This case focuses on studying the effects of albumin and saline fluid evaluations by asking the question: What is the effect of fluid resuscitation with albumin or saline on outcomes in the intensive care unit (ICU)? This large, multicenter, prospective, randomized, double-blind trial failed to demonstrate a benefit of albumin vs. crystalloid solution for resuscitation in the ICU. These findings are consistent with other studies. Post hoc analyses from the SAFE Study have, however, suggested certain patient subgroups that may benefit from receiving saline over albumin (severe brain injury patients) and albumin over saline (severe sepsis patients). These findings require further validation, however.