Misfolded proteins go their separate ways
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Bernasconi et al. clarify how mammalian cells remove misfolded ER proteins for disposal—how a particular protein exits depends on its ER location.
Newly made proteins idle in the ER while they fold into shape. Proteins that make a mistake during the process are usually expelled from the ER and
[1] Riccardo Bernasconi,et al. Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates , 2010, The Journal of cell biology.