Advances in telemetric continuous intraocular pressure assessment

With an ageing population showing an increasing prevalence of glaucoma, there is a pressing demand for continuous intraocular pressure (IOP) measurements which could surpass clinic-based measurements such as routine applanation tonometry. Glaucoma patients have fluctuations in IOP, and it has been proposed that these fluctuations are relevant to glaucoma progression. In addition, interindividual and intraindividual variation in corneal thickness and rigidity can lead to significant and poorly quantitated errors in applanation-based methods of estimating IOP. Microelectrical mechanical systems and complementary metal oxide semiconductor-based technology has enabled the development of smart miniaturised devices by augmenting the computational ability of microelectronics with capabilities of microsensors and microactuators. This review addresses various sensor technologies and both invasive and non-invasive approaches to the measurement of IOP. Advances in wireless communication (telemetry) between the implanted sensors and the external readout device are reviewed. In addition, biocompatibility of implantable sensors is discussed.

[1]  B G Gilman,et al.  Intraocular pressure measurement with instrumented contact lenses. , 1974, Investigative ophthalmology.

[2]  O. Nissen.  CONTINUOUS RECORDING OF THE INTRAOCULAR PRESSURE IN HUMAN AND RABBIT EYES WITH A SIMPLE APPLANATING SUCTION CUP , 1977, Acta ophthalmologica.

[3]  J. McLaren,et al.  Continuous measurement of intraocular pressure in rabbits by telemetry. , 1996, Investigative ophthalmology & visual science.

[4]  Craig A. Grimes,et al.  Design and application of a wireless, passive, resonant-circuit environmental monitoring sensor , 2001 .

[5]  S. Gedde,et al.  Glaucoma drainage implants: a critical comparison of types , 2006, Current opinion in ophthalmology.

[6]  Lars Rosengren,et al.  Passive silicon transensor intended for biomedical, remote pressure monitoring , 1990 .

[7]  R. L. Cooper,et al.  Radio telemetry of intraocular pressure in vitro. , 1977, Investigative ophthalmology & visual science.

[8]  B.J. Hosticka,et al.  A programmable intraocular CMOS pressure sensor system implant , 2001, Proceedings of the 26th European Solid-State Circuits Conference.

[9]  David A. Lee,et al.  Glaucoma and its treatment: a review. , 2005, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

[10]  I. Constable,et al.  Continual monitoring of intraocular pressure: effect of central venous pressure, respiration, and eye movements on continual recordings of intraocular pressure in the rabbit, dog, and man. , 1979, The British journal of ophthalmology.

[11]  J. Wortman,et al.  A scleral buckle pressure gauge for continuous monitoring of intraocular pressure , 1980, International Ophthalmology.

[12]  C. Collins,et al.  Miniature passive pressure transensor for implanting in the eye. , 1967, IEEE transactions on bio-medical engineering.

[13]  M. Doughty,et al.  Human corneal thickness and its impact on intraocular pressure measures: a review and meta-analysis approach. , 2000, Survey of ophthalmology.

[14]  I. Constable,et al.  Passive radiotelemetry of intraocular pressure in vivo: calibration and validation of continual scleral guard-ring applanation transensors in the dog and rabbit. , 1979, Investigative ophthalmology & visual science.

[15]  Ylva Bäcklund,et al.  A system for wireless intra-ocular pressure measurements using a silicon micromachined sensor , 1992 .

[16]  B Ziaie,et al.  Intraocular pressure measurement at the choroid surface: a feasibility study with implications for implantable microsystems , 2001, The British journal of ophthalmology.

[17]  F.A. Miranda,et al.  RF telemetry system for an implantable bio-MEMS sensor , 2004, 2004 IEEE MTT-S International Microwave Symposium Digest (IEEE Cat. No.04CH37535).

[18]  Fred Hendrikse,et al.  Intraocular pressure-lowering effects of all commonly used glaucoma drugs: a meta-analysis of randomized clinical trials. , 2005, Ophthalmology.

[19]  P. Renaud,et al.  First steps toward noninvasive intraocular pressure monitoring with a sensing contact lens. , 2004, Investigative ophthalmology & visual science.

[20]  Rainer Laur,et al.  Wireless intra-ocular pressure monitoring system integrated into an artificial lens , 2000, 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451).

[21]  Wilfried Mokwa,et al.  Development of a Completely Encapsulated Intraocular Pressure Sensor , 2000, Ophthalmic Research.

[23]  E. Meng,et al.  Implantable parylene MEMS for glaucoma therapy , 2005, 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology.

[24]  Bernardo Tellini,et al.  Design of a system for continuous intraocular pressure monitoring , 2004, IEEE Transactions on Instrumentation and Measurement.

[25]  Anders Heijl,et al.  Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial. , 2003, Archives of ophthalmology.

[26]  Factors for glaucoma progression and the effect of treatment , 2003 .

[27]  Uwe Schnakenberg,et al.  Device for measuring intraocular pressure , 1997 .

[28]  F. Dannheim.  Clinical experiences with a semi-automated perimeter (Fieldmaster) , 1980, International ophtalmology.