Emerging targets in osteoarthritis therapy.
暂无分享,去创建一个
[1] Yangzi Jiang,et al. Origin and function of cartilage stem/progenitor cells in osteoarthritis , 2015, Nature Reviews Rheumatology.
[2] M. Karsdal,et al. Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials. , 2015, Osteoarthritis and cartilage.
[3] G. Herrero-Beaumont,et al. TLR4 signalling in osteoarthritis—finding targets for candidate DMOADs , 2015, Nature Reviews Rheumatology.
[4] M. Koenders,et al. TGF-β is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain? , 2015, Osteoarthritis and cartilage.
[5] Georg Schett,et al. Signature of circulating microRNAs in osteoarthritis. , 2015, Annals of the rheumatic diseases.
[6] B. Cronstein,et al. Direct or indirect stimulation of adenosine A2A receptors enhances bone regeneration as well as bone morphogenetic protein‐2 , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[7] D. Spray,et al. Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model , 2014, Arthritis Research & Therapy.
[8] J. Kim,et al. Intra-articular delivery of kartogenin-conjugated chitosan nano/microparticles for cartilage regeneration. , 2014, Biomaterials.
[9] V. Geoffroy,et al. Dkk‐1–Mediated Inhibition of Wnt Signaling in Bone Ameliorates Osteoarthritis in Mice , 2014, Arthritis & rheumatology.
[10] G. Burmester,et al. Hydroxychloroquine in patients with inflammatory and erosive osteoarthritis of the hands (OA TREAT): study protocol for a randomized controlled trial , 2014, Trials.
[11] D. Walsh,et al. Structural Associations of Symptomatic Knee Osteoarthritis , 2014, Arthritis & rheumatology.
[12] K. Jacobson,et al. A3 Adenosine Receptor Allosteric Modulator Induces an Anti-Inflammatory Effect: In Vivo Studies and Molecular Mechanism of Action , 2014, Mediators of inflammation.
[13] Jae-Wook Jeong,et al. Disturbed Cartilage and Joint Homeostasis Resulting From a Loss of Mitogen‐Inducible Gene 6 in a Mouse Model of Joint Dysfunction , 2014, Arthritis & rheumatology.
[14] F. Dell’Accio,et al. Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin. , 2014, Biochemical pharmacology.
[15] V. Kraus,et al. Biomarkers and proteomic analysis of osteoarthritis. , 2014, Matrix biology : journal of the International Society for Matrix Biology.
[16] Weikai Zhang,et al. Bortezomib prevents the expression of MMP-13 and the degradation of collagen type 2 in human chondrocytes. , 2014, Biochemical and biophysical research communications.
[17] Masato Sato,et al. Bevacizumab, an anti-vascular endothelial growth factor antibody, inhibits osteoarthritis , 2014, Arthritis Research & Therapy.
[18] R. Loeser. Integrins and chondrocyte–matrix interactions in articular cartilage , 2014, Matrix biology : journal of the International Society for Matrix Biology.
[19] D. Patra,et al. Cartilage-Specific Ablation of Site-1 Protease in Mice Results in the Endoplasmic Reticulum Entrapment of Type IIB Procollagen and Down-Regulation of Cholesterol and Lipid Homeostasis , 2014, PloS one.
[20] F. Luyten,et al. A homeostatic function of CXCR2 signalling in articular cartilage , 2014, Annals of the rheumatic diseases.
[21] S. Goldring,et al. A hyaluronic acid-salmon calcitonin conjugate for the local treatment of osteoarthritis: chondro-protective effect in a rabbit model of early OA. , 2014, Journal of controlled release : official journal of the Controlled Release Society.
[22] W. Yin,et al. Aging and Oxidative Stress Reduce the Response of Human Articular Chondrocytes to Insulin‐like Growth Factor 1 and Osteogenic Protein 1 , 2014, Arthritis & rheumatology.
[23] A. Mobasheri,et al. Peripheral Calcitonin Gene-Related Peptide Receptor Activation and Mechanical Sensitization of the Joint in Rat Models of Osteoarthritis Pain , 2014, Arthritis & rheumatology.
[24] F. Berenbaum,et al. Protective role of frizzled-related protein B on matrix metalloproteinase induction in mouse chondrocytes , 2014, Arthritis Research & Therapy.
[25] S. Oyadomari,et al. Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C/EBP homologous protein. , 2014, Osteoarthritis and cartilage.
[26] F. Eckstein,et al. Intraarticular Sprifermin (Recombinant Human Fibroblast Growth Factor 18) in Knee Osteoarthritis: A Randomized, Double‐Blind, Placebo‐Controlled Trial , 2014, Arthritis & rheumatology.
[27] Y. Henrotin. Does signaling pathway inhibition hold therapeutic promise for osteoarthritis? , 2014, Joint, bone, spine : revue du rhumatisme.
[28] A. So,et al. Dispensable role of myeloid differentiation primary response gene 88 (MyD88) and MyD88-dependent toll-like receptors (TLRs) in a murine model of osteoarthritis. , 2014, Joint, bone, spine : revue du rhumatisme.
[29] Zhen-Zhong Xu,et al. Emerging targets in neuroinflammation-driven chronic pain , 2014, Nature Reviews Drug Discovery.
[30] A. Uitterlinden,et al. Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis , 2014, Annals of the rheumatic diseases.
[31] R. Baron,et al. Osteoarthritis pain: nociceptive or neuropathic? , 2014, Nature Reviews Rheumatology.
[32] L. Reynard,et al. CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis susceptibility SNP rs143383 , 2014, Human Genetics.
[33] S. Honsawek,et al. Plasma and synovial fluid sclerostin are inversely associated with radiographic severity of knee osteoarthritis. , 2014, Clinical biochemistry.
[34] Richard T. Lee,et al. Targeted Delivery to Cartilage Is Critical for In Vivo Efficacy of Insulin‐like Growth Factor 1 in a Rat Model of Osteoarthritis , 2014, Arthritis & rheumatology.
[35] Lin Xu,et al. Induction of high temperature requirement A1, a serine protease, by TGF-beta1 in articular chondrocytes of mouse models of OA. , 2014, Histology and histopathology.
[36] T. Minashima,et al. Lithium Protects Against Cartilage Degradation in Osteoarthritis , 2014, Arthritis & rheumatology.
[37] W. B. van den Berg,et al. Canonical Wnt signaling skews TGF-β signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8. , 2014, Cellular signalling.
[38] Simon W. Jones,et al. The hallmarks of osteoarthritis and the potential to develop personalised disease-modifying pharmacological therapeutics. , 2014, Osteoarthritis and cartilage.
[39] L. Miller,et al. Open Access Journal of Sports Medicine Dovepress Post-traumatic Knee Osteoarthritis in the Young Patient: Therapeutic Dilemmas and Emerging Technologies , 2022 .
[40] E. Lewiecki. Role of sclerostin in bone and cartilage and its potential as a therapeutic target in bone diseases , 2014, Therapeutic advances in musculoskeletal disease.
[41] M. Kloppenburg. Hand osteoarthritis—nonpharmacological and pharmacological treatments , 2014, Nature Reviews Rheumatology.
[42] A. Noël,et al. Gene Expression Pattern of Cells From Inflamed and Normal Areas of Osteoarthritis Synovial Membrane , 2014, Arthritis & rheumatology.
[43] A. Hofman,et al. Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies , 2014, Arthritis & rheumatology.
[44] W. B. van den Berg,et al. Inhibition of TAK1 and/or JAK can rescue impaired chondrogenic differentiation of human mesenchymal stem cells in osteoarthritis-like conditions. , 2014, Tissue engineering. Part A.
[45] J. Pelletier,et al. Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis , 2014, Annals of the rheumatic diseases.
[46] L. Setton,et al. In Vivo Luminescence Imaging of NF‐κB Activity and Serum Cytokine Levels Predict Pain Sensitivities in a Rodent Model of Osteoarthritis , 2014, Arthritis & rheumatology.
[47] M. Nevitt,et al. Synovitis in Knee Osteoarthritis Assessed by Contrast-enhanced Magnetic Resonance Imaging (MRI) is Associated with Radiographic Tibiofemoral Osteoarthritis and MRI-detected Widespread Cartilage Damage: The MOST Study , 2014, The Journal of Rheumatology.
[48] Song Ho Chang,et al. Identification of Fibroblast Growth Factor-18 as a Molecule to Protect Adult Articular Cartilage by Gene Expression Profiling* , 2014, The Journal of Biological Chemistry.
[49] R. Boot-Handford,et al. Abnormal Chondrocyte Apoptosis in the Cartilage Growth Plate is Influenced by Genetic Background and Deletion of CHOP in a Targeted Mouse Model of Pseudoachondroplasia , 2014, PloS one.
[50] Jin-Hong Kim,et al. Regulation of the Catabolic Cascade in Osteoarthritis by the Zinc-ZIP8-MTF1 Axis , 2014, Cell.
[51] M. Kurosaka,et al. PTEN regulates matrix synthesis in adult human chondrocytes under oxidative stress , 2014, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
[52] R. Jiang,et al. ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage. , 2014, Cellular signalling.
[53] Katherine C. Hall,et al. Lack of ADAM10 in endothelial cells affects osteoclasts at the chondro‐osseus junction , 2014, Journal of Orthopaedic Research.
[54] S. Abramson,et al. TSG-6 activity as a novel biomarker of progression in knee osteoarthritis. , 2014, Osteoarthritis and cartilage.
[55] Di Huang,et al. Endoplasmic Reticulum Stress-Unfolding Protein Response-Apoptosis Cascade Causes Chondrodysplasia in a col2a1 p.Gly1170Ser Mutated Mouse Model , 2014, PloS one.
[56] Farshid Guilak,et al. TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading , 2014, Proceedings of the National Academy of Sciences.
[57] W. Robinson,et al. Brief Report: Carboxypeptidase B Serves as a Protective Mediator in Osteoarthritis , 2014, Arthritis & rheumatology.
[58] R. Terkeltaub,et al. C/EBP homologous protein drives pro-catabolic responses in chondrocytes , 2013, Arthritis Research & Therapy.
[59] M. Greenblatt,et al. NFATc1 and NFATc2 repress spontaneous osteoarthritis , 2013, Proceedings of the National Academy of Sciences.
[60] S. Mohan,et al. Proteomic profiling and functional characterization of early and late shoulder osteoarthritis , 2013, Arthritis Research & Therapy.
[61] A. Mobasheri. The Future of Osteoarthritis Therapeutics: Emerging Biological Therapy , 2013, Current Rheumatology Reports.
[62] G. Dubyak,et al. The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes , 2013, Arthritis Research & Therapy.
[63] A. Gonzalez,et al. Osteoarthritis year 2013 in review: genetics and genomics. , 2013, Osteoarthritis and cartilage.
[64] F. Lafeber,et al. Osteoarthritis year 2013 in review: biomarkers; reflecting before moving forward, one step at a time. , 2013, Osteoarthritis and cartilage.
[65] L. Reynard,et al. Insights from human genetic studies into the pathways involved in osteoarthritis , 2013, Nature Reviews Rheumatology.
[66] R. O’Keefe,et al. RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance. , 2013, Arthritis and rheumatism.
[67] F. Berenbaum,et al. Homeostatic Mechanisms in Articular Cartilage and Role of Inflammation in Osteoarthritis , 2013, Current Rheumatology Reports.
[68] A. Mobasheri. The Future of Osteoarthritis Therapeutics: Targeted Pharmacological Therapy , 2013, Current Rheumatology Reports.
[69] M. D. de Andrés,et al. Nitric oxide compounds have different effects profiles on human articular chondrocyte metabolism , 2013, Arthritis Research & Therapy.
[70] F. Flamigni,et al. IKKα/CHUK Regulates Extracellular Matrix Remodeling Independent of Its Kinase Activity to Facilitate Articular Chondrocyte Differentiation , 2013, PloS one.
[71] J. Katz,et al. The influence of synovial inflammation and hyperplasia on symptomatic outcomes up to 2 years post-operatively in patients undergoing partial meniscectomy. , 2013, Osteoarthritis and cartilage.
[72] Magnus Rattray,et al. The Circadian Clock in Murine Chondrocytes Regulates Genes Controlling Key Aspects of Cartilage Homeostasis , 2013, Arthritis and rheumatism.
[73] D. Patra,et al. Transcriptome analysis of injured human meniscus reveals a distinct phenotype of meniscus degeneration with aging. , 2013, Arthritis and rheumatism.
[74] D. Hunter,et al. Post-traumatic osteoarthritis: from mouse models to clinical trials , 2013, Nature Reviews Rheumatology.
[75] C. Cooper,et al. Value of biomarkers in osteoarthritis: current status and perspectives , 2013, Annals of the rheumatic diseases.
[76] R. Terkeltaub,et al. Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes , 2013, Arthritis Research & Therapy.
[77] Leslie J Crofford,et al. Use of NSAIDs in treating patients with arthritis , 2013, Arthritis Research & Therapy.
[78] M. Tortorella,et al. Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets , 2013, Current Rheumatology Reports.
[79] P. Richette,et al. Biologic agents in osteoarthritis: hopes and disappointments , 2013, Nature Reviews Rheumatology.
[80] F Eckstein,et al. Imaging biomarker validation and qualification report: sixth OARSI Workshop on Imaging in Osteoarthritis combined with third OA Biomarkers Workshop. , 2013, Osteoarthritis and cartilage.
[81] J. Koziol,et al. Glucosamine activates autophagy in vitro and in vivo. , 2013, Arthritis and rheumatism.
[82] K. Tsai,et al. Advanced Glycation End Products Induce Peroxisome Proliferator-Activated Receptor γ Down-Regulation-Related Inflammatory Signals in Human Chondrocytes via Toll-Like Receptor-4 and Receptor for Advanced Glycation End Products , 2013, PloS one.
[83] Manuel Serrano,et al. The Hallmarks of Aging , 2013, Cell.
[84] Katherine C. Hall,et al. ADAM17 Controls Endochondral Ossification by Regulating Terminal Differentiation of Chondrocytes , 2013, Molecular and Cellular Biology.
[85] N. Lane,et al. To Wnt or not to Wnt: the bone and joint health dilemma , 2013, Nature Reviews Rheumatology.
[86] L. Reynard,et al. The Identification of Trans-acting Factors That Regulate the Expression of GDF5 via the Osteoarthritis Susceptibility SNP rs143383 , 2013, PLoS genetics.
[87] F. Beier,et al. TGF-β and osteoarthritis—the good and the bad , 2013, Nature Medicine.
[88] T. Matsushita,et al. Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice , 2013, Annals of the rheumatic diseases.
[89] L. Riley,et al. Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis , 2013, Nature Medicine.
[90] T. Matsushita,et al. The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin‐1β in human chondrocytes , 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
[91] H. An,et al. Fibroblast growth factor control of cartilage homeostasis , 2013, Journal of cellular biochemistry.
[92] J. Pelletier,et al. Adult cartilage-specific peroxisome proliferator-activated receptor gamma knockout mice exhibit the spontaneous osteoarthritis phenotype. , 2013, The American journal of pathology.
[93] Mary F. Lopez,et al. Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues. , 2013, Arthritis and rheumatism.
[94] K. Johnson. A stem cell-based approach to cartilage repair , 2013 .
[95] R. Liu-Bryan. Synovium and the Innate Inflammatory Network in Osteoarthritis Progression , 2013, Current Rheumatology Reports.
[96] B. Dawson,et al. Proteoglycan 4 Expression Protects Against the Development of Osteoarthritis , 2013, Science Translational Medicine.
[97] R. Black,et al. Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury. , 2013, Arthritis and rheumatism.
[98] J. Campisi,et al. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. , 2013, The Journal of clinical investigation.
[99] G. Valesini,et al. Cartilage as a target of autoimmunity: a thin layer. , 2013, Autoimmunity reviews.
[100] Sang-Youel Park,et al. SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes. , 2013, Osteoarthritis and cartilage.
[101] A. Haseeb,et al. Immunopathogenesis of osteoarthritis. , 2013, Clinical immunology.
[102] H. Roach,et al. Regulated Transcription of Human Matrix Metalloproteinase 13 (MMP13) and Interleukin-1β (IL1B) Genes in Chondrocytes Depends on Methylation of Specific Proximal Promoter CpG Sites* , 2013, The Journal of Biological Chemistry.
[103] Roland Baron,et al. WNT signaling in bone homeostasis and disease: from human mutations to treatments , 2013, Nature Medicine.
[104] J. Buckwalter,et al. Mechanical stress and ATP synthesis are coupled by mitochondrial oxidants in articular cartilage , 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
[105] Robert W. Taylor,et al. Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2. , 2013, Arthritis and rheumatism.
[106] A. Içağasioğlu,et al. Effects of calcitonin on knee osteoarthritis and quality of life , 2013, Rheumatology International.
[107] H. Akiyama,et al. Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development , 2013, Proceedings of the National Academy of Sciences.
[108] P. Conaghan. Osteoarthritis in 2012: Parallel evolution of OA phenotypes and therapies , 2013, Nature Reviews Rheumatology.
[109] H. Im,et al. MMP13 is a critical target gene during the progression of osteoarthritis , 2013, Arthritis Research & Therapy.
[110] T. Alliston,et al. Load Regulates Bone Formation and Sclerostin Expression through a TGFβ-Dependent Mechanism , 2013, PloS one.
[111] Jonathan Samuels,et al. Prognostic biomarkers in osteoarthritis , 2013, Current opinion in rheumatology.
[112] L. Pulsatelli,et al. New findings in osteoarthritis pathogenesis: therapeutic implications , 2013, Therapeutic advances in chronic disease.
[113] A Nakajima,et al. Angiogenic activity of subchondral bone during the progression of osteoarthritis in a rabbit anterior cruciate ligament transection model. , 2012, Osteoarthritis and cartilage.
[114] L. White,et al. Serum non-coding RNAs as biomarkers for osteoarthritis progression after ACL injury. , 2012, Osteoarthritis and cartilage.
[115] J. Schoones,et al. Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review. , 2012, Osteoarthritis and cartilage.
[116] T. Vincent. Explaining the fibroblast growth factor paradox in osteoarthritis: lessons from conditional knockout mice. , 2012, Arthritis and rheumatism.
[117] Richard J. Miller,et al. CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis , 2012, Proceedings of the National Academy of Sciences.
[118] A. Blom,et al. The C-Type Lectin of the Aggrecan G3 Domain Activates Complement , 2012, PloS one.
[119] A. Silman,et al. Mapping pathogenesis of arthritis through small animal models. , 2012, Rheumatology.
[120] David B. Burr,et al. Bone remodelling in osteoarthritis , 2012, Nature Reviews Rheumatology.
[121] M. Hirata,et al. A novel disease-modifying osteoarthritis drug candidate targeting Runx1 , 2012, Annals of the rheumatic diseases.
[122] Ruth Nussinov,et al. Structure and dynamics of molecular networks: A novel paradigm of drug discovery. A comprehensive review , 2012, Pharmacology & therapeutics.
[123] W. B. van den Berg,et al. Enhanced suppressor of cytokine signaling 3 in arthritic cartilage dysregulates human chondrocyte function. , 2012, Arthritis and rheumatism.
[124] A. Hofman,et al. Gremlin 1, frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis. , 2012, Arthritis and rheumatism.
[125] J. Timmons,et al. Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis. , 2012, Arthritis and rheumatism.
[126] E. Williams,et al. High resolution micro arthrography of hard and soft tissues in a murine model. , 2012, Osteoarthritis and cartilage.
[127] F. Blanco,et al. Mitochondrial dysfunction increases inflammatory responsiveness to cytokines in normal human chondrocytes. , 2012, Arthritis and rheumatism.
[128] Frances M D Henson,et al. The effect of recombinant human fibroblast growth factor‐18 on articular cartilage following single impact load , 2012, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
[129] J. Chun,et al. Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice. , 2012, Arthritis and rheumatism.
[130] Bin Wang,et al. Elevated cross-talk between subchondral bone and cartilage in osteoarthritic joints. , 2012, Bone.
[131] Jos W. M. van der Meer,et al. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases , 2012, Nature Reviews Drug Discovery.
[132] S. Goldring,et al. The role of synovitis in osteoarthritis pathogenesis. , 2012, Bone.
[133] D. Walsh,et al. Osteochondral alterations in osteoarthritis. , 2012, Bone.
[134] Gunwoo Kim,et al. Transforming growth factor alpha controls the transition from hypertrophic cartilage to bone during endochondral bone growth. , 2012, Bone.
[135] R. Terkeltaub,et al. The growing array of innate inflammatory ignition switches in osteoarthritis. , 2012, Arthritis and rheumatism.
[136] T. Glant,et al. Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to toll-like receptor 4 and toll-like receptor 2 ligands via soluble CD14. , 2012, Arthritis and rheumatism.
[137] N. Oreiro,et al. Differential protein profiling of synovial fluid from rheumatoid arthritis and osteoarthritis patients using LC-MALDI TOF/TOF. , 2012, Journal of proteomics.
[138] S. Goldring,et al. Osteoarthritis: a disease of the joint as an organ. , 2012, Arthritis and rheumatism.
[139] T. Matsushita,et al. Autophagy modulates osteoarthritis-related gene expression in human chondrocytes. , 2012, Arthritis and rheumatism.
[140] L. Duong,et al. Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis. , 2012, Bone.
[141] D. Iliopoulos,et al. Central Role of SREBP-2 in the Pathogenesis of Osteoarthritis , 2012, PloS one.
[142] Charles E McCulloch,et al. Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis. , 2012, Arthritis and rheumatism.
[143] F. Dell’Accio,et al. Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice , 2012, Annals of the rheumatic diseases.
[144] A. Salminen,et al. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network , 2012, Ageing Research Reviews.
[145] M. Lotz,et al. Autophagy: a new therapeutic target in cartilage injury and osteoarthritis. , 2012, The Journal of the American Academy of Orthopaedic Surgeons.
[146] Robert Clarke,et al. Guidelines for the use and interpretation of assays for monitoring autophagy , 2012 .
[147] D. D’Lima,et al. Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection. , 2012, Arthritis and rheumatism.
[148] J. Takahashi,et al. Regulation of Circadian Behavior and Metabolism by Synthetic REV-ERB Agonists , 2012, Nature.
[149] R. Brophy,et al. Molecular analysis of age and sex-related gene expression in meniscal tears with and without a concomitant anterior cruciate ligament tear. , 2012, The Journal of bone and joint surgery. American volume.
[150] P. D. Kraan,et al. Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration? , 2012 .
[151] Kozo Nakamura,et al. C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes. , 2012, Human molecular genetics.
[152] Cristina Ruiz-Romero,et al. Osteoarthritis: Metabolomic characterization of metabolic phenotypes in OA , 2012, Nature Reviews Rheumatology.
[153] A. Ekici,et al. Molecular differentiation between osteophytic and articular cartilage--clues for a transient and permanent chondrocyte phenotype. , 2012, Osteoarthritis and cartilage.
[154] M. Goldring,et al. Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis. , 2012, Trends in molecular medicine.
[155] A. Blom,et al. Serum COMP-C3b complexes in rheumatic diseases and relation to anti-TNF-α treatment , 2012, Arthritis Research & Therapy.
[156] C. Sanchez,et al. Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice , 2012, Annals of the rheumatic diseases.
[157] Wolfgang Baum,et al. Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis , 2012, Annals of the rheumatic diseases.
[158] L. Sandell. Etiology of osteoarthritis: genetics and synovial joint development , 2012, Nature Reviews Rheumatology.
[159] A. Cuervo,et al. Autophagy and disease: always two sides to a problem , 2012, The Journal of pathology.
[160] Ko Hashimoto,et al. E74-like Factor 3 (ELF3) Impacts on Matrix Metalloproteinase 13 (MMP13) Transcriptional Control in Articular Chondrocytes under Proinflammatory Stress* , 2011, The Journal of Biological Chemistry.
[161] Frank Beier,et al. Emerging Frontiers in cartilage and chondrocyte biology. , 2011, Best practice & research. Clinical rheumatology.
[162] A. Palou,et al. Molecular players at the intersection of obesity and osteoarthritis. , 2011, Current drug targets.
[163] M. Lotz,et al. Autophagy activation by rapamycin reduces severity of experimental osteoarthritis , 2011, Annals of the rheumatic diseases.
[164] Xianrong Zhang,et al. The Critical Role of the Epidermal Growth Factor Receptor in Endochondral Ossification , 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[165] T. Wyss-Coray,et al. Identification of a central role for complement in osteoarthritis , 2011, Nature Medicine.
[166] N. Oreiro,et al. Identification of a panel of novel serum osteoarthritis biomarkers. , 2011, Journal of proteome research.
[167] E. Schwarz,et al. Teriparatide as a Chondroregenerative Therapy for Injury-Induced Osteoarthritis , 2011, Science Translational Medicine.
[168] Harrie Weinans,et al. Osteoarthritis induction leads to early and temporal subchondral plate porosity in the tibial plateau of mice: an in vivo microfocal computed tomography study. , 2011, Arthritis and rheumatism.
[169] R. Shaw,et al. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism , 2011, Nature Cell Biology.
[170] D. Hunter,et al. Emerging drugs for osteoarthritis , 2011, Expert opinion on emerging drugs.
[171] K. Mikecz,et al. Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes , 2011, Arthritis research & therapy.
[172] M. Lotz,et al. Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA , 2011, Nature Reviews Rheumatology.
[173] P. Sambrook,et al. Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis. , 2011, Osteoarthritis and cartilage.
[174] R. Terkeltaub,et al. Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α. , 2011, Arthritis and rheumatism.
[175] F. Berenbaum,et al. Osteoarthritis: an update with relevance for clinical practice , 2011, The Lancet.
[176] Takashi Nakamura,et al. Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways , 2011, Development.
[177] H. Roach,et al. Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis. , 2011, Biochemical and biophysical research communications.
[178] F. Blanco,et al. The role of mitochondria in osteoarthritis , 2011, Nature Reviews Rheumatology.
[179] H. Roach,et al. Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis. , 2011, European cells & materials.
[180] J. Katz,et al. Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms. , 2011, Arthritis and rheumatism.
[181] D. Hunter,et al. Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis , 2010, BMC musculoskeletal disorders.
[182] Kozo Nakamura,et al. Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development , 2010, Nature Medicine.
[183] Jonghwan Kim,et al. Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction , 2010, Nature Medicine.
[184] R. Loeser,et al. Biology and pathology of Rho GTPase, PI‐3 kinase‐Akt, and MAP kinase signaling pathways in chondrocytes , 2010, Journal of cellular biochemistry.
[185] M. Goldring,et al. NF-kappaB signaling: multiple angles to target OA. , 2010, Current drug targets.
[186] B. Alman,et al. Modulating hedgehog signaling can attenuate the severity of osteoarthritis , 2009, Nature Medicine.
[187] Baltazar D. Aguda,et al. Biomechanical Thresholds Regulate Inflammation through the NF-κB Pathway: Experiments and Modeling , 2009, PloS one.
[188] Peter J Millett,et al. High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis , 2007, Arthritis research & therapy.
[189] R. Terkeltaub,et al. Emerging regulators of the inflammatory process in osteoarthritis , 2015, Nature Reviews Rheumatology.
[190] Neil,et al. Green Tea Polyphenol Treatment Is Chondroprotective, Anti-inflammatory And Palliative In A Mouse Post-traumatic Osteoarthritis Model , 2015 .
[191] P. M. van der Kraan. Age-related alterations in TGF beta signaling as a causal factor of cartilage degeneration in osteoarthritis. , 2014, Bio-medical materials and engineering.
[192] P. D. Kraan. Age-related alterations in TGF beta signaling as a causal factor of cartilage degeneration in osteoarthritis , 2014 .
[193] M. McBurney,et al. Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model. , 2013, Arthritis and rheumatism.
[194] F. Berenbaum,et al. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). , 2013, Osteoarthritis and cartilage.
[195] N. Oreiro,et al. Mitochondrial genetics and osteoarthritis. , 2013, Frontiers in bioscience.
[196] J. Bertrand,et al. Syndecans in cartilage breakdown and synovial inflammation , 2013, Nature Reviews Rheumatology.
[197] M. Dvir-Ginzberg,et al. Towards elucidating the role of SirT1 in osteoarthritis. , 2013, Frontiers in bioscience.
[198] 温春毅,et al. Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis , 2013 .
[199] W. B. van den Berg,et al. Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration? , 2012, Osteoarthritis and cartilage.