UV Spectrophotometric Method for Determination of Glimepiride in Pharmaceutical Dosage Forms

Glimiperide is an anti-diabetic drug which is used for the treatment of diabetes. In present work, a simple, sensitive, accurate and economical spectroscopic method has been developed for the estimation of glimepiride in bulk and in pharmaceutical dosage forms. An absorption maximum was found to be at 249 nm with the solvent system of chloroform. The drug follows Beer’s law limits in the range of 5-30 µg/ml with correlation coefficient of 0.999732. Results of the analysis were validated for accuracy, precision, LOD were found to be satisfactory. The proposed method is simple, rapid and suitable for the routine quality control analysis.

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