论文信息 - Microwave-Assisted Synthesis of Novel 1,3,4-Thiadiazolyl-Substituted 1,2,4-Triazines as Potential Antitubercular Agents

Microwave-Assisted Synthesis of Novel 1,3,4-Thiadiazolyl-Substituted 1,2,4-Triazines as Potential Antitubercular Agents

Abstract A series of triazines have been synthesized starting from 5-alkyl-1,3,4-thiadiazole-2-thioles ( 1a–d ). On reaction with ethyl bromoacetate in the presence of anhydrous K 2 CO 3 under microwave irradiation (MWI), these yielded corresponding esters ( 2a–d ) which on hydrazinolysis under MWI produced (5-alkyl-1,3,4-thiadiazol-2-yl sulfanyl) acetohydrazides ( 3a–d ). The reaction of 3a–d with ω-bromoacetophenone under MWI yielded 6-aryl-3-[(5-alkyl-1,3,4-thiadiazol-2-yl sulfanyl)methyl]-1,2,4-triazines ( 4a–h ). All the synthesized triazines showed in vitro antitubercular activity.

R. Kumar | M. Kidwai | A. Srivastava | H. P. Gupta

[1] M. Kidwai,et al. Microwave-induced Selective Mercuration of 1,4-Naphthoquinone† , 1998 .

[2] M. Kidwai,et al. Synthesis of some novel substituted quinolines as potent analgesic agents , 1997 .

[3] M. Kidwai,et al. New indolyl phthalazinones and phthalazine derivatives as spermicidal agents , 1997 .

[4] M. Kidwai,et al. MICROWAVE-INDUCED SELECTIVE ALKOXYLATION OF 1,4-NAPHTHOQUINONES , 1997 .

[5] M. Kidwai,et al. Microwave induced novel synthetic route to organomercurials , 1996 .

[6] S. Caddick,et al. Microwave assisted organic reactions , 1995 .

[7] G. Badiger,et al. Synthesis of Biheterocycles Containing an Indole Nucleus. , 2010 .

[8] K. Kariyone,et al. Cefazolin, a new semisynthetic cephalosporin antibiotic. I. Synthesis and chemical properties of cefazolin. , 1970, The Journal of antibiotics.