FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance
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M. Del Rio | C. Gongora | Fengzhi Li | D. Westover | M. Wani | X. Ling | Chunyang Jin | H. Lam | J. Welch
[1] Fengzhi Li,et al. FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX. , 2014, Cancer research.
[2] Fengzhi Li. Anticancer drug FL118 is more than a survivin inhibitor: where is the Achilles' heel of cancer? , 2014, American journal of cancer research.
[3] Fengzhi Li,et al. Antitumor activity of FL118, a survivin, Mcl-1, XIAP, and cIAP2 selective inhibitor, is highly dependent on its primary structure and steric configuration. , 2014, Molecular pharmaceutics.
[4] V. Patriarca,et al. Preclinical evaluation of the novel 7-substituted camptothecin Namitecan (ST1968) in paediatric tumour models , 2012, Cancer Chemotherapy and Pharmacology.
[5] Fengzhi Li,et al. A Novel Small Molecule FL118 That Selectively Inhibits Survivin, Mcl-1, XIAP and cIAP2 in a p53-Independent Manner, Shows Superior Antitumor Activity , 2012, PloS one.
[6] T. Gauler,et al. A German multicenter, randomized phase III trial comparing irinotecan-carboplatin with etoposide-carboplatin as first-line therapy for extensive-disease small-cell lung cancer. , 2011, Annals of oncology : official journal of the European Society for Medical Oncology.
[7] A. Causse,et al. New Topoisomerase I mutations are associated with resistance to camptothecin , 2011, Molecular Cancer.
[8] A. Ohtsu,et al. Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study. , 2009, The Lancet. Oncology.
[9] G. Szakács,et al. Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti‐cancer effects and pharmacological properties , 2009, British journal of pharmacology.
[10] Taehoon Kim,et al. CHARMM‐GUI: A web‐based graphical user interface for CHARMM , 2008, J. Comput. Chem..
[11] Sunhwan Jo,et al. PBEQ-Solver for online visualization of electrostatic potential of biomolecules , 2008, Nucleic Acids Res..
[12] E. Shin,et al. Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan‐pharmacokinetics and clinical outcome in patients with advanced non‐small cell lung cancer , 2007, Cancer.
[13] A. Ohtsu,et al. Randomized phase III study of 5-fluorouracil (5-FU) alone versus combination of irinotecan and cisplatin (CP) versus S-1 alone in advanced gastric cancer (JCOG9912) , 2007 .
[14] Mitchell Ho,et al. Mesothelin Expression in Human Lung Cancer , 2007, Clinical Cancer Research.
[15] Y. Pommier. Topoisomerase I inhibitors: camptothecins and beyond , 2006, Nature Reviews Cancer.
[16] E. Shin,et al. Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[17] D. V. Von Hoff,et al. Hydrophilic Camptothecin Analogs That Form Extremely Stable Cleavable Complexes with DNA and Topoisomerase I , 2004, Cancer Research.
[18] T. Ishikawa,et al. Novel camptothecin analogues that circumvent ABCG2‐associated drug resistance in human tumor cells , 2004, International journal of cancer.
[19] G. Kéri,et al. High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter. , 2004, Molecular pharmacology.
[20] Y. Pommier,et al. ABCG2 overexpression in colon cancer cells resistant to SN38 and in irinotecan‐treated metastases , 2004, International journal of cancer.
[21] Fengzhi Li,et al. Induction of Survivin Expression by Taxol (Paclitaxel) Is an Early Event, Which Is Independent of Taxol-mediated G2/M Arrest* , 2004, Journal of Biological Chemistry.
[22] E. L. Volk,et al. Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. , 2003, Cancer research.
[23] S. Bates,et al. Differential effects of the breast cancer resistance protein on the cellular accumulation and cytotoxicity of 9-aminocamptothecin and 9-nitrocamptothecin. , 2003, Cancer research.
[24] M. Hawkins,et al. Bryostatin-I—An Antineoplastic Treasure from the Deep? , 2002, Cancer biology & therapy.
[25] J. Schellens,et al. Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C. , 2002, Molecular cancer therapeutics.
[26] Masahiro Fukuoka,et al. Point mutations in the topoisomerase I gene in patients with non-small cell lung cancer treated with irinotecan. , 2002, Lung cancer.
[27] T. Ishikawa,et al. Transport of 7-ethyl-10-hydroxycamptothecin (SN-38) by breast cancer resistance protein ABCG2 in human lung cancer cells. , 2001, Biochemical and biophysical research communications.
[28] T. Litman,et al. Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells. , 2001, Cancer research.
[29] A. Ferrari,et al. Novel 7-substituted camptothecins with potent antitumor activity. , 2000, Journal of medicinal chemistry.
[30] M. Kuo,et al. BCRP/MXR/ABCP expression in topotecan-resistant human breast carcinoma cells. , 2000, Biochemical pharmacology.
[31] Hanqing Wu. Chemical Property Calculation through JavaScript and Applications in QSAR , 1999 .
[32] L. Doyle,et al. A multidrug resistance transporter from human MCF-7 breast cancer cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[33] M. Bjornsti,et al. A Camptothecin-resistant DNA Topoisomerase I Mutant Exhibits Altered Sensitivities to Other DNA Topoisomerase Poisons (*) , 1995, The Journal of Biological Chemistry.
[34] S. Sawada,et al. Chemical modification of an antitumor alkaloid camptothecin: synthesis and antitumor activity of 7-C-substituted camptothecins. , 1991, Chemical & pharmaceutical bulletin.
[35] R. Hertzberg,et al. On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex. , 1989, Biochemistry.
[36] Shozo Masuda,et al. REVISED METHOD FOR CALCULATION OF GROUP ELECTRONEGATIVITIES , 1982 .
[37] James E. Huheey,et al. The Electronegativity of Multiply Bonded Groups , 1966 .
[38] James E. Huheey,et al. The Electronegativity of Groups , 1965 .
[39] Fengzhi Li,et al. An intravenous (i.v.) route-compatible formulation of FL118, a survivin, Mcl-1, XIAP, and cIAP2 selective inhibitor, improves FL118 antitumor efficacy and therapeutic index (TI). , 2013, American journal of translational research.
[40] Y. Pommier,et al. Camptothecin analogs with enhanced activity against human breast cancer cells. I. Correlation of potency with lipophilicity and persistence in the cleavage complex , 2005, Cancer Chemotherapy and Pharmacology.
[41] Daniel J Sargent,et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[42] D. Ross,et al. Reversal of breast cancer resistance protein (BCRP/ABCG2)‐mediated drug resistance by novobiocin, a coumermycin antibiotic , 2004, International journal of cancer.
[43] L. Liu,et al. Tumor cell death induced by topoisomerase-targeting drugs. , 2001, Annual review of pharmacology and toxicology.