during rebreathing. , 1972, Journal of applied physiology.

[55]  N. Anthonisen,et al.  Pulmonary gas exchange in dogs breathing SF 6 at 4 ata. , 1972, Journal of applied physiology.

[56]  Correction for mechanical dead space in the calculation of physiological dead space. , 1972, The Journal of clinical investigation.

[57]  M P Hlastala,et al.  A model of fluctuating alveolar gas exchange during the respiratory cycle. , 1972, Respiration physiology.

[58]  R. M. Efros Pulmonary capillary carbon dioxide gradients and the Wien effect. , 1972, Journal of applied physiology.

[59]  A. Otis,et al.  Studies on alveolar-mixed venous CO 2 and O 2 gradients in the rebreathing dog lung. , 1973, Respiration physiology.

[60]  M Paiva,et al.  Gas transport in the human lung. , 1972, Journal of applied physiology.

[61]  P. Macklem,et al.  Gas mixing during inspiration. , 1973, Journal of applied physiology.

[62]  E P Hill,et al.  Mathematical simulation of pulmonary O 2 and CO 2 exchange. , 1973, The American journal of physiology.

[63]  P. Macklem,et al.  Gas mixing during breath holding studied by intrapulmonary gas sampling. , 1973, Journal of applied physiology.

[64]  J. Ultman,et al.  Simultaneous gas flow and diffusion in a symmetric airway system: a mathematical model. , 1974, Respiration physiology.

[65]  N. M. Greene,et al.  Measurement of axial diffusivities in a model of the bronchial airways. , 1975, Journal of applied physiology.

[66]  L. van der Linden,et al.  Transport of H2 and SF6 in the lung. , 1975, Respiration physiology.

[67]  R. Forster,et al.  Time course of exchanges between red cells and extracellular fluid during CO2 uptake. , 1975, Journal of applied physiology.

[68]  D. B. Jennings,et al.  Negative arterial-mixed expired PC02 gradient during acute and chronic hypercapnia. , 1975, Journal of applied physiology.

[69]  M. Paiva,et al.  Gas transport in a model derived from Hansen-Ampaya anatomical data of the human lung. , 1976, Journal of applied physiology.

[70]  P. Macklem,et al.  Convection, diffusion and cardiogenic mixing of inspired gas in the lung; an experimental approach. , 1976, Respiration physiology.

[71]  J. Piiper,et al.  Convective and diffusive gas mixing in human lungs: experiments and model analysis. , 1976, Journal of applied physiology.

[72]  H. Robertson,et al.  Elevated alveolar PCO2 relative to predicted values during normal gas exchange. , 1977, Journal of applied physiology: respiratory, environmental and exercise physiology.

[73]  R. Forster Can alveolar pCO2 exceed pulmonary end-capillary CO2? No. , 1977, Journal of applied physiology: respiratory, environmental and exercise physiology.

[74]  G. Gurtner Can alveolar pCO2 exceed pulmonary end-capillary CO2? Yes. , 1977, Journal of applied physiology: respiratory, environmental and exercise physiology.

[75]  Penetration of inhaled He and SF6 into alveolar space at low tidal volumes. , 1977, Journal of applied physiology: respiratory, environmental and exercise physiology.

[76]  A. Pack,et al.  A computational model of pulmonary gas transport incorporating effective diffusion. , 1977, Respiration physiology.

[77]  Model experiments on diffusional equilibration of oxygen and carbon dioxide between inspired and alveolar gas. , 1978, Respiration physiology.

[78]  H. Robertson,et al.  Inert gas elimination characteristics of the normal and abnormal lung. , 1978, Journal of applied physiology: respiratory, environmental and exercise physiology.

[79]  E. Crandall,et al.  Direct evidence of participation of rat lung carbonic anhydrase in CO2 reactions. , 1978, The Journal of clinical investigation.

[80]  P. Hugh-Jones,et al.  Dead space and tidal volume of the giraffe compared with some other mammals. , 1978, Respiration physiology.

[81]  R. S. Chang,et al.  Acceleration of plasma bicarbonate conversion to carbon dioxide by pulmonary carbonic anhydrase. , 1978, Science.

[82]  R. Whitlock,et al.  Revised standards for normal resting dead-space volume and venous admixture in men and women. , 1978, Clinical science and molecular medicine.

[83]  R. Klocke Catalysis of CO2 reactions by lung carbonic anhydrase. , 1978, Journal of applied physiology: respiratory, environmental and exercise physiology.

[84]  J. Loeppky,et al.  Mean alveolar gases and alveolar-arterial gradients in pulmonary patients. , 1979, Journal of applied physiology: respiratory, environmental and exercise physiology.

[85]  R. Traystman,et al.  Gas-to-blood PCO2 differences during severe hypercapnia. , 1979, Journal of applied physiology: respiratory, environmental and exercise physiology.

[86]  C. J. Martin,et al.  Characteristics of the washout dead space. , 1979, Respiration physiology.

[87]  P. Wagner,et al.  Effects of common dead space on inert gas exchange in mathematical models of the lung. , 1979, Journal of applied physiology: respiratory, environmental and exercise physiology.

[88]  A. C. Young,et al.  Measurements of the dead space volume. , 1979, Journal of applied physiology: respiratory, environmental and exercise physiology.

[89]  J. Piiper,et al.  Blood/gas equilibrium of carbon dioxide in lungs. A critical review. , 1980, Respiration physiology.

[90]  J. Fredberg Augmented diffusion in the airways can support pulmonary gas exchange. , 1980, Journal of applied physiology: respiratory, environmental and exercise physiology.

[91]  R. Klocke Equilibrium of CO2 reactions in the pulmonary capillary. , 1980, Journal of applied physiology: respiratory, environmental and exercise physiology.

[92]  Effect of altered gas diffusivity on alveolar gas exchange-a theoretical study. , 1980, Journal of applied physiology: respiratory, environmental and exercise physiology.

[93]  Ternary diffusion and effective diffusion coefficients in alveolar spaces. , 1980, Respiration physiology.

[94]  Non-equimolar counter-diffusion in ternary gas systems. , 1980, Respiration physiology.

[95]  K Miyasaka,et al.  Ventilation by high-frequency oscillation. , 1980, Journal of applied physiology: respiratory, environmental and exercise physiology.

[96]  F. Haselton,et al.  Bronchial bifurcations and respiratory mass transport. , 1980, Science.

[97]  Arthur S Slutsky,et al.  Effective pulmonary ventilation with small-volume oscillations at high frequency. , 1980, Science.

[98]  K. Strohl,et al.  Effect of transrespiratory pressure on PETCO2-PaCO2 and ventilatory reflexes in humans. , 1981, Journal of applied physiology: respiratory, environmental and exercise physiology.

[99]  Hanson Ma,et al.  Studies on the localization of pulmonary carbonic anhydrase in the cat. , 1981 .

[100]  J. Piiper,et al.  Interpretation of inert gas retention and excretion in the presence of stratified inhomogeneity. , 1981, Respiration physiology.

[101]  Measurement of dead space ventilation using a pHa servo-controlled ventilator. , 1981, Journal of applied physiology: respiratory, environmental and exercise physiology.

[102]  Ventilation by high-frequency oscillation in rabbits with oleic acid lung disease. , 1981 .

[103]  Oscillatory flow and quasi-steady behavior in a model of human central airways. , 1981, Journal of applied physiology: respiratory, environmental and exercise physiology.

[104]  E. Schmid,et al.  Intrapulmonary gas transport and perfusion during high-frequency oscillation. , 1981, Journal of applied physiology: respiratory, environmental and exercise physiology.

[105]  A S Slutsky,et al.  Gas mixing by cardiogenic oscillations: a theoretical quantitative analysis. , 1981, Journal of applied physiology: respiratory, environmental and exercise physiology.

[106]  Arthur S Slutsky,et al.  Effects of frequency, tidal volume, and lung volume on CO2 elimination in dogs by high frequency (2-30 Hz), low tidal volume ventilation. , 1981, The Journal of clinical investigation.

[107]  L. A. Engel,et al.  Influence of bronchial asymmetry on cardiogenic gas mixing in the lung. , 1982, Respiration physiology.

[108]  The contribution of heart beat to gas mixing in the lungs of dogs. , 1982, Respiration physiology.

[109]  W. Mitzner,et al.  A new system for ventilating with high-frequency oscillation. , 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

[110]  I. Gabe,et al.  Effect of heart rate and stroke volume on gas mixing in dog lung. , 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

[111]  G. Maloiy,et al.  Respiration and metabolism in the giraffe. , 1982, Respiration physiology.

[112]  H. Robertson,et al.  Interaction of series and parallel dead space in the lung. , 1983, Respiration physiology.

[113]  L. A. Engel Gas mixing within the acinus of the lung. , 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

[114]  J. Mortola Dysanaptic lung growth: an experimental and allometric approach. , 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

[115]  Gas mixing in the airways of dog lungs during high-frequency ventilation. , 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

[116]  Reversal of arterial-to-expired CO2 partial pressure differences during rebreathing in goats. , 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

[117]  High-frequency oscillations via the pleural surface: an alternative mode of ventilation? , 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

[118]  H. K. Chang Mechanisms of gas transport during ventilation by high-frequency oscillation. , 1984 .

[119]  J. Drazen,et al.  High-frequency ventilation. , 1984, Physiological reviews.

[120]  A. Harf,et al.  Alveolar ventilation during high-frequency oscillation: core dead space concept. , 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

[121]  Gas concentration profiles along airways of dog lungs during high-frequency ventilation. , 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

[122]  W. Mitzner,et al.  Model of gas transport during high-frequency ventilation. , 1985, Journal of applied physiology.

[123]  Fritz Rohrer,et al.  Der Strömungswiderstand in den menschlichen Atemwegen und der Einfluss der unregelmässigen Verzweigung des Bronchialsystems auf den Atmungsverlauf in verschiedenen Lungenbezirken , 1915, Pflüger's Archiv für die gesamte Physiologie des Menschen und der Tiere.

[124]  A. Loewy Ueber die Bestimmung der Grösse des „schädlichen Luftraumes“ im Thorax und der alveolaren Sauerstoffspannung , 1894, Archiv für die gesamte Physiologie des Menschen und der Tiere.

[125]  W. Schoedel,et al.  Über den effektiven schädlichen Raum der Atmung , 1940, Pflüger's Archiv für die gesamte Physiologie des Menschen und der Tiere.