Leptin signaling in skeletal muscle after bed rest in healthy humans

[1]  S. Upadhyay,et al.  Absence of Functional Leptin Receptor Isoforms in the POUND (Leprdb/lb) Mouse Is Associated with Muscle Atrophy and Altered Myoblast Proliferation and Differentiation , 2013, PloS one.

[2]  J. Helge,et al.  Insulin resistance and mitochondrial function in skeletal muscle. , 2013, The international journal of biochemistry & cell biology.

[3]  Ian A. Trounce,et al.  Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity , 2012, Diabetes.

[4]  F. Amati,et al.  Revisiting the diacylglycerol‐induced insulin resistance hypothesis , 2012, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[5]  Zhenggang Yang,et al.  Regulation of Insulin and Leptin Signaling by Muscle Suppressor of Cytokine Signaling 3 (SOCS3) , 2012, PloS one.

[6]  R. Gebhardt,et al.  Novel Regulatory Mechanisms for Generation of the Soluble Leptin Receptor: Implications for Leptin Action , 2012, PloS one.

[7]  B. Saltin,et al.  GLUT4 and Glycogen Synthase Are Key Players in Bed Rest–Induced Insulin Resistance , 2012, Diabetes.

[8]  M. Tremblay,et al.  Modulation of leptin resistance by protein tyrosine phosphatases. , 2012, Cell metabolism.

[9]  E. Weiss,et al.  Preferential reductions in intermuscular and visceral adipose tissue with exercise-induced weight loss compared with calorie restriction. , 2012, Journal of applied physiology.

[10]  B. Pedersen,et al.  The role of leptin in human lipid and glucose metabolism: the effects of acute recombinant human leptin infusion in young healthy males. , 2011, The American journal of clinical nutrition.

[11]  Henriette Pilegaard,et al.  Bed rest reduces metabolic protein content and abolishes exercise-induced mRNA responses in human skeletal muscle. , 2011, American journal of physiology. Endocrinology and metabolism.

[12]  B. Saltin,et al.  Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest. , 2011, Journal of applied physiology.

[13]  P. Pfluger,et al.  Voluntary exercise improves high-fat diet-induced leptin resistance independent of adiposity. , 2011, Endocrinology.

[14]  J. Calbet,et al.  Training, leptin receptors and SOCS3 in human muscle. , 2011, International journal of sports medicine.

[15]  J. Helge,et al.  Improved glucose tolerance after intensive life style intervention occurs without changes in muscle ceramide or triacylglycerol in morbidly obese subjects , 2011, Acta physiologica.

[16]  K. Eckardt,et al.  Obesity-associated insulin resistance in skeletal muscle: Role of lipid accumulation and physical inactivity , 2011, Reviews in Endocrine and Metabolic Disorders.

[17]  K. Westerterp,et al.  Associations between energy demands , physical activity , and body composition in adult humans between 18 and 96 y of age 1 – 3 , 2010 .

[18]  Q. Mi,et al.  The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice. , 2010, Biochemical and biophysical research communications.

[19]  B. Pedersen,et al.  A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity. , 2010, Journal of applied physiology.

[20]  I. Ara,et al.  Leptin receptor 170 kDa (OB‐R170) protein expression is reduced in obese human skeletal muscle: a potential mechanism of leptin resistance , 2010, Experimental physiology.

[21]  J. Ponce-González,et al.  Muscle hypertrophy and increased expression of leptin receptors in the musculus triceps brachii of the dominant arm in professional tennis players , 2010, European Journal of Applied Physiology.

[22]  Qi Sun.  Leptin and Soluble Leptin Receptor Levels in Plasma and Risk of Type 2 Diabetes in US Women: A Prospective Study , 2009 .

[23]  G. Frühbeck,et al.  Leptin Administration Favors Muscle Mass Accretion by Decreasing FoxO3a and Increasing PGC-1α in ob/ob Mice , 2009, PloS one.

[24]  P. Scarpace,et al.  The soluble leptin receptor neutralizes leptin‐mediated STAT3 signalling and anorexic responses in vivo , 2009, British journal of pharmacology.

[25]  K. Birkeland,et al.  Insulin-stimulated increase in serum leptin levels precedes and correlates with weight gain during insulin therapy in type 2 diabetes. , 2009, The Journal of clinical endocrinology and metabolism.

[26]  K. Ozawa,et al.  Endoplasmic Reticulum Stress Induces Leptin Resistance , 2008, Molecular Pharmacology.

[27]  J. Ponce-González,et al.  Gender Dimorphism in Skeletal Muscle Leptin Receptors, Serum Leptin and Insulin Sensitivity , 2008, PloS one.

[28]  P. D. di Prampero,et al.  Positive energy balance is associated with accelerated muscle atrophy and increased erythrocyte glutathione turnover during 5 wk of bed rest. , 2008, The American journal of clinical nutrition.

[29]  Martina Heer,et al.  Calorie restriction modulates inactivity-induced changes in the inflammatory markers C-reactive protein and pentraxin-3. , 2008, The Journal of clinical endocrinology and metabolism.

[30]  Z. Nagy,et al.  STAT3: An Important Regulator of Multiple Cytokine Functions , 2008, Transplantation.

[31]  B. Neel,et al.  Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammation in Vivo* , 2008, Journal of Biological Chemistry.

[32]  D. Allen,et al.  Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice. , 2008, American journal of physiology. Endocrinology and metabolism.

[33]  Heike Münzberg,et al.  Mechanisms of leptin action and leptin resistance. , 2008, Annual review of physiology.

[34]  Krista Vandenborne,et al.  Transcriptional pathways associated with skeletal muscle disuse atrophy in humans. , 2007, Physiological genomics.

[35]  Q. Zhai,et al.  SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. , 2007, Cell metabolism.

[36]  B. Pedersen,et al.  Body mass index‐independent effect of fitness and physical activity for all‐cause mortality , 2007, Scandinavian journal of medicine & science in sports.

[37]  J. Calbet,et al.  Leptin receptors in human skeletal muscle , 2007, Journal of applied physiology.

[38]  M. Eguchi,et al.  Regulation of SOCS-3 expression by leptin and its co-localization with insulin receptor in rat skeletal muscle cells , 2007, Molecular and Cellular Endocrinology.

[39]  I. Ara,et al.  Serum free testosterone, leptin and soluble leptin receptor changes in a 6-week strength-training programme , 2006, British Journal of Nutrition.

[40]  B. Jenkins,et al.  STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis. , 2006, Gastroenterology.

[41]  B. Kemp,et al.  The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans. , 2006, The Journal of clinical endocrinology and metabolism.

[42]  M. Tremblay,et al.  Involvement of the small protein tyrosine phosphatases TC-PTP and PTP1B in signal transduction and diseases: from diabetes, obesity to cell cycle, and cancer. , 2005, Biochimica et biophysica acta.

[43]  B. Saltin,et al.  Glucose clearance is higher in arm than leg muscle in type 2 diabetes , 2005, The Journal of physiology.

[44]  R. DiMarchi,et al.  Leptin: structure, function and biology. , 2005, Vitamins and hormones.

[45]  T. Ohzeki,et al.  Effects of leptin and dexamethasone on long and short leptin receptor mRNA , 2004, Pediatrics international : official journal of the Japan Pediatric Society.

[46]  G. Shulman,et al.  Transgenic Overexpression of Protein-tyrosine Phosphatase 1B in Muscle Causes Insulin Resistance, but Overexpression with Leukocyte Antigen-related Phosphatase Does Not Additively Impair Insulin Action* , 2004, Journal of Biological Chemistry.

[47]  Guoqing Yang,et al.  Modulation of direct leptin signaling by soluble leptin receptor. , 2004, Molecular endocrinology.

[48]  M. Taskinen,et al.  Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM , 1996, Diabetologia.

[49]  G. Steinberg,et al.  Endurance training partially reverses dietary-induced leptin resistance in rodent skeletal muscle. , 2004, American journal of physiology. Endocrinology and metabolism.

[50]  B. Kahn,et al.  Leptin signaling in the central nervous system and the periphery. , 2004, Recent progress in hormone research.

[51]  J. Kratzsch,et al.  The soluble leptin receptor is crucial for leptin action: evidence from clinical and experimental data , 2003, International Journal of Obesity.

[52]  M. Elia,et al.  Techniques for the study of energy balance in man , 2003, Proceedings of the Nutrition Society.

[53]  Alexander S. Banks,et al.  STAT3 signalling is required for leptin regulation of energy balance but not reproduction , 2003, Nature.

[54]  S. Kaser,et al.  Weight loss increases soluble leptin receptor levels and the soluble receptor bound fraction of leptin. , 2002, Obesity research.

[55]  G. Heigenhauser,et al.  Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance. , 2002, American journal of physiology. Endocrinology and metabolism.

[56]  M. Suchard,et al.  Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans. , 2002, Diabetes.

[57]  B. Kennedy,et al.  Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. , 2002, Developmental cell.

[58]  W. Buurman,et al.  Leptin and soluble leptin receptor levels in obese and weight-losing individuals. , 2002, The Journal of clinical endocrinology and metabolism.

[59]  A. Lammert,et al.  Soluble leptin receptor represents the main leptin binding activity in human blood. , 2001, Biochemical and biophysical research communications.

[60]  J. Flier,et al.  SOCS3 Mediates Feedback Inhibition of the Leptin Receptor via Tyr985 * , 2000, The Journal of Biological Chemistry.

[61]  S. Kalra,et al.  Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling. , 2000, Biochemical and biophysical research communications.

[62]  S. Normand,et al.  Leptin responses to physical inactivity induced by simulated weightlessness. , 2000, American journal of physiology. Regulatory, integrative and comparative physiology.

[63]  N. Morisaki,et al.  Differential regulation of leptin receptor expression by insulin and leptin in neuroblastoma cells. , 2000, Biochemical and biophysical research communications.

[64]  S. Akira.  Roles of STAT3 defined by tissue-specific gene targeting , 2000, Oncogene.

[65]  A. Loucks,et al.  Low energy availability, not exercise stress, suppresses the diurnal rhythm of leptin in healthy young women. , 2000, American journal of physiology. Endocrinology and metabolism.

[66]  G. Colditz,et al.  The disease burden associated with overweight and obesity. , 1999, JAMA.

[67]  H. Beck-Nielsen,et al.  The significance of phosphotyrosine phosphatase (PTPase) 1B in insulin signalling , 1999, Diabetologia.

[68]  D. Bandyopadhyay,et al.  Marked impairment of protein tyrosine phosphatase 1B activity in adipose tissue of obese subjects with and without type 2 diabetes mellitus. , 1999, The Journal of laboratory and clinical medicine.

[69]  G. Steil,et al.  Physiological insulinemia acutely modulates plasma leptin. , 1998, Diabetes.

[70]  B. Goldstein,et al.  Improved sensitivity to insulin in obese subjects following weight loss is accompanied by reduced protein-tyrosine phosphatases in adipose tissue. , 1997, Metabolism: clinical and experimental.

[71]  G. Dohm,et al.  Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes. , 1997, The Journal of clinical investigation.

[72]  X. Remesar,et al.  Is leptin an insulin counter‐regulatory hormone? , 1997, FEBS letters.

[73]  R. Henry,et al.  Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance. , 1994, The Journal of clinical investigation.

[74]  P. K. Smith,et al.  Measurement of protein using bicinchoninic acid. , 1985, Analytical biochemistry.