Alignment and calibration of high frequency ultrasound (HFUS) and optical coherence tomography (OCT) 1D transducers using a dual wedge-tri step phantom

This paper introduces a novel alignment and calibration method for high frequency ultrasound (HFUS) and optical coherence tomography (OCT) 1D transducers. 2D images are constructed by means of translation of the transducers using a linear motor stage. Physical alignment of the transducers is needed in order to capture images of the same crosssectional plane, and calibration is needed to determine the relative coordinates of the images, including the image skew. A dual wedge-tri step phantom is created for both alignment and calibration. This phantom includes two symmetrical wedges and three steps that provide the user with visual feedback on how well the scan plane is aligned with the midplane of the phantom. The phantom image consists of five line segments, each of which corresponds to one of the wedges or steps. The slopes and positions of the lines are extracted from the image and compared with the phantom model. The scan plane parameters are found so that the difference between the model and extracted features is minimized. The main advantage of this phantom is that only one frame is required to determine translations, orientations, and skew parameters of the scan plane with respect to the phantom. Experimental results with ocular imaging show the ability to achieve alignment based on this method and its potential for medical applications.

[1]  G. Kymionis,et al.  Corneal ectasia induced by laser in situ keratomileusis , 2001, Journal of cataract and refractive surgery.

[2]  Richard W Prager,et al.  A mechanical instrument for 3D ultrasound probe calibration. , 2005, Ultrasound in medicine & biology.

[3]  Andrew H. Gee,et al.  3D ultrasound probe calibration without a position sensor , 2004 .

[4]  L. Herndon,et al.  Central corneal thickness as a risk factor for advanced glaucoma damage. , 2003, Archives of ophthalmology.

[5]  J. McLaren,et al.  Corneal thickness measurement by confocal microscopy, ultrasound, and scanning slit methods. , 2004, American journal of ophthalmology.

[6]  K. Seung,et al.  Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound. , 2002, Journal of the American College of Cardiology.

[7]  Lihong V. Wang Ultrasound-Mediated Biophotonic Imaging: A Review of Acousto-Optical Tomography and Photo-Acoustic Tomography , 2004, Disease markers.

[8]  Bin Liu,et al.  Ultrasound-enhanced optical coherence tomography: improved penetration and resolution. , 2008, Journal of the Optical Society of America. A, Optics, image science, and vision.

[9]  Gabor Fichtinger,et al.  Bootstrapped ultrasound calibration. , 2006, Studies in health technology and informatics.

[10]  Barry YM Yeung,et al.  Comparison between central corneal thickness measurements by ultrasound pachymetry and optical coherence tomography , 2006, Clinical & experimental ophthalmology.

[11]  Laurence Mercier,et al.  A review of calibration techniques for freehand 3-D ultrasound systems. , 2005, Ultrasound in medicine & biology.

[12]  D. Rubens,et al.  Imaging the elastic properties of tissue: the 20 year perspective , 2011, Physics in medicine and biology.

[13]  Po-Wei Hsu,et al.  Freehand 3D Ultrasound Calibration: A Review , 2009 .

[14]  David A. Jackson,et al.  Three dimensional OCT images from retina and skin. , 2000, Optics express.

[15]  Mark E Brezinski,et al.  Ultrasound induced improvement in optical coherence tomography (OCT) resolution , 2002, Proceedings of the National Academy of Sciences of the United States of America.