An intronic MYLK variant associated with inflammatory lung disease regulates promoter activity of the smooth muscle myosin light chain kinase isoform

[1]  R. Wunderink,et al.  Genetic variation in MYLK and lung injury in children and adults with community-acquired pneumonia* , 2010, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

[2]  A. McCallion,et al.  Genomics of long-range regulatory elements. , 2010, Annual review of genomics and human genetics.

[3]  Dongmei Cheng,et al.  Alternative splicing attenuates transgenic expression directed by the apolipoprotein E promoter-enhancer based expression vector pLIV11[S] , 2010, Journal of Lipid Research.

[4]  Anuj Kumar,et al.  An Overview of Nested Genes in Eukaryotic Genomes , 2009, Eukaryotic Cell.

[5]  F. Collins,et al.  Potential etiologic and functional implications of genome-wide association loci for human diseases and traits , 2009, Proceedings of the National Academy of Sciences.

[6]  H. Shin,et al.  MYLK polymorphism associated with blood eosinophil level among asthmatic patients in a Korean population , 2009, Molecules and cells.

[7]  Mingyao Li,et al.  Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma* , 2008, Critical care medicine.

[8]  John P A Ioannidis,et al.  Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database , 2008, Nature Genetics.

[9]  A. Malik,et al.  Regulation of Endothelial Junctional Permeability , 2008, Annals of the New York Academy of Sciences.

[10]  Thomas R Gingeras,et al.  Origin of phenotypes: genes and transcripts. , 2007, Genome research.

[11]  T. Gingeras,et al.  Genome-wide transcription and the implications for genomic organization , 2007, Nature Reviews Genetics.

[12]  B. de Massy,et al.  Cis- and Trans-Acting Elements Regulate the Mouse Psmb9 Meiotic Recombination Hotspot , 2007, PLoS genetics.

[13]  T. Beaty,et al.  Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma. , 2007, The Journal of allergy and clinical immunology.

[14]  C. Ober,et al.  A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans , 2007, Genetic epidemiology.

[15]  M. Piano,et al.  Increased myosin light chain kinase expression in hypertension: Regulation by serum response factor via an insertion mutation in the promoter. , 2006, Molecular biology of the cell.

[16]  J. Mattick,et al.  Non-coding RNA. , 2006, Human molecular genetics.

[17]  T. Beaty,et al.  Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury. , 2006, American journal of respiratory cell and molecular biology.

[18]  W. Moore,et al.  Severe asthma: an overview. , 2006, The Journal of allergy and clinical immunology.

[19]  Jun Kawai,et al.  CAGE Basic/Analysis Databases: the CAGE resource for comprehensive promoter analysis , 2005, Nucleic Acids Res..

[20]  Dalong Ma,et al.  Nested genes in the human genome. , 2005, Genomics.

[21]  A. Børglum,et al.  Highly significant linkage to chromosome 3q13.31 for rhinitis and related allergic diseases , 2005, Journal of Medical Genetics.

[22]  D. J. Driscoll,et al.  Characterization of cis- and trans-acting elements in the imprinted human SNURF-SNRPN locus , 2005, Nucleic acids research.

[23]  E. Hoffman,et al.  ACTN3 and MLCK genotype associations with exertional muscle damage. , 2005, Journal of applied physiology.

[24]  K. Lindblad-Toh,et al.  Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals , 2005, Nature.

[25]  K. Strauch,et al.  A genome‐wide screen on the genetics of atopy in a multiethnic European population reveals a major atopy locus on chromosome 3q21.3 , 2005, Allergy.

[26]  P. Coffer,et al.  Forkhead-box transcription factors and their role in the immune system , 2004, Nature Reviews Immunology.

[27]  R. Tjian,et al.  Transcription regulation and animal diversity , 2003, Nature.

[28]  P. Green,et al.  Unusual deep intronic mutations in the COL4A5 gene cause X linked Alport syndrome , 2002, Human Genetics.

[29]  M. Krempf,et al.  Intronic mutations outside of Alu-repeat-rich domains of the LDL receptor gene are a cause of familial hypercholesterolemia , 2002, Human Genetics.

[30]  A. Verin,et al.  Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. , 2001, The Journal of clinical investigation.

[31]  C. Szpirer,et al.  Identification of an enhancer and an alternative promoter in the first intron of the alpha-fetoprotein gene. , 2000, Nucleic acids research.

[32]  A. Malik,et al.  Mechanisms regulating endothelial cell barrier function. , 2000, American journal of physiology. Lung cellular and molecular physiology.

[33]  Joe G. N. Garcia,et al.  A single human myosin light chain kinase gene (MLCK; MYLK). , 1999, Genomics.

[34]  H. Davis,et al.  Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation , 1995, Journal of cellular physiology.

[35]  J. Garcia,et al.  Regulation of endothelial cell gap formation and paracellular permeability. , 1995, Journal of investigative medicine : the official publication of the American Federation for Clinical Research.

[36]  P. Gallagher,et al.  The carboxyl terminus of the smooth muscle myosin light chain kinase is expressed as an independent protein, telokin. , 1991, The Journal of biological chemistry.

[37]  W. Gilbert.  Why genes in pieces? , 1978, Nature.

[38]  K. Nishikura,et al.  ADAR gene family and A-to-I RNA editing: diverse roles in posttranscriptional gene regulation. , 2005, Progress in nucleic acid research and molecular biology.

[39]  Brenda L Bass,et al.  RNA editing by adenosine deaminases that act on RNA. , 2002, Annual review of biochemistry.

[40]  H. Müller-Hermelink,et al.  Transcription of the nude gene (WHN) in human normal organs and mediastinal and pulmonary tumors. , 1999, Pathology, research and practice.

[41]  P J Gallagher,et al.  Myosin light chain kinase in endothelium: molecular cloning and regulation. , 1997, American journal of respiratory cell and molecular biology.