Cerebral Malaria for the Development of Experimental Chemokine Receptor CCR2 Is Not Essential

ANKA induces cerebral malaria in susceptible mice. Brain-sequesteredCD8 T cells are responsible for this pathology. We have evaluated the role of CCR2, a chemokine receptorexpressed on CD8 T cells. Infected CCR2-deficient mice were as susceptible to cerebral malaria as wild-typemice were, and CD8 T-cell migration to the brain was not abolished.

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