Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level

[1]  James M. Harris,et al.  17beta-estradiol has a biphasic effect on the formation of hematopoietic stem cells , 2013 .

[2]  D. Papatsenko,et al.  Induction of a hemogenic program in mouse fibroblasts. , 2013, Cell stem cell.

[3]  Fabian J Theis,et al.  Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis , 2013, Nature Cell Biology.

[4]  Y. Yashiro‐Ohtani,et al.  The expression of Sox17 identifies and regulates haemogenic endothelium , 2013, Nature Cell Biology.

[5]  N. Speck,et al.  Endothelio-mesenchymal interaction controls runx1 expression and modulates the notch pathway to initiate aortic hematopoiesis. , 2013, Developmental cell.

[6]  D. Sugiyama,et al.  Hemogenic endothelium: a vessel for blood production. , 2013, The international journal of biochemistry & cell biology.

[7]  A. Iwama,et al.  Role of SOX17 in hematopoietic development from human embryonic stem cells. , 2013, Blood.

[8]  Gordon Keller,et al.  T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures. , 2012, Cell reports.

[9]  Salam A. Assi,et al.  RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis , 2012, The EMBO journal.

[10]  Mitchell D. Probasco,et al.  Identification of the hemogenic endothelial progenitor and its direct precursor in human pluripotent stem cell differentiation cultures. , 2012, Cell reports.

[11]  Nicola K. Wilson,et al.  GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment. , 2012, Blood.

[12]  Carsten Peterson,et al.  Inferring rules of lineage commitment in haematopoiesis , 2012, Nature Cell Biology.

[13]  Yosuke Tanaka,et al.  Etv2/ER71 induces vascular mesoderm from Flk1+PDGFRα+ primitive mesoderm. , 2011, Blood.

[14]  N. Speck,et al.  Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells. , 2011, Cell stem cell.

[15]  J. Frampton,et al.  Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region , 2011, The Journal of experimental medicine.

[16]  S. Rybtsov,et al.  Embryonic origin of the adult hematopoietic system: advances and questions , 2011, Development.

[17]  A. Schnerch,et al.  Direct conversion of human fibroblasts to multilineage blood progenitors , 2010, Nature.

[18]  W. Ouwehand,et al.  Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. , 2010, Cell stem cell.

[19]  Kathryn E. Crosier,et al.  Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells. , 2010, Blood.

[20]  N. Wilson,et al.  Gfi1 Expression Is Controlled by Five Distinct Regulatory Regions Spread over 100 Kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 Acting as Upstream Regulators in Early Hematopoietic Cells , 2010, Molecular and Cellular Biology.

[21]  G. Swiers,et al.  Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis. , 2010, Blood.

[22]  K. Kissa,et al.  Blood stem cells emerge from aortic endothelium by a novel type of cell transition , 2010, Nature.

[23]  N. Galjart,et al.  In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium , 2010, Nature.

[24]  D. Stainier,et al.  Hematopoietic stem cells derive directly from aortic endothelium during development , 2009, Nature.

[25]  Shin-Ichi Nishikawa,et al.  Continuous single-cell imaging of blood generation from haemogenic endothelium , 2009, Nature.

[26]  Georges Lacaud,et al.  The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage , 2009, Nature.

[27]  Elaine Dzierzak,et al.  Runx1 is required for the endothelial to hematopoietic cell transition but not thereafter , 2009, Nature.

[28]  K. Moore,et al.  Extensive hematopoietic stem cell generation in the AGM region via maturation of VE-cadherin+CD45+ pre-definitive HSCs. , 2008, Cell stem cell.

[29]  M. Stojkovic,et al.  Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches. , 2008, Cell stem cell.

[30]  Caroline L. Speck,et al.  Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer. , 2007, Blood.

[31]  G. Swiers,et al.  Genetic regulatory networks programming hematopoietic stem cells and erythroid lineage specification. , 2006, Developmental biology.

[32]  A. M. Morrison,et al.  Progressive divergence of definitive haematopoietic stem cells from the endothelial compartment does not depend on contact with the foetal liver , 2005, Development.

[33]  S. Nishikawa,et al.  Involvement of Runx1 in the down-regulation of fetal liver kinase-1 expression during transition of endothelial cells to hematopoietic cells. , 2005, Blood.

[34]  M. D. de Bruijn,et al.  From hemangioblast to hematopoietic stem cell: an endothelial connection? , 2005, Experimental hematology.

[35]  C. Martínez-A,et al.  The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo. , 2005, Developmental biology.

[36]  Benjamin M. Bolstad,et al.  affy - analysis of Affymetrix GeneChip data at the probe level , 2004, Bioinform..

[37]  P. Morrison,et al.  CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo , 2003, Development.

[38]  G. Anderson,et al.  Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c‐Myb , 2003, The EMBO journal.

[39]  S. Nishikawa,et al.  Hemogenic and nonhemogenic endothelium can be distinguished by the activity of fetal liver kinase (Flk)-1 promoter/enhancer during mouse embryogenesis. , 2003, Blood.

[40]  S. Orkin,et al.  Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. , 2003, Blood.

[41]  Elaine Dzierzak,et al.  Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo. , 2002, Immunity.

[42]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[43]  S. Nishikawa,et al.  Requirement of Runx1/AML1/PEBP2αB for the generation of haematopoietic cells from endothelial cells , 2001, Genes to cells : devoted to molecular & cellular mechanisms.

[44]  N. Speck,et al.  Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo , 2000, The EMBO journal.

[45]  T. Gu,et al.  Cbfa2 is required for the formation of intra-aortic hematopoietic clusters. , 1999, Development.

[46]  T. Noda,et al.  AML1(−/−) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene , 1998, Oncogene.

[47]  F. Dieterlen-Lièvre Hematopoiesis: Progenitors and their genetic program , 1998, Current Biology.

[48]  S. Nishikawa,et al.  In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos. , 1998, Immunity.

[49]  S. Nishikawa,et al.  Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin+ cells at a diverging point of endothelial and hemopoietic lineages. , 1998, Development.

[50]  A. Medvinsky,et al.  Definitive Hematopoiesis Is Autonomously Initiated by the AGM Region , 1996, Cell.

[51]  T. Honjo,et al.  Generation of lymphohematopoietic cells from embryonic stem cells in culture. , 1994, Science.

[52]  Sabrina Gordon-Keylock,et al.  HEMATOPOIESIS AND STEM CELLS Mouse extraembryonic arterial vessels harbor precursors capable of maturing into de fi nitive HSCs , 2013 .

[53]  E. Dzierzak,et al.  Analysis and manipulation of hematopoietic progenitor and stem cells from murine embryonic tissues. , 2008, Current protocols in stem cell biology.

[54]  Gordon K. Smyth,et al.  limma: Linear Models for Microarray Data , 2005 .

[55]  Pinna,et al.  Advances and Questions , 2022 .