Use of GeIS for Early Diagnosis of Alcohol Sensitivity

This study focuses on the importance of Genomic Information Systems (GeIS) today; the results of this research provide great benefits to the medical community through technological potential. The development of SILE (Search-Identification-Load-Exploitation) to GeIS improves the databases management with curated data. The studies are focused on improving the quality of data and time optimization. With SILE we perform a selective loading of genes and variations found for a specific disease from different data sources like: NCBI, dbSNP and others. When we worked with a selected group of genes/variations it is possible guaranteeing a more reliable diagnosis, thus sustaining the increase accuracy of the results with respect to data quality and improvements over time. Also, we integrate the association of genes/variations with population studies, for this way providing an early diagnosis for any disease of genetic origin.

[1]  José Fabián,et al.  Integración de haplotipos al modelo conceptual del genoma humano utilizando la metodología sile , 2014 .

[2]  A. Mayordomo Integración de bases de datos genómicas: una aproximación basada en modelado conceptual , 2012 .

[3]  Maria José Villanueva,et al.  Diagen: A model-based bioinformatic tool for genetic analysis , 2012, 2012 Sixth International Conference on Research Challenges in Information Science (RCIS).

[4]  Ming D. Li,et al.  Genes and Pathways Co-associated with the Exposure to Multiple Drugs of Abuse, Including Alcohol, Amphetamine/Methamphetamine, Cocaine, Marijuana, Morphine, and/or Nicotine: a Review of Proteomics Analyses , 2011, Molecular Neurobiology.

[5]  Matilde Celma,et al.  Integrating Human Genome Variation Data: An Information System Approach , 2011, 2011 22nd International Workshop on Database and Expert Systems Applications.

[6]  Maria José,et al.  Diagen: Modelado e Implementación de un framework para el análisis personalizado del ADN , 2011 .

[7]  L. Bierut Genetic Vulnerability and Susceptibility to Substance Dependence , 2011, Neuron.

[8]  Tom Dedeurwaerdere,et al.  Contributions of bioinformatics and intellectual property rights in sharing biological information , 2006 .

[9]  M. D. E. Arrieta Alteraciones genéticas relacionadas con el alcoholismo , 2003 .

[10]  Alan F. Scott,et al.  Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders , 2002, Nucleic Acids Res..

[11]  Philip Lijnzaad,et al.  The Ensembl genome database project , 2002, Nucleic Acids Res..

[12]  Elizabeth M. Smigielski,et al.  dbSNP: the NCBI database of genetic variation , 2001, Nucleic Acids Res..

[13]  Andreas D. Baxevanis,et al.  Bioinformatics - a practical guide to the analysis of genes and proteins , 2001, Methods of biochemical analysis.