Evolutionary Multiobjective Optimization for Intensity Modulated Radiation Therapy

As cancer diseases take nowadays a heavy toll on societies worldwide, extensive research is being conducted to provide more accurate diagnoses and more effective treatments. In particular, Multiobjective Optimization has turned out to be an appropriate and efficient framework for timely and accurate radiotherapy planning. In the paper, we sketch briefly the background of Multiobjective Optimization research to Intensity Modulated Radiation Therapy, and next we present a rudimentary formulation of the problem. We also present a generic methodology we developed for Multiple Criteria Decision Making, and we present preliminary results with it when applied to radiation treatment planning.

[1]  I. Kaliszewski,et al.  Mechanical design, multiple criteria decision making and Pareto optimality gap , 2016 .

[2]  Ignacy Kaliszewski,et al.  Decision Maker's Preferences, Airport Gate Assignment Problem and Multiobjective Optimisation , 2013 .

[3]  Matthias Ehrgott,et al.  Multicriteria Optimization (2. ed.) , 2005 .

[4]  T. Bortfeld,et al.  Improved planning time and plan quality through multicriteria optimization for intensity-modulated radiotherapy. , 2012, International journal of radiation oncology, biology, physics.

[5]  Kalyanmoy Deb,et al.  Towards a Quick Computation of Well-Spread Pareto-Optimal Solutions , 2003, EMO.

[6]  Ben J M Heijmen,et al.  iCycle: Integrated, multicriterial beam angle, and profile optimization for generation of coplanar and noncoplanar IMRT plans. , 2012, Medical physics.

[7]  Susana Cecilia Esquivel Evolutionary algorithms for solving multi-objetive problems . Carlos A. Coello Coello, David A. van Veldhuizen and Gary R., Lamont , 2002 .

[8]  Ignacy Kaliszewski,et al.  Soft Computing for Complex Multiple Criteria Decision Making , 2006 .

[9]  Carlos A. Coello Coello,et al.  Use of cooperative coevolution for solving large scale multiobjective optimization problems , 2013, 2013 IEEE Congress on Evolutionary Computation.

[10]  Ignacy Kaliszewski,et al.  Out of the mist--towards decision-maker-friendly multiple criteria decision making support , 2004, Eur. J. Oper. Res..

[11]  Kaisa Miettinen,et al.  Nonlinear multiobjective optimization , 1998, International series in operations research and management science.

[12]  Rasmus Bokrantz,et al.  Distributed approximation of Pareto surfaces in multicriteria radiation therapy treatment planning , 2013, Physics in medicine and biology.

[13]  Gary B. Lamont,et al.  Evolutionary Algorithms for Solving Multi-Objective Problems , 2002, Genetic Algorithms and Evolutionary Computation.

[14]  T. Bortfeld,et al.  Realization and verification of three-dimensional conformal radiotherapy with modulated fields. , 1994, International journal of radiation oncology, biology, physics.

[15]  Matthias Ehrgott,et al.  Multicriteria Optimization , 2005 .

[16]  Dmitry Podkopaev,et al.  Interactive Multiple Criteria Decision Making based on preference driven Evolutionary Multiobjective Optimization with controllable accuracy , 2012, Eur. J. Oper. Res..

[17]  R. K. Ursem Multi-objective Optimization using Evolutionary Algorithms , 2009 .