Stored RBC metabolism as a function of caffeine levels

Coffee consumption is extremely common in the United States. Coffee is rich with caffeine, a psychoactive, purinergic antagonist of adenosine receptors, which regulate red blood cell energy and redox metabolism. Since red blood cell (purine) metabolism is a critical component to the red cell storage lesion, here we set out to investigate whether caffeine levels correlated with alterations of energy and redox metabolism in stored red blood cells.

[1]  L. Santambrogio,et al.  Parabiosis Incompletely Reverses Aging-Induced Metabolic Changes and Oxidant Stress in Mouse Red Blood Cells , 2019, Nutrients.

[2]  S. Srivastava,et al.  Metabolism of lipid peroxidation product, 4-hydroxynonenal (HNE) in rat erythrocytes: role of aldose reductase. , 2000, Free radical biology & medicine.

[3]  L. Vasovic,et al.  Red blood cells donated by smokers: A pilot investigation of recipient transfusion outcomes , 2019, Transfusion.

[4]  J. Armer,et al.  The Performance of Alcohol Markers Including Ethyl Glucuronide and Ethyl Sulphate to Detect Alcohol Use in Clients in a Community Alcohol Treatment Programme , 2017, Alcohol and alcoholism.

[5]  泊 博雅.  performance OR[映像作品] , 1999 .

[6]  A. Subudhi,et al.  Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent , 2017, Nature Communications.

[7]  M. Busch,et al.  Diversity in a blood bag: application of omics technologies to inform precision Transfusion Medicine. , 2019, Blood transfusion = Trasfusione del sangue.

[8]  M. Gladwin,et al.  AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia. , 2016, Journal of proteome research.

[9]  D. Miller,et al.  Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. , 1989, The American journal of clinical nutrition.

[10]  Davide Pirolli,et al.  Caffeine inhibits erythrocyte membrane derangement by antioxidant activity and by blocking caspase 3 activation. , 2012, Biochimie.

[11]  G. Page,et al.  Nicotine exposure increases markers of oxidant stress in stored red blood cells from healthy donor volunteers , 2020, Transfusion.

[12]  Grier P Page,et al.  Blood, sweat, and tears: Red Blood Cell‐Omics study objectives, design, and recruitment activities , 2018, Transfusion.

[13]  A. D’Alessandro,et al.  High-Throughput Metabolomics: Isocratic and Gradient Mass Spectrometry-Based Methods. , 2019, Methods in molecular biology.

[14]  David S. Wishart,et al.  MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis , 2018, Nucleic Acids Res..

[15]  Marion C Lanteri,et al.  Intradonor reproducibility and changes in hemolytic variables during red blood cell storage: results of recall phase of the REDS‐III RBC‐Omics study , 2018, Transfusion.

[16]  A. D’Alessandro,et al.  Red blood cell storage lesion: causes and potential clinical consequences. , 2019, Blood transfusion = Trasfusione del sangue.

[17]  A. D’Alessandro,et al.  Metabolomics in transfusion medicine , 2016, Transfusion.

[18]  T. Townes,et al.  Role of the b93cys, ATP and adenosine in red cell dependent hypoxic vasorelaxation. , 2013, International journal of physiology, pathophysiology and pharmacology.

[19]  Aarash Bordbar,et al.  Citrate metabolism in red blood cells stored in additive solution‐3 , 2017, Transfusion.

[20]  Raffaella Casadei,et al.  An estimation of the number of cells in the human body , 2013, Annals of human biology.

[21]  W. Willett,et al.  Coffee, caffeine, and risk of depression among women. , 2011, Archives of internal medicine.

[22]  M. Schwarzschild,et al.  Neuroprotection by Caffeine and A2A Adenosine Receptor Inactivation in a Model of Parkinson's Disease , 2001, The Journal of Neuroscience.

[23]  J. Zimring,et al.  Correlation Between Red Blood Cell Survival and Cytochrome P450 1A2 Enzyme Activity , 2013 .

[24]  M. Thun,et al.  Coffee consumption, gender, and Parkinson's disease mortality in the cancer prevention study II cohort: the modifying effects of estrogen. , 2004, American journal of epidemiology.

[25]  B. Palsson,et al.  Biomarkers defining the metabolic age of red blood cells during cold storage. , 2016, Blood.

[26]  Mostafa H. Ahmed,et al.  Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease , 2017, Scientific Reports.

[27]  A. Spisni,et al.  Hypoxanthine: a new paradigm to interpret the origin of transfusion toxicity. , 2015, Blood transfusion = Trasfusione del sangue.

[28]  S. Clarke,et al.  Enzymatic methylation of band 3 anion transporter in intact human erythrocytes. , 1987, Biochemistry.

[29]  A P Smith,et al.  Investigation of the effects of coffee on alertness and performance during the day and night. , 1993, Neuropsychobiology.

[30]  C. Finch,et al.  Erythrocyte preservation. V. Relationship between chemical changes and viability of stored blood treated with adenosine. , 1955, The Journal of clinical investigation.

[31]  E. Eisenmesser,et al.  Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells , 2018, Transfusion.

[32]  E. Hod,et al.  Reexamination of the chromium‐51–labeled posttransfusion red blood cell recovery method , 2019, Transfusion.

[33]  A. D’Alessandro,et al.  Glucose 6-phosphate dehydrogenase deficient subjects may be better "storers" than donors of red blood cells. , 2016, Free radical biology & medicine.

[34]  J. Murray,et al.  The heritability of hemolysis in stored human red blood cells , 2015, Transfusion.

[35]  Junichi Azuma,et al.  Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production , 2011, Amino Acids.

[36]  James J. Ellinger,et al.  Role of aminotransferases in glutamate metabolism of human erythrocytes , 2011, Journal of biomolecular NMR.

[37]  A. D’Alessandro,et al.  Metabolic effect of alkaline additives and guanosine/gluconate in storage solutions for red blood cells , 2018, Transfusion.

[38]  A. D’Alessandro,et al.  A three-minute method for high-throughput quantitative metabolomics and quantitative tracing experiments of central carbon and nitrogen pathways. , 2017, Rapid communications in mass spectrometry : RCM.

[39]  S. Glynn,et al.  Association of donor age, body mass index, hemoglobin, and smoking status with in‐hospital mortality and length of stay among red blood cell–transfused recipients , 2019, Transfusion.

[40]  Grier P Page,et al.  Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study. , 2017, Blood advances.

[41]  H. Howie,et al.  Metabolic pathways that correlate with post-transfusion circulation of stored murine red blood cells , 2016, Haematologica.

[42]  I. Hindmarch,et al.  A naturalistic investigation of the effects of day-long consumption of tea, coffee and water on alertness, sleep onset and sleep quality , 2000, Psychopharmacology.

[43]  S. Kleinman,et al.  Impact of taurine on red blood cell metabolism and implications for blood storage , 2020, Transfusion.

[44]  E. Hod,et al.  Transfusional iron overload and intravenous iron infusions modify the mouse gut microbiota similarly to dietary iron , 2019, npj Biofilms and Microbiomes.

[45]  B. Palsson,et al.  Metabolomics comparison of red cells stored in four additive solutions reveals differences in citrate anticoagulant permeability and metabolism , 2017, Vox sanguinis.

[46]  A. D’Alessandro,et al.  Differences in Steap3 expression are a mechanism of genetic variation of RBC storage and oxidative damage in mice. , 2019, Blood advances.

[47]  Frank Hu,et al.  The Relationship of Coffee Consumption with Mortality , 2008, Annals of Internal Medicine.

[48]  Jianguo Xia,et al.  OmicsNet: a web-based tool for creation and visual analysis of biological networks in 3D space , 2018, Nucleic Acids Res..

[49]  A. D’Alessandro,et al.  Storing red blood cells with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions: a metabolomics overview. , 2014, Blood transfusion = Trasfusione del sangue.

[50]  Xiaoyun Fu,et al.  Bioactive lipids accumulate in stored red blood cells despite leukoreduction: a targeted metabolomics study , 2016, Transfusion.

[51]  L. Andersen,et al.  Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. , 2004, The Journal of nutrition.

[52]  A. D’Alessandro,et al.  An update on red blood cell storage lesions, as gleaned through biochemistry and omics technologies , 2015, Transfusion.

[53]  A. D’Alessandro,et al.  Untargeted and Semi-targeted Lipid Analysis of Biological Samples Using Mass Spectrometry-Based Metabolomics. , 2019, Methods in molecular biology.

[54]  A. D’Alessandro,et al.  Time-course investigation of SAGM-stored leukocyte-filtered red bood cell concentrates: from metabolism to proteomics , 2012, Haematologica.

[55]  D. Grobbee,et al.  Coffee and tea consumption and risk of type 2 diabetes , 2009, Diabetologia.

[56]  R. Sluyter.  P2X and P2Y receptor signaling in red blood cells , 2015, Front. Mol. Biosci..

[57]  E. Hod,et al.  Transfusional iron overload and intravenous iron infusions modify the mouse gut microbiota similarly to dietary iron , 2019, npj Biofilms and Microbiomes.

[58]  A. D’Alessandro,et al.  Purinergic control of red blood cell metabolism: novel strategies to improve red cell storage quality. , 2017, Blood transfusion = Trasfusione del sangue.

[59]  G. AlsabriSami,et al.  Kinetic and Dynamic Description of Caffeine , 2017 .

[60]  Mars Stone,et al.  Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS‐III—Omics , 2018, Transfusion.

[61]  A. de Mendonça,et al.  Does caffeine intake protect from Alzheimer's disease? , 2002, European journal of neurology.

[62]  Grier P Page,et al.  Piloting and implementation of quality assessment and quality control procedures in RBC‐Omics: a large multi‐center study of red blood cell hemolysis during storage , 2019, Transfusion.

[63]  E. Moore,et al.  Routine storage of red blood cell (RBC) units in additive solution‐3: a comprehensive investigation of the RBC metabolome , 2015, Transfusion.

[64]  W. Bloch,et al.  Does endurance training improve red blood cell aging and hemorheology in moderate-trained healthy individuals? , 2019, Journal of sport and health science.

[65]  F. Montes,et al.  Caffeine's Vascular Mechanisms of Action , 2010, International journal of vascular medicine.

[66]  B B Fredholm,et al.  Astra Award Lecture. Adenosine, adenosine receptors and the actions of caffeine. , 1995, Pharmacology & toxicology.

[67]  E. Hod,et al.  Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage , 2017, Haematologica.

[68]  J. AuBuchon,et al.  Evaluation of proposed FDA criteria for the evaluation of radiolabeled red cell recovery trials , 2008, Transfusion.

[69]  Rani K. Powers,et al.  Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors , 2019, Nature Communications.

[70]  J. Cancelas,et al.  Hypoxic storage of red blood cells improves metabolism and post‐transfusion recovery , 2020, Transfusion.

[71]  A. Subudhi,et al.  Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia , 2016, Nature Communications.

[72]  R. Beninger,et al.  Picolinic acid blocks the neurotoxic but not the neuroexcitant properties of quinolinic acid in the rat brain: Evidence from turning behaviour and tyrosine hydroxylase immunohistochemistry , 1994, Neuroscience.

[73]  D. Kessler,et al.  Donor glucose-6-phosphate dehydrogenase deficiency decreases blood quality for transfusion. , 2020, The Journal of clinical investigation.

[74]  E. Hod,et al.  The controversy over the age of blood: what do the clinical trials really teach us? , 2017, Blood transfusion = Trasfusione del sangue.

[75]  G. Friedman,et al.  Coffee, cirrhosis, and transaminase enzymes. , 2006, Archives of internal medicine.

[76]  A. Subudhi,et al.  Beneficial Role of Erythrocyte Adenosine A2B Receptor–Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia , 2016, Circulation.