Protein kinase C isoforms α, δ and θ require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells)

[1]  H. Mischak,et al.  Protein kinase C (PKC) ϵ enhances the inhibitory effect of TNFα on insulin signaling in HEK293 cells , 1997 .

[2]  R A Roth,et al.  Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612. , 1997, Biochemistry.

[3]  A. Ullrich,et al.  Protein kinase C isoforms β 1 and β 2 inhibit the tyrosine kinase activity of the insulin receptor , 1997, Diabetologia.

[4]  E. Kraegen,et al.  Alterations in the Expression and Cellular Localization of Protein Kinase C Isozymes ε and θ Are Associated With Insulin Resistance in Skeletal Muscle of the High-Fat–Fed Rat , 1997, Diabetes.

[5]  E. Van Obberghen,et al.  Phosphorylation of Insulin Receptor Substrate-1 on Multiple Serine Residues, 612, 632, 662, and 731, Modulates Insulin Action (*) , 1996, The Journal of Biological Chemistry.

[6]  B. Spiegelman,et al.  IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance , 1996, Science.

[7]  L. Groop,et al.  Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes mellitus. , 1994, The Journal of clinical investigation.

[8]  H. Häring,et al.  Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase. , 1994, The Journal of biological chemistry.

[9]  Y. Nishizuka.  Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. , 1992, Science.

[10]  Y. Nishizuka,et al.  The molecular heterogeneity of protein kinase C and its implications for cellular regulation , 1988, Nature.

[11]  A. Ullrich,et al.  Protein kinase C isoforms beta 1 and beta 2 inhibit the tyrosine kinase activity of the insulin receptor. , 1997, Diabetologia.

[12]  E. Kraegen,et al.  Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat. , 1997, Diabetes.

[13]  H. Mischak,et al.  Protein kinase C (PKC) epsilon enhances the inhibitory effect of TNF alpha on insulin signaling in HEK293 cells. , 1997, FEBS Letters.