How Does the Quality of Phospholipidosis Data Influence the Predictivity of Structural Alerts?
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Mark T. D. Cronin | Katarzyna R. Przybylak | Abdullah Rzgallah Alzahrani | M. Cronin | A. Alzahrani | K. Przybylak
[1] D. Gerhold,et al. Phospholipidosis assay in HepG2 cells and rat or rhesus hepatocytes using phospholipid probe NBD-PE. , 2008, Assay and drug development technologies.
[2] Roger G. Ulrich,et al. An in Vitro Fluorescence Assay for the Detection of Drug-Induced Cytoplasmic Lamellar Bodies , 1991 .
[3] Naomi L Kruhlak,et al. Construction and Consensus Performance of (Q)SAR Models for Predicting Phospholipidosis Using a Dataset of 743 Compounds , 2012, Molecular informatics.
[4] Mark J. Reasor,et al. Drug-Induced Phospholipidosis: Are There Functional Consequences? , 2001, Experimental biology and medicine.
[5] Jill M. Wetter,et al. Synthesis and SAR of 5-amino- and 5-(aminomethyl)benzofuran histamine H3 receptor antagonists with improved potency. , 2005, Journal of medicinal chemistry.
[6] Ronald D Snyder,et al. In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. , 2007, Toxicological sciences : an official journal of the Society of Toxicology.
[7] Johannes Kornhuber,et al. Identification of Drugs Inducing Phospholipidosis by Novel in vitro Data , 2012, ChemMedChem.
[8] R. Ulrich,et al. Drug-induced phospholipidosis: issues and future directions , 2006, Expert opinion on drug safety.
[9] Gabriele Cruciani,et al. Modeling Phospholipidosis Induction: Reliability and Warnings , 2013, J. Chem. Inf. Model..
[10] C. Pantos,et al. Amiodarone attenuates apoptosis, but induces phospholipidosis in rat alveolar epithelial cells. , 2010, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
[11] Kenji Takami,et al. A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.
[12] P. Kinnunen,et al. Assessment of drug-lipid complex formation by a high-throughput Langmuir-balance and correlation to phospholipidosis. , 2008, Journal of medicinal chemistry.
[13] Masaki Kobayashi,et al. Amiodarone increases the accumulation of DEA in a human alveolar epithelium-derived cell line. , 2008, Biological & pharmaceutical bulletin.
[14] R. Rajewski,et al. Mechanisms of amine accumulation in, and egress from, lysosomes. , 2009, Bioanalysis.
[15] Mesens Natalie,et al. A 96-well flow cytometric screening assay for detecting in vitro phospholipidosis-induction in the drug discovery phase. , 2009, Toxicology in vitro : an international journal published in association with BIBRA.
[16] M. Cronin,et al. Pitfalls in QSAR , 2003 .
[17] Akira Abe,et al. A role for lysosomal phospholipase A2 in drug induced phospholipidosis. , 2007, Drug metabolism letters.
[18] Jan Kelder,et al. Use of physicochemical calculation of pKa and CLogP to predict phospholipidosis-inducing potential: a case study with structurally related piperazines. , 2004, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
[19] M. d’Yvoire,et al. Lysosomal alterations induced in cultured rat fibroblasts by long-term exposure to low concentrations of azithromycin. , 1998, The Journal of antimicrobial chemotherapy.
[20] J. Corradi,et al. Phospholipidosis as a function of basicity, lipophilicity, and volume of distribution of compounds. , 2010, Chemical research in toxicology.
[21] Katarzyna R Przybylak,et al. In Silico Studies of the Relationship Between Chemical Structure and Drug Induced Phospholipidosis , 2011, Molecular informatics.
[22] U. Kodavanti,et al. Cationic amphiphilic drugs and phospholipid storage disorder. , 1990, Pharmacological reviews.
[23] Kiyohiko Sugano,et al. Physicochemical and cell-based approach for early screening of phospholipidosis-inducing potential. , 2006, The Journal of toxicological sciences.
[24] F. Crivellente,et al. A cell-based approach for the early assessment of the phospholipidogenic potential in pharmaceutical research and drug development , 2003, Cell Biology and Toxicology.
[25] M. Abraham,et al. Rapid-gradient HPLC method for measuring drug interactions with immobilized artificial membrane: comparison with other lipophilicity measures. , 2000, Journal of pharmaceutical sciences.
[26] Naomi L Kruhlak,et al. Development of a Phospholipidosis Database and Predictive Quantitative Structure-Activity Relationship (QSAR) Models , 2008, Toxicology mechanisms and methods.
[27] Jasper Dingemanse,et al. Phospholipidosis in healthy subjects participating in clinical studies: ultrastructural findings in white blood cells. , 2010, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
[28] K Chiba,et al. Phenacetin deacetylase activity in human liver microsomes: distribution, kinetics, and chemical inhibition and stimulation. , 2000, The Journal of pharmacology and experimental therapeutics.
[29] Nigel Greene,et al. Evaluation of a Published in Silico Model and Construction of a Novel Bayesian Model for Predicting Phospholipidosis Inducing Potential , 2007, J. Chem. Inf. Model..
[30] G. Balogh,et al. pH-gradient PAMPA-based in vitro model assay for drug-induced phospholipidosis in early stage of drug discovery. , 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[31] S Kacew,et al. Amiodarone-induced phospholipidosis in rat alveolar macrophages. , 1988, The American review of respiratory disease.
[32] Jianling Wang,et al. Predicting phospholipidosis: a fluorescence noncell based in vitro assay for the determination of drug-phospholipid complex formation in early drug discovery. , 2011, Analytical chemistry.
[33] K. Hostetler,et al. Effect of amiodarone on the phospholipid and lamellar body content of lymphoblasts in vitro and peripheral blood lymphocytes in vivo. , 1991, Biochemical pharmacology.
[34] John Reilly,et al. Chromatography approaches for early screening of the phospholipidosis-inducing potential of pharmaceuticals. , 2012, Journal of pharmaceutical and biomedical analysis.
[35] W. Schoonen,et al. High content screening analysis of phospholipidosis: validation of a 96-well assay with CHO-K1 and HepG2 cells for the prediction of in vivo based phospholipidosis. , 2011, Toxicology in vitro : an international journal published in association with BIBRA.
[36] Walter A. Korfmacher,et al. Metabolism of methapyrilene by Fischer-344 rat and B6C3F1 mouse hepatocytes. , 1992, Xenobiotica; the fate of foreign compounds in biological systems.
[37] M J Reasor,et al. A review of the biology and toxicologic implications of the induction of lysosomal lamellar bodies by drugs. , 1989, Toxicology and applied pharmacology.
[38] R G Ulrich,et al. Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes(1). , 2001, Biochemical pharmacology.
[39] Robert C. Glen,et al. Predicting Phospholipidosis Using Machine Learning , 2010, Molecular pharmaceutics.
[40] Y-K Lee,et al. Validation of an in vitro screen for phospholipidosis using a high-content biology platform , 2006, Cell Biology and Toxicology.
[41] Takashi Nonoyama,et al. Drug-induced Phospholipidosis : Pathological Aspects and Its Prediction , 2008 .
[42] P. H. Rowe. Chapter 10:Statistical Methods for Categorised Endpoints in In Silico Toxicology , 2010 .
[43] Tsuyoshi Harada,et al. Establishment of an in vitro high-throughput screening assay for detecting phospholipidosis-inducing potential. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.
[44] Helga Gerets,et al. Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.
[45] J. Depierre,et al. Tricyclic antidepressant-induced lipidosis in human peripheral monocytes in vitro, as well as in a monocyte-derived cell line, as monitored by spectrofluorimetry and flow cytometry after staining with Nile red. , 1997, Biochemical pharmacology.
[46] Luis G Valerio,et al. In silico modeling to predict drug-induced phospholipidosis. , 2013, Toxicology and applied pharmacology.
[47] Yukihiro Kuroda,et al. Prediction of phospholipidosis-inducing potential of drugs by in vitro biochemical and physicochemical assays followed by multivariate analysis. , 2010, Toxicology in vitro : an international journal published in association with BIBRA.
[48] R. Lüllmann-Rauch,et al. Drug-induced phospholipidoses. II. Tissue distribution of the amphiphilic drug chlorphentermine. , 1975, CRC critical reviews in toxicology.
[49] W. J. Johnson,et al. Lysosomal metabolism of lipids. , 1996, Sub-cellular biochemistry.
[50] Ruili Huang,et al. Structure Based Model for the Prediction of Phospholipidosis Induction Potential of Small Molecules , 2012, J. Chem. Inf. Model..
[51] M. T. D. Cronin. Chapter 3:Finding the Data to Develop and Evaluate (Q)SARs and Populate Categories for Toxicity Prediction , 2010 .
[52] G. Hook,et al. Alveolar proteinosis and phospholipidoses of the lungs. , 1991, Toxicologic pathology.
[53] W H Halliwell,et al. Cationic Amphiphilic Drug-Induced Phospholipidosis , 1997, Toxicologic pathology.