The study of reservoirs' macro-heterogeneity is one of the important research contents of secondary development and tertiary oil recovery in high water cut period reservoirs. The GX oilfield is a terrestrial sedimentary fault block reservoir. In the development area, there main develop structure reservoir, and the faults are developed intricately. Due to the combined effects of sedimentary environment, diagenesis and tectonism, the heterogeneity of reservoir plane and longitudinal are extremely strong, and the geological characteristics and development effects of different development units in the same interval are great different. In this paper, the GX1 fault block is taken as an example. The thickness of the reservoir, the geometry of the oil layer and the uneven distribution of the permeability are considered on the plane. The overlap of the sand body, the interlayer and the intra-layer permeability difference are considered on the longitudinal direction. Through the conduct research on the well pairs that have established the corresponding relationship between injection and production, regarding the quantitative results of the seepage capability between wells as basis, also considering the characteristics of stage development, to carry out the time-varying of heterogeneous and the target block's seepage capacity from the dynamic point of view. The research provides scientific support for the secondary development adjustment, tertiary oil recovery design and "two-three combination" enhanced oil recovery technology research to GX oilfield.