Mammalian odorant binding proteins.

Odorant binding proteins (OBPs) pertain to one of the most abundant classes of proteins found in the olfactory apparatus. OBPs are a sub-class of lipocalins, defined by their property of reversibly binding volatile chemicals, that we call 'odorants'. Numerous sequences of OBPs are now available, derived from protein sequencing from nasal mucus material, or from DNA sequences. The structural knowledge of OBPs has been improved too in recent years, with the availability of two X-ray structures. The physiological role of OBPs remains, however, essentially hypothetical, and most probably, not linked to a function of odor transport. The present knowledge on OBP biochemistry, sequence and structure will be examined here in relation to the different functional hypotheses proposed for OBPs.

[1]  H Breer,et al.  Cloning and expression of odorant-binding proteins Ia and Ib from mouse nasal tissue. , 1998, Gene.

[2]  J. Findlay,et al.  Membrane receptor for odour-binding proteins. , 1996, The Biochemical journal.

[3]  Jonathan Pevsner,et al.  The three-dimensional structure of bovine odorant binding protein and its mechanism of odor recognition , 1996, Nature Structural Biology.

[4]  T. Haertlé,et al.  Conformational stability and binding properties of porcine odorant binding protein. , 1999, Biochemistry.

[5]  P. Pelosi,et al.  Odorant-binding proteins. , 1994, Critical reviews in biochemistry and molecular biology.

[6]  C. Mucignat-Caretta,et al.  Acceleration of puberty onset in female mice by male urinary proteins. , 1995, The Journal of physiology.

[7]  F. Tanfani,et al.  Porcine odorant-binding protein: structural stability and ligand affinities measured by fourier-transform infrared spectroscopy and fluorescence spectroscopy. , 1999, Biochimica et biophysica acta.

[8]  H. Breer,et al.  Expression and Functional Analysis of Olfactory Receptors a , 1998, Annals of the New York Academy of Sciences.

[9]  C Cambillau,et al.  The structure of the monomeric porcine odorant binding protein sheds light on the domain swapping mechanism. , 1998, Biochemistry.

[10]  C. Cambillau,et al.  Complexes of porcine odorant binding protein with odorant molecules belonging to different chemical classes. , 2000, Journal of molecular biology.

[11]  W. Forssmann,et al.  cDNA sequence and expression pattern of the putative pheromone carrier aphrodisin. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[12]  K C Persaud,et al.  Purification and characterisation of an odorant-binding protein from cow nasal tissue. , 1985, European journal of biochemistry.

[13]  A. Miyawaki,et al.  Possible pheromone‐carrier function of two lipocalin proteins in the vomeronasal organ. , 1994, The EMBO journal.

[14]  A. Scaloni,et al.  Lipocalins of boar salivary glands binding odours and pheromones. , 1998, European journal of biochemistry.

[15]  T. Gudermann,et al.  Selective Activation of G Protein Subtypes in the Vomeronasal Organ upon Stimulation with Urine-derived Compounds* , 1999, The Journal of Biological Chemistry.

[16]  E. Bignetti,et al.  Specificity of an immunoaffinity column for odorant-binding protein from bovine nasal mucosa , 1987 .

[17]  M. Tamura,et al.  Expression of major urinary protein genes in the nasal glands associated with general olfaction. , 1999, Journal of neurobiology.

[18]  T A Jones,et al.  Crystallographic refinement of human serum retinol binding protein at 2Å resolution , 1990, Proteins.

[19]  P. Pelosi,et al.  Plasma membrane receptor for beta‐lactoglobulin and retinol‐binding protein in murine hybridomas , 1998, BioFactors.

[20]  D. Koshland.  Biochemistry of sensing and adaptation in a simple bacterial system. , 1981, Annual review of biochemistry.

[21]  P. Schofield.  Carrier-bound odorant delivery to olfactory receptors , 1988, Trends in Neurosciences.

[22]  A Coda,et al.  Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein. , 1995, Science.

[23]  C. Cambillau,et al.  Domain swapping creates a third putative combining site in bovine odorant binding protein dimer , 1996, Nature Structural Biology.

[24]  P. Pelosi,et al.  Odorant-binding proteins of the mouse. , 1995, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

[25]  R. Steinbrecht,et al.  Odorant‐Binding Proteins: Expression and Function , 1998, Annals of the New York Academy of Sciences.

[26]  E. Lacazette,et al.  A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres. , 2000, Human molecular genetics.

[27]  D Eisenberg,et al.  3D domain swapping: A mechanism for oligomer assembly , 1995, Protein science : a publication of the Protein Society.

[28]  Frederick W. Dahlquist,et al.  Molecular components of bacterial chemotaxis , 1987 .

[29]  S. Snyder,et al.  Odorant-binding protein: odorant transport function in the vertebrate nasal epithelium , 1990 .

[30]  P. Pelosi,et al.  Subtypes of odorant-binding proteins--heterologous expression and ligand binding. , 1998, European journal of biochemistry.

[31]  P. Pelosi,et al.  Perireceptor events in olfaction. , 1996, Journal of neurobiology.

[32]  A. North,et al.  Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography , 1992, Nature.

[33]  P. Pelosi.  Odorant‐Binding Proteins: Structural Aspects , 1998, Annals of the New York Academy of Sciences.

[34]  A. Scaloni,et al.  Microheterogeneity of odorant-binding proteins in the porcupine revealed by N-terminal sequencing and mass spectrometry. , 1997, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

[35]  Solubilization and purification of the retinol-binding protein receptor from human placental membranes. , 1994, The Biochemical journal.

[36]  S. Snyder,et al.  Isolation and characterization of an olfactory receptor protein for odorant pyrazines. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[37]  K. Mikoshiba,et al.  Functional expression of a mammalian odorant receptor. , 1998, Science.

[38]  T. Rabbitts,et al.  Molecular cloning of putative odorant-binding and odorant-metabolizing proteins. , 1991, Biochemistry.

[39]  P. Pelosi,et al.  Binding of selected odorants to bovine and porcine odorant-binding proteins. , 1993 .

[40]  H. Esterbauer,et al.  Genotoxic properties of 4-hydroxyalkenals and analogous aldehydes. , 1993, Mutation research.

[41]  S. Snyder,et al.  Odorant-binding protein. Characterization of ligand binding. , 1990, The Journal of biological chemistry.

[42]  B. Burchell,et al.  Turning on and turning off the sense of smell , 1991, Nature.

[43]  G. Brambilla,et al.  DNA‐damaging activity of biotic and xenobiotic aldehydes in chinese hamster ovary cells , 1984, Cell biochemistry and function.

[44]  G. Gisselmann,et al.  Cloning, functional expression and characterization of a human olfactory receptor. , 1999, Cellular and molecular biology.

[45]  H Breer,et al.  Expression of an olfactory receptor in Escherichia coli: purification, reconstitution, and ligand binding. , 1996, Biochemistry.

[46]  R. Tirindelli,et al.  Ligand binding characteristics of homologous rat and mouse urinary proteins and pyrazine-binding protein of calf. , 1990, Comparative biochemistry and physiology. B, Comparative biochemistry.

[47]  A. Pisanelli,et al.  Three odorant-binding proteins from rabbit nasal mucosa. , 1997, Chemical senses.

[48]  P. Pelosi,et al.  Affinities of nutty and green-smelling pyrazines and thiazoles to odorant-binding proteins, in relation with their lipophilicity. , 1995, Chemical senses.

[49]  P. Pelosi,et al.  Expression of a Lipocalin in Human Nasal Mucosa , 1997 .

[50]  A. Pisanelli,et al.  Identification of a specific olfactory receptor for 2-isobutyl-3-methoxypyrazine. , 1982, The Biochemical journal.

[51]  D R Flower,et al.  The lipocalin protein family: structure and function. , 1996, The Biochemical journal.

[52]  Dietmar Krautwurst,et al.  Identification of Ligands for Olfactory Receptors by Functional Expression of a Receptor Library , 1998, Cell.