Self-fluorescence of chemically crosslinked MRI nanoprobes to enable multimodal imaging of therapeutic cells.

Old chemistry for novel materials: Self-fluorescent high-relaxivity T(2)-weighted magnetic resonance imaging (MRI) contrast agents are produced. They are a novel type of MR/optical dual-modality in vivo imaging nanoprobe using glutaraldehyde crosslinking chemistry, and they are used to label and monitor therapeutic cells both in vitro and in vivo.

[1]  Hak Soo Choi,et al.  Synthesis and in vivo fate of zwitterionic near-infrared fluorophores. , 2011, Angewandte Chemie.

[2]  P. Padmanabhan,et al.  Bimodal magnetic–fluorescent probes for bioimaging , 2011, Microscopy research and technique.

[3]  Flora L Thorp-Greenwood,et al.  Multimodal radio- (PET/SPECT) and fluorescence imaging agents based on metallo-radioisotopes: current applications and prospects for development of new agents. , 2011, Dalton transactions.

[4]  Hakho Lee,et al.  Highly magnetic core-shell nanoparticles with a unique magnetization mechanism. , 2011, Angewandte Chemie.

[5]  Bradley J Roth,et al.  The role of magnetic forces in biology and medicine , 2011, Experimental biology and medicine.

[6]  Taeghwan Hyeon,et al.  Magnetosome-like ferrimagnetic iron oxide nanocubes for highly sensitive MRI of single cells and transplanted pancreatic islets , 2011, Proceedings of the National Academy of Sciences.

[7]  Zahi A Fayad,et al.  Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging. , 2009, Biomaterials.

[8]  K. Hong,et al.  Multiplexed imaging of therapeutic cells with multispectrally encoded magnetofluorescent nanocomposite emulsions. , 2009, Journal of the American Chemical Society.

[9]  Klaas Nicolay,et al.  Magnetic quantum dots for multimodal imaging. , 2009, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[10]  B. MacCraith,et al.  Nanoparticle strategies for enhancing the sensitivity of fluorescence-based biochips. , 2009, Nanomedicine.

[11]  Bing Xu,et al.  Multifunctional magnetic nanoparticles: design, synthesis, and biomedical applications. , 2009, Accounts of chemical research.

[12]  Hua Ai,et al.  Manganese ferrite nanoparticle micellar nanocomposites as MRI contrast agent for liver imaging. , 2009, Biomaterials.

[13]  John V Frangioni,et al.  New technologies for human cancer imaging. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[14]  Sangjin Park,et al.  Drug-loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy in vivo. , 2008, Angewandte Chemie.

[15]  Z. Su,et al.  Preparation and Application of Novel Microspheres Possessing Autofluorescent Properties , 2007 .

[16]  Tae Woo Kim,et al.  Oral Administration of High Molecular Mass Poly-γ-Glutamate Induces NK Cell-Mediated Antitumor Immunity1 , 2007, The Journal of Immunology.

[17]  Joerg M. Buescher,et al.  Microbial Biosynthesis of Polyglutamic Acid Biopolymer and Applications in the Biopharmaceutical, Biomedical and Food Industries , 2007, Critical reviews in biotechnology.

[18]  Scott C. Brown,et al.  Nanoparticles for bioimaging. , 2006, Advances in colloid and interface science.

[19]  A. Palucka,et al.  Dendritic cells as therapeutic vaccines against cancer , 2005, Nature Reviews Immunology.

[20]  Alan P Koretsky,et al.  MRI detection of single particles for cellular imaging. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[21]  J. Frangioni.  In vivo near-infrared fluorescence imaging. , 2003, Current opinion in chemical biology.

[22]  H. Thelen,et al.  Glutardialdehyde induced fluorescence technique (GIFT): a new method for the imaging of platelet adhesion on biomaterials. , 2000, Journal of biomedical materials research.

[23]  R. Steinman,et al.  Dendritic cells and the control of immunity , 1998, Nature.

[24]  C. J. Lewis,et al.  Cyanine dye labeling reagents: sulfoindocyanine succinimidyl esters. , 1993, Bioconjugate chemistry.

[25]  C. Parish,et al.  New fluorescent dyes for lymphocyte migration studies. Analysis by flow cytometry and fluorescence microscopy. , 1990, Journal of immunological methods.

[26]  Jinwoo Cheon,et al.  Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging , 2007, Nature Medicine.