A miniaturized high-voltage integrated power supply for portable microfluidic applications.

In this work a portable microfluidic device with a reusable integrated high voltage power supply is presented, which allows for quick exchange of inexpensive disposable poly(dimethylsiloxane)(PDMS) microfluidic chips on a carrier only slightly larger than a microscope slide. The device is powered by an onboard MN21 cell battery (5 mm radius, 30 mm long) and is demonstrated through the rapid and controlled transport of a fluorescent dye through an expansion chamber geometry. Power consumption experiments demonstrate the device's ability to complete over 40 dispense-flushing cycles on a single battery.

[1]  G. Whitesides,et al.  Poly(dimethylsiloxane) as a material for fabricating microfluidic devices. , 2002, Accounts of chemical research.

[2]  David Erickson,et al.  Modeling of DNA hybridization kinetics for spatially resolved biochips. , 2003, Analytical biochemistry.

[3]  M. Gijs,et al.  Modular microsystem for epithelial cell culture and electrical characterisation. , 2001, Biosensors & bioelectronics.

[4]  E. Delamarche,et al.  Patterned delivery of immunoglobulins to surfaces using microfluidic networks. , 1997, Science.

[5]  A D Stroock,et al.  An integrated fluorescence detection system in poly(dimethylsiloxane) for microfluidic applications. , 2001, Analytical chemistry.

[6]  大房 健 基礎講座 電気泳動(Electrophoresis) , 2005 .

[7]  Peter J Dyck,et al.  Microfluidic chip-based method for genotyping microsatellites, VNTRs and insertion/deletion polymorphisms. , 2003, Clinical biochemistry.

[8]  G. Whitesides,et al.  Components for integrated poly(dimethylsiloxane) microfluidic systems , 2002, Electrophoresis.

[9]  H. John Crabtree,et al.  Microchip injection and separation anomalies due to pressure effects. , 2001, Analytical chemistry.

[10]  Douglas J Jackson,et al.  Fully integrated on-chip electrochemical detection for capillary electrophoresis in a microfabricated device. , 2002, Analytical chemistry.

[11]  G. Whitesides,et al.  Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane). , 1998, Analytical chemistry.

[12]  W S Hancock,et al.  Analysis of recombinant adenoviruses using an integrated microfluidic chip-based system. , 2001, Analytical biochemistry.

[13]  Thomas Kappes,et al.  Portable capillary electrophoresis instrument with amperometric, potentiometric and conductometric detection , 2001 .

[14]  Ralf Lenigk,et al.  DNA amplification and hybridization assays in integrated plastic monolithic devices. , 2002, Analytical chemistry.

[15]  H. Becker,et al.  Polymer microfluidic devices. , 2002, Talanta.

[16]  Thomas Kappes,et al.  Field-portable capillary electrophoresis instrument with potentiometric and amperometric detection , 1999 .

[17]  James P Landers,et al.  A simple PDMS-based electro-fluidic interface for microchip electrophoretic separations. , 2002, The Analyst.

[18]  Gwo-Bin Lee,et al.  Microfabricated plastic chips by hot embossing methods and their applications for DNA separation and detection , 2000, SPIE MOEMS-MEMS.

[19]  M. Madou,et al.  Development of a fully integrated analysis system for ions based on ion-selective optodes and centrifugal microfluidics. , 2001, Analytical chemistry.

[20]  Evan O. Jones,et al.  Microfuel processor for use in a miniature power supply , 2002 .

[21]  M. Tarlov,et al.  Surface characterization of laser-ablated polymers used for microfluidics. , 2002, Analytical chemistry.

[22]  Joseph Wang,et al.  Portable electrochemical systems , 2002 .

[23]  Yong Wang,et al.  Development of a soldier-portable fuel cell power system. Part I: A bread-board methanol fuel processor , 2002 .

[24]  Shuichi Takayama,et al.  Passively driven integrated microfluidic system for separation of motile sperm. , 2003, Analytical chemistry.