Variation in rates of oestrogen receptor positivity in breast cancer again
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EDITOR—Mayor reports the findings of a postal survey showing an alarming wide variation in rates of oestrogen receptor positivity in women with breast cancer.1 The results of this questionnaire showed that the rate of breast tumours positive for oestrogen receptor that were detected at different breast cancer centres varied from as low as 5% to around the expected 80%.
For several years the UK …
[1] L. Bobrow,et al. Study of interlaboratory reliability and reproducibility of estrogen and progesterone receptor assays in Europe. Documentation of poor reliability and identification of insufficient microwave antigen retrieval time as a major contributory element of unreliable assays. , 2001, American journal of clinical pathology.
[2] D. Barnes,et al. Frequency of oestrogen and progesterone receptor positivity by immunohistochemical analysis in 7016 breast carcinomas: correlation with patient age, assay sensitivity, threshold value, and mammographic screening , 2000, Journal of clinical pathology.