Visualization and quantification of eye tracking data for the evaluation of oculomotor function

Oculomotor dysfunction may originate from physical, physiological or psychological causes and may be a marker for schizophrenia or other disorders. Observational tests for oculomotor dysfunction are easy to administer, but are subjective and transient, and it is difficult to quantify deviations. To date, video-based eye tracking systems have not provided a contextual overview of gaze data that integrates the eye video recording with the stimulus and gaze data together with quantitative feedback of metrics in relation to typical values. A system was developed with an interactive timeline to allow the analyst to scroll through a recording frame-by-frame while comparing data from three different sources. The visual and integrated nature of the analysis allows localisation and quantification of saccadic under- and overshoots as well as determination of the frequency and amplitude of catch-up and anticipatory saccades. Clinicians will be able to apply their expertise to diagnose disorders based on abnormal patterns in the gaze plots. They can use the line charts to quantify deviations from benchmark values for reaction time, saccadic accuracy and smooth pursuit gain. A clinician can refer to the eye video at any time to confirm that observed deviations originated from gaze behaviour and not from systemic errors.

[1]  Tim J Anderson,et al.  Eye movements in neurodegenerative diseases. , 2016, Current opinion in neurology.

[2]  David Fitzpatrick,et al.  Types of Eye Movements and Their Functions , 2001 .

[3]  Michael Burch,et al.  A Task-Based View on the Visual Analysis of Eye-Tracking Data , 2015, ETVIS.

[4]  T. Anderson,et al.  Eye movements in patients with neurodegenerative disorders , 2013, Nature Reviews Neurology.

[5]  S de Brouwer,et al.  Role of retinal slip in the prediction of target motion during smooth and saccadic pursuit. , 2001, Journal of neurophysiology.

[6]  M. Mackeben,et al.  Eye Movement Training and Suggested Gaze Strategies in Tunnel Vision - A Randomized and Controlled Pilot Study , 2016, PloS one.

[7]  D. Robinson,et al.  The upper limit of human smooth pursuit velocity , 1985, Vision Research.

[8]  R. Haber,et al.  Visual Perception , 2018, Encyclopedia of Database Systems.

[9]  Michael Burch,et al.  Visualization of Eye Tracking Data: A Taxonomy and Survey , 2017, Comput. Graph. Forum.

[10]  B. J. Wilkes,et al.  Oculomotor performance in children with high-functioning Autism Spectrum Disorders. , 2015, Research in developmental disabilities.

[11]  Raimund Dachselt,et al.  3D attentional maps: aggregated gaze visualizations in three-dimensional virtual environments , 2010, AVI.

[12]  M. Leboyer,et al.  Reduced saccadic inhibition of return to moving eyes in autism spectrum disorders , 2016, Vision Research.

[13]  Oriane Landry,et al.  Eye-Tracking Reveals that the Strength of the Vertical-Horizontal Illusion Increases as the Retinal Image Becomes More Stable with Fixation , 2017, Front. Hum. Neurosci..

[14]  Eileen Kowler,et al.  Sensitivity of smooth eye movement to small differences in target velocity , 1987, Vision Research.

[15]  G. Barnes,et al.  Cognitive processes involved in smooth pursuit eye movements , 2008, Brain and Cognition.

[16]  Thiago Santini,et al.  Bayesian identification of fixations, saccades, and smooth pursuits , 2015, ETRA.

[17]  G. O'driscoll,et al.  Smooth pursuit in schizophrenia: A meta-analytic review of research since 1993 , 2008, Brain and Cognition.

[18]  S. Martinez-Conde,et al.  Fixational eye movements across vertebrates: comparative dynamics, physiology, and perception. , 2008, Journal of vision.

[19]  A. Fuchs,et al.  Prediction in the oculomotor system: smooth pursuit during transient disappearance of a visual target , 2004, Experimental Brain Research.

[20]  Hrishikesh M. Rao,et al.  Incorporating Prediction in Models for Two-Dimensional Smooth Pursuit , 2010, PloS one.

[21]  W. C. Maples,et al.  The VisionPrint System: A new tool in the diagnosis of ocular motor dysfunction , 2011 .

[22]  W A Fletcher,et al.  Smooth pursuit dysfunction in Alzheimer's disease , 1988, Neurology.

[23]  K. Zadnik.  Clinical Procedures in Primary Eye Care (3rd ed.) , 2009 .

[24]  J. Sharpe.  Neurophysiology and neuroanatomy of smooth pursuit: Lesion studies , 2008, Brain and Cognition.

[25]  E. J. Morris,et al.  Visual motion processing and sensory-motor integration for smooth pursuit eye movements. , 1987, Annual review of neuroscience.

[26]  P. Holzman,et al.  Antisaccades and smooth pursuit eye tracking and schizotypy. , 1998, Archives of general psychiatry.

[27]  H. J. Wyatt,et al.  The role of target position in smooth pursuit deceleration and termination , 2001, Vision Research.

[28]  Francesco Di Nocera,et al.  A Simple(r) Tool For Examining Fixations , 2016 .

[29]  R. Simons,et al.  Smooth pursuit eye movements in subjects reporting physical anhedonia and perceptual aberrations , 1985, Psychiatry Research.

[30]  S. Fletcher‐Watson,et al.  Atypical saccadic scanning in autistic spectrum disorder , 2009, Neuropsychologia.

[31]  Enkelejda Kasneci,et al.  Eye-Tracking as a Tool to Evaluate Functional Ability in Everyday Tasks in Glaucoma , 2017, Journal of ophthalmology.

[32]  Nicholas M. Ross,et al.  The relative contributions of internal motor cues and external semantic cues to anticipatory smooth pursuit , 2014, ETRA.

[33]  Ralf Engbert,et al.  Microsaccades uncover the orientation of covert attention , 2003, Vision Research.

[34]  C Kennard,et al.  Ocular motor abnormalities in neurodegenerative disorders , 2015, Eye.

[35]  H. Barlow.  Eye movements during fixation , 1952, The Journal of physiology.

[36]  D. Kerzel,et al.  Attentional constraints on target selection for smooth pursuit eye movements , 2011, Vision Research.

[37]  Stanislav Popelka,et al.  ScanGraph: A Novel Scanpath Comparison Method Using Visualisation of Graph Cliques , 2016 .

[38]  Jean-Jacques Orban de Xivry,et al.  Saccades and pursuit: two outcomes of a single sensorimotor process , 2007, The Journal of physiology.

[39]  P. van Donkelaar,et al.  The allocation of attention during smooth pursuit eye movements. , 2002, Progress in brain research.

[40]  Miriam Spering,et al.  Contextual effects on motion perception and smooth pursuit eye movements , 2008, Brain Research.

[41]  D. Robinson,et al.  Smooth pursuit eye movements in schizophrenics: quantitative measurements with the search-coil technique. , 1988, Journal of psychiatric research.

[42]  W. Einhäuser,et al.  Effects of aging on eye movements in the real world , 2015, Front. Hum. Neurosci..

[43]  C. Hofsten,et al.  Development of smooth pursuit tracking in young infants , 1997, Vision Research.

[44]  D. Levy,et al.  Smooth pursuit eye movements, attention, and schizophrenia. , 1976, Archives of general psychiatry.

[45]  R. Greer.  Clinical Procedures in Primary Eye Care , 1998 .

[46]  Marcus Nyström,et al.  Eye tracker data quality: what it is and how to measure it , 2012, ETRA.

[47]  L. K. Smith.  Functional tests. , 1954, The Physical therapy review.

[48]  Peter Thier,et al.  The neural basis of smooth pursuit eye movements in the rhesus monkey brain , 2008, Brain and Cognition.

[49]  F. Binkofski,et al.  Altered Velocity Processing in Schizophrenia during Pursuit Eye Tracking , 2012, PloS one.

[50]  P. Gelder,et al.  Anticipatory saccades in smooth pursuit: Task effects and pursuit vector after saccades , 1995, Vision Research.

[51]  A. Terry Bahill,et al.  Smooth pursuit eye movements in response to predictable target motions , 1983, Vision Research.

[52]  U. Polat,et al.  ADHD subjects fail to suppress eye blinks and microsaccades while anticipating visual stimuli but recover with medication , 2014, Vision Research.

[53]  E. Poulton,et al.  On reading and visual fatigue. , 1958, The American journal of psychology.

[54]  J. F. Soechting,et al.  Similarity in the response of smooth pursuit and manual tracking to a change in the direction of target motion. , 2000, Journal of neurophysiology.

[55]  H. K. Lewis.  Text-Book of Ophthalmology , 1894, Bristol Medico-Chirurgical Journal (1883).

[56]  H. J. Wyatt,et al.  Offset dynamics of human smooth pursuit eye movements: Effects of target presence and subject attention , 1997, Vision Research.

[57]  N. Rinehart,et al.  Ocular motor disturbances in autism spectrum disorders: Systematic review and comprehensive meta-analysis , 2016, Neuroscience & Biobehavioral Reviews.

[58]  D. Robinson.  The mechanics of human smooth pursuit eye movement. , 1965, The Journal of physiology.

[59]  Cecilia Laschi,et al.  A model of the smooth pursuit eye movement with prediction and learning , 2010 .

[60]  Laurent Madelain,et al.  Spatial deployment of attention influences both saccadic and pursuit tracking , 2005, Vision Research.

[61]  J. Steen,et al.  Quantification of visual function assessment using remote eye tracking in children: validity and applicability , 2016, Acta ophthalmologica.

[62]  J. Sharpe,et al.  Smooth pursuit initiation in young and elderly subjects , 1993, Vision Research.

[63]  D. Levy,et al.  Smooth pursuit eye movements and functional psychoses; a review. , 1977, Schizophrenia bulletin.

[64]  A. Fuchs,et al.  Further properties of the human saccadic system: eye movements and correction saccades with and without visual fixation points. , 1969, Vision research.

[65]  D. B. E. P. M. Faao.  Clinical Procedures in Primary Eye Care , 2003 .

[66]  S. B. Hutton,et al.  The effects of dividing attention on smooth pursuit eye tracking , 2005, Experimental Brain Research.

[67]  Oleg Špakov,et al.  APPLICATION OF CLUSTERING ALGORITHMS IN EYE GAZE VISUALIZATIONS , 2007 .

[68]  Thomas R Kwapil,et al.  Smooth pursuit eye tracking and visual fixation in psychosis-prone individuals , 2000, Psychiatry Research.